Incidental Mutation 'IGL03008:Sertad2'
ID407685
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sertad2
Ensembl Gene ENSMUSG00000049800
Gene NameSERTA domain containing 2
SynonymsSei2, Trip-Br2, SEI-2
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.484) question?
Stock #IGL03008
Quality Score
Status
Chromosome11
Chromosomal Location20543253-20653021 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to T at 20647798 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105215 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093292] [ENSMUST00000109585] [ENSMUST00000109586]
Predicted Effect probably benign
Transcript: ENSMUST00000093292
SMART Domains Protein: ENSMUSP00000090981
Gene: ENSMUSG00000049800

DomainStartEndE-ValueType
Pfam:SERTA 40 77 1.6e-20 PFAM
low complexity region 89 99 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 226 248 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109585
SMART Domains Protein: ENSMUSP00000105214
Gene: ENSMUSG00000049800

DomainStartEndE-ValueType
Pfam:SERTA 40 77 5.3e-20 PFAM
low complexity region 89 99 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 226 248 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109586
SMART Domains Protein: ENSMUSP00000105215
Gene: ENSMUSG00000049800

DomainStartEndE-ValueType
Pfam:SERTA 40 77 5.3e-20 PFAM
low complexity region 89 99 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 226 248 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit enhanced lipolysis, thermogenesis, and oxidative metabolism with resistance to diet induced obesity and steatosis and improved when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830010M20Rik T G 5: 107,491,598 probably null Het
AF529169 A G 9: 89,596,678 Y772H probably damaging Het
Aga T C 8: 53,511,826 S8P probably benign Het
Ankrd34c C T 9: 89,730,284 M1I probably null Het
Ankrd44 T C 1: 54,766,809 H146R probably damaging Het
Bst1 A G 5: 43,826,262 probably null Het
Cdh12 A T 15: 21,480,330 I211F probably damaging Het
Cenpj G T 14: 56,526,949 D1335E probably benign Het
Clpx G A 9: 65,322,775 V502I possibly damaging Het
Cntnap4 T C 8: 112,773,590 S505P probably benign Het
Cog2 T C 8: 124,535,392 probably benign Het
Cped1 A G 6: 22,233,602 Q819R probably benign Het
Cspg4 A G 9: 56,898,475 E2190G possibly damaging Het
Ctsa G A 2: 164,837,448 R359Q probably damaging Het
Cul9 A G 17: 46,502,697 probably benign Het
Dab1 G T 4: 104,727,580 V306F probably damaging Het
Dysf A G 6: 84,073,894 I438V probably benign Het
Eif4g3 G T 4: 138,120,388 G380W probably damaging Het
Exd1 T A 2: 119,520,381 K466N probably benign Het
Eya3 A C 4: 132,706,983 D325A probably damaging Het
Fmn1 A G 2: 113,365,100 T382A unknown Het
Fry T A 5: 150,345,556 D106E possibly damaging Het
Gm21957 T A 7: 125,219,561 noncoding transcript Het
Gm44511 A G 6: 128,784,096 probably benign Het
Gm884 T C 11: 103,620,467 E225G unknown Het
Itga4 A G 2: 79,325,638 I983V probably benign Het
Lrpprc A T 17: 84,751,247 D5E probably benign Het
Ltbp4 G T 7: 27,324,364 N747K probably damaging Het
Mlh3 T C 12: 85,240,851 Q1308R probably benign Het
Mtfr2 T A 10: 20,353,439 C63S possibly damaging Het
Myh11 T A 16: 14,204,753 M1661L probably benign Het
Myo1c T C 11: 75,658,414 M137T probably benign Het
Myocd A C 11: 65,187,566 L340V probably damaging Het
Napsa A T 7: 44,585,796 Q335L possibly damaging Het
Nlrp4b C A 7: 10,714,589 Q240K probably benign Het
Npepps A C 11: 97,238,158 F400C probably damaging Het
Nxpe4 A T 9: 48,393,438 E275V probably benign Het
Ofd1 T C X: 166,409,534 D501G probably benign Het
Olfr1310 A G 2: 112,008,523 I221T possibly damaging Het
Olfr228 A T 2: 86,483,334 M136K probably damaging Het
Olfr507 T G 7: 108,622,283 L157R probably damaging Het
Olfr525 T C 7: 140,323,532 Y278H probably damaging Het
P2ry1 A T 3: 61,003,526 T29S probably benign Het
Papss1 T C 3: 131,585,099 V201A possibly damaging Het
Paxip1 A G 5: 27,752,766 V864A probably benign Het
Pcdhgc5 T A 18: 37,821,834 H720Q probably benign Het
Pdxdc1 T C 16: 13,876,159 N133S possibly damaging Het
Prkar1a T C 11: 109,653,864 I27T probably damaging Het
Rnf10 G T 5: 115,251,296 H271N possibly damaging Het
Scn9a A G 2: 66,562,511 S246P probably damaging Het
Slc22a27 A G 19: 7,909,702 I274T possibly damaging Het
Slc22a5 A T 11: 53,891,232 V103E probably damaging Het
Slc5a9 A T 4: 111,890,941 F225I probably benign Het
Slc6a3 G A 13: 73,558,285 probably null Het
Smcr8 A G 11: 60,778,461 E145G probably damaging Het
Spen A T 4: 141,476,137 D1726E possibly damaging Het
Sphkap A T 1: 83,276,831 S779T probably damaging Het
Stag1 A T 9: 100,776,791 N144Y probably damaging Het
Strada T C 11: 106,170,957 H156R probably damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tas2r138 A C 6: 40,613,182 D43E probably damaging Het
Tdpoz3 A T 3: 93,826,335 K106* probably null Het
Trbv13-1 A G 6: 41,116,295 D54G probably damaging Het
Ttc39b A G 4: 83,247,695 V218A probably benign Het
Ttn G A 2: 76,780,859 T15697I probably damaging Het
Ugt2b38 G A 5: 87,412,423 T344I probably benign Het
Vmn2r94 T C 17: 18,257,646 M168V probably benign Het
Wdr11 T C 7: 129,606,991 probably benign Het
Wipf2 T C 11: 98,892,728 probably benign Het
Zranb2 T A 3: 157,546,665 probably null Het
Other mutations in Sertad2
AlleleSourceChrCoordTypePredicted EffectPPH Score
wisteria UTSW 11 20648664 frame shift probably null
PIT4366001:Sertad2 UTSW 11 20648116 missense probably benign 0.03
R1171:Sertad2 UTSW 11 20648091 missense probably benign 0.01
R1306:Sertad2 UTSW 11 20648388 missense probably benign
R3834:Sertad2 UTSW 11 20648482 missense probably benign 0.15
R4087:Sertad2 UTSW 11 20648664 frame shift probably null
R4940:Sertad2 UTSW 11 20647899 missense possibly damaging 0.52
R5232:Sertad2 UTSW 11 20648344 missense possibly damaging 0.72
R5621:Sertad2 UTSW 11 20648061 missense possibly damaging 0.61
R5891:Sertad2 UTSW 11 20647884 missense probably benign 0.30
R5956:Sertad2 UTSW 11 20647884 missense probably benign 0.30
R6006:Sertad2 UTSW 11 20647884 missense probably benign 0.30
R6007:Sertad2 UTSW 11 20647884 missense probably benign 0.30
R6048:Sertad2 UTSW 11 20648436 missense probably benign
Posted On2016-08-02