Incidental Mutation 'IGL03009:Olfr613'
ID407687
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr613
Ensembl Gene ENSMUSG00000078624
Gene Nameolfactory receptor 613
SynonymsMOR20-1, Olfr614, GA_x6K02T2PBJ9-6271959-6272393, GA_x6K02T2PBJ9-6275524-6276477, MOR20-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL03009
Quality Score
Status
Chromosome7
Chromosomal Location103548074-103555506 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 103552527 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 247 (C247*)
Ref Sequence ENSEMBL: ENSMUSP00000149332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106888] [ENSMUST00000214173] [ENSMUST00000214345] [ENSMUST00000215673]
Predicted Effect probably null
Transcript: ENSMUST00000106888
AA Change: C247*
SMART Domains Protein: ENSMUSP00000102501
Gene: ENSMUSG00000078624
AA Change: C247*

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 1.1e-99 PFAM
Pfam:7tm_1 42 293 5.6e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214173
AA Change: C247*
Predicted Effect probably benign
Transcript: ENSMUST00000214345
Predicted Effect probably benign
Transcript: ENSMUST00000215673
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adsl C A 15: 80,952,243 S67* probably null Het
Arrdc4 A G 7: 68,739,493 V411A probably damaging Het
Cnnm2 A G 19: 46,877,355 Y794C probably damaging Het
Flt4 G T 11: 49,627,124 K330N probably benign Het
Foxs1 T C 2: 152,932,929 H68R probably damaging Het
Gm21969 C T 4: 139,607,654 S333L probably damaging Het
Gm7008 T A 12: 40,223,547 probably benign Het
Gmppa A G 1: 75,439,370 Y137C probably damaging Het
Grwd1 A G 7: 45,827,137 probably benign Het
Kdm5a C T 6: 120,430,086 R1421W probably damaging Het
Myo5b A G 18: 74,760,968 T1749A possibly damaging Het
Neb A G 2: 52,179,456 probably benign Het
Ntng1 T C 3: 109,934,702 K252E possibly damaging Het
Nup133 A G 8: 123,933,500 I353T possibly damaging Het
Osbpl11 T C 16: 33,241,730 probably benign Het
Pcsk9 C T 4: 106,454,345 G230S probably damaging Het
Polr1b A G 2: 129,126,068 N1127S probably damaging Het
Rasgrf1 A T 9: 89,991,703 K688N possibly damaging Het
Rhot1 A G 11: 80,220,254 probably null Het
Rims2 A T 15: 39,566,997 Q1159L possibly damaging Het
Ros1 T C 10: 52,145,907 I594V probably benign Het
Slc43a2 G A 11: 75,572,376 C536Y probably benign Het
Stip1 A T 19: 7,021,121 V537E probably damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Vav1 A T 17: 57,296,582 T94S probably benign Het
Zfr A T 15: 12,162,235 I824F probably damaging Het
Other mutations in Olfr613
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00937:Olfr613 APN 7 103551857 missense probably damaging 0.99
R0047:Olfr613 UTSW 7 103552322 missense probably damaging 1.00
R0047:Olfr613 UTSW 7 103552322 missense probably damaging 1.00
R1559:Olfr613 UTSW 7 103552165 missense possibly damaging 0.82
R2247:Olfr613 UTSW 7 103551890 unclassified probably null
R4622:Olfr613 UTSW 7 103552154 missense probably benign 0.00
R4674:Olfr613 UTSW 7 103551976 missense probably damaging 1.00
R4675:Olfr613 UTSW 7 103551976 missense probably damaging 1.00
R5101:Olfr613 UTSW 7 103551943 missense probably damaging 1.00
R6396:Olfr613 UTSW 7 103552681 nonsense probably null
R6860:Olfr613 UTSW 7 103551868 missense probably benign
R7310:Olfr613 UTSW 7 103552685 missense probably damaging 1.00
R7318:Olfr613 UTSW 7 103552091 missense probably damaging 0.98
Posted On2016-08-02