Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03010:Vmn2r113'

407727

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r113

Ensembl Gene

ENSMUSG00000092111

Gene Name

vomeronasal 2, receptor 113

Synonyms

EG434701

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

IGL03010

Quality Score

Status

Chromosome

Chromosomal Location

23162158-23177788 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23175038 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 550 (T550A)

Ref Sequence

ENSEMBL: ENSMUSP00000127981 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170322]

AlphaFold

E9PZA6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170322
AA Change: T550A

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000127981
Gene: ENSMUSG00000092111
AA Change: T550A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	146	470	9e-26	PFAM
Pfam:NCD3G	512	564	5.1e-21	PFAM
Pfam:7tm_3	595	832	5.7e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1b	A	G	15: 101,100,959 (GRCm39)	R374G	probably damaging	Het
Adamts4	T	C	1: 171,078,985 (GRCm39)	C202R	probably damaging	Het
Afap1l1	T	C	18: 61,876,390 (GRCm39)	D409G	probably benign	Het
Atp6v1b2	T	C	8: 69,558,534 (GRCm39)	I334T	probably damaging	Het
Btn2a2	A	T	13: 23,670,375 (GRCm39)	Y119*	probably null	Het
Cct2	T	C	10: 116,894,019 (GRCm39)	D245G	probably damaging	Het
Ercc2	A	G	7: 19,125,491 (GRCm39)	K486E	possibly damaging	Het
Fam186b	T	C	15: 99,178,508 (GRCm39)	S273G	possibly damaging	Het
Fbxw24	T	A	9: 109,452,678 (GRCm39)	I106L	probably benign	Het
Ghrhr	T	C	6: 55,361,742 (GRCm39)	I303T	probably damaging	Het
Habp2	T	C	19: 56,299,655 (GRCm39)		probably null	Het
Haus3	T	A	5: 34,323,631 (GRCm39)	E326D	probably benign	Het
Hdac7	C	T	15: 97,691,810 (GRCm39)		probably null	Het
Hectd2	T	A	19: 36,593,002 (GRCm39)	D722E	probably benign	Het
Il20ra	G	T	10: 19,624,960 (GRCm39)	G80W	probably damaging	Het
Jag1	T	C	2: 136,935,118 (GRCm39)		probably benign	Het
Lrp1b	A	G	2: 42,213,618 (GRCm39)	S65P	possibly damaging	Het
Lypd2	A	G	15: 74,606,102 (GRCm39)	I12T	probably benign	Het
Nat2	T	A	8: 67,954,664 (GRCm39)	L258Q	probably damaging	Het
Nwd1	T	C	8: 73,414,688 (GRCm39)		probably benign	Het
Or2y1b	T	A	11: 49,208,973 (GRCm39)	V200E	probably damaging	Het
Or5ac24	A	G	16: 59,165,135 (GRCm39)		probably benign	Het
Or6c3	G	T	10: 129,308,843 (GRCm39)	C94F	probably damaging	Het
Pcdh15	T	A	10: 74,221,777 (GRCm39)	D692E	probably damaging	Het
Prkcz	G	T	4: 155,371,262 (GRCm39)	H134N	probably damaging	Het
Prmt8	T	C	6: 127,706,498 (GRCm39)	T98A	probably benign	Het
Rps6kc1	C	A	1: 190,643,803 (GRCm39)	E19*	probably null	Het
Rrp8	A	G	7: 105,383,598 (GRCm39)	S223P	probably benign	Het
Septin10	G	A	10: 59,006,777 (GRCm39)		probably benign	Het
Serpinb7	T	C	1: 107,379,741 (GRCm39)		probably benign	Het
Spaca6	C	A	17: 18,058,667 (GRCm39)	Q72K	probably benign	Het
Spag1	A	G	15: 36,233,419 (GRCm39)	H712R	probably benign	Het
Spg11	C	A	2: 121,918,801 (GRCm39)	A943S	probably damaging	Het
Tmem104	T	C	11: 115,134,360 (GRCm39)	S298P	probably benign	Het
Ttn	A	G	2: 76,565,432 (GRCm39)	I28265T	probably damaging	Het
Usp33	G	T	3: 152,074,233 (GRCm39)	V360F	probably benign	Het
Zscan4d	A	T	7: 10,897,070 (GRCm39)	V128D	probably damaging	Het

Other mutations in Vmn2r113

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Vmn2r113	APN	17	23,177,309 (GRCm39)	missense	probably benign	0.01
IGL01386:Vmn2r113	APN	17	23,175,024 (GRCm39)	missense	possibly damaging	0.94
IGL01743:Vmn2r113	APN	17	23,177,285 (GRCm39)	missense	probably benign	0.03
IGL02224:Vmn2r113	APN	17	23,174,960 (GRCm39)	nonsense	probably null
IGL02498:Vmn2r113	APN	17	23,177,349 (GRCm39)	missense	probably damaging	0.99
IGL02969:Vmn2r113	APN	17	23,177,591 (GRCm39)	missense	probably benign	0.13
IGL03240:Vmn2r113	APN	17	23,174,931 (GRCm39)	missense	probably benign	0.19
R1853:Vmn2r113	UTSW	17	23,164,501 (GRCm39)	missense	probably benign
R2058:Vmn2r113	UTSW	17	23,177,223 (GRCm39)	nonsense	probably null
R3010:Vmn2r113	UTSW	17	23,177,105 (GRCm39)	missense	probably damaging	0.97
R4942:Vmn2r113	UTSW	17	23,177,321 (GRCm39)	missense	probably damaging	0.97
R5072:Vmn2r113	UTSW	17	23,177,329 (GRCm39)	nonsense	probably null
R5755:Vmn2r113	UTSW	17	23,176,955 (GRCm39)	missense	probably benign	0.00
R6513:Vmn2r113	UTSW	17	23,177,715 (GRCm39)	missense	probably damaging	0.99
R7164:Vmn2r113	UTSW	17	23,167,137 (GRCm39)	missense	probably benign
R7936:Vmn2r113	UTSW	17	23,176,917 (GRCm39)	missense	probably benign	0.05
R8087:Vmn2r113	UTSW	17	23,177,711 (GRCm39)	missense	possibly damaging	0.66
R8193:Vmn2r113	UTSW	17	23,164,501 (GRCm39)	missense	probably benign	0.06
R8196:Vmn2r113	UTSW	17	23,176,938 (GRCm39)	missense	probably damaging	0.99
R8414:Vmn2r113	UTSW	17	23,177,753 (GRCm39)	nonsense	probably null
R8490:Vmn2r113	UTSW	17	23,177,372 (GRCm39)	missense	probably benign	0.18

Posted On

2016-08-02