Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03012:Vmn1r78'

407815

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL03012

Quality Score

Status

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12153364 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 301 (S301T)

Ref Sequence

ENSEMBL: ENSMUSP00000154797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

Predicted Effect

probably benign
Transcript: ENSMUST00000078039
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: S301T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

probably benign
Transcript: ENSMUST00000228244
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000228664
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaa1b	A	C	9: 119,156,946	S17A	probably benign	Het
Acp1	T	G	12: 30,895,949	N135T	probably benign	Het
Adamts2	A	G	11: 50,776,269		probably benign	Het
Arfgef2	C	T	2: 166,868,888		probably benign	Het
Atp10b	T	A	11: 43,194,655	I287N	probably damaging	Het
Camta1	T	A	4: 151,453,299	K141N	probably damaging	Het
Carmil1	T	C	13: 24,036,372	D719G	probably benign	Het
Cntnap5c	T	A	17: 58,359,234	H1086Q	probably benign	Het
Dsg3	A	G	18: 20,537,243		probably null	Het
Emilin3	G	A	2: 160,908,729	Q320*	probably null	Het
G6pd2	A	G	5: 61,809,473	Y197C	probably damaging	Het
Il13ra1	G	T	X: 36,130,594		probably benign	Het
Ivl	G	A	3: 92,572,426	P111S	probably benign	Het
Kmt2a	T	C	9: 44,810,966		probably benign	Het
Lztr1	T	C	16: 17,521,484	S57P	possibly damaging	Het
Mtss1	T	G	15: 59,058,400	D32A	probably damaging	Het
Mylk	G	A	16: 34,952,781	D1250N	probably benign	Het
Ncln	A	G	10: 81,489,965	F349L	probably benign	Het
Pgap1	A	G	1: 54,533,413		probably benign	Het
Rarres2	T	C	6: 48,570,305	D107G	probably benign	Het
Ric3	T	C	7: 109,038,718	D276G	probably benign	Het
Trim54	A	G	5: 31,137,145	D339G	probably benign	Het
Trip11	G	A	12: 101,883,936	H1005Y	probably damaging	Het
Tulp4	G	T	17: 6,213,379		probably benign	Het
Unc93a	C	T	17: 13,109,608	E453K	probably benign	Het
Vmn1r181	A	T	7: 23,984,602	D164V	probably damaging	Het
Vmn1r85	T	C	7: 13,084,765	N151D	probably benign	Het
Wnk2	T	C	13: 49,044,389	K2008E	probably damaging	Het
Wrap73	A	G	4: 154,145,234		probably benign	Het
Zfp408	G	A	2: 91,647,808	A41V	probably benign	Het
Zfp472	A	G	17: 32,977,571	S207G	probably benign	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02154:Vmn1r78	APN	7	12152545	missense	probably benign	0.22
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03256:Vmn1r78	APN	7	12152798	missense	probably damaging	1.00
IGL03373:Vmn1r78	APN	7	12153343	missense	possibly damaging	0.86
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4330:Vmn1r78	UTSW	7	12152459	splice site	probably null
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4769:Vmn1r78	UTSW	7	12152798	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Posted On

2016-08-02