Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03012:Wrap73'

407823

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wrap73

Ensembl Gene

ENSMUSG00000029029

Gene Name

WD repeat containing, antisense to Trp73

Synonyms

DD57, 2610044M17Rik, Wdr8, 5330425N03Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.743) question?

Stock #

IGL03012

Quality Score

Status

Chromosome

Chromosomal Location

154226811-154241278 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 154229691 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000030895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030895]

AlphaFold

Q9JM98

Predicted Effect

probably benign
Transcript: ENSMUST00000030895

SMART Domains

Protein: ENSMUSP00000030895
Gene: ENSMUSG00000029029

Domain	Start	End	E-Value	Type
Blast:WD40	38	77	4e-18	BLAST
Blast:WD40	81	120	6e-16	BLAST
Blast:WD40	125	163	9e-6	BLAST
WD40	167	208	2.28e2	SMART
WD40	215	251	1.58e-2	SMART
WD40	319	360	2.29e1	SMART
WD40	363	401	4.18e-2	SMART
Blast:WD40	402	443	2e-19	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142665

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaa1b	A	C	9: 118,986,014 (GRCm39)	S17A	probably benign	Het
Acp1	T	G	12: 30,945,948 (GRCm39)	N135T	probably benign	Het
Adamts2	A	G	11: 50,667,096 (GRCm39)		probably benign	Het
Arfgef2	C	T	2: 166,710,808 (GRCm39)		probably benign	Het
Atp10b	T	A	11: 43,085,482 (GRCm39)	I287N	probably damaging	Het
Camta1	T	A	4: 151,537,756 (GRCm39)	K141N	probably damaging	Het
Carmil1	T	C	13: 24,220,355 (GRCm39)	D719G	probably benign	Het
Cntnap5c	T	A	17: 58,666,229 (GRCm39)	H1086Q	probably benign	Het
Dsg3	A	G	18: 20,670,300 (GRCm39)		probably null	Het
Emilin3	G	A	2: 160,750,649 (GRCm39)	Q320*	probably null	Het
G6pd2	A	G	5: 61,966,816 (GRCm39)	Y197C	probably damaging	Het
Il13ra1	G	T	X: 35,394,247 (GRCm39)		probably benign	Het
Ivl	G	A	3: 92,479,733 (GRCm39)	P111S	probably benign	Het
Kmt2a	T	C	9: 44,722,263 (GRCm39)		probably benign	Het
Lztr1	T	C	16: 17,339,348 (GRCm39)	S57P	possibly damaging	Het
Mtss1	T	G	15: 58,930,249 (GRCm39)	D32A	probably damaging	Het
Mylk	G	A	16: 34,773,151 (GRCm39)	D1250N	probably benign	Het
Ncln	A	G	10: 81,325,799 (GRCm39)	F349L	probably benign	Het
Pgap1	A	G	1: 54,572,572 (GRCm39)		probably benign	Het
Rarres2	T	C	6: 48,547,239 (GRCm39)	D107G	probably benign	Het
Ric3	T	C	7: 108,637,925 (GRCm39)	D276G	probably benign	Het
Trim54	A	G	5: 31,294,489 (GRCm39)	D339G	probably benign	Het
Trip11	G	A	12: 101,850,195 (GRCm39)	H1005Y	probably damaging	Het
Tulp4	G	T	17: 6,263,654 (GRCm39)		probably benign	Het
Unc93a	C	T	17: 13,328,495 (GRCm39)	E453K	probably benign	Het
Vmn1r181	A	T	7: 23,684,027 (GRCm39)	D164V	probably damaging	Het
Vmn1r78	T	A	7: 11,887,291 (GRCm39)	S301T	probably benign	Het
Vmn1r85	T	C	7: 12,818,692 (GRCm39)	N151D	probably benign	Het
Wnk2	T	C	13: 49,197,865 (GRCm39)	K2008E	probably damaging	Het
Zfp408	G	A	2: 91,478,153 (GRCm39)	A41V	probably benign	Het
Zfp472	A	G	17: 33,196,545 (GRCm39)	S207G	probably benign	Het

Other mutations in Wrap73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Wrap73	APN	4	154,237,096 (GRCm39)	missense	probably damaging	0.99
IGL01562:Wrap73	APN	4	154,229,794 (GRCm39)	missense	possibly damaging	0.63
IGL01863:Wrap73	APN	4	154,229,790 (GRCm39)	missense	probably benign	0.02
IGL02342:Wrap73	APN	4	154,233,237 (GRCm39)	missense	probably benign	0.36
IGL03303:Wrap73	APN	4	154,231,000 (GRCm39)	missense	probably damaging	0.98
R0128:Wrap73	UTSW	4	154,226,957 (GRCm39)	missense	possibly damaging	0.81
R0455:Wrap73	UTSW	4	154,233,200 (GRCm39)	missense	possibly damaging	0.63
R0524:Wrap73	UTSW	4	154,229,764 (GRCm39)	missense	probably damaging	1.00
R0528:Wrap73	UTSW	4	154,229,776 (GRCm39)	missense	probably damaging	1.00
R0533:Wrap73	UTSW	4	154,240,611 (GRCm39)	missense	possibly damaging	0.91
R0533:Wrap73	UTSW	4	154,236,106 (GRCm39)	missense	probably damaging	1.00
R0633:Wrap73	UTSW	4	154,226,948 (GRCm39)	missense	probably damaging	0.98
R1118:Wrap73	UTSW	4	154,236,884 (GRCm39)	splice site	probably null
R1669:Wrap73	UTSW	4	154,240,588 (GRCm39)	missense	probably damaging	0.99
R1725:Wrap73	UTSW	4	154,233,209 (GRCm39)	missense	possibly damaging	0.73
R2070:Wrap73	UTSW	4	154,233,200 (GRCm39)	missense	possibly damaging	0.63
R4530:Wrap73	UTSW	4	154,241,164 (GRCm39)	unclassified	probably benign
R4669:Wrap73	UTSW	4	154,236,153 (GRCm39)	missense	probably benign	0.26
R4969:Wrap73	UTSW	4	154,237,138 (GRCm39)	missense	probably damaging	1.00
R5254:Wrap73	UTSW	4	154,239,803 (GRCm39)	missense	probably benign	0.00
R5334:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5428:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5431:Wrap73	UTSW	4	154,229,731 (GRCm39)	missense	probably damaging	0.97
R5728:Wrap73	UTSW	4	154,239,099 (GRCm39)	critical splice donor site	probably null
R7338:Wrap73	UTSW	4	154,237,043 (GRCm39)	missense	probably benign	0.26
R7426:Wrap73	UTSW	4	154,240,584 (GRCm39)	missense	probably damaging	1.00
R7480:Wrap73	UTSW	4	154,237,043 (GRCm39)	missense	probably benign	0.26
R7680:Wrap73	UTSW	4	154,241,079 (GRCm39)	missense	probably benign	0.20

Posted On

2016-08-02