Incidental Mutation 'IGL03013:Leng9'
ID |
407841 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Leng9
|
Ensembl Gene |
ENSMUSG00000043432 |
Gene Name |
leukocyte receptor cluster (LRC) member 9 |
Synonyms |
9530024C23Rik, F630035L11Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.062)
|
Stock # |
IGL03013
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
4151182-4152871 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 4151737 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Alanine
at position 313
(V313A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000061079
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037472]
[ENSMUST00000058358]
[ENSMUST00000076831]
[ENSMUST00000121270]
[ENSMUST00000140410]
[ENSMUST00000143825]
|
AlphaFold |
Q8BTN6 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000037472
|
SMART Domains |
Protein: ENSMUSP00000046465 Gene: ENSMUSG00000035545
Domain | Start | End | E-Value | Type |
low complexity region
|
47 |
69 |
N/A |
INTRINSIC |
low complexity region
|
73 |
118 |
N/A |
INTRINSIC |
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
low complexity region
|
413 |
447 |
N/A |
INTRINSIC |
low complexity region
|
453 |
468 |
N/A |
INTRINSIC |
Pfam:SAC3_GANP
|
567 |
762 |
8.2e-66 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000058358
AA Change: V313A
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000061079 Gene: ENSMUSG00000043432 AA Change: V313A
Domain | Start | End | E-Value | Type |
ZnF_C3H1
|
8 |
34 |
1.72e-4 |
SMART |
Pfam:DUF504
|
77 |
128 |
1.9e-11 |
PFAM |
Pfam:AKAP7_NLS
|
305 |
484 |
2.5e-24 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000076831
|
SMART Domains |
Protein: ENSMUSP00000092508 Gene: ENSMUSG00000063838
Domain | Start | End | E-Value | Type |
PBD
|
23 |
57 |
5.86e-6 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121270
|
SMART Domains |
Protein: ENSMUSP00000112428 Gene: ENSMUSG00000035545
Domain | Start | End | E-Value | Type |
low complexity region
|
47 |
69 |
N/A |
INTRINSIC |
low complexity region
|
73 |
118 |
N/A |
INTRINSIC |
low complexity region
|
156 |
174 |
N/A |
INTRINSIC |
low complexity region
|
383 |
396 |
N/A |
INTRINSIC |
low complexity region
|
413 |
447 |
N/A |
INTRINSIC |
low complexity region
|
453 |
468 |
N/A |
INTRINSIC |
Pfam:SAC3_GANP
|
567 |
764 |
7.4e-67 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127723
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000140410
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146434
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000143825
|
SMART Domains |
Protein: ENSMUSP00000117257 Gene: ENSMUSG00000063838
Domain | Start | End | E-Value | Type |
PBD
|
23 |
57 |
5.86e-6 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acvr1b |
A |
G |
15: 101,100,959 (GRCm39) |
R374G |
probably damaging |
Het |
B3galt6 |
G |
A |
4: 156,076,215 (GRCm39) |
Q287* |
probably null |
Het |
C2 |
A |
G |
17: 35,091,435 (GRCm39) |
V353A |
probably damaging |
Het |
Cntnap2 |
A |
T |
6: 47,072,483 (GRCm39) |
Y1017F |
possibly damaging |
Het |
Copz1 |
T |
A |
15: 103,204,995 (GRCm39) |
M118K |
probably benign |
Het |
Dnm1 |
T |
C |
2: 32,226,296 (GRCm39) |
N298D |
probably benign |
Het |
Exog |
T |
C |
9: 119,291,679 (GRCm39) |
S295P |
possibly damaging |
Het |
Ext2 |
A |
T |
2: 93,537,571 (GRCm39) |
|
probably benign |
Het |
Garin5b |
A |
G |
7: 4,761,632 (GRCm39) |
L360S |
probably benign |
Het |
Gpatch8 |
T |
C |
11: 102,399,023 (GRCm39) |
I70V |
unknown |
Het |
Krt5 |
T |
A |
15: 101,620,103 (GRCm39) |
I205L |
probably benign |
Het |
Macrod2 |
A |
G |
2: 141,357,147 (GRCm39) |
I148V |
probably benign |
Het |
Mapk14 |
G |
T |
17: 28,947,323 (GRCm39) |
|
probably benign |
Het |
Mfsd4b3-ps |
A |
T |
10: 39,823,891 (GRCm39) |
M123K |
probably benign |
Het |
Mmp8 |
A |
G |
9: 7,561,690 (GRCm39) |
D205G |
probably benign |
Het |
Muc5b |
A |
T |
7: 141,417,665 (GRCm39) |
H3537L |
possibly damaging |
Het |
Nde1 |
C |
T |
16: 14,009,611 (GRCm39) |
P324L |
probably benign |
Het |
Nlrp9b |
A |
T |
7: 19,782,750 (GRCm39) |
H888L |
probably damaging |
Het |
Npy2r |
A |
G |
3: 82,447,819 (GRCm39) |
F319L |
probably damaging |
Het |
Nup210 |
A |
G |
6: 91,030,361 (GRCm39) |
V156A |
probably benign |
Het |
Nxph2 |
T |
C |
2: 23,289,945 (GRCm39) |
I99T |
probably benign |
Het |
Parpbp |
A |
G |
10: 87,975,840 (GRCm39) |
I91T |
probably damaging |
Het |
Pld2 |
A |
G |
11: 70,432,003 (GRCm39) |
Y75C |
probably damaging |
Het |
Pramel12 |
A |
G |
4: 143,144,037 (GRCm39) |
T128A |
possibly damaging |
Het |
Pramel33 |
A |
T |
5: 93,630,391 (GRCm39) |
S394T |
probably damaging |
Het |
Prkcb |
C |
A |
7: 122,226,905 (GRCm39) |
D630E |
probably damaging |
Het |
Prl3c1 |
T |
C |
13: 27,383,349 (GRCm39) |
V5A |
probably benign |
Het |
Ro60 |
A |
G |
1: 143,646,446 (GRCm39) |
S100P |
probably damaging |
Het |
Sdcbp2 |
A |
G |
2: 151,429,255 (GRCm39) |
T192A |
probably benign |
Het |
Sema6a |
C |
T |
18: 47,381,461 (GRCm39) |
A1046T |
probably benign |
Het |
Serpinb3a |
A |
G |
1: 106,973,813 (GRCm39) |
F366S |
probably damaging |
Het |
Serpinb9d |
T |
A |
13: 33,380,521 (GRCm39) |
W136R |
probably damaging |
Het |
Smc2 |
G |
T |
4: 52,442,280 (GRCm39) |
V66F |
probably damaging |
Het |
Speg |
A |
G |
1: 75,407,923 (GRCm39) |
D3206G |
probably damaging |
Het |
Syne2 |
C |
T |
12: 75,976,111 (GRCm39) |
A1187V |
probably benign |
Het |
Unc5cl |
G |
A |
17: 48,772,049 (GRCm39) |
M442I |
possibly damaging |
Het |
|
Other mutations in Leng9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01903:Leng9
|
APN |
7 |
4,151,746 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01970:Leng9
|
APN |
7 |
4,151,326 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02197:Leng9
|
APN |
7 |
4,151,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R1616:Leng9
|
UTSW |
7 |
4,151,902 (GRCm39) |
missense |
probably benign |
0.00 |
R2352:Leng9
|
UTSW |
7 |
4,152,409 (GRCm39) |
missense |
probably damaging |
1.00 |
R2419:Leng9
|
UTSW |
7 |
4,151,626 (GRCm39) |
missense |
probably benign |
0.32 |
R4156:Leng9
|
UTSW |
7 |
4,152,433 (GRCm39) |
missense |
possibly damaging |
0.70 |
R4832:Leng9
|
UTSW |
7 |
4,152,029 (GRCm39) |
missense |
probably damaging |
0.99 |
R4841:Leng9
|
UTSW |
7 |
4,152,385 (GRCm39) |
missense |
probably damaging |
1.00 |
R4842:Leng9
|
UTSW |
7 |
4,152,385 (GRCm39) |
missense |
probably damaging |
1.00 |
R7468:Leng9
|
UTSW |
7 |
4,151,800 (GRCm39) |
missense |
probably benign |
|
R7627:Leng9
|
UTSW |
7 |
4,151,617 (GRCm39) |
missense |
probably damaging |
1.00 |
R7679:Leng9
|
UTSW |
7 |
4,152,659 (GRCm39) |
missense |
probably benign |
0.11 |
R8885:Leng9
|
UTSW |
7 |
4,151,774 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8951:Leng9
|
UTSW |
7 |
4,152,782 (GRCm39) |
unclassified |
probably benign |
|
R9062:Leng9
|
UTSW |
7 |
4,151,666 (GRCm39) |
missense |
probably damaging |
1.00 |
R9140:Leng9
|
UTSW |
7 |
4,152,657 (GRCm39) |
missense |
probably benign |
|
R9275:Leng9
|
UTSW |
7 |
4,151,447 (GRCm39) |
missense |
probably benign |
0.02 |
R9418:Leng9
|
UTSW |
7 |
4,151,354 (GRCm39) |
missense |
probably benign |
0.01 |
R9582:Leng9
|
UTSW |
7 |
4,152,263 (GRCm39) |
missense |
probably damaging |
1.00 |
X0058:Leng9
|
UTSW |
7 |
4,152,382 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Posted On |
2016-08-02 |