Incidental Mutation 'IGL03013:Leng9'
ID 407841
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Leng9
Ensembl Gene ENSMUSG00000043432
Gene Name leukocyte receptor cluster (LRC) member 9
Synonyms 9530024C23Rik, F630035L11Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL03013
Quality Score
Status
Chromosome 7
Chromosomal Location 4151182-4152871 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4151737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 313 (V313A)
Ref Sequence ENSEMBL: ENSMUSP00000061079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037472] [ENSMUST00000058358] [ENSMUST00000076831] [ENSMUST00000121270] [ENSMUST00000140410] [ENSMUST00000143825]
AlphaFold Q8BTN6
Predicted Effect probably benign
Transcript: ENSMUST00000037472
SMART Domains Protein: ENSMUSP00000046465
Gene: ENSMUSG00000035545

DomainStartEndE-ValueType
low complexity region 47 69 N/A INTRINSIC
low complexity region 73 118 N/A INTRINSIC
low complexity region 156 174 N/A INTRINSIC
low complexity region 383 396 N/A INTRINSIC
low complexity region 413 447 N/A INTRINSIC
low complexity region 453 468 N/A INTRINSIC
Pfam:SAC3_GANP 567 762 8.2e-66 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000058358
AA Change: V313A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000061079
Gene: ENSMUSG00000043432
AA Change: V313A

DomainStartEndE-ValueType
ZnF_C3H1 8 34 1.72e-4 SMART
Pfam:DUF504 77 128 1.9e-11 PFAM
Pfam:AKAP7_NLS 305 484 2.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000076831
SMART Domains Protein: ENSMUSP00000092508
Gene: ENSMUSG00000063838

DomainStartEndE-ValueType
PBD 23 57 5.86e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121270
SMART Domains Protein: ENSMUSP00000112428
Gene: ENSMUSG00000035545

DomainStartEndE-ValueType
low complexity region 47 69 N/A INTRINSIC
low complexity region 73 118 N/A INTRINSIC
low complexity region 156 174 N/A INTRINSIC
low complexity region 383 396 N/A INTRINSIC
low complexity region 413 447 N/A INTRINSIC
low complexity region 453 468 N/A INTRINSIC
Pfam:SAC3_GANP 567 764 7.4e-67 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127723
Predicted Effect probably benign
Transcript: ENSMUST00000140410
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146434
Predicted Effect probably benign
Transcript: ENSMUST00000143825
SMART Domains Protein: ENSMUSP00000117257
Gene: ENSMUSG00000063838

DomainStartEndE-ValueType
PBD 23 57 5.86e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1b A G 15: 101,100,959 (GRCm39) R374G probably damaging Het
B3galt6 G A 4: 156,076,215 (GRCm39) Q287* probably null Het
C2 A G 17: 35,091,435 (GRCm39) V353A probably damaging Het
Cntnap2 A T 6: 47,072,483 (GRCm39) Y1017F possibly damaging Het
Copz1 T A 15: 103,204,995 (GRCm39) M118K probably benign Het
Dnm1 T C 2: 32,226,296 (GRCm39) N298D probably benign Het
Exog T C 9: 119,291,679 (GRCm39) S295P possibly damaging Het
Ext2 A T 2: 93,537,571 (GRCm39) probably benign Het
Garin5b A G 7: 4,761,632 (GRCm39) L360S probably benign Het
Gpatch8 T C 11: 102,399,023 (GRCm39) I70V unknown Het
Krt5 T A 15: 101,620,103 (GRCm39) I205L probably benign Het
Macrod2 A G 2: 141,357,147 (GRCm39) I148V probably benign Het
Mapk14 G T 17: 28,947,323 (GRCm39) probably benign Het
Mfsd4b3-ps A T 10: 39,823,891 (GRCm39) M123K probably benign Het
Mmp8 A G 9: 7,561,690 (GRCm39) D205G probably benign Het
Muc5b A T 7: 141,417,665 (GRCm39) H3537L possibly damaging Het
Nde1 C T 16: 14,009,611 (GRCm39) P324L probably benign Het
Nlrp9b A T 7: 19,782,750 (GRCm39) H888L probably damaging Het
Npy2r A G 3: 82,447,819 (GRCm39) F319L probably damaging Het
Nup210 A G 6: 91,030,361 (GRCm39) V156A probably benign Het
Nxph2 T C 2: 23,289,945 (GRCm39) I99T probably benign Het
Parpbp A G 10: 87,975,840 (GRCm39) I91T probably damaging Het
Pld2 A G 11: 70,432,003 (GRCm39) Y75C probably damaging Het
Pramel12 A G 4: 143,144,037 (GRCm39) T128A possibly damaging Het
Pramel33 A T 5: 93,630,391 (GRCm39) S394T probably damaging Het
Prkcb C A 7: 122,226,905 (GRCm39) D630E probably damaging Het
Prl3c1 T C 13: 27,383,349 (GRCm39) V5A probably benign Het
Ro60 A G 1: 143,646,446 (GRCm39) S100P probably damaging Het
Sdcbp2 A G 2: 151,429,255 (GRCm39) T192A probably benign Het
Sema6a C T 18: 47,381,461 (GRCm39) A1046T probably benign Het
Serpinb3a A G 1: 106,973,813 (GRCm39) F366S probably damaging Het
Serpinb9d T A 13: 33,380,521 (GRCm39) W136R probably damaging Het
Smc2 G T 4: 52,442,280 (GRCm39) V66F probably damaging Het
Speg A G 1: 75,407,923 (GRCm39) D3206G probably damaging Het
Syne2 C T 12: 75,976,111 (GRCm39) A1187V probably benign Het
Unc5cl G A 17: 48,772,049 (GRCm39) M442I possibly damaging Het
Other mutations in Leng9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01903:Leng9 APN 7 4,151,746 (GRCm39) missense probably damaging 1.00
IGL01970:Leng9 APN 7 4,151,326 (GRCm39) missense probably damaging 0.99
IGL02197:Leng9 APN 7 4,151,723 (GRCm39) missense probably damaging 1.00
R1616:Leng9 UTSW 7 4,151,902 (GRCm39) missense probably benign 0.00
R2352:Leng9 UTSW 7 4,152,409 (GRCm39) missense probably damaging 1.00
R2419:Leng9 UTSW 7 4,151,626 (GRCm39) missense probably benign 0.32
R4156:Leng9 UTSW 7 4,152,433 (GRCm39) missense possibly damaging 0.70
R4832:Leng9 UTSW 7 4,152,029 (GRCm39) missense probably damaging 0.99
R4841:Leng9 UTSW 7 4,152,385 (GRCm39) missense probably damaging 1.00
R4842:Leng9 UTSW 7 4,152,385 (GRCm39) missense probably damaging 1.00
R7468:Leng9 UTSW 7 4,151,800 (GRCm39) missense probably benign
R7627:Leng9 UTSW 7 4,151,617 (GRCm39) missense probably damaging 1.00
R7679:Leng9 UTSW 7 4,152,659 (GRCm39) missense probably benign 0.11
R8885:Leng9 UTSW 7 4,151,774 (GRCm39) missense possibly damaging 0.95
R8951:Leng9 UTSW 7 4,152,782 (GRCm39) unclassified probably benign
R9062:Leng9 UTSW 7 4,151,666 (GRCm39) missense probably damaging 1.00
R9140:Leng9 UTSW 7 4,152,657 (GRCm39) missense probably benign
R9275:Leng9 UTSW 7 4,151,447 (GRCm39) missense probably benign 0.02
R9418:Leng9 UTSW 7 4,151,354 (GRCm39) missense probably benign 0.01
R9582:Leng9 UTSW 7 4,152,263 (GRCm39) missense probably damaging 1.00
X0058:Leng9 UTSW 7 4,152,382 (GRCm39) missense possibly damaging 0.56
Posted On 2016-08-02