Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03014:Dock11'

407898

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dock11

Ensembl Gene

ENSMUSG00000031093

Gene Name

dedicator of cytokinesis 11

Synonyms

5033414A21Rik, Zizimin2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.217) question?

Stock #

IGL03014 (G1)

Quality Score

Status

Chromosome

Chromosomal Location

35152485-35340215 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 35310699 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110921 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115264] [ENSMUST00000115266]

AlphaFold

A2AF47

Predicted Effect

probably benign
Transcript: ENSMUST00000033419

SMART Domains

Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
Pfam:DUF3398	52	145	4.2e-39	PFAM
PH	166	274	1.4e-17	SMART
Blast:PH	329	440	4e-58	BLAST
Pfam:DOCK-C2	636	827	2.4e-53	PFAM
low complexity region	1254	1270	N/A	INTRINSIC
Pfam:DHR-2	1510	2029	7.3e-210	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115264

SMART Domains

Protein: ENSMUSP00000110919
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	184	192	N/A	INTRINSIC
Pfam:Ded_cyto	344	521	1.6e-69	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115266

SMART Domains

Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
PH	1	90	6.82e-7	SMART
Blast:PH	145	256	5e-58	BLAST
Pfam:DOCK-C2	451	644	1.3e-60	PFAM
low complexity region	1083	1099	N/A	INTRINSIC
low complexity region	1521	1529	N/A	INTRINSIC
Pfam:Ded_cyto	1681	1858	1.2e-68	PFAM

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

96% (51/53)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933416I08Rik	TCC	TCCC	X: 52,692,862 (GRCm39)		noncoding transcript	Het
AW112010	A	G	19: 11,025,456 (GRCm39)		noncoding transcript	Het
Ccdc134	T	C	15: 82,014,306 (GRCm39)	L13P	probably damaging	Het
Ccdc150	G	T	1: 54,329,861 (GRCm39)	V395F	probably damaging	Het
Cdh22	G	T	2: 164,954,331 (GRCm39)	S730*	probably null	Het
Cfap20dc	A	G	14: 8,431,608 (GRCm38)	*675Q	probably null	Het
Chrng	G	T	1: 87,138,759 (GRCm39)		probably null	Het
Cilp	TGGG	TGG	9: 65,187,412 (GRCm39)		probably null	Het
Crb1	CG	C	1: 139,164,824 (GRCm39)		probably null	Het
Csmd2	G	T	4: 128,190,222 (GRCm39)	M387I	probably benign	Het
Cux1	T	C	5: 136,594,379 (GRCm39)		probably benign	Het
D130043K22Rik	C	T	13: 25,042,075 (GRCm39)	P335S	possibly damaging	Het
Dctn1	A	G	6: 83,174,351 (GRCm39)		probably benign	Het
Dsn1	A	T	2: 156,838,739 (GRCm39)	M292K	possibly damaging	Het
Efemp1	A	G	11: 28,876,218 (GRCm39)	Y461C	probably damaging	Het
Efl1	A	G	7: 82,301,094 (GRCm39)	T33A	probably damaging	Het
Fbln2	T	C	6: 91,242,901 (GRCm39)		probably benign	Het
Fcna	G	C	2: 25,520,693 (GRCm39)		probably benign	Het
Hecw1	T	A	13: 14,420,393 (GRCm39)	Y1010F	probably damaging	Het
Igha	A	G	12: 113,222,713 (GRCm39)	V236A	unknown	Het
Igsf9b	T	C	9: 27,233,932 (GRCm39)	M377T	probably benign	Het
Itga9	A	G	9: 118,457,212 (GRCm39)	T108A	probably benign	Het
Kcna3	A	T	3: 106,945,206 (GRCm39)	M490L	probably benign	Het
Lama3	A	T	18: 12,673,024 (GRCm39)	Y886F	possibly damaging	Het
Lcorl	T	C	5: 45,931,371 (GRCm39)		probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Mmp1a	TG	TGG	9: 7,465,083 (GRCm38)		probably null	Het
Odr4	C	A	1: 150,258,804 (GRCm39)		probably benign	Het
Or1a1b	G	A	11: 74,097,653 (GRCm39)	L130F	probably damaging	Het
Or51a39	A	T	7: 102,362,753 (GRCm39)	V289E	probably null	Het
Pex10	A	G	4: 155,155,076 (GRCm39)		probably benign	Het
Plcl2	G	A	17: 50,918,029 (GRCm39)	V943M	possibly damaging	Het
Prkcd	T	A	14: 30,329,294 (GRCm39)	T164S	probably damaging	Het
Ptprn2	T	A	12: 117,212,308 (GRCm39)	L910Q	probably damaging	Het
Rab1b	T	C	19: 5,154,923 (GRCm39)	I41V	probably benign	Het
Scpep1	T	A	11: 88,824,271 (GRCm39)		probably null	Het
Sergef	T	C	7: 46,240,180 (GRCm39)	T288A	probably damaging	Het
Setdb1	G	A	3: 95,248,726 (GRCm39)	P397S	probably damaging	Het
Setx	T	A	2: 29,029,423 (GRCm39)	D230E	probably damaging	Het
Sin3a	C	A	9: 57,002,539 (GRCm39)		probably benign	Het
Smad5	T	C	13: 56,883,754 (GRCm39)	L380P	probably damaging	Het
Speer4c1	A	C	5: 15,919,214 (GRCm39)		probably benign	Het
Stard9	A	T	2: 120,532,675 (GRCm39)		probably benign	Het
Tek	A	G	4: 94,715,500 (GRCm39)	D346G	probably benign	Het
Trav7d-4	T	A	14: 53,007,353 (GRCm39)	W12R	unknown	Het
Trmt1l	G	T	1: 151,333,681 (GRCm39)	W728L	probably damaging	Het
Ubash3a	C	A	17: 31,458,198 (GRCm39)	T559K	probably damaging	Het
Vmn1r72	T	A	7: 11,403,711 (GRCm39)	I246F	possibly damaging	Het
Zfp618	A	T	4: 62,998,325 (GRCm39)	Q109L	probably damaging	Het

Other mutations in Dock11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00536:Dock11	APN	X	35,258,087 (GRCm39)	missense	probably benign	0.15
IGL00650:Dock11	APN	X	35,270,246 (GRCm39)	splice site	probably benign
IGL00769:Dock11	APN	X	35,267,715 (GRCm39)	missense	possibly damaging	0.74
IGL00963:Dock11	APN	X	35,296,035 (GRCm39)	missense	possibly damaging	0.63
IGL01389:Dock11	APN	X	35,256,701 (GRCm39)	missense	probably benign	0.43
IGL01410:Dock11	APN	X	35,301,296 (GRCm39)	missense	probably damaging	1.00
IGL01519:Dock11	APN	X	35,227,006 (GRCm39)	missense	probably benign
IGL02023:Dock11	APN	X	35,232,422 (GRCm39)	missense	probably benign	0.09
IGL02253:Dock11	APN	X	35,304,781 (GRCm39)	missense	probably damaging	1.00
IGL02416:Dock11	APN	X	35,283,739 (GRCm39)	missense	probably damaging	0.97
IGL02583:Dock11	APN	X	35,270,370 (GRCm39)	missense	possibly damaging	0.48
IGL03037:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03065:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03277:Dock11	APN	X	35,277,603 (GRCm39)	missense	probably benign	0.32
R0816:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0819:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0820:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R1430:Dock11	UTSW	X	35,333,565 (GRCm39)	missense	probably benign	0.00
R1512:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock11	UTSW	X	35,266,186 (GRCm39)	missense	probably benign	0.01
Z1176:Dock11	UTSW	X	35,248,501 (GRCm39)	missense	possibly damaging	0.69

Posted On

2016-08-02