Incidental Mutation 'IGL03018:Olfr1101'
ID407961
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1101
Ensembl Gene ENSMUSG00000075167
Gene Nameolfactory receptor 1101
SynonymsGA_x6K02T2Q125-48475870-48474938, MOR179-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL03018
Quality Score
Status
Chromosome2
Chromosomal Location86986291-86991221 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 86989005 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Serine at position 57 (Y57S)
Ref Sequence ENSEMBL: ENSMUSP00000151171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099870] [ENSMUST00000214411]
Predicted Effect probably damaging
Transcript: ENSMUST00000099870
AA Change: Y57S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097455
Gene: ENSMUSG00000075167
AA Change: Y57S

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-51 PFAM
Pfam:7tm_1 38 287 5.1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214411
AA Change: Y57S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a T A 5: 8,702,451 V474E probably damaging Het
Casc1 A G 6: 145,183,305 F394S probably damaging Het
Cpsf6 A T 10: 117,367,956 D30E probably benign Het
Edem1 T C 6: 108,829,142 F135L probably damaging Het
Elf3 C T 1: 135,256,065 E239K possibly damaging Het
Farp1 C T 14: 121,102,169 A53V probably benign Het
Gli3 T A 13: 15,660,132 L400Q probably damaging Het
Gm7257 A G 9: 36,433,427 T84A possibly damaging Het
Gtf2i T A 5: 134,289,335 I109F possibly damaging Het
Lat2 A T 5: 134,602,591 I191N probably damaging Het
Mtf1 G A 4: 124,838,663 A505T probably benign Het
Naa30 G T 14: 49,173,240 E208D probably benign Het
Nlrp5 T C 7: 23,417,747 Y299H probably benign Het
Npc1 T A 18: 12,214,379 N195Y probably damaging Het
Olfr1182 T C 2: 88,446,819 N40D probably damaging Het
Olfr453 A G 6: 42,744,814 Y259C probably damaging Het
Olfr830 T C 9: 18,876,227 M300T probably benign Het
Olfr832 A T 9: 18,944,881 I78F probably damaging Het
Pcdh9 G A 14: 93,015,576 A1217V probably null Het
Pdhb C T 14: 8,171,537 probably benign Het
Pknox2 A G 9: 36,954,697 Y75H probably damaging Het
Ptprn2 T C 12: 117,211,943 S748P probably damaging Het
Ranbp6 A G 19: 29,811,389 V521A probably damaging Het
Samd7 A G 3: 30,762,145 K347E probably damaging Het
Selenom A G 11: 3,516,508 D63G probably damaging Het
Sema6d T C 2: 124,659,600 V487A possibly damaging Het
Tapt1 A T 5: 44,204,324 M109K probably damaging Het
Trib1 T C 15: 59,654,484 F301S probably damaging Het
Tspyl1 T C 10: 34,283,116 V279A probably damaging Het
Ubr2 C T 17: 46,954,046 V1184I possibly damaging Het
Urb1 T C 16: 90,788,156 I526V probably benign Het
Vtcn1 A G 3: 100,883,910 D88G probably damaging Het
Yod1 T G 1: 130,718,958 L191V probably benign Het
Other mutations in Olfr1101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Olfr1101 APN 2 86988254 missense probably benign
IGL03265:Olfr1101 APN 2 86989080 missense probably damaging 1.00
R0627:Olfr1101 UTSW 2 86989014 missense probably benign 0.21
R2871:Olfr1101 UTSW 2 86988848 nonsense probably null
R2871:Olfr1101 UTSW 2 86988848 nonsense probably null
R7012:Olfr1101 UTSW 2 86988707 missense possibly damaging 0.50
R7144:Olfr1101 UTSW 2 86988820 missense probably damaging 1.00
R7151:Olfr1101 UTSW 2 86989041 missense probably benign 0.16
R7521:Olfr1101 UTSW 2 86988610 missense probably damaging 1.00
R7672:Olfr1101 UTSW 2 86988319 missense possibly damaging 0.93
R7725:Olfr1101 UTSW 2 86988979 missense probably benign 0.00
R7863:Olfr1101 UTSW 2 86989080 missense probably damaging 1.00
R7946:Olfr1101 UTSW 2 86989080 missense probably damaging 1.00
Posted On2016-08-02