Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03022:Vmn2r24'

408006

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL03022

Quality Score

Status

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123755967 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 13 (L13H)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

probably damaging
Transcript: ENSMUST00000075095
AA Change: L13H

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: L13H

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr2b	G	T	9: 119,256,587 (GRCm39)	R40L	probably benign	Het
Asph	T	C	4: 9,517,668 (GRCm39)	N402D	possibly damaging	Het
Brip1	T	C	11: 85,968,776 (GRCm39)	Y803C	probably damaging	Het
Cenpc1	T	C	5: 86,170,234 (GRCm39)		probably benign	Het
Dynlt5	A	G	4: 102,859,714 (GRCm39)	T85A	probably benign	Het
Fam110b	A	G	4: 5,799,448 (GRCm39)	M289V	probably benign	Het
Fam193b	T	C	13: 55,691,475 (GRCm39)	N429S	probably damaging	Het
Folh1	T	C	7: 86,395,379 (GRCm39)	Y351C	possibly damaging	Het
Fryl	G	A	5: 73,216,726 (GRCm39)	A2188V	possibly damaging	Het
Gtf2f1	C	T	17: 57,317,971 (GRCm39)		probably null	Het
Gucy1a1	T	C	3: 82,016,404 (GRCm39)	K195E	probably benign	Het
H2-Oa	T	C	17: 34,313,023 (GRCm39)	V100A	probably damaging	Het
Kcnu1	A	T	8: 26,427,614 (GRCm39)	K310N	probably damaging	Het
Mtss1	A	G	15: 58,825,439 (GRCm39)	S254P	probably damaging	Het
N4bp2l2	A	G	5: 150,566,761 (GRCm39)	S516P	probably benign	Het
Nrcam	A	G	12: 44,645,225 (GRCm39)	D1139G	probably damaging	Het
Nxpe4	T	C	9: 48,304,548 (GRCm39)	S212P	probably damaging	Het
Or1ab2	A	C	8: 72,863,968 (GRCm39)	K186T	probably damaging	Het
Or5d47	C	T	2: 87,804,341 (GRCm39)	V223I	probably benign	Het
Or5p52	A	T	7: 107,502,188 (GRCm39)	H88L	probably benign	Het
Parp2	T	C	14: 51,058,553 (GRCm39)	Y528H	probably damaging	Het
Pdgfd	T	C	9: 6,288,495 (GRCm39)	Y50H	probably damaging	Het
Prkaca	A	G	8: 84,721,976 (GRCm39)	D329G	possibly damaging	Het
Rbbp8	A	G	18: 11,858,559 (GRCm39)		probably benign	Het
Sele	A	G	1: 163,882,248 (GRCm39)	T578A	probably benign	Het
Shroom2	A	G	X: 151,443,089 (GRCm39)	V692A	probably benign	Het
Stxbp3	G	A	3: 108,708,072 (GRCm39)	L410F	probably damaging	Het
Tcaf1	C	A	6: 42,655,060 (GRCm39)	G553*	probably null	Het
Ttn	G	A	2: 76,576,862 (GRCm39)	T24677M	probably damaging	Het
Zfp106	C	A	2: 120,359,120 (GRCm39)		probably benign	Het
Zfp616	A	G	11: 73,973,800 (GRCm39)	D23G	possibly damaging	Het
Zfp84	T	C	7: 29,474,759 (GRCm39)		probably benign	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r24	APN	6	123,792,596 (GRCm39)	missense	probably damaging	1.00
IGL01382:Vmn2r24	APN	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5879:Vmn2r24	UTSW	6	123,764,226 (GRCm39)	missense	possibly damaging	0.89
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6050:Vmn2r24	UTSW	6	123,792,691 (GRCm39)	missense	probably damaging	1.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6630:Vmn2r24	UTSW	6	123,763,981 (GRCm39)	missense	probably benign	0.00
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02