Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03024:Cdc20b'

408071

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdc20b

Ensembl Gene

ENSMUSG00000078926

Gene Name

cell division cycle 20B

Synonyms

EG238896, EG622422

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL03024

Quality Score

Status

Chromosome

Chromosomal Location

113171645-113227729 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 113227576 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 485 (R485S)

Ref Sequence

ENSEMBL: ENSMUSP00000137915 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023897] [ENSMUST00000109244] [ENSMUST00000181117] [ENSMUST00000181568] [ENSMUST00000224282]

AlphaFold

D3Z3I0

Predicted Effect

probably benign
Transcript: ENSMUST00000023897

SMART Domains

Protein: ENSMUSP00000023897
Gene: ENSMUSG00000023132

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Tryp_SPc	28	252	1.1e-80	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109244
AA Change: R489S

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000104867
Gene: ENSMUSG00000078926
AA Change: R489S

Domain	Start	End	E-Value	Type
low complexity region	85	97	N/A	INTRINSIC
WD40	218	257	6.6e1	SMART
WD40	266	301	5.75e-1	SMART
WD40	304	341	9.24e-1	SMART
WD40	345	383	9.02e-7	SMART
WD40	391	432	3.55e1	SMART
WD40	473	517	2.01e-4	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000181117
AA Change: R485S

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000137915
Gene: ENSMUSG00000078926
AA Change: R485S

Domain	Start	End	E-Value	Type
low complexity region	85	97	N/A	INTRINSIC
WD40	218	257	6.6e1	SMART
WD40	266	301	5.75e-1	SMART
WD40	304	341	9.24e-1	SMART
WD40	345	383	9.02e-7	SMART
WD40	391	432	3.55e1	SMART
WD40	473	513	1.78e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000181568
AA Change: R447S

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000137849
Gene: ENSMUSG00000078926
AA Change: R447S

Domain	Start	End	E-Value	Type
low complexity region	85	97	N/A	INTRINSIC
WD40	218	257	6.6e1	SMART
WD40	266	301	5.75e-1	SMART
WD40	304	341	9.24e-1	SMART
WD40	345	383	9.02e-7	SMART
WD40	431	475	2.01e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000224282

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	C	17: 9,212,464 (GRCm39)	F257L	probably benign	Het
Aaas	A	G	15: 102,258,926 (GRCm39)		probably benign	Het
AI661453	C	T	17: 47,757,513 (GRCm39)	R57W	probably damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Bahd1	T	C	2: 118,746,597 (GRCm39)	V72A	probably damaging	Het
Bcl3	A	G	7: 19,543,059 (GRCm39)		probably benign	Het
Blnk	A	T	19: 40,982,445 (GRCm39)		probably benign	Het
Cd81	T	C	7: 142,621,089 (GRCm39)	I230T	probably benign	Het
Cenpp	C	A	13: 49,617,730 (GRCm39)	A273S	probably benign	Het
Cep295	A	G	9: 15,236,868 (GRCm39)	V2022A	probably benign	Het
Ces1d	C	A	8: 93,896,346 (GRCm39)		probably null	Het
Cfap61	C	A	2: 145,781,919 (GRCm39)		probably benign	Het
Col8a1	T	A	16: 57,448,727 (GRCm39)	H261L	unknown	Het
Cyp2j5	A	T	4: 96,517,760 (GRCm39)	M484K	probably benign	Het
D930020B18Rik	T	C	10: 121,521,527 (GRCm39)		probably benign	Het
Dhdds	A	T	4: 133,710,160 (GRCm39)	L203Q	probably damaging	Het
Dusp6	A	G	10: 99,102,156 (GRCm39)	T381A	probably damaging	Het
Elp1	A	G	4: 56,774,686 (GRCm39)		probably null	Het
Fnbp4	A	G	2: 90,581,523 (GRCm39)	D192G	probably benign	Het
Gbp2	G	T	3: 142,337,780 (GRCm39)	V299F	probably damaging	Het
Gfpt1	G	T	6: 87,030,813 (GRCm39)	V66F	probably damaging	Het
Heatr1	T	C	13: 12,422,390 (GRCm39)		probably benign	Het
Irf8	T	A	8: 121,480,097 (GRCm39)	S112T	probably damaging	Het
Jmy	G	T	13: 93,635,707 (GRCm39)	N36K	probably damaging	Het
Kcnt2	T	C	1: 140,498,193 (GRCm39)	I866T	probably benign	Het
Kif1c	A	T	11: 70,596,015 (GRCm39)	M210L	probably damaging	Het
Kng1	G	A	16: 22,893,442 (GRCm39)	V272I	possibly damaging	Het
Lrig2	A	C	3: 104,401,389 (GRCm39)	M166R	probably damaging	Het
Mastl	A	G	2: 23,029,931 (GRCm39)	L265P	probably damaging	Het
Mmp27	A	G	9: 7,581,377 (GRCm39)	T547A	probably benign	Het
Myh4	T	C	11: 67,139,305 (GRCm39)	C541R	probably damaging	Het
Naip2	A	T	13: 100,325,862 (GRCm39)	F15L	possibly damaging	Het
Nipal1	G	T	5: 72,820,968 (GRCm39)		probably null	Het
Nrp2	A	T	1: 62,810,893 (GRCm39)	N645Y	probably damaging	Het
Or1j19	T	A	2: 36,676,858 (GRCm39)	F107Y	possibly damaging	Het
Or4g17	T	A	2: 111,209,935 (GRCm39)	F197I	possibly damaging	Het
Or7d9	T	A	9: 20,197,280 (GRCm39)	M103K	probably benign	Het
Plcl1	T	A	1: 55,734,946 (GRCm39)	S96T	probably damaging	Het
Prl2c1	A	C	13: 28,040,524 (GRCm39)	D139A	probably benign	Het
Prmt5	A	T	14: 54,754,055 (GRCm39)	M43K	possibly damaging	Het
Ptpn21	T	A	12: 98,646,315 (GRCm39)	M1048L	probably benign	Het
Ptprq	T	C	10: 107,521,427 (GRCm39)	E653G	possibly damaging	Het
Rbm6	A	G	9: 107,664,567 (GRCm39)	S689P	probably damaging	Het
Rtn3	A	G	19: 7,460,455 (GRCm39)		probably benign	Het
Shoc2	T	C	19: 53,991,458 (GRCm39)	I241T	probably benign	Het
Sipa1	A	T	19: 5,706,189 (GRCm39)	D380E	probably damaging	Het
Slc1a6	T	C	10: 78,650,442 (GRCm39)	V560A	probably benign	Het
Speer2	T	C	16: 69,655,003 (GRCm39)	H154R	possibly damaging	Het
Tlk1	A	T	2: 70,576,380 (GRCm39)	C247*	probably null	Het
Trim15	A	G	17: 37,177,785 (GRCm39)	L70P	probably damaging	Het
Ttc9b	T	C	7: 27,354,358 (GRCm39)	L148P	probably damaging	Het
Vwa8	C	T	14: 79,232,538 (GRCm39)	P627S	probably benign	Het

Other mutations in Cdc20b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01625:Cdc20b	APN	13	113,196,319 (GRCm39)	missense	possibly damaging	0.74
IGL02603:Cdc20b	APN	13	113,215,289 (GRCm39)	missense	possibly damaging	0.88
IGL02663:Cdc20b	APN	13	113,192,665 (GRCm39)	critical splice donor site	probably null
IGL03379:Cdc20b	APN	13	113,217,736 (GRCm39)	missense	probably damaging	1.00
H8930:Cdc20b	UTSW	13	113,220,500 (GRCm39)	missense	probably damaging	1.00
R0207:Cdc20b	UTSW	13	113,215,146 (GRCm39)	missense	probably damaging	1.00
R0347:Cdc20b	UTSW	13	113,196,361 (GRCm39)	missense	probably damaging	0.97
R0448:Cdc20b	UTSW	13	113,215,191 (GRCm39)	missense	probably damaging	1.00
R0499:Cdc20b	UTSW	13	113,192,484 (GRCm39)	missense	probably benign	0.00
R1573:Cdc20b	UTSW	13	113,192,478 (GRCm39)	missense	probably benign	0.26
R1651:Cdc20b	UTSW	13	113,215,258 (GRCm39)	nonsense	probably null
R1786:Cdc20b	UTSW	13	113,217,668 (GRCm39)	missense	probably damaging	1.00
R1929:Cdc20b	UTSW	13	113,208,451 (GRCm39)	missense	probably benign	0.07
R2118:Cdc20b	UTSW	13	113,215,232 (GRCm39)	missense	probably benign	0.30
R3436:Cdc20b	UTSW	13	113,215,233 (GRCm39)	missense	probably damaging	0.99
R3508:Cdc20b	UTSW	13	113,217,576 (GRCm39)	missense	possibly damaging	0.80
R3837:Cdc20b	UTSW	13	113,220,542 (GRCm39)	missense	probably damaging	1.00
R4050:Cdc20b	UTSW	13	113,200,819 (GRCm39)	missense	probably benign
R4521:Cdc20b	UTSW	13	113,217,725 (GRCm39)	missense	probably damaging	1.00
R4786:Cdc20b	UTSW	13	113,215,268 (GRCm39)	missense	probably damaging	1.00
R6079:Cdc20b	UTSW	13	113,220,576 (GRCm39)	missense	probably damaging	1.00
R6610:Cdc20b	UTSW	13	113,200,796 (GRCm39)	missense	probably benign	0.02
R6814:Cdc20b	UTSW	13	113,220,509 (GRCm39)	missense	probably damaging	1.00
R6872:Cdc20b	UTSW	13	113,220,509 (GRCm39)	missense	probably damaging	1.00
R6887:Cdc20b	UTSW	13	113,215,187 (GRCm39)	missense	possibly damaging	0.88
R7144:Cdc20b	UTSW	13	113,219,905 (GRCm39)	missense	probably benign	0.36
R7579:Cdc20b	UTSW	13	113,173,582 (GRCm39)	splice site	probably null
R7770:Cdc20b	UTSW	13	113,215,193 (GRCm39)	missense	probably benign	0.01
R8669:Cdc20b	UTSW	13	113,208,460 (GRCm39)	missense	possibly damaging	0.83
R8985:Cdc20b	UTSW	13	113,196,330 (GRCm39)	nonsense	probably null
R9182:Cdc20b	UTSW	13	113,208,503 (GRCm39)	critical splice donor site	probably null
R9309:Cdc20b	UTSW	13	113,216,472 (GRCm39)	missense	probably damaging	1.00
R9378:Cdc20b	UTSW	13	113,192,631 (GRCm39)	missense	probably benign	0.03
U15987:Cdc20b	UTSW	13	113,220,576 (GRCm39)	missense	probably damaging	1.00
X0064:Cdc20b	UTSW	13	113,196,276 (GRCm39)	missense	possibly damaging	0.59

Posted On

2016-08-02