Incidental Mutation 'IGL03026:Vmn1r181'
ID408154
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r181
Ensembl Gene ENSMUSG00000097425
Gene Namevomeronasal 1 receptor 181
SynonymsV1rd20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL03026
Quality Score
Status
Chromosome7
Chromosomal Location23974615-23988139 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 23984575 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Serine at position 155 (I155S)
Ref Sequence ENSEMBL: ENSMUSP00000154403 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000181796] [ENSMUST00000226843] [ENSMUST00000226978] [ENSMUST00000227637] [ENSMUST00000228399] [ENSMUST00000228842]
Predicted Effect possibly damaging
Transcript: ENSMUST00000181796
AA Change: I155S

PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000137685
Gene: ENSMUSG00000097425
AA Change: I155S

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 3.9e-9 PFAM
Pfam:V1R 41 295 2.7e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226843
AA Change: I155S

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000226978
AA Change: I155S

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227637
AA Change: I155S

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228399
AA Change: I155S

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228531
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228607
Predicted Effect possibly damaging
Transcript: ENSMUST00000228842
AA Change: I155S

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly A G 11: 100,519,690 V154A possibly damaging Het
Adcy4 T C 14: 55,778,010 Y481C probably damaging Het
Adcy5 T C 16: 35,157,042 V315A probably benign Het
Atf7ip G A 6: 136,605,382 S1130N possibly damaging Het
Ctss A G 3: 95,538,830 D87G probably benign Het
Cwf19l2 A T 9: 3,428,777 K254N probably benign Het
Dnajc10 A G 2: 80,349,303 D727G probably damaging Het
Dsg3 G A 18: 20,536,972 probably null Het
Ehmt1 T C 2: 24,852,734 M478V probably benign Het
Enam A T 5: 88,503,299 N889I probably benign Het
Exo1 G T 1: 175,908,437 *148L probably null Het
Fam133b G T 5: 3,559,646 probably benign Het
Foxj2 G A 6: 122,838,180 A392T probably benign Het
Gbp4 G T 5: 105,120,000 A460E possibly damaging Het
Has3 A T 8: 106,878,610 I483F probably benign Het
Hist1h1b G A 13: 21,779,947 probably benign Het
Irak2 T A 6: 113,676,651 V260E probably damaging Het
Kcnj8 T C 6: 142,566,473 probably null Het
Lama5 A G 2: 180,195,967 V936A probably benign Het
Lmo7 C T 14: 101,929,333 probably benign Het
Morc3 T A 16: 93,862,724 probably benign Het
Muc6 T C 7: 141,640,147 probably benign Het
Nkx2-2 T C 2: 147,185,822 Y66C probably damaging Het
Oaz1 G A 10: 80,828,800 probably benign Het
Olfr1392 A T 11: 49,293,458 I46F probably damaging Het
Olfr768 G A 10: 129,093,188 A262V possibly damaging Het
Olfr808 A T 10: 129,768,041 M182L probably benign Het
Pkd2 A T 5: 104,494,887 probably benign Het
Plcb4 A G 2: 135,950,429 probably benign Het
Ralgapa2 C A 2: 146,460,775 probably benign Het
Rfx7 T C 9: 72,619,685 S1386P probably damaging Het
Ric1 T G 19: 29,599,833 W1046G probably benign Het
Rrp12 C A 19: 41,872,997 R957L probably damaging Het
Scn7a T C 2: 66,676,098 I1482M probably damaging Het
Sema3b T C 9: 107,602,063 N236S probably damaging Het
Skint6 T A 4: 112,991,244 probably null Het
Slfn5 T C 11: 82,956,561 Y91H probably benign Het
Sptbn2 T A 19: 4,724,233 probably null Het
Szt2 A G 4: 118,391,849 L546P probably benign Het
Tas1r3 A G 4: 155,861,843 probably benign Het
Trim75 A G 8: 64,983,786 V4A probably benign Het
Usp19 T C 9: 108,493,145 L56P probably damaging Het
Vmn2r43 G T 7: 8,255,097 D372E probably benign Het
Vstm2b C A 7: 40,902,521 S99* probably null Het
Wdr11 A G 7: 129,624,336 D735G probably damaging Het
Wee2 T A 6: 40,461,981 M346K probably benign Het
Zap70 A G 1: 36,779,717 K371R possibly damaging Het
Zfp990 A T 4: 145,537,110 H226L possibly damaging Het
Other mutations in Vmn1r181
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Vmn1r181 APN 7 23984581 missense possibly damaging 0.91
IGL02055:Vmn1r181 APN 7 23984553 missense probably damaging 1.00
IGL02444:Vmn1r181 APN 7 23984523 missense probably damaging 1.00
IGL03012:Vmn1r181 APN 7 23984602 missense probably damaging 0.98
R0255:Vmn1r181 UTSW 7 23984334 missense probably benign 0.02
R1481:Vmn1r181 UTSW 7 23984712 missense probably damaging 1.00
R2847:Vmn1r181 UTSW 7 23984518 missense possibly damaging 0.88
R2848:Vmn1r181 UTSW 7 23984518 missense possibly damaging 0.88
R2849:Vmn1r181 UTSW 7 23984518 missense possibly damaging 0.88
R3441:Vmn1r181 UTSW 7 23984883 missense probably benign 0.05
R3757:Vmn1r181 UTSW 7 23984484 missense possibly damaging 0.90
R3945:Vmn1r181 UTSW 7 23984152 missense probably damaging 0.98
R3983:Vmn1r181 UTSW 7 23984809 missense probably benign 0.23
R4780:Vmn1r181 UTSW 7 23984583 missense possibly damaging 0.64
R4999:Vmn1r181 UTSW 7 23984365 missense probably damaging 0.99
R5463:Vmn1r181 UTSW 7 23984362 missense probably benign 0.02
R5672:Vmn1r181 UTSW 7 23984316 missense probably damaging 1.00
R6229:Vmn1r181 UTSW 7 23984155 missense probably damaging 1.00
R6315:Vmn1r181 UTSW 7 23984758 missense probably benign 0.23
R6316:Vmn1r181 UTSW 7 23984758 missense probably benign 0.23
R6317:Vmn1r181 UTSW 7 23984758 missense probably benign 0.23
R6324:Vmn1r181 UTSW 7 23984758 missense probably benign 0.23
R6326:Vmn1r181 UTSW 7 23984758 missense probably benign 0.23
R6988:Vmn1r181 UTSW 7 23984847 missense probably damaging 1.00
R7446:Vmn1r181 UTSW 7 23984931 missense probably benign 0.01
X0067:Vmn1r181 UTSW 7 23984901 missense probably benign 0.00
Posted On2016-08-02