Incidental Mutation 'IGL03026:Slfn5'
ID 408170
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slfn5
Ensembl Gene ENSMUSG00000054404
Gene Name schlafen 5
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL03026
Quality Score
Status
Chromosome 11
Chromosomal Location 82842175-82855666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 82847387 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 91 (Y91H)
Ref Sequence ENSEMBL: ENSMUSP00000103793 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067443] [ENSMUST00000108157] [ENSMUST00000108158]
AlphaFold Q8CBA2
Predicted Effect probably benign
Transcript: ENSMUST00000067443
AA Change: Y91H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000064819
Gene: ENSMUSG00000054404
AA Change: Y91H

DomainStartEndE-ValueType
Pfam:AlbA_2 187 319 4.7e-13 PFAM
low complexity region 537 547 N/A INTRINSIC
Pfam:DUF2075 567 743 4.7e-8 PFAM
transmembrane domain 848 870 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108157
AA Change: Y91H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103792
Gene: ENSMUSG00000054404
AA Change: Y91H

DomainStartEndE-ValueType
Pfam:AAA_4 187 320 1.9e-15 PFAM
low complexity region 537 547 N/A INTRINSIC
Pfam:DUF2075 567 739 9.4e-9 PFAM
transmembrane domain 848 870 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108158
AA Change: Y91H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103793
Gene: ENSMUSG00000054404
AA Change: Y91H

DomainStartEndE-ValueType
Pfam:AAA_4 187 320 3.4e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127074
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150687
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216469
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly A G 11: 100,410,516 (GRCm39) V154A possibly damaging Het
Adcy4 T C 14: 56,015,467 (GRCm39) Y481C probably damaging Het
Adcy5 T C 16: 34,977,412 (GRCm39) V315A probably benign Het
Atf7ip G A 6: 136,582,380 (GRCm39) S1130N possibly damaging Het
Ctss A G 3: 95,446,141 (GRCm39) D87G probably benign Het
Cwf19l2 A T 9: 3,428,777 (GRCm39) K254N probably benign Het
Dnajc10 A G 2: 80,179,647 (GRCm39) D727G probably damaging Het
Dsg3 G A 18: 20,670,029 (GRCm39) probably null Het
Ehmt1 T C 2: 24,742,746 (GRCm39) M478V probably benign Het
Enam A T 5: 88,651,158 (GRCm39) N889I probably benign Het
Exo1 G T 1: 175,736,003 (GRCm39) *148L probably null Het
Fam133b G T 5: 3,609,646 (GRCm39) probably benign Het
Foxj2 G A 6: 122,815,139 (GRCm39) A392T probably benign Het
Gbp4 G T 5: 105,267,866 (GRCm39) A460E possibly damaging Het
H1f5 G A 13: 21,964,117 (GRCm39) probably benign Het
Has3 A T 8: 107,605,242 (GRCm39) I483F probably benign Het
Irak2 T A 6: 113,653,612 (GRCm39) V260E probably damaging Het
Kcnj8 T C 6: 142,512,199 (GRCm39) probably null Het
Lama5 A G 2: 179,837,760 (GRCm39) V936A probably benign Het
Lmo7 C T 14: 102,166,769 (GRCm39) probably benign Het
Morc3 T A 16: 93,659,612 (GRCm39) probably benign Het
Muc6 T C 7: 141,226,414 (GRCm39) probably benign Het
Nkx2-2 T C 2: 147,027,742 (GRCm39) Y66C probably damaging Het
Oaz1 G A 10: 80,664,634 (GRCm39) probably benign Het
Or2y1f A T 11: 49,184,285 (GRCm39) I46F probably damaging Het
Or6c38 G A 10: 128,929,057 (GRCm39) A262V possibly damaging Het
Or6c65 A T 10: 129,603,910 (GRCm39) M182L probably benign Het
Pkd2 A T 5: 104,642,753 (GRCm39) probably benign Het
Plcb4 A G 2: 135,792,349 (GRCm39) probably benign Het
Ralgapa2 C A 2: 146,302,695 (GRCm39) probably benign Het
Rfx7 T C 9: 72,526,967 (GRCm39) S1386P probably damaging Het
Ric1 T G 19: 29,577,233 (GRCm39) W1046G probably benign Het
Rrp12 C A 19: 41,861,436 (GRCm39) R957L probably damaging Het
Scn7a T C 2: 66,506,442 (GRCm39) I1482M probably damaging Het
Sema3b T C 9: 107,479,262 (GRCm39) N236S probably damaging Het
Skint6 T A 4: 112,848,441 (GRCm39) probably null Het
Sptbn2 T A 19: 4,774,261 (GRCm39) probably null Het
Szt2 A G 4: 118,249,046 (GRCm39) L546P probably benign Het
Tas1r3 A G 4: 155,946,300 (GRCm39) probably benign Het
Trim75 A G 8: 65,436,438 (GRCm39) V4A probably benign Het
Usp19 T C 9: 108,370,344 (GRCm39) L56P probably damaging Het
Vmn1r181 T G 7: 23,684,000 (GRCm39) I155S possibly damaging Het
Vmn2r43 G T 7: 8,258,096 (GRCm39) D372E probably benign Het
Vstm2b C A 7: 40,551,945 (GRCm39) S99* probably null Het
Wdr11 A G 7: 129,226,060 (GRCm39) D735G probably damaging Het
Wee2 T A 6: 40,438,915 (GRCm39) M346K probably benign Het
Zap70 A G 1: 36,818,798 (GRCm39) K371R possibly damaging Het
Zfp990 A T 4: 145,263,680 (GRCm39) H226L possibly damaging Het
Other mutations in Slfn5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Slfn5 APN 11 82,847,807 (GRCm39) missense probably damaging 0.97
IGL01773:Slfn5 APN 11 82,852,157 (GRCm39) missense probably damaging 1.00
IGL03368:Slfn5 APN 11 82,847,211 (GRCm39) missense possibly damaging 0.88
R0531:Slfn5 UTSW 11 82,851,866 (GRCm39) missense probably damaging 0.99
R0690:Slfn5 UTSW 11 82,852,229 (GRCm39) missense probably damaging 1.00
R0939:Slfn5 UTSW 11 82,852,164 (GRCm39) missense probably benign 0.04
R1005:Slfn5 UTSW 11 82,850,984 (GRCm39) missense probably damaging 1.00
R1214:Slfn5 UTSW 11 82,850,917 (GRCm39) missense probably benign 0.01
R1978:Slfn5 UTSW 11 82,847,442 (GRCm39) missense probably benign 0.17
R4092:Slfn5 UTSW 11 82,851,893 (GRCm39) missense probably damaging 1.00
R4620:Slfn5 UTSW 11 82,852,478 (GRCm39) missense probably damaging 1.00
R4789:Slfn5 UTSW 11 82,847,226 (GRCm39) missense probably benign 0.00
R5113:Slfn5 UTSW 11 82,852,522 (GRCm39) missense probably benign 0.01
R5120:Slfn5 UTSW 11 82,851,754 (GRCm39) missense probably damaging 1.00
R5262:Slfn5 UTSW 11 82,847,496 (GRCm39) missense possibly damaging 0.56
R5307:Slfn5 UTSW 11 82,847,211 (GRCm39) missense probably damaging 0.96
R5451:Slfn5 UTSW 11 82,850,912 (GRCm39) missense probably damaging 1.00
R5498:Slfn5 UTSW 11 82,847,973 (GRCm39) missense possibly damaging 0.84
R5651:Slfn5 UTSW 11 82,851,490 (GRCm39) missense probably benign 0.00
R5777:Slfn5 UTSW 11 82,851,830 (GRCm39) missense probably damaging 0.99
R5906:Slfn5 UTSW 11 82,848,102 (GRCm39) missense probably benign 0.37
R5934:Slfn5 UTSW 11 82,847,418 (GRCm39) missense probably damaging 1.00
R6521:Slfn5 UTSW 11 82,851,241 (GRCm39) missense probably damaging 0.99
R6543:Slfn5 UTSW 11 82,849,492 (GRCm39) splice site probably null
R6681:Slfn5 UTSW 11 82,847,204 (GRCm39) missense possibly damaging 0.73
R7129:Slfn5 UTSW 11 82,851,976 (GRCm39) nonsense probably null
R7309:Slfn5 UTSW 11 82,847,529 (GRCm39) missense probably damaging 1.00
R7478:Slfn5 UTSW 11 82,851,442 (GRCm39) missense probably damaging 1.00
R7573:Slfn5 UTSW 11 82,849,585 (GRCm39) missense probably damaging 1.00
R7610:Slfn5 UTSW 11 82,852,310 (GRCm39) missense probably damaging 1.00
R7834:Slfn5 UTSW 11 82,851,278 (GRCm39) missense possibly damaging 0.88
R7957:Slfn5 UTSW 11 82,847,613 (GRCm39) missense probably benign 0.00
R8205:Slfn5 UTSW 11 82,851,544 (GRCm39) missense probably benign 0.04
R8264:Slfn5 UTSW 11 82,847,376 (GRCm39) missense probably damaging 1.00
R8982:Slfn5 UTSW 11 82,850,966 (GRCm39) nonsense probably null
R9130:Slfn5 UTSW 11 82,851,446 (GRCm39) missense probably damaging 1.00
R9135:Slfn5 UTSW 11 82,851,503 (GRCm39) missense probably benign 0.00
R9209:Slfn5 UTSW 11 82,850,933 (GRCm39) missense possibly damaging 0.94
R9454:Slfn5 UTSW 11 82,850,885 (GRCm39) missense probably benign 0.03
R9534:Slfn5 UTSW 11 82,849,523 (GRCm39) missense probably benign 0.01
R9565:Slfn5 UTSW 11 82,847,699 (GRCm39) missense possibly damaging 0.94
R9608:Slfn5 UTSW 11 82,852,321 (GRCm39) missense probably benign 0.05
R9608:Slfn5 UTSW 11 82,851,830 (GRCm39) missense possibly damaging 0.92
R9686:Slfn5 UTSW 11 82,848,001 (GRCm39) missense probably benign 0.15
Posted On 2016-08-02