Incidental Mutation 'IGL03027:Wdr59'
ID 408212
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr59
Ensembl Gene ENSMUSG00000031959
Gene Name WD repeat domain 59
Synonyms 5430401O09Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03027
Quality Score
Status
Chromosome 8
Chromosomal Location 112175429-112248724 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 112188824 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 720 (A720V)
Ref Sequence ENSEMBL: ENSMUSP00000043671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034437] [ENSMUST00000038193] [ENSMUST00000211981]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000034437
AA Change: A739V

PolyPhen 2 Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000034437
Gene: ENSMUSG00000031959
AA Change: A739V

DomainStartEndE-ValueType
WD40 41 91 1.37e2 SMART
WD40 94 134 9.52e-6 SMART
WD40 138 176 4.46e-1 SMART
WD40 180 220 2.59e-7 SMART
WD40 271 315 8.59e-1 SMART
RWD 393 494 4.13e-14 SMART
low complexity region 620 632 N/A INTRINSIC
low complexity region 802 813 N/A INTRINSIC
Blast:RING 941 980 3e-10 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000038193
AA Change: A720V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043671
Gene: ENSMUSG00000031959
AA Change: A720V

DomainStartEndE-ValueType
WD40 41 91 1.37e2 SMART
WD40 94 134 9.52e-6 SMART
WD40 138 176 4.46e-1 SMART
WD40 180 220 2.59e-7 SMART
WD40 271 315 8.59e-1 SMART
RWD 393 494 4.13e-14 SMART
low complexity region 803 814 N/A INTRINSIC
Pfam:Zn_ribbon_17 937 992 2e-14 PFAM
Pfam:zinc_ribbon_16 949 990 1.6e-10 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211981
AA Change: A720V

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf1 A T 17: 43,607,605 (GRCm39) Y108F probably damaging Het
Afap1 T C 5: 36,119,094 (GRCm39) I243T probably benign Het
Ano5 A G 7: 51,216,025 (GRCm39) D320G probably damaging Het
Arhgef1 T A 7: 24,623,157 (GRCm39) I423K probably damaging Het
Casp9 A G 4: 141,539,584 (GRCm39) E410G probably benign Het
Ccdc39 A C 3: 33,884,267 (GRCm39) H358Q probably benign Het
Ces5a A T 8: 94,249,742 (GRCm39) probably null Het
Clip1 A T 5: 123,759,919 (GRCm39) M935K probably benign Het
Col12a1 A G 9: 79,548,833 (GRCm39) Y2171H probably benign Het
Cyp2f2 A T 7: 26,831,996 (GRCm39) N417I possibly damaging Het
Dock3 G A 9: 106,870,677 (GRCm39) P579L probably damaging Het
Dock7 T C 4: 98,866,164 (GRCm39) M1209V probably benign Het
Dock7 T C 4: 98,958,450 (GRCm39) T334A possibly damaging Het
Dst A T 1: 34,225,106 (GRCm39) I1171F possibly damaging Het
Eya1 G T 1: 14,241,190 (GRCm39) H576N probably damaging Het
Fam117a A G 11: 95,268,399 (GRCm39) T267A probably benign Het
Fam43a C T 16: 30,419,922 (GRCm39) R169C probably damaging Het
Gabra6 T C 11: 42,205,980 (GRCm39) H291R probably damaging Het
Gm7145 T C 1: 117,895,417 (GRCm39) S27P probably benign Het
Gpt C T 15: 76,582,289 (GRCm39) probably benign Het
Grip2 A G 6: 91,755,852 (GRCm39) I586T probably benign Het
Hif1a C T 12: 73,987,251 (GRCm39) P448L probably benign Het
Hmcn1 C T 1: 150,684,290 (GRCm39) V427I probably benign Het
Ipo8 C A 6: 148,678,737 (GRCm39) V954L probably benign Het
Kdm5a G T 6: 120,351,951 (GRCm39) probably null Het
Klhl36 T A 8: 120,603,229 (GRCm39) S495T probably benign Het
Lpar5 T A 6: 125,059,203 (GRCm39) L308Q probably damaging Het
Lrp2 T G 2: 69,367,897 (GRCm39) D205A probably benign Het
Lrriq1 A G 10: 103,063,057 (GRCm39) I83T probably benign Het
Mapk8ip2 A T 15: 89,342,310 (GRCm39) D507V probably damaging Het
Mical1 T C 10: 41,355,501 (GRCm39) probably benign Het
Myef2 T A 2: 124,930,954 (GRCm39) H539L possibly damaging Het
Myh7 T C 14: 55,221,007 (GRCm39) E972G probably damaging Het
Naip5 A G 13: 100,359,524 (GRCm39) Y571H probably benign Het
Nfasc T A 1: 132,538,207 (GRCm39) N478I probably damaging Het
Or6c1b A G 10: 129,272,780 (GRCm39) Y33C probably damaging Het
Pde2a A T 7: 101,130,627 (GRCm39) Q89L probably benign Het
Ppard C A 17: 28,518,765 (GRCm39) T422K possibly damaging Het
Ppp1r13b G T 12: 111,796,830 (GRCm39) Y904* probably null Het
Ptx4 T A 17: 25,344,022 (GRCm39) I424K possibly damaging Het
Rab19 A G 6: 39,360,927 (GRCm39) D25G probably damaging Het
Rbl2 T A 8: 91,805,534 (GRCm39) I197N possibly damaging Het
Rttn A G 18: 88,997,814 (GRCm39) D273G probably damaging Het
Sec16a G A 2: 26,313,601 (GRCm39) R1920C probably benign Het
Sec23b A T 2: 144,429,465 (GRCm39) N731I possibly damaging Het
Serpinb9d G A 13: 33,386,698 (GRCm39) W255* probably null Het
Sim2 G A 16: 93,910,351 (GRCm39) probably benign Het
Tbl3 T C 17: 24,920,167 (GRCm39) probably null Het
Tmem176b C T 6: 48,812,573 (GRCm39) A131T probably damaging Het
Tmem181a T A 17: 6,348,494 (GRCm39) V332D probably damaging Het
Trgc1 G T 13: 19,398,563 (GRCm39) G97* probably null Het
Tuba3b T A 6: 145,565,117 (GRCm39) L195Q probably damaging Het
Ubc A T 5: 125,464,565 (GRCm39) V254D probably damaging Het
Ube4b G T 4: 149,465,734 (GRCm39) P239T probably damaging Het
Vars1 G T 17: 35,232,663 (GRCm39) M862I probably damaging Het
Vmn2r66 T C 7: 84,644,777 (GRCm39) probably benign Het
Zfhx3 G A 8: 109,519,820 (GRCm39) R314Q probably damaging Het
Other mutations in Wdr59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00737:Wdr59 APN 8 112,185,368 (GRCm39) missense probably damaging 0.98
IGL01330:Wdr59 APN 8 112,208,565 (GRCm39) missense possibly damaging 0.87
IGL01413:Wdr59 APN 8 112,227,706 (GRCm39) missense probably benign 0.23
IGL02306:Wdr59 APN 8 112,219,365 (GRCm39) missense probably damaging 1.00
IGL03057:Wdr59 APN 8 112,202,750 (GRCm39) missense probably damaging 1.00
IGL03204:Wdr59 APN 8 112,212,002 (GRCm39) missense probably benign 0.05
electron UTSW 8 112,185,270 (GRCm39) missense probably benign 0.00
photon UTSW 8 112,187,445 (GRCm39) missense probably benign 0.00
R0056:Wdr59 UTSW 8 112,207,239 (GRCm39) splice site probably benign
R0096:Wdr59 UTSW 8 112,231,005 (GRCm39) missense probably damaging 1.00
R0096:Wdr59 UTSW 8 112,231,005 (GRCm39) missense probably damaging 1.00
R0440:Wdr59 UTSW 8 112,207,172 (GRCm39) small deletion probably benign
R0452:Wdr59 UTSW 8 112,248,604 (GRCm39) missense possibly damaging 0.87
R0472:Wdr59 UTSW 8 112,213,629 (GRCm39) critical splice acceptor site probably null
R0501:Wdr59 UTSW 8 112,185,579 (GRCm39) missense possibly damaging 0.90
R0526:Wdr59 UTSW 8 112,207,172 (GRCm39) small deletion probably benign
R0534:Wdr59 UTSW 8 112,207,172 (GRCm39) small deletion probably benign
R0601:Wdr59 UTSW 8 112,207,172 (GRCm39) small deletion probably benign
R1144:Wdr59 UTSW 8 112,213,576 (GRCm39) missense probably benign 0.09
R1415:Wdr59 UTSW 8 112,225,228 (GRCm39) missense probably damaging 1.00
R1571:Wdr59 UTSW 8 112,177,682 (GRCm39) missense probably damaging 0.98
R1661:Wdr59 UTSW 8 112,205,994 (GRCm39) missense probably damaging 1.00
R1665:Wdr59 UTSW 8 112,205,994 (GRCm39) missense probably damaging 1.00
R1839:Wdr59 UTSW 8 112,211,972 (GRCm39) missense probably benign
R1856:Wdr59 UTSW 8 112,202,813 (GRCm39) missense probably damaging 1.00
R1872:Wdr59 UTSW 8 112,185,649 (GRCm39) missense probably damaging 1.00
R1921:Wdr59 UTSW 8 112,213,582 (GRCm39) nonsense probably null
R1965:Wdr59 UTSW 8 112,177,709 (GRCm39) missense probably damaging 1.00
R1966:Wdr59 UTSW 8 112,177,535 (GRCm39) missense possibly damaging 0.92
R1977:Wdr59 UTSW 8 112,185,270 (GRCm39) missense probably benign 0.00
R2019:Wdr59 UTSW 8 112,193,425 (GRCm39) missense probably damaging 1.00
R4245:Wdr59 UTSW 8 112,216,996 (GRCm39) missense possibly damaging 0.63
R4471:Wdr59 UTSW 8 112,193,419 (GRCm39) critical splice donor site probably null
R4820:Wdr59 UTSW 8 112,207,446 (GRCm39) missense probably benign 0.19
R5198:Wdr59 UTSW 8 112,208,620 (GRCm39) missense probably benign 0.00
R5540:Wdr59 UTSW 8 112,211,816 (GRCm39) missense possibly damaging 0.84
R5571:Wdr59 UTSW 8 112,192,463 (GRCm39) missense probably damaging 1.00
R6166:Wdr59 UTSW 8 112,199,293 (GRCm39) missense probably damaging 1.00
R6732:Wdr59 UTSW 8 112,227,684 (GRCm39) missense probably damaging 1.00
R6767:Wdr59 UTSW 8 112,202,733 (GRCm39) missense probably damaging 1.00
R6823:Wdr59 UTSW 8 112,185,672 (GRCm39) missense possibly damaging 0.95
R6841:Wdr59 UTSW 8 112,223,512 (GRCm39) missense probably damaging 1.00
R6888:Wdr59 UTSW 8 112,177,675 (GRCm39) missense probably benign 0.00
R6974:Wdr59 UTSW 8 112,187,420 (GRCm39) missense possibly damaging 0.86
R6982:Wdr59 UTSW 8 112,187,445 (GRCm39) missense probably benign 0.00
R7066:Wdr59 UTSW 8 112,192,477 (GRCm39) missense probably benign 0.07
R7154:Wdr59 UTSW 8 112,185,367 (GRCm39) missense
R7176:Wdr59 UTSW 8 112,219,388 (GRCm39) missense
R7286:Wdr59 UTSW 8 112,192,494 (GRCm39) missense
R7332:Wdr59 UTSW 8 112,220,986 (GRCm39) missense
R7537:Wdr59 UTSW 8 112,217,001 (GRCm39) missense
R7614:Wdr59 UTSW 8 112,219,394 (GRCm39) missense
R7758:Wdr59 UTSW 8 112,207,117 (GRCm39) missense
R7800:Wdr59 UTSW 8 112,248,570 (GRCm39) missense
R7861:Wdr59 UTSW 8 112,220,912 (GRCm39) missense
R8137:Wdr59 UTSW 8 112,212,011 (GRCm39) missense
R8726:Wdr59 UTSW 8 112,223,466 (GRCm39) missense
R8942:Wdr59 UTSW 8 112,211,808 (GRCm39) missense probably benign
R9318:Wdr59 UTSW 8 112,177,700 (GRCm39) missense
X0026:Wdr59 UTSW 8 112,205,972 (GRCm39) missense possibly damaging 0.95
Posted On 2016-08-02