Incidental Mutation 'IGL03028:Olfr368'
ID 408262
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr368
Ensembl Gene ENSMUSG00000049018
Gene Name olfactory receptor 368
Synonyms MOR178-1, GA_x6K02T2NLDC-34015743-34016726
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.134) question?
Stock # IGL03028
Quality Score
Status
Chromosome 2
Chromosomal Location 37326515-37332772 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 37331956 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 70 (L70F)
Ref Sequence ENSEMBL: ENSMUSP00000149348 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053990] [ENSMUST00000217299]
AlphaFold Q8VF22
Predicted Effect probably damaging
Transcript: ENSMUST00000053990
AA Change: L70F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054082
Gene: ENSMUSG00000049018
AA Change: L70F

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.2e-45 PFAM
Pfam:7tm_1 45 294 1.2e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217299
AA Change: L70F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 A C 9: 53,594,762 V86G probably benign Het
Adgra3 A T 5: 50,016,852 W115R probably benign Het
Ahr G A 12: 35,504,710 A470V probably benign Het
AI481877 A C 4: 59,094,274 I150S possibly damaging Het
Aoah A T 13: 20,816,582 Q62L possibly damaging Het
Arhgef12 A T 9: 43,026,228 D100E possibly damaging Het
Asic1 A G 15: 99,672,157 N120D probably benign Het
Atp2b2 A G 6: 113,759,142 L988P probably damaging Het
Atxn2 T A 5: 121,810,909 H789Q probably damaging Het
Clk1 G T 1: 58,421,102 S123* probably null Het
Col10a1 C T 10: 34,395,016 A328V probably benign Het
Col26a1 G T 5: 136,743,118 D415E possibly damaging Het
Ctla2a A G 13: 60,935,459 probably benign Het
Cwf19l2 A G 9: 3,430,622 E318G probably benign Het
Dnajc16 C T 4: 141,767,732 W523* probably null Het
Ehhadh T C 16: 21,762,394 E616G probably damaging Het
F5 A T 1: 164,193,000 K1015* probably null Het
Fam78a A G 2: 32,082,882 W9R possibly damaging Het
Frs2 A T 10: 117,073,933 M508K possibly damaging Het
Gm3164 A T 14: 4,440,111 M200L probably benign Het
Gm44511 T C 6: 128,780,395 S179G probably damaging Het
Gpr25 G A 1: 136,260,812 S21L probably benign Het
Hsdl2 A G 4: 59,594,471 D34G probably damaging Het
Kcnt1 A G 2: 25,909,203 probably null Het
Kl A G 5: 150,991,550 Y914C probably damaging Het
Map3k3 T G 11: 106,110,751 V45G probably damaging Het
Mppe1 A C 18: 67,227,684 C261W probably damaging Het
Nin T C 12: 70,035,270 T1640A probably benign Het
Olfr483 T A 7: 108,104,173 M288K probably damaging Het
Olfr570 T A 7: 102,900,829 I154N possibly damaging Het
Olfr616 A G 7: 103,564,589 probably null Het
Olfr844 A T 9: 19,319,368 Y284F probably damaging Het
Oxr1 A G 15: 41,817,163 N166D probably damaging Het
Pank4 T A 4: 154,969,985 probably benign Het
Pgd A G 4: 149,161,627 probably null Het
Pitrm1 C T 13: 6,574,393 H831Y probably benign Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Rad51 A C 2: 119,116,314 M1L possibly damaging Het
Recql5 G T 11: 115,894,431 S746R possibly damaging Het
Rhbdl3 C T 11: 80,323,461 Q133* probably null Het
Rpp40 A T 13: 35,904,511 L59Q probably damaging Het
Rtca C A 3: 116,493,092 probably benign Het
Rtkn C T 6: 83,147,872 Q108* probably null Het
Sirt6 C T 10: 81,627,541 probably benign Het
Slc9a4 G A 1: 40,610,377 V517M probably benign Het
Smarca2 G T 19: 26,678,312 probably benign Het
Snx33 A T 9: 56,926,451 D111E probably benign Het
Tgfb1 T C 7: 25,704,196 I311T probably damaging Het
Tgfb2 C T 1: 186,630,609 probably null Het
Tmem232 T C 17: 65,256,389 T670A probably benign Het
Tnfsf4 T C 1: 161,395,642 F21L possibly damaging Het
Ubr5 T C 15: 38,047,593 T47A probably benign Het
Unc79 T C 12: 103,173,526 V2515A possibly damaging Het
Utp6 T C 11: 79,953,624 K192E probably damaging Het
Vmn2r102 T C 17: 19,694,066 F631S possibly damaging Het
Zfp516 A C 18: 82,955,913 I79L possibly damaging Het
Other mutations in Olfr368
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Olfr368 APN 2 37332011 missense possibly damaging 0.60
IGL02955:Olfr368 APN 2 37332001 missense probably benign 0.07
IGL03084:Olfr368 APN 2 37332401 missense probably damaging 1.00
R1626:Olfr368 UTSW 2 37332762 splice site probably null
R1655:Olfr368 UTSW 2 37331939 missense probably damaging 1.00
R1771:Olfr368 UTSW 2 37332418 missense probably benign 0.23
R1937:Olfr368 UTSW 2 37331884 missense probably damaging 1.00
R2297:Olfr368 UTSW 2 37332143 missense probably benign 0.04
R4354:Olfr368 UTSW 2 37331876 missense probably damaging 1.00
R4888:Olfr368 UTSW 2 37332589 missense probably damaging 1.00
R4974:Olfr368 UTSW 2 37332566 missense probably damaging 1.00
R5121:Olfr368 UTSW 2 37332589 missense probably damaging 1.00
R6144:Olfr368 UTSW 2 37332113 missense probably damaging 0.97
R6449:Olfr368 UTSW 2 37331825 missense possibly damaging 0.93
R7670:Olfr368 UTSW 2 37331759 missense probably benign 0.10
R8049:Olfr368 UTSW 2 37332334 missense probably damaging 1.00
R8486:Olfr368 UTSW 2 37332650 missense probably damaging 1.00
R8893:Olfr368 UTSW 2 37332376 missense probably damaging 1.00
R9147:Olfr368 UTSW 2 37332005 missense possibly damaging 0.68
R9148:Olfr368 UTSW 2 37332005 missense possibly damaging 0.68
R9401:Olfr368 UTSW 2 37332281 missense possibly damaging 0.94
R9574:Olfr368 UTSW 2 37332136 missense possibly damaging 0.92
Z1177:Olfr368 UTSW 2 37332004 missense probably damaging 1.00
Posted On 2016-08-02