Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03028:Dnajc16'

408299

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dnajc16

Ensembl Gene

ENSMUSG00000040697

Gene Name

DnaJ heat shock protein family (Hsp40) member C16

Synonyms

4732437J24Rik, 2900037O03Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.763) question?

Stock #

IGL03028

Quality Score

Status

Chromosome

Chromosomal Location

141760189-141790931 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 141767732 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 523 (W523*)

Ref Sequence

ENSEMBL: ENSMUSP00000048714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038014]

AlphaFold

Q80TN4

PDB Structure

Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962 [SOLUTION NMR]

Predicted Effect

probably null
Transcript: ENSMUST00000038014
AA Change: W523*

SMART Domains

Protein: ENSMUSP00000048714
Gene: ENSMUSG00000040697
AA Change: W523*

Domain	Start	End	E-Value	Type
DnaJ	28	85	4.5e-30	SMART
Pfam:Thioredoxin	142	243	4.4e-8	PFAM
low complexity region	537	549	N/A	INTRINSIC
low complexity region	730	750	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138654

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acat1	A	C	9: 53,594,762 (GRCm38)	V86G	probably benign	Het
Adgra3	A	T	5: 50,016,852 (GRCm38)	W115R	probably benign	Het
Ahr	G	A	12: 35,504,710 (GRCm38)	A470V	probably benign	Het
Aoah	A	T	13: 20,816,582 (GRCm38)	Q62L	possibly damaging	Het
Arhgef12	A	T	9: 43,026,228 (GRCm38)	D100E	possibly damaging	Het
Asic1	A	G	15: 99,672,157 (GRCm38)	N120D	probably benign	Het
Atp2b2	A	G	6: 113,759,142 (GRCm38)	L988P	probably damaging	Het
Atxn2	T	A	5: 121,810,909 (GRCm38)	H789Q	probably damaging	Het
Clk1	G	T	1: 58,421,102 (GRCm38)	S123*	probably null	Het
Col10a1	C	T	10: 34,395,016 (GRCm38)	A328V	probably benign	Het
Col26a1	G	T	5: 136,743,118 (GRCm38)	D415E	possibly damaging	Het
Ctla2a	A	G	13: 60,935,459 (GRCm38)		probably benign	Het
Cwf19l2	A	G	9: 3,430,622 (GRCm38)	E318G	probably benign	Het
Ehhadh	T	C	16: 21,762,394 (GRCm38)	E616G	probably damaging	Het
F5	A	T	1: 164,193,000 (GRCm38)	K1015*	probably null	Het
Fam78a	A	G	2: 32,082,882 (GRCm38)	W9R	possibly damaging	Het
Frs2	A	T	10: 117,073,933 (GRCm38)	M508K	possibly damaging	Het
Gm3164	A	T	14: 4,440,111 (GRCm38)	M200L	probably benign	Het
Gm44511	T	C	6: 128,780,395 (GRCm38)	S179G	probably damaging	Het
Gpr25	G	A	1: 136,260,812 (GRCm38)	S21L	probably benign	Het
Hsdl2	A	G	4: 59,594,471 (GRCm38)	D34G	probably damaging	Het
Kcnt1	A	G	2: 25,909,203 (GRCm38)		probably null	Het
Kl	A	G	5: 150,991,550 (GRCm38)	Y914C	probably damaging	Het
Map3k3	T	G	11: 106,110,751 (GRCm38)	V45G	probably damaging	Het
Mppe1	A	C	18: 67,227,684 (GRCm38)	C261W	probably damaging	Het
Nin	T	C	12: 70,035,270 (GRCm38)	T1640A	probably benign	Het
Or51a8	T	A	7: 102,900,829 (GRCm38)	I154N	possibly damaging	Het
Or51ac3	A	G	7: 103,564,589 (GRCm38)		probably null	Het
Or5c1	C	T	2: 37,331,956 (GRCm38)	L70F	probably damaging	Het
Or5p59	T	A	7: 108,104,173 (GRCm38)	M288K	probably damaging	Het
Or7g26	A	T	9: 19,319,368 (GRCm38)	Y284F	probably damaging	Het
Oxr1	A	G	15: 41,817,163 (GRCm38)	N166D	probably damaging	Het
Pank4	T	A	4: 154,969,985 (GRCm38)		probably benign	Het
Pgd	A	G	4: 149,161,627 (GRCm38)		probably null	Het
Pitrm1	C	T	13: 6,574,393 (GRCm38)	H831Y	probably benign	Het
Pkd1l2	G	A	8: 117,065,745 (GRCm38)	T436I	probably benign	Het
Rad51	A	C	2: 119,116,314 (GRCm38)	M1L	possibly damaging	Het
Recql5	G	T	11: 115,894,431 (GRCm38)	S746R	possibly damaging	Het
Rhbdl3	C	T	11: 80,323,461 (GRCm38)	Q133*	probably null	Het
Rpp40	A	T	13: 35,904,511 (GRCm38)	L59Q	probably damaging	Het
Rtca	C	A	3: 116,493,092 (GRCm38)		probably benign	Het
Rtkn	C	T	6: 83,147,872 (GRCm38)	Q108*	probably null	Het
Shoc1	A	C	4: 59,094,274 (GRCm38)	I150S	possibly damaging	Het
Sirt6	C	T	10: 81,627,541 (GRCm38)		probably benign	Het
Slc9a4	G	A	1: 40,610,377 (GRCm38)	V517M	probably benign	Het
Smarca2	G	T	19: 26,678,312 (GRCm38)		probably benign	Het
Snx33	A	T	9: 56,926,451 (GRCm38)	D111E	probably benign	Het
Tgfb1	T	C	7: 25,704,196 (GRCm38)	I311T	probably damaging	Het
Tgfb2	C	T	1: 186,630,609 (GRCm38)		probably null	Het
Tmem232	T	C	17: 65,256,389 (GRCm38)	T670A	probably benign	Het
Tnfsf4	T	C	1: 161,395,642 (GRCm38)	F21L	possibly damaging	Het
Ubr5	T	C	15: 38,047,593 (GRCm38)	T47A	probably benign	Het
Unc79	T	C	12: 103,173,526 (GRCm38)	V2515A	possibly damaging	Het
Utp6	T	C	11: 79,953,624 (GRCm38)	K192E	probably damaging	Het
Vmn2r102	T	C	17: 19,694,066 (GRCm38)	F631S	possibly damaging	Het
Zfp516	A	C	18: 82,955,913 (GRCm38)	I79L	possibly damaging	Het

Other mutations in Dnajc16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00495:Dnajc16	APN	4	141,763,563 (GRCm38)	splice site	probably null
IGL00840:Dnajc16	APN	4	141,768,003 (GRCm38)	missense	probably damaging	1.00
IGL01503:Dnajc16	APN	4	141,763,697 (GRCm38)	missense	possibly damaging	0.65
IGL01919:Dnajc16	APN	4	141,774,629 (GRCm38)	missense	probably benign	0.06
IGL02065:Dnajc16	APN	4	141,776,933 (GRCm38)	missense	probably damaging	1.00
IGL02544:Dnajc16	APN	4	141,764,647 (GRCm38)	missense	probably damaging	1.00
PIT4418001:Dnajc16	UTSW	4	141,770,949 (GRCm38)	missense	probably damaging	0.99
PIT4585001:Dnajc16	UTSW	4	141,764,685 (GRCm38)	missense	probably damaging	1.00
R0071:Dnajc16	UTSW	4	141,768,007 (GRCm38)	missense	probably benign
R0415:Dnajc16	UTSW	4	141,789,048 (GRCm38)	nonsense	probably null
R0532:Dnajc16	UTSW	4	141,789,009 (GRCm38)	missense	probably damaging	1.00
R1418:Dnajc16	UTSW	4	141,767,741 (GRCm38)	nonsense	probably null
R2959:Dnajc16	UTSW	4	141,766,545 (GRCm38)	nonsense	probably null
R3025:Dnajc16	UTSW	4	141,774,611 (GRCm38)	missense	probably benign
R3796:Dnajc16	UTSW	4	141,767,737 (GRCm38)	missense	probably benign
R3854:Dnajc16	UTSW	4	141,763,653 (GRCm38)	nonsense	probably null
R3856:Dnajc16	UTSW	4	141,763,653 (GRCm38)	nonsense	probably null
R4661:Dnajc16	UTSW	4	141,763,548 (GRCm38)	missense	probably damaging	1.00
R4841:Dnajc16	UTSW	4	141,774,625 (GRCm38)	missense	probably damaging	1.00
R4842:Dnajc16	UTSW	4	141,774,625 (GRCm38)	missense	probably damaging	1.00
R5116:Dnajc16	UTSW	4	141,767,969 (GRCm38)	nonsense	probably null
R5126:Dnajc16	UTSW	4	141,774,509 (GRCm38)	missense	probably benign	0.01
R5140:Dnajc16	UTSW	4	141,764,683 (GRCm38)	missense	possibly damaging	0.85
R5275:Dnajc16	UTSW	4	141,767,928 (GRCm38)	missense	possibly damaging	0.82
R5295:Dnajc16	UTSW	4	141,767,928 (GRCm38)	missense	possibly damaging	0.82
R5891:Dnajc16	UTSW	4	141,775,392 (GRCm38)	missense	probably benign
R6888:Dnajc16	UTSW	4	141,776,992 (GRCm38)	missense	probably benign	0.24
R7062:Dnajc16	UTSW	4	141,766,690 (GRCm38)	missense	probably damaging	1.00
R7441:Dnajc16	UTSW	4	141,763,813 (GRCm38)	missense	probably damaging	1.00
R7684:Dnajc16	UTSW	4	141,774,568 (GRCm38)	missense	probably benign	0.02
R8843:Dnajc16	UTSW	4	141,764,691 (GRCm38)	missense	possibly damaging	0.87
R8924:Dnajc16	UTSW	4	141,766,707 (GRCm38)	nonsense	probably null
R9005:Dnajc16	UTSW	4	141,764,634 (GRCm38)	missense	possibly damaging	0.95
R9053:Dnajc16	UTSW	4	141,783,060 (GRCm38)	missense	probably benign	0.28
R9550:Dnajc16	UTSW	4	141,767,747 (GRCm38)	missense	possibly damaging	0.95

Posted On

2016-08-02