Incidental Mutation 'IGL03030:Myo3b'
ID 408421
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myo3b
Ensembl Gene ENSMUSG00000042064
Gene Name myosin IIIB
Synonyms A430065P19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03030
Quality Score
Status
Chromosome 2
Chromosomal Location 69869470-70259542 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 70257160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060208] [ENSMUST00000112243]
AlphaFold Q1EG27
Predicted Effect probably benign
Transcript: ENSMUST00000060208
SMART Domains Protein: ENSMUSP00000055362
Gene: ENSMUSG00000042064

DomainStartEndE-ValueType
S_TKc 43 309 2.24e-85 SMART
MYSc 353 1075 6.61e-260 SMART
IQ 1075 1097 9.51e1 SMART
IQ 1102 1124 1.73e-5 SMART
low complexity region 1319 1324 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112243
SMART Domains Protein: ENSMUSP00000107862
Gene: ENSMUSG00000042064

DomainStartEndE-ValueType
S_TKc 15 281 2.24e-85 SMART
MYSc 325 1047 6.61e-260 SMART
IQ 1047 1069 9.51e1 SMART
IQ 1074 1096 1.73e-5 SMART
low complexity region 1291 1296 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik A G 7: 43,145,057 (GRCm39) V367A possibly damaging Het
Abcb5 A T 12: 118,904,104 (GRCm39) S200R possibly damaging Het
Adam29 T C 8: 56,326,100 (GRCm39) D118G probably damaging Het
Adh4 A G 3: 138,134,906 (GRCm39) D360G probably benign Het
Ankle2 A G 5: 110,399,476 (GRCm39) Q611R possibly damaging Het
Ankra2 C T 13: 98,409,881 (GRCm39) probably benign Het
Ap1g2 T A 14: 55,343,504 (GRCm39) I28F probably damaging Het
Baz2a C T 10: 127,961,015 (GRCm39) T1608I possibly damaging Het
Cacnb4 T C 2: 52,364,894 (GRCm39) D123G probably damaging Het
Cage1 G A 13: 38,212,123 (GRCm39) T51M probably benign Het
Ccdc63 A G 5: 122,260,876 (GRCm39) V216A probably benign Het
Ccnd2 A G 6: 127,125,841 (GRCm39) V65A probably damaging Het
Cfap20dc A G 14: 8,511,113 (GRCm38) S434P probably damaging Het
Chd3 T A 11: 69,245,230 (GRCm39) T1163S possibly damaging Het
Cmbl A G 15: 31,589,823 (GRCm39) probably benign Het
Cobl G T 11: 12,204,241 (GRCm39) N813K possibly damaging Het
Cog5 G A 12: 31,840,921 (GRCm39) V249M probably damaging Het
Cps1 A G 1: 67,182,080 (GRCm39) N98S probably damaging Het
Cracd A G 5: 77,005,463 (GRCm39) D608G unknown Het
D630045J12Rik A T 6: 38,126,648 (GRCm39) I1454N probably damaging Het
Elmo2 A G 2: 165,136,237 (GRCm39) V603A possibly damaging Het
F12 A G 13: 55,569,332 (GRCm39) probably benign Het
Ficd G A 5: 113,874,990 (GRCm39) V20I probably benign Het
Gatad2b G T 3: 90,249,244 (GRCm39) G94V probably benign Het
Gm4845 G A 1: 141,184,403 (GRCm39) noncoding transcript Het
Hrnr G A 3: 93,227,908 (GRCm39) V9I possibly damaging Het
Kifc3 A G 8: 95,829,040 (GRCm39) S584P probably damaging Het
Klk1b24 C A 7: 43,840,790 (GRCm39) Q73K probably benign Het
Lrp10 C A 14: 54,706,619 (GRCm39) N518K possibly damaging Het
Lsr A G 7: 30,658,706 (GRCm39) V247A possibly damaging Het
Mfsd6 A T 1: 52,748,862 (GRCm39) M1K probably null Het
Mprip T A 11: 59,631,941 (GRCm39) probably null Het
Oprd1 A G 4: 131,844,696 (GRCm39) F104S possibly damaging Het
Or1l4 T C 2: 37,091,883 (GRCm39) V210A probably benign Het
Or2g1 T A 17: 38,107,162 (GRCm39) Y276N probably damaging Het
Or4b1d A T 2: 89,969,006 (GRCm39) I159N possibly damaging Het
Or5ar1 T C 2: 85,671,416 (GRCm39) T240A probably damaging Het
Or5b109 C T 19: 13,212,418 (GRCm39) S268L probably damaging Het
Palb2 A G 7: 121,712,479 (GRCm39) V591A probably damaging Het
Pcdhb18 A T 18: 37,623,786 (GRCm39) D372V probably damaging Het
Phc3 A G 3: 30,991,002 (GRCm39) V405A probably damaging Het
Phf20l1 A T 15: 66,513,796 (GRCm39) probably benign Het
Pik3ip1 A G 11: 3,283,259 (GRCm39) K57E possibly damaging Het
Pkhd1l1 G A 15: 44,455,372 (GRCm39) M4044I probably benign Het
Pkhd1l1 T C 15: 44,460,298 (GRCm39) V4169A probably benign Het
Pklr A T 3: 89,049,963 (GRCm39) I313F probably damaging Het
Plxna4 T A 6: 32,179,160 (GRCm39) T952S probably benign Het
Pop4 A T 7: 37,962,730 (GRCm39) I178N probably damaging Het
Prorp A G 12: 55,351,429 (GRCm39) D246G probably damaging Het
Prss40 A C 1: 34,597,182 (GRCm39) V122G probably damaging Het
Rapgef2 C A 3: 78,981,614 (GRCm39) probably null Het
Rbm19 A G 5: 120,269,311 (GRCm39) D538G probably damaging Het
Rnf44 G A 13: 54,829,803 (GRCm39) R312* probably null Het
Rock1 T C 18: 10,070,215 (GRCm39) probably benign Het
Rrp1b A G 17: 32,275,875 (GRCm39) E474G probably damaging Het
Ryr2 T A 13: 11,699,365 (GRCm39) I2959F probably damaging Het
Sidt2 A G 9: 45,850,803 (GRCm39) S801P probably damaging Het
Skint6 T C 4: 112,870,153 (GRCm39) I602V probably benign Het
Slc6a19 C A 13: 73,848,590 (GRCm39) V55L probably damaging Het
Smarca4 C T 9: 21,547,132 (GRCm39) T219I probably benign Het
Trappc11 C A 8: 47,966,964 (GRCm39) V440F probably damaging Het
Vmn1r236 G A 17: 21,507,108 (GRCm39) W75* probably null Het
Vmn2r52 A G 7: 9,892,799 (GRCm39) F780S probably benign Het
Vmn2r82 G T 10: 79,217,149 (GRCm39) A494S possibly damaging Het
Vwa3b A T 1: 37,084,049 (GRCm39) K74M probably damaging Het
Wrn T A 8: 33,738,989 (GRCm39) I1037F possibly damaging Het
Zfp13 T C 17: 23,799,819 (GRCm39) T82A probably benign Het
Zfp82 T C 7: 29,756,890 (GRCm39) E64G probably benign Het
Other mutations in Myo3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00736:Myo3b APN 2 69,935,989 (GRCm39) splice site probably benign
IGL00959:Myo3b APN 2 70,144,636 (GRCm39) missense probably damaging 1.00
IGL01069:Myo3b APN 2 70,075,735 (GRCm39) missense probably benign 0.22
IGL01116:Myo3b APN 2 70,119,730 (GRCm39) missense probably damaging 1.00
IGL02097:Myo3b APN 2 70,069,173 (GRCm39) missense probably damaging 1.00
IGL02220:Myo3b APN 2 70,119,923 (GRCm39) splice site probably benign
IGL02553:Myo3b APN 2 69,925,568 (GRCm39) missense probably benign 0.00
IGL02557:Myo3b APN 2 70,085,663 (GRCm39) missense probably benign 0.16
IGL02648:Myo3b APN 2 69,935,716 (GRCm39) splice site probably benign
IGL02902:Myo3b APN 2 70,119,745 (GRCm39) missense probably benign 0.36
IGL02981:Myo3b APN 2 69,938,969 (GRCm39) missense probably damaging 1.00
IGL03031:Myo3b APN 2 70,085,721 (GRCm39) missense possibly damaging 0.64
IGL03068:Myo3b APN 2 70,257,160 (GRCm39) splice site probably benign
IGL03078:Myo3b APN 2 70,117,335 (GRCm39) missense probably damaging 1.00
IGL03224:Myo3b APN 2 70,180,283 (GRCm39) missense probably benign
IGL03329:Myo3b APN 2 70,084,803 (GRCm39) missense probably damaging 1.00
R0079:Myo3b UTSW 2 69,925,502 (GRCm39) missense possibly damaging 0.58
R0226:Myo3b UTSW 2 70,047,510 (GRCm39) missense probably benign 0.00
R0238:Myo3b UTSW 2 69,935,769 (GRCm39) missense probably benign 0.00
R0238:Myo3b UTSW 2 69,935,769 (GRCm39) missense probably benign 0.00
R0239:Myo3b UTSW 2 69,935,769 (GRCm39) missense probably benign 0.00
R0239:Myo3b UTSW 2 69,935,769 (GRCm39) missense probably benign 0.00
R0313:Myo3b UTSW 2 70,179,303 (GRCm39) nonsense probably null
R0331:Myo3b UTSW 2 69,925,605 (GRCm39) missense probably damaging 1.00
R0371:Myo3b UTSW 2 70,083,304 (GRCm39) splice site probably benign
R0442:Myo3b UTSW 2 70,069,305 (GRCm39) critical splice donor site probably null
R0964:Myo3b UTSW 2 70,257,193 (GRCm39) missense probably damaging 1.00
R1217:Myo3b UTSW 2 70,161,224 (GRCm39) missense probably benign 0.02
R1429:Myo3b UTSW 2 70,083,351 (GRCm39) missense probably damaging 0.97
R1460:Myo3b UTSW 2 70,062,798 (GRCm39) missense probably benign 0.31
R1617:Myo3b UTSW 2 70,111,562 (GRCm39) missense probably benign 0.00
R1628:Myo3b UTSW 2 70,117,306 (GRCm39) missense probably benign 0.01
R1708:Myo3b UTSW 2 70,075,729 (GRCm39) nonsense probably null
R1940:Myo3b UTSW 2 70,088,419 (GRCm39) missense probably benign 0.01
R2407:Myo3b UTSW 2 70,085,597 (GRCm39) missense probably damaging 1.00
R3081:Myo3b UTSW 2 70,086,927 (GRCm39) splice site probably benign
R3687:Myo3b UTSW 2 70,075,658 (GRCm39) missense probably benign
R3745:Myo3b UTSW 2 70,064,829 (GRCm39) splice site probably benign
R4011:Myo3b UTSW 2 69,926,720 (GRCm39) missense probably benign 0.15
R4074:Myo3b UTSW 2 70,119,808 (GRCm39) missense probably damaging 1.00
R4419:Myo3b UTSW 2 69,926,706 (GRCm39) missense probably damaging 1.00
R4496:Myo3b UTSW 2 70,084,748 (GRCm39) missense probably benign
R4539:Myo3b UTSW 2 69,869,491 (GRCm39) start codon destroyed probably null 0.00
R4643:Myo3b UTSW 2 70,069,186 (GRCm39) missense possibly damaging 0.49
R4657:Myo3b UTSW 2 70,069,243 (GRCm39) missense possibly damaging 0.95
R4807:Myo3b UTSW 2 69,936,056 (GRCm39) missense probably damaging 1.00
R4849:Myo3b UTSW 2 70,075,253 (GRCm39) missense probably damaging 0.98
R4997:Myo3b UTSW 2 70,088,427 (GRCm39) missense possibly damaging 0.49
R5008:Myo3b UTSW 2 70,088,412 (GRCm39) missense probably damaging 0.99
R5070:Myo3b UTSW 2 70,083,456 (GRCm39) missense probably damaging 1.00
R5072:Myo3b UTSW 2 69,925,593 (GRCm39) missense possibly damaging 0.96
R5082:Myo3b UTSW 2 70,088,374 (GRCm39) missense probably benign 0.01
R5103:Myo3b UTSW 2 69,926,747 (GRCm39) missense probably benign 0.08
R5109:Myo3b UTSW 2 69,925,637 (GRCm39) missense possibly damaging 0.66
R5304:Myo3b UTSW 2 70,257,232 (GRCm39) missense probably damaging 0.97
R5396:Myo3b UTSW 2 69,957,329 (GRCm39) missense probably damaging 0.99
R5400:Myo3b UTSW 2 69,935,724 (GRCm39) missense probably damaging 1.00
R5468:Myo3b UTSW 2 70,064,785 (GRCm39) missense probably benign 0.00
R5620:Myo3b UTSW 2 70,069,254 (GRCm39) missense probably benign 0.04
R5646:Myo3b UTSW 2 70,144,774 (GRCm39) missense probably damaging 0.97
R5729:Myo3b UTSW 2 69,936,083 (GRCm39) missense probably damaging 1.00
R5943:Myo3b UTSW 2 70,117,285 (GRCm39) missense probably benign 0.03
R5971:Myo3b UTSW 2 70,069,243 (GRCm39) missense possibly damaging 0.95
R6091:Myo3b UTSW 2 70,069,113 (GRCm39) missense probably benign 0.00
R6138:Myo3b UTSW 2 70,069,243 (GRCm39) missense possibly damaging 0.95
R6164:Myo3b UTSW 2 70,075,754 (GRCm39) critical splice donor site probably null
R6177:Myo3b UTSW 2 70,143,707 (GRCm39) missense probably benign 0.00
R6421:Myo3b UTSW 2 70,143,700 (GRCm39) missense probably benign 0.02
R6478:Myo3b UTSW 2 70,179,304 (GRCm39) missense probably benign
R6606:Myo3b UTSW 2 70,062,829 (GRCm39) missense possibly damaging 0.94
R6752:Myo3b UTSW 2 70,119,856 (GRCm39) missense probably damaging 1.00
R6982:Myo3b UTSW 2 70,256,409 (GRCm39) missense probably benign 0.02
R6997:Myo3b UTSW 2 69,957,329 (GRCm39) missense probably damaging 0.99
R7032:Myo3b UTSW 2 69,925,608 (GRCm39) missense probably damaging 0.98
R7038:Myo3b UTSW 2 69,925,552 (GRCm39) missense probably benign 0.00
R7062:Myo3b UTSW 2 70,047,501 (GRCm39) missense probably benign 0.00
R7537:Myo3b UTSW 2 70,047,513 (GRCm39) missense probably benign 0.01
R7861:Myo3b UTSW 2 69,939,032 (GRCm39) missense probably damaging 1.00
R7955:Myo3b UTSW 2 69,925,623 (GRCm39) missense probably benign 0.37
R7977:Myo3b UTSW 2 70,161,277 (GRCm39) missense probably benign
R7978:Myo3b UTSW 2 70,083,458 (GRCm39) missense probably damaging 1.00
R7987:Myo3b UTSW 2 70,161,277 (GRCm39) missense probably benign
R8803:Myo3b UTSW 2 70,083,338 (GRCm39) missense probably benign
R8843:Myo3b UTSW 2 70,088,325 (GRCm39) missense probably damaging 1.00
R8896:Myo3b UTSW 2 70,069,160 (GRCm39) missense probably damaging 1.00
R8904:Myo3b UTSW 2 70,257,252 (GRCm39) missense probably benign 0.07
R8909:Myo3b UTSW 2 70,083,440 (GRCm39) missense probably damaging 1.00
R9031:Myo3b UTSW 2 70,082,094 (GRCm39) missense probably damaging 0.99
R9052:Myo3b UTSW 2 70,062,747 (GRCm39) missense probably benign 0.00
R9251:Myo3b UTSW 2 70,088,425 (GRCm39) nonsense probably null
R9268:Myo3b UTSW 2 70,257,305 (GRCm39) makesense probably null
R9334:Myo3b UTSW 2 70,047,360 (GRCm39) missense probably damaging 1.00
R9377:Myo3b UTSW 2 70,069,242 (GRCm39) missense possibly damaging 0.78
R9457:Myo3b UTSW 2 69,925,553 (GRCm39) missense probably benign 0.01
R9520:Myo3b UTSW 2 70,062,753 (GRCm39) missense possibly damaging 0.67
R9593:Myo3b UTSW 2 70,075,648 (GRCm39) missense probably benign 0.43
R9671:Myo3b UTSW 2 70,086,908 (GRCm39) missense probably damaging 1.00
R9790:Myo3b UTSW 2 70,180,287 (GRCm39) missense probably benign 0.35
R9791:Myo3b UTSW 2 70,180,287 (GRCm39) missense probably benign 0.35
U15987:Myo3b UTSW 2 70,069,243 (GRCm39) missense possibly damaging 0.95
X0025:Myo3b UTSW 2 70,062,747 (GRCm39) missense probably benign 0.00
X0065:Myo3b UTSW 2 70,088,313 (GRCm39) missense probably damaging 1.00
Z1177:Myo3b UTSW 2 70,088,371 (GRCm39) missense probably benign 0.01
Z1177:Myo3b UTSW 2 69,926,705 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02