Incidental Mutation 'IGL03031:Olfr894'
ID408424
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr894
Ensembl Gene ENSMUSG00000070311
Gene Nameolfactory receptor 894
SynonymsGA_x6K02T2PVTD-31898993-31899934, MOR170-5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL03031
Quality Score
Status
Chromosome9
Chromosomal Location38218055-38221706 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 38219065 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Proline at position 81 (T81P)
Ref Sequence ENSEMBL: ENSMUSP00000091389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093866] [ENSMUST00000212992]
Predicted Effect probably damaging
Transcript: ENSMUST00000093866
AA Change: T81P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000091389
Gene: ENSMUSG00000070311
AA Change: T81P

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 8.8e-47 PFAM
Pfam:7tm_1 44 293 1.1e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212992
AA Change: T78P

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,314,024 D753G probably benign Het
Adat2 T C 10: 13,556,846 probably benign Het
Ahsa2 A G 11: 23,490,426 L275S probably benign Het
Arhgef38 C T 3: 133,132,067 D118N possibly damaging Het
Bicra A T 7: 15,975,801 H1097Q probably benign Het
C4b T C 17: 34,731,130 T1389A possibly damaging Het
Cd180 A G 13: 102,705,027 S194G probably benign Het
Chgb C A 2: 132,793,514 Q459K probably benign Het
Clvs1 G T 4: 9,449,385 probably benign Het
Cpox G A 16: 58,672,560 G186R probably damaging Het
Cul5 A G 9: 53,642,675 probably benign Het
Epsti1 G A 14: 77,974,581 R249K probably benign Het
Gabrg1 A T 5: 70,794,682 Y90* probably null Het
Gabrp T C 11: 33,554,980 R274G probably damaging Het
Gm597 A G 1: 28,778,583 F123L probably benign Het
Gm6401 C T 14: 41,966,894 E73K possibly damaging Het
Gm9825 T C 6: 7,982,857 noncoding transcript Het
Hectd4 C T 5: 121,348,794 T3284M possibly damaging Het
Hoxc9 T C 15: 102,984,090 M245T probably damaging Het
Lpar6 T C 14: 73,239,442 V281A possibly damaging Het
Med18 G T 4: 132,459,613 Q192K possibly damaging Het
Mis18bp1 A G 12: 65,161,930 V3A probably benign Het
Mpped2 G T 2: 106,783,623 probably benign Het
Ms4a10 A G 19: 10,968,671 V32A probably benign Het
Mthfd1l T A 10: 4,018,601 probably null Het
Myh1 A T 11: 67,206,387 Q422L possibly damaging Het
Myo3b A T 2: 70,255,377 Q819L possibly damaging Het
Ncoa1 G A 12: 4,274,818 T921I possibly damaging Het
Olfr807 A G 10: 129,755,369 L27P possibly damaging Het
Olfr960 A G 9: 39,623,398 I92V probably damaging Het
Phf3 A G 1: 30,804,653 S1742P probably benign Het
Plxdc2 G A 2: 16,650,232 probably null Het
Poc5 A G 13: 96,401,615 T263A probably benign Het
Prss41 T A 17: 23,842,422 I132F probably damaging Het
Pxylp1 A G 9: 96,825,142 I329T probably benign Het
Rbm27 T C 18: 42,333,399 probably null Het
Rpgrip1l A T 8: 91,260,783 V882E probably damaging Het
Sec16b T C 1: 157,560,799 S579P probably benign Het
Senp7 A G 16: 56,175,886 E776G probably damaging Het
Smc2 A G 4: 52,449,638 I207V probably benign Het
Spats2 A G 15: 99,180,688 T211A probably benign Het
Sphkap A T 1: 83,276,831 S779T probably damaging Het
Syt11 A T 3: 88,748,841 M1K probably null Het
Tacc2 A G 7: 130,623,855 T757A possibly damaging Het
Tecta A C 9: 42,345,493 M1629R probably benign Het
Ufsp2 T A 8: 45,984,100 I101N probably damaging Het
Unc13b T A 4: 43,235,368 C892S probably damaging Het
Ush1c A G 7: 46,224,937 probably benign Het
Vwde A T 6: 13,208,382 V167E probably benign Het
Wdfy4 A G 14: 33,140,651 L588P probably damaging Het
Zfyve1 T C 12: 83,574,821 T267A probably damaging Het
Other mutations in Olfr894
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Olfr894 APN 9 38219743 missense probably benign 0.18
IGL01772:Olfr894 APN 9 38219609 missense probably damaging 0.97
IGL02253:Olfr894 APN 9 38219735 missense probably benign 0.01
IGL02279:Olfr894 APN 9 38219093 missense probably benign 0.00
IGL03163:Olfr894 APN 9 38219414 missense probably benign 0.00
R0417:Olfr894 UTSW 9 38219455 missense probably benign 0.01
R0458:Olfr894 UTSW 9 38219048 missense probably damaging 0.97
R1498:Olfr894 UTSW 9 38219380 missense probably damaging 1.00
R1765:Olfr894 UTSW 9 38219252 missense probably benign 0.01
R2020:Olfr894 UTSW 9 38219432 missense possibly damaging 0.47
R2282:Olfr894 UTSW 9 38218828 missense probably benign 0.01
R3928:Olfr894 UTSW 9 38218835 start codon destroyed probably null 0.63
R4716:Olfr894 UTSW 9 38219418 missense probably damaging 0.99
R4911:Olfr894 UTSW 9 38219096 missense probably damaging 0.99
R5148:Olfr894 UTSW 9 38219021 missense probably benign 0.01
R7677:Olfr894 UTSW 9 38219028 missense probably damaging 1.00
X0050:Olfr894 UTSW 9 38219150 missense probably benign 0.00
Posted On2016-08-02