Incidental Mutation 'IGL03031:Gm6401'
ID408442
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm6401
Ensembl Gene ENSMUSG00000095044
Gene Namepredicted gene 6401
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.193) question?
Stock #IGL03031
Quality Score
Status
Chromosome14
Chromosomal Location41962708-41967927 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 41966894 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Lysine at position 73 (E73K)
Ref Sequence ENSEMBL: ENSMUSP00000133168 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064162] [ENSMUST00000164232] [ENSMUST00000168972]
Predicted Effect probably benign
Transcript: ENSMUST00000064162
SMART Domains Protein: ENSMUSP00000064211
Gene: ENSMUSG00000052334

DomainStartEndE-ValueType
Pfam:Takusan 10 93 3.7e-35 PFAM
coiled coil region 108 141 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000163566
AA Change: E80K
SMART Domains Protein: ENSMUSP00000129907
Gene: ENSMUSG00000095044
AA Change: E80K

DomainStartEndE-ValueType
Pfam:Takusan 57 137 2.2e-26 PFAM
coiled coil region 164 186 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000164232
AA Change: E73K

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000133168
Gene: ENSMUSG00000095044
AA Change: E73K

DomainStartEndE-ValueType
Pfam:Takusan 49 129 1.5e-26 PFAM
coiled coil region 157 179 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168972
SMART Domains Protein: ENSMUSP00000127922
Gene: ENSMUSG00000052334

DomainStartEndE-ValueType
Pfam:Takusan 10 93 8.6e-36 PFAM
coiled coil region 108 141 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,314,024 D753G probably benign Het
Adat2 T C 10: 13,556,846 probably benign Het
Ahsa2 A G 11: 23,490,426 L275S probably benign Het
Arhgef38 C T 3: 133,132,067 D118N possibly damaging Het
Bicra A T 7: 15,975,801 H1097Q probably benign Het
C4b T C 17: 34,731,130 T1389A possibly damaging Het
Cd180 A G 13: 102,705,027 S194G probably benign Het
Chgb C A 2: 132,793,514 Q459K probably benign Het
Clvs1 G T 4: 9,449,385 probably benign Het
Cpox G A 16: 58,672,560 G186R probably damaging Het
Cul5 A G 9: 53,642,675 probably benign Het
Epsti1 G A 14: 77,974,581 R249K probably benign Het
Gabrg1 A T 5: 70,794,682 Y90* probably null Het
Gabrp T C 11: 33,554,980 R274G probably damaging Het
Gm597 A G 1: 28,778,583 F123L probably benign Het
Gm9825 T C 6: 7,982,857 noncoding transcript Het
Hectd4 C T 5: 121,348,794 T3284M possibly damaging Het
Hoxc9 T C 15: 102,984,090 M245T probably damaging Het
Lpar6 T C 14: 73,239,442 V281A possibly damaging Het
Med18 G T 4: 132,459,613 Q192K possibly damaging Het
Mis18bp1 A G 12: 65,161,930 V3A probably benign Het
Mpped2 G T 2: 106,783,623 probably benign Het
Ms4a10 A G 19: 10,968,671 V32A probably benign Het
Mthfd1l T A 10: 4,018,601 probably null Het
Myh1 A T 11: 67,206,387 Q422L possibly damaging Het
Myo3b A T 2: 70,255,377 Q819L possibly damaging Het
Ncoa1 G A 12: 4,274,818 T921I possibly damaging Het
Olfr807 A G 10: 129,755,369 L27P possibly damaging Het
Olfr894 A C 9: 38,219,065 T81P probably damaging Het
Olfr960 A G 9: 39,623,398 I92V probably damaging Het
Phf3 A G 1: 30,804,653 S1742P probably benign Het
Plxdc2 G A 2: 16,650,232 probably null Het
Poc5 A G 13: 96,401,615 T263A probably benign Het
Prss41 T A 17: 23,842,422 I132F probably damaging Het
Pxylp1 A G 9: 96,825,142 I329T probably benign Het
Rbm27 T C 18: 42,333,399 probably null Het
Rpgrip1l A T 8: 91,260,783 V882E probably damaging Het
Sec16b T C 1: 157,560,799 S579P probably benign Het
Senp7 A G 16: 56,175,886 E776G probably damaging Het
Smc2 A G 4: 52,449,638 I207V probably benign Het
Spats2 A G 15: 99,180,688 T211A probably benign Het
Sphkap A T 1: 83,276,831 S779T probably damaging Het
Syt11 A T 3: 88,748,841 M1K probably null Het
Tacc2 A G 7: 130,623,855 T757A possibly damaging Het
Tecta A C 9: 42,345,493 M1629R probably benign Het
Ufsp2 T A 8: 45,984,100 I101N probably damaging Het
Unc13b T A 4: 43,235,368 C892S probably damaging Het
Ush1c A G 7: 46,224,937 probably benign Het
Vwde A T 6: 13,208,382 V167E probably benign Het
Wdfy4 A G 14: 33,140,651 L588P probably damaging Het
Zfyve1 T C 12: 83,574,821 T267A probably damaging Het
Other mutations in Gm6401
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02943:Gm6401 APN 14 41966894 missense possibly damaging 0.89
IGL03006:Gm6401 APN 14 41966894 missense possibly damaging 0.89
IGL03091:Gm6401 APN 14 41964658 missense possibly damaging 0.78
R1710:Gm6401 UTSW 14 41966883 missense probably benign 0.04
R5048:Gm6401 UTSW 14 41967767 splice site probably null
R5106:Gm6401 UTSW 14 41965506 missense probably damaging 1.00
R6257:Gm6401 UTSW 14 41967871 missense probably benign
R6362:Gm6401 UTSW 14 41967770 missense probably benign 0.01
R6571:Gm6401 UTSW 14 41965495 missense probably damaging 0.99
R6599:Gm6401 UTSW 14 41966864 nonsense probably null
R6802:Gm6401 UTSW 14 41966917 missense probably damaging 0.98
Posted On2016-08-02