Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03031:Prss41'

408463

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss41

Ensembl Gene

ENSMUSG00000024114

Gene Name

serine protease 41

Synonyms

Tessp1, 4931440B09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL03031

Quality Score

Status

Chromosome

Chromosomal Location

24055759-24063146 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 24061396 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 132 (I132F)

Ref Sequence

ENSEMBL: ENSMUSP00000122453 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024926] [ENSMUST00000122936] [ENSMUST00000151797]

AlphaFold

Q920S2

Predicted Effect

probably damaging
Transcript: ENSMUST00000024926
AA Change: I132F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000024926
Gene: ENSMUSG00000024114
AA Change: I132F

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Tryp_SPc	52	289	2.48e-79	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000122936
AA Change: I92F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000120141
Gene: ENSMUSG00000024114
AA Change: I92F

Domain	Start	End	E-Value	Type
Tryp_SPc	12	249	2.48e-79	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141788

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144925

Predicted Effect

probably damaging
Transcript: ENSMUST00000151797
AA Change: I132F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000122453
Gene: ENSMUSG00000024114
AA Change: I132F

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Tryp_SPc	52	204	2.91e-12	SMART
low complexity region	228	244	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,353,183 (GRCm39)	D753G	probably benign	Het
Adat2	T	C	10: 13,432,590 (GRCm39)		probably benign	Het
Ahsa2	A	G	11: 23,440,426 (GRCm39)	L275S	probably benign	Het
Arhgef38	C	T	3: 132,837,828 (GRCm39)	D118N	possibly damaging	Het
Bicra	A	T	7: 15,709,726 (GRCm39)	H1097Q	probably benign	Het
C4b	T	C	17: 34,950,104 (GRCm39)	T1389A	possibly damaging	Het
Cd180	A	G	13: 102,841,535 (GRCm39)	S194G	probably benign	Het
Chgb	C	A	2: 132,635,434 (GRCm39)	Q459K	probably benign	Het
Clvs1	G	T	4: 9,449,385 (GRCm39)		probably benign	Het
Cpox	G	A	16: 58,492,923 (GRCm39)	G186R	probably damaging	Het
Cul5	A	G	9: 53,553,975 (GRCm39)		probably benign	Het
Epsti1	G	A	14: 78,212,021 (GRCm39)	R249K	probably benign	Het
Gabrg1	A	T	5: 70,952,025 (GRCm39)	Y90*	probably null	Het
Gabrp	T	C	11: 33,504,980 (GRCm39)	R274G	probably damaging	Het
Gm6401	C	T	14: 41,788,851 (GRCm39)	E73K	possibly damaging	Het
Hectd4	C	T	5: 121,486,857 (GRCm39)	T3284M	possibly damaging	Het
Hoxc9	T	C	15: 102,892,522 (GRCm39)	M245T	probably damaging	Het
Lpar6	T	C	14: 73,476,882 (GRCm39)	V281A	possibly damaging	Het
Med18	G	T	4: 132,186,924 (GRCm39)	Q192K	possibly damaging	Het
Mis18bp1	A	G	12: 65,208,704 (GRCm39)	V3A	probably benign	Het
Mpped2	G	T	2: 106,613,968 (GRCm39)		probably benign	Het
Ms4a10	A	G	19: 10,946,035 (GRCm39)	V32A	probably benign	Het
Mthfd1l	T	A	10: 3,968,601 (GRCm39)		probably null	Het
Myh1	A	T	11: 67,097,213 (GRCm39)	Q422L	possibly damaging	Het
Myo3b	A	T	2: 70,085,721 (GRCm39)	Q819L	possibly damaging	Het
Ncoa1	G	A	12: 4,324,818 (GRCm39)	T921I	possibly damaging	Het
Or10d4b	A	G	9: 39,534,694 (GRCm39)	I92V	probably damaging	Het
Or6c214	A	G	10: 129,591,238 (GRCm39)	L27P	possibly damaging	Het
Or8c16	A	C	9: 38,130,361 (GRCm39)	T81P	probably damaging	Het
Phf3	A	G	1: 30,843,734 (GRCm39)	S1742P	probably benign	Het
Plxdc2	G	A	2: 16,655,043 (GRCm39)		probably null	Het
Poc5	A	G	13: 96,538,123 (GRCm39)	T263A	probably benign	Het
Pxylp1	A	G	9: 96,707,195 (GRCm39)	I329T	probably benign	Het
Rbm27	T	C	18: 42,466,464 (GRCm39)		probably null	Het
Rnps1-ps	T	C	6: 7,982,857 (GRCm39)		noncoding transcript	Het
Rpgrip1l	A	T	8: 91,987,411 (GRCm39)	V882E	probably damaging	Het
Sec16b	T	C	1: 157,388,369 (GRCm39)	S579P	probably benign	Het
Senp7	A	G	16: 55,996,249 (GRCm39)	E776G	probably damaging	Het
Smc2	A	G	4: 52,449,638 (GRCm39)	I207V	probably benign	Het
Spata31e5	A	G	1: 28,817,664 (GRCm39)	F123L	probably benign	Het
Spats2	A	G	15: 99,078,569 (GRCm39)	T211A	probably benign	Het
Sphkap	A	T	1: 83,254,552 (GRCm39)	S779T	probably damaging	Het
Syt11	A	T	3: 88,656,148 (GRCm39)	M1K	probably null	Het
Tacc2	A	G	7: 130,225,585 (GRCm39)	T757A	possibly damaging	Het
Tecta	A	C	9: 42,256,789 (GRCm39)	M1629R	probably benign	Het
Ufsp2	T	A	8: 46,437,137 (GRCm39)	I101N	probably damaging	Het
Unc13b	T	A	4: 43,235,368 (GRCm39)	C892S	probably damaging	Het
Ush1c	A	G	7: 45,874,361 (GRCm39)		probably benign	Het
Vwde	A	T	6: 13,208,381 (GRCm39)	V167E	probably benign	Het
Wdfy4	A	G	14: 32,862,608 (GRCm39)	L588P	probably damaging	Het
Zfyve1	T	C	12: 83,621,595 (GRCm39)	T267A	probably damaging	Het

Other mutations in Prss41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02215:Prss41	APN	17	24,062,830 (GRCm39)	missense	probably benign	0.01
IGL03131:Prss41	APN	17	24,061,498 (GRCm39)	missense	probably benign	0.00
FR4737:Prss41	UTSW	17	24,063,071 (GRCm39)	small deletion	probably benign
R0491:Prss41	UTSW	17	24,061,477 (GRCm39)	missense	possibly damaging	0.91
R2014:Prss41	UTSW	17	24,056,464 (GRCm39)	critical splice donor site	probably null
R3813:Prss41	UTSW	17	24,056,596 (GRCm39)	nonsense	probably null
R4888:Prss41	UTSW	17	24,055,977 (GRCm39)	missense	probably benign	0.08
R5707:Prss41	UTSW	17	24,061,390 (GRCm39)	missense	probably benign	0.00
R6904:Prss41	UTSW	17	24,056,622 (GRCm39)	missense	probably benign	0.15
R7486:Prss41	UTSW	17	24,063,072 (GRCm39)	small deletion	probably benign
R7782:Prss41	UTSW	17	24,056,087 (GRCm39)	missense	probably benign	0.40
R8087:Prss41	UTSW	17	24,056,076 (GRCm39)	missense	probably damaging	1.00
R8141:Prss41	UTSW	17	24,056,607 (GRCm39)	missense	probably damaging	1.00
R9189:Prss41	UTSW	17	24,061,361 (GRCm39)	missense	probably damaging	0.98

Posted On

2016-08-02