Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03031:Plxdc2'

408468

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Plxdc2

Ensembl Gene

ENSMUSG00000026748

Gene Name

plexin domain containing 2

Synonyms

1200007L24Rik, Tem7r, 5430431D22Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03031

Quality Score

Status

Chromosome

Chromosomal Location

16361115-16760650 bp(+) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

G to A at 16655043 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110351 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028081] [ENSMUST00000114702] [ENSMUST00000114703]

AlphaFold

Q9DC11

Predicted Effect

probably null
Transcript: ENSMUST00000028081

SMART Domains

Protein: ENSMUSP00000028081
Gene: ENSMUSG00000026748

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
PSI	327	372	1.52e-3	SMART
low complexity region	390	401	N/A	INTRINSIC
transmembrane domain	455	477	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000114702

SMART Domains

Protein: ENSMUSP00000110350
Gene: ENSMUSG00000026748

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
PSI	327	372	1.52e-3	SMART
low complexity region	388	399	N/A	INTRINSIC
transmembrane domain	453	475	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000114703

SMART Domains

Protein: ENSMUSP00000110351
Gene: ENSMUSG00000026748

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
PSI	278	323	1.52e-3	SMART
low complexity region	339	350	N/A	INTRINSIC
transmembrane domain	404	426	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126173

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a hypomorphic reporter allele are viable and behaviorally normal with no apparent abnormalities in the developing and mature nervous system. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,353,183 (GRCm39)	D753G	probably benign	Het
Adat2	T	C	10: 13,432,590 (GRCm39)		probably benign	Het
Ahsa2	A	G	11: 23,440,426 (GRCm39)	L275S	probably benign	Het
Arhgef38	C	T	3: 132,837,828 (GRCm39)	D118N	possibly damaging	Het
Bicra	A	T	7: 15,709,726 (GRCm39)	H1097Q	probably benign	Het
C4b	T	C	17: 34,950,104 (GRCm39)	T1389A	possibly damaging	Het
Cd180	A	G	13: 102,841,535 (GRCm39)	S194G	probably benign	Het
Chgb	C	A	2: 132,635,434 (GRCm39)	Q459K	probably benign	Het
Clvs1	G	T	4: 9,449,385 (GRCm39)		probably benign	Het
Cpox	G	A	16: 58,492,923 (GRCm39)	G186R	probably damaging	Het
Cul5	A	G	9: 53,553,975 (GRCm39)		probably benign	Het
Epsti1	G	A	14: 78,212,021 (GRCm39)	R249K	probably benign	Het
Gabrg1	A	T	5: 70,952,025 (GRCm39)	Y90*	probably null	Het
Gabrp	T	C	11: 33,504,980 (GRCm39)	R274G	probably damaging	Het
Gm6401	C	T	14: 41,788,851 (GRCm39)	E73K	possibly damaging	Het
Hectd4	C	T	5: 121,486,857 (GRCm39)	T3284M	possibly damaging	Het
Hoxc9	T	C	15: 102,892,522 (GRCm39)	M245T	probably damaging	Het
Lpar6	T	C	14: 73,476,882 (GRCm39)	V281A	possibly damaging	Het
Med18	G	T	4: 132,186,924 (GRCm39)	Q192K	possibly damaging	Het
Mis18bp1	A	G	12: 65,208,704 (GRCm39)	V3A	probably benign	Het
Mpped2	G	T	2: 106,613,968 (GRCm39)		probably benign	Het
Ms4a10	A	G	19: 10,946,035 (GRCm39)	V32A	probably benign	Het
Mthfd1l	T	A	10: 3,968,601 (GRCm39)		probably null	Het
Myh1	A	T	11: 67,097,213 (GRCm39)	Q422L	possibly damaging	Het
Myo3b	A	T	2: 70,085,721 (GRCm39)	Q819L	possibly damaging	Het
Ncoa1	G	A	12: 4,324,818 (GRCm39)	T921I	possibly damaging	Het
Or10d4b	A	G	9: 39,534,694 (GRCm39)	I92V	probably damaging	Het
Or6c214	A	G	10: 129,591,238 (GRCm39)	L27P	possibly damaging	Het
Or8c16	A	C	9: 38,130,361 (GRCm39)	T81P	probably damaging	Het
Phf3	A	G	1: 30,843,734 (GRCm39)	S1742P	probably benign	Het
Poc5	A	G	13: 96,538,123 (GRCm39)	T263A	probably benign	Het
Prss41	T	A	17: 24,061,396 (GRCm39)	I132F	probably damaging	Het
Pxylp1	A	G	9: 96,707,195 (GRCm39)	I329T	probably benign	Het
Rbm27	T	C	18: 42,466,464 (GRCm39)		probably null	Het
Rnps1-ps	T	C	6: 7,982,857 (GRCm39)		noncoding transcript	Het
Rpgrip1l	A	T	8: 91,987,411 (GRCm39)	V882E	probably damaging	Het
Sec16b	T	C	1: 157,388,369 (GRCm39)	S579P	probably benign	Het
Senp7	A	G	16: 55,996,249 (GRCm39)	E776G	probably damaging	Het
Smc2	A	G	4: 52,449,638 (GRCm39)	I207V	probably benign	Het
Spata31e5	A	G	1: 28,817,664 (GRCm39)	F123L	probably benign	Het
Spats2	A	G	15: 99,078,569 (GRCm39)	T211A	probably benign	Het
Sphkap	A	T	1: 83,254,552 (GRCm39)	S779T	probably damaging	Het
Syt11	A	T	3: 88,656,148 (GRCm39)	M1K	probably null	Het
Tacc2	A	G	7: 130,225,585 (GRCm39)	T757A	possibly damaging	Het
Tecta	A	C	9: 42,256,789 (GRCm39)	M1629R	probably benign	Het
Ufsp2	T	A	8: 46,437,137 (GRCm39)	I101N	probably damaging	Het
Unc13b	T	A	4: 43,235,368 (GRCm39)	C892S	probably damaging	Het
Ush1c	A	G	7: 45,874,361 (GRCm39)		probably benign	Het
Vwde	A	T	6: 13,208,381 (GRCm39)	V167E	probably benign	Het
Wdfy4	A	G	14: 32,862,608 (GRCm39)	L588P	probably damaging	Het
Zfyve1	T	C	12: 83,621,595 (GRCm39)	T267A	probably damaging	Het

Other mutations in Plxdc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01420:Plxdc2	APN	2	16,654,950 (GRCm39)	missense	probably damaging	1.00
IGL01700:Plxdc2	APN	2	16,516,926 (GRCm39)	missense	probably benign	0.00
IGL02306:Plxdc2	APN	2	16,665,585 (GRCm39)	missense	probably benign	0.06
IGL02555:Plxdc2	APN	2	16,734,152 (GRCm39)	missense	probably benign	0.02
IGL02558:Plxdc2	APN	2	16,674,409 (GRCm39)	splice site	probably benign
IGL03114:Plxdc2	APN	2	16,654,935 (GRCm39)	missense	probably damaging	1.00
R1024:Plxdc2	UTSW	2	16,716,917 (GRCm39)	missense	probably benign	0.00
R1449:Plxdc2	UTSW	2	16,665,592 (GRCm39)	missense	possibly damaging	0.82
R1840:Plxdc2	UTSW	2	16,674,667 (GRCm39)	missense	probably benign	0.11
R2091:Plxdc2	UTSW	2	16,718,494 (GRCm39)	missense	probably damaging	1.00
R2129:Plxdc2	UTSW	2	16,516,902 (GRCm39)	missense	probably benign
R2192:Plxdc2	UTSW	2	16,570,147 (GRCm39)	missense	probably damaging	0.99
R2287:Plxdc2	UTSW	2	16,517,001 (GRCm39)	missense	probably benign	0.00
R2567:Plxdc2	UTSW	2	16,716,995 (GRCm39)	missense	probably benign	0.00
R3964:Plxdc2	UTSW	2	16,665,651 (GRCm39)	missense	probably damaging	0.98
R4167:Plxdc2	UTSW	2	16,570,196 (GRCm39)	missense	probably damaging	0.99
R4496:Plxdc2	UTSW	2	16,517,040 (GRCm39)	missense	probably damaging	1.00
R4876:Plxdc2	UTSW	2	16,708,129 (GRCm39)	missense	probably damaging	1.00
R4891:Plxdc2	UTSW	2	16,716,957 (GRCm39)	missense	probably benign
R5238:Plxdc2	UTSW	2	16,655,026 (GRCm39)	missense	probably damaging	1.00
R5389:Plxdc2	UTSW	2	16,654,998 (GRCm39)	missense	probably damaging	1.00
R5984:Plxdc2	UTSW	2	16,665,666 (GRCm39)	missense	probably benign	0.28
R6675:Plxdc2	UTSW	2	16,716,932 (GRCm39)	missense	probably benign
R6751:Plxdc2	UTSW	2	16,552,952 (GRCm39)	missense	probably benign	0.14
R7676:Plxdc2	UTSW	2	16,716,894 (GRCm39)	missense	probably benign	0.01
R7757:Plxdc2	UTSW	2	16,734,187 (GRCm39)	missense	probably benign	0.37
R7813:Plxdc2	UTSW	2	16,665,678 (GRCm39)	missense	possibly damaging	0.56
R7919:Plxdc2	UTSW	2	16,553,036 (GRCm39)	missense	probably damaging	0.98
R9783:Plxdc2	UTSW	2	16,674,349 (GRCm39)	nonsense	probably null
Z1176:Plxdc2	UTSW	2	16,570,214 (GRCm39)	missense	possibly damaging	0.82

Posted On

2016-08-02