Incidental Mutation 'IGL03032:Parp12'
ID 408496
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Parp12
Ensembl Gene ENSMUSG00000038507
Gene Name poly (ADP-ribose) polymerase family, member 12
Synonyms Zc3hdc1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # IGL03032
Quality Score
Status
Chromosome 6
Chromosomal Location 39063346-39095283 bp(-) (GRCm39)
Type of Mutation splice site (3001 bp from exon)
DNA Base Change (assembly) G to A at 39064520 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000003017 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003017] [ENSMUST00000038398]
AlphaFold Q8BZ20
Predicted Effect probably null
Transcript: ENSMUST00000003017
SMART Domains Protein: ENSMUSP00000003017
Gene: ENSMUSG00000029925

DomainStartEndE-ValueType
low complexity region 16 28 N/A INTRINSIC
Pfam:p450 44 530 1.5e-95 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000038398
AA Change: T622I

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000039704
Gene: ENSMUSG00000038507
AA Change: T622I

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
low complexity region 17 32 N/A INTRINSIC
low complexity region 51 83 N/A INTRINSIC
ZnF_C3H1 99 127 2.79e1 SMART
ZnF_C3H1 186 210 1.36e-2 SMART
ZnF_C3H1 280 306 2.03e1 SMART
Pfam:WWE 385 468 1.3e-16 PFAM
Pfam:PARP 506 689 5.2e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161781
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A T 5: 88,119,774 (GRCm39) Y177F possibly damaging Het
Als2 C A 1: 59,255,189 (GRCm39) probably benign Het
Arhgap44 A G 11: 64,915,038 (GRCm39) L410P probably damaging Het
Atp13a2 C T 4: 140,727,666 (GRCm39) A481V possibly damaging Het
Bod1l C A 5: 41,988,927 (GRCm39) L393F probably benign Het
Cflar T A 1: 58,780,179 (GRCm39) I258N probably damaging Het
Col24a1 T C 3: 145,244,458 (GRCm39) probably null Het
Csmd2 A T 4: 128,412,834 (GRCm39) N2542I probably benign Het
Cyp2b9 T C 7: 25,898,025 (GRCm39) probably benign Het
Dip2c A T 13: 9,601,814 (GRCm39) I258F probably damaging Het
Dock7 A G 4: 98,854,585 (GRCm39) S1560P probably benign Het
Drc7 C T 8: 95,802,875 (GRCm39) probably benign Het
Gm3667 T A 14: 18,269,522 (GRCm39) S203C probably null Het
Gramd2a A G 9: 59,619,410 (GRCm39) E190G probably benign Het
Gstm4 T C 3: 107,951,263 (GRCm39) D8G probably damaging Het
Heatr5b A T 17: 79,067,928 (GRCm39) M1820K probably benign Het
Irs4 A G X: 140,505,794 (GRCm39) Y801H unknown Het
Loxhd1 C T 18: 77,374,169 (GRCm39) T80I possibly damaging Het
Lrrc40 G A 3: 157,747,302 (GRCm39) probably benign Het
Mapk8ip1 T G 2: 92,216,958 (GRCm39) K446Q probably damaging Het
Mettl21e C A 1: 44,249,319 (GRCm39) probably null Het
Mmp8 T A 9: 7,558,530 (GRCm39) probably benign Het
Muc19 A T 15: 91,808,424 (GRCm39) noncoding transcript Het
Nipsnap3b T A 4: 53,015,016 (GRCm39) V21E possibly damaging Het
Or1j15 C A 2: 36,458,716 (GRCm39) Y35* probably null Het
Or5al6 A G 2: 85,977,043 (GRCm39) F12L probably damaging Het
Or7a38 A T 10: 78,753,471 (GRCm39) I266F probably benign Het
Pramel14 C A 4: 143,719,815 (GRCm39) L183F probably damaging Het
Rgsl1 T A 1: 153,701,948 (GRCm39) T169S possibly damaging Het
Rnf38 T C 4: 44,152,529 (GRCm39) R12G probably damaging Het
Slc9c1 T C 16: 45,363,624 (GRCm39) probably benign Het
Slpi T C 2: 164,197,367 (GRCm39) probably benign Het
Snx17 G A 5: 31,353,355 (GRCm39) V165I probably benign Het
Tnfaip3 A G 10: 18,880,357 (GRCm39) V570A probably benign Het
Vmn1r63 A G 7: 5,806,350 (GRCm39) M94T probably benign Het
Vmn2r95 A G 17: 18,672,575 (GRCm39) I771V probably benign Het
Wiz A G 17: 32,575,532 (GRCm39) V868A probably benign Het
Other mutations in Parp12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02199:Parp12 APN 6 39,073,524 (GRCm39) missense probably benign 0.01
IGL02937:Parp12 APN 6 39,079,515 (GRCm39) missense probably damaging 1.00
IGL03149:Parp12 APN 6 39,091,165 (GRCm39) missense probably benign 0.07
IGL03365:Parp12 APN 6 39,079,581 (GRCm39) missense probably damaging 1.00
I1329:Parp12 UTSW 6 39,064,505 (GRCm39) missense probably damaging 1.00
R1016:Parp12 UTSW 6 39,088,660 (GRCm39) missense probably damaging 1.00
R1446:Parp12 UTSW 6 39,079,495 (GRCm39) missense probably benign 0.00
R1640:Parp12 UTSW 6 39,088,612 (GRCm39) missense probably damaging 1.00
R1640:Parp12 UTSW 6 39,073,574 (GRCm39) missense probably benign 0.38
R4794:Parp12 UTSW 6 39,094,744 (GRCm39) missense probably benign 0.02
R5324:Parp12 UTSW 6 39,079,546 (GRCm39) missense probably damaging 0.99
R5411:Parp12 UTSW 6 39,067,142 (GRCm39) missense probably damaging 1.00
R6862:Parp12 UTSW 6 39,088,670 (GRCm39) missense probably benign 0.02
R6864:Parp12 UTSW 6 39,088,670 (GRCm39) missense probably benign 0.02
R6865:Parp12 UTSW 6 39,088,670 (GRCm39) missense probably benign 0.02
R7124:Parp12 UTSW 6 39,088,670 (GRCm39) missense probably benign 0.02
R7126:Parp12 UTSW 6 39,088,670 (GRCm39) missense probably benign 0.02
R7935:Parp12 UTSW 6 39,079,612 (GRCm39) missense possibly damaging 0.70
R8050:Parp12 UTSW 6 39,066,038 (GRCm39) missense probably damaging 1.00
R8403:Parp12 UTSW 6 39,068,279 (GRCm39) missense probably benign 0.06
R8686:Parp12 UTSW 6 39,094,856 (GRCm39) missense probably benign 0.00
R8792:Parp12 UTSW 6 39,065,984 (GRCm39) missense probably benign 0.00
R8813:Parp12 UTSW 6 39,073,508 (GRCm39) missense probably damaging 1.00
R9797:Parp12 UTSW 6 39,067,185 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02