Incidental Mutation 'IGL03035:Prl3b1'
ID408636
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Nameprolactin family 3, subfamily b, member 1
SynonymsmplII, Csh2, Pl2, prolactin-like, Pl-2, PL, mPL-II
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock #IGL03035
Quality Score
Status
Chromosome13
Chromosomal Location27241847-27249683 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 27249533 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153139 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
Predicted Effect probably benign
Transcript: ENSMUST00000035273
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,627,593 L1004P probably damaging Het
Adgrf5 T C 17: 43,430,627 I385T possibly damaging Het
Alpk3 T C 7: 81,078,604 V494A probably benign Het
Camta2 C A 11: 70,671,509 E1021* probably null Het
Ccdc6 T A 10: 70,182,176 S334T probably benign Het
Cd84 T C 1: 171,852,034 V93A probably damaging Het
Ceacam20 T C 7: 19,977,908 probably null Het
Crip2 A C 12: 113,144,125 T103P probably benign Het
Cyp4f14 T A 17: 32,914,634 T83S probably benign Het
Dapk1 T A 13: 60,716,773 V127D probably damaging Het
Dnah7c A G 1: 46,524,117 E609G probably benign Het
Dscam T A 16: 96,819,970 I513F possibly damaging Het
Ell2 T A 13: 75,763,648 L351* probably null Het
Emcn G T 3: 137,372,851 probably null Het
Fdft1 A T 14: 63,163,389 C98* probably null Het
Fer1l4 A G 2: 156,022,606 S1663P possibly damaging Het
Flt4 C A 11: 49,645,897 Y1231* probably null Het
Gatb A G 3: 85,601,947 K139E probably damaging Het
Gm13212 C A 4: 145,622,232 Q80K possibly damaging Het
Gtf2a1 C A 12: 91,572,637 probably benign Het
Gtf3c2 A C 5: 31,166,014 V574G possibly damaging Het
Heatr1 T C 13: 12,413,219 probably benign Het
Homer2 T A 7: 81,624,278 T57S possibly damaging Het
Ice2 C A 9: 69,425,688 F825L probably benign Het
Lepr C A 4: 101,764,980 L370I probably damaging Het
Nalcn G A 14: 123,278,218 Q1724* probably null Het
Nufip1 A G 14: 76,115,818 D222G probably damaging Het
Olfr1289 T C 2: 111,483,823 V159A probably benign Het
Ptbp3 A T 4: 59,477,218 M393K probably benign Het
Ptgds T C 2: 25,469,610 T22A probably benign Het
Rapgef2 T A 3: 79,094,424 H282L probably damaging Het
Rars2 T C 4: 34,656,865 probably null Het
Rnf213 G A 11: 119,445,626 probably benign Het
Ros1 C A 10: 52,075,984 probably benign Het
Slx4ip A G 2: 137,067,703 D206G possibly damaging Het
Sprr1a T A 3: 92,484,577 D39V probably benign Het
Stab1 A G 14: 31,147,769 V1442A probably benign Het
Tbx3 C A 5: 119,683,096 probably benign Het
Ubl3 A G 5: 148,506,137 *118Q probably null Het
Vmn2r55 G A 7: 12,670,816 S220L probably benign Het
Vps36 A G 8: 22,218,415 K362E probably benign Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02385:Prl3b1 APN 13 27249383 missense possibly damaging 0.51
IGL02669:Prl3b1 APN 13 27245812 missense probably benign 0.24
IGL03077:Prl3b1 APN 13 27245776 missense probably benign 0.00
Gabby UTSW 13 27247945 missense probably damaging 1.00
peaches UTSW 13 27242490 start codon destroyed probably null 1.00
Pits UTSW 13 27247974 critical splice donor site probably null
R0716:Prl3b1 UTSW 13 27243796 missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1364:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1366:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1367:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1530:Prl3b1 UTSW 13 27243865 missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27247903 missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27245792 missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27247912 missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27247965 missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27249522 missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27243906 splice site probably null
R4580:Prl3b1 UTSW 13 27249467 missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27249477 missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27245875 missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27247945 missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27243892 missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27247974 critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27243844 missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27242490 start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27247923 missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27243759 missense probably benign 0.23
Posted On2016-08-02