Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03037:Dock11'

408767

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dock11

Ensembl Gene

ENSMUSG00000031093

Gene Name

dedicator of cytokinesis 11

Synonyms

5033414A21Rik, Zizimin2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.217) question?

Stock #

IGL03037

Quality Score

Status

Chromosome

Chromosomal Location

35152485-35340215 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 35310699 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110921 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115264] [ENSMUST00000115266]

AlphaFold

A2AF47

Predicted Effect

probably benign
Transcript: ENSMUST00000033419

SMART Domains

Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
Pfam:DUF3398	52	145	4.2e-39	PFAM
PH	166	274	1.4e-17	SMART
Blast:PH	329	440	4e-58	BLAST
Pfam:DOCK-C2	636	827	2.4e-53	PFAM
low complexity region	1254	1270	N/A	INTRINSIC
Pfam:DHR-2	1510	2029	7.3e-210	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115264

SMART Domains

Protein: ENSMUSP00000110919
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	184	192	N/A	INTRINSIC
Pfam:Ded_cyto	344	521	1.6e-69	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115266

SMART Domains

Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093

Domain	Start	End	E-Value	Type
PH	1	90	6.82e-7	SMART
Blast:PH	145	256	5e-58	BLAST
Pfam:DOCK-C2	451	644	1.3e-60	PFAM
low complexity region	1083	1099	N/A	INTRINSIC
low complexity region	1521	1529	N/A	INTRINSIC
Pfam:Ded_cyto	1681	1858	1.2e-68	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actl11	T	C	9: 107,807,294 (GRCm39)	L539P	probably damaging	Het
Adam23	A	T	1: 63,610,176 (GRCm39)	Q726L	possibly damaging	Het
Ago1	T	C	4: 126,355,587 (GRCm39)	E74G	probably benign	Het
Atp6v1d	C	A	12: 78,904,122 (GRCm39)		probably benign	Het
Bltp1	C	A	3: 37,023,356 (GRCm39)	S2227R	probably benign	Het
Bltp1	T	C	3: 37,023,357 (GRCm39)	S2229P	probably damaging	Het
Cadm4	T	A	7: 24,200,220 (GRCm39)	L243Q	probably damaging	Het
Camsap2	C	A	1: 136,202,595 (GRCm39)	L1274F	probably damaging	Het
Car10	A	G	11: 92,991,044 (GRCm39)		probably benign	Het
Catsperd	A	T	17: 56,948,583 (GRCm39)	D186V	possibly damaging	Het
Cdc42bpg	A	G	19: 6,361,230 (GRCm39)	Y285C	probably damaging	Het
Cenpi	T	A	X: 133,250,017 (GRCm39)	C599S	possibly damaging	Het
Cln8	A	T	8: 14,944,679 (GRCm39)		probably benign	Het
Cnksr1	T	C	4: 133,962,417 (GRCm39)		probably null	Het
Cripto	C	A	9: 110,772,288 (GRCm39)	W36L	probably benign	Het
Ddx5	T	C	11: 106,672,930 (GRCm39)	N532D	possibly damaging	Het
Dock8	A	G	19: 25,063,545 (GRCm39)	E249G	probably benign	Het
Espnl	T	C	1: 91,269,643 (GRCm39)	V393A	probably benign	Het
Fhip1b	A	T	7: 105,028,293 (GRCm39)	H885Q	probably benign	Het
Frrs1	T	C	3: 116,696,116 (GRCm39)		probably benign	Het
Fstl4	C	A	11: 53,059,050 (GRCm39)	A503D	possibly damaging	Het
Gda	T	A	19: 21,411,673 (GRCm39)	I42L	possibly damaging	Het
Gprc5d	C	A	6: 135,093,319 (GRCm39)	C196F	probably damaging	Het
Hnrnpa0	A	G	13: 58,275,767 (GRCm39)	F121L	probably damaging	Het
Hsd3b7	C	T	7: 127,400,322 (GRCm39)	H24Y	probably damaging	Het
Ift140	T	C	17: 25,311,368 (GRCm39)	S1188P	probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Mcemp1	C	A	8: 3,717,055 (GRCm39)	Y65*	probably null	Het
Mmp16	C	T	4: 17,996,222 (GRCm39)	P104S	probably damaging	Het
Mpst	C	A	15: 78,294,798 (GRCm39)	R177S	probably benign	Het
Nek1	A	T	8: 61,487,086 (GRCm39)	T279S	probably benign	Het
Or1q1	C	T	2: 36,887,560 (GRCm39)	T246I	probably benign	Het
Or1x2	A	T	11: 50,918,117 (GRCm39)	Y96F	probably damaging	Het
Or4c11b	A	G	2: 88,625,299 (GRCm39)	Y191C	probably damaging	Het
Or7g18	T	A	9: 18,786,668 (GRCm39)	I12N	probably damaging	Het
Pard3	A	T	8: 128,032,975 (GRCm39)	T190S	probably benign	Het
Pik3r4	A	G	9: 105,528,012 (GRCm39)	D455G	probably damaging	Het
Piwil4	T	C	9: 14,616,308 (GRCm39)	I756V	possibly damaging	Het
Pkhd1	A	G	1: 20,592,923 (GRCm39)	L1730P	probably benign	Het
Pnpla3	T	C	15: 84,056,960 (GRCm39)	I155T	probably damaging	Het
Prmt8	T	C	6: 127,680,940 (GRCm39)	Y243C	possibly damaging	Het
Rbfox1	T	A	16: 7,110,147 (GRCm39)		probably benign	Het
Rps6ka2	G	A	17: 7,521,849 (GRCm39)		probably null	Het
Scaf8	A	G	17: 3,240,496 (GRCm39)	K623E	probably damaging	Het
Slc26a4	A	T	12: 31,581,686 (GRCm39)		probably benign	Het
Slfn8	T	A	11: 82,894,078 (GRCm39)	I854F	probably damaging	Het
Smarca4	T	C	9: 21,544,231 (GRCm39)		probably benign	Het
Sos1	T	C	17: 80,727,758 (GRCm39)	D775G	probably damaging	Het
Spag17	G	A	3: 99,979,486 (GRCm39)		probably null	Het
Spata31d1d	T	A	13: 59,873,947 (GRCm39)	E1196V	possibly damaging	Het
Sqle	T	A	15: 59,193,246 (GRCm39)	Y208N	probably damaging	Het
Tcl1b5	C	T	12: 105,145,273 (GRCm39)	T79M	probably benign	Het
Tenm3	A	G	8: 48,751,913 (GRCm39)	F959L	possibly damaging	Het
Tnfrsf19	T	A	14: 61,261,721 (GRCm39)	K26I	possibly damaging	Het
Trappc10	A	T	10: 78,034,869 (GRCm39)		probably benign	Het
Trim80	T	C	11: 115,332,419 (GRCm39)	W204R	possibly damaging	Het
Trpm3	A	G	19: 22,866,776 (GRCm39)	T536A	possibly damaging	Het
Ttbk1	G	A	17: 46,757,256 (GRCm39)	T1126I	probably benign	Het
Uaca	A	G	9: 60,748,147 (GRCm39)	D37G	probably damaging	Het
Ube3a	T	C	7: 58,896,971 (GRCm39)		probably benign	Het
Ubqln2	C	T	X: 152,282,692 (GRCm39)	Q415*	probably null	Het
Ugp2	T	A	11: 21,282,540 (GRCm39)	K151*	probably null	Het
Wasf1	A	G	10: 40,806,654 (GRCm39)	K99R	probably benign	Het
Wnt4	C	T	4: 137,016,472 (GRCm39)	T42M	possibly damaging	Het
Zfp54	T	A	17: 21,650,477 (GRCm39)	D17E	probably damaging	Het

Other mutations in Dock11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00536:Dock11	APN	X	35,258,087 (GRCm39)	missense	probably benign	0.15
IGL00650:Dock11	APN	X	35,270,246 (GRCm39)	splice site	probably benign
IGL00769:Dock11	APN	X	35,267,715 (GRCm39)	missense	possibly damaging	0.74
IGL00963:Dock11	APN	X	35,296,035 (GRCm39)	missense	possibly damaging	0.63
IGL01389:Dock11	APN	X	35,256,701 (GRCm39)	missense	probably benign	0.43
IGL01410:Dock11	APN	X	35,301,296 (GRCm39)	missense	probably damaging	1.00
IGL01519:Dock11	APN	X	35,227,006 (GRCm39)	missense	probably benign
IGL02023:Dock11	APN	X	35,232,422 (GRCm39)	missense	probably benign	0.09
IGL02253:Dock11	APN	X	35,304,781 (GRCm39)	missense	probably damaging	1.00
IGL02416:Dock11	APN	X	35,283,739 (GRCm39)	missense	probably damaging	0.97
IGL02583:Dock11	APN	X	35,270,370 (GRCm39)	missense	possibly damaging	0.48
IGL03014:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03065:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03277:Dock11	APN	X	35,277,603 (GRCm39)	missense	probably benign	0.32
R0816:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0819:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0820:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R1430:Dock11	UTSW	X	35,333,565 (GRCm39)	missense	probably benign	0.00
R1512:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock11	UTSW	X	35,266,186 (GRCm39)	missense	probably benign	0.01
Z1176:Dock11	UTSW	X	35,248,501 (GRCm39)	missense	possibly damaging	0.69

Posted On

2016-08-02