Incidental Mutation 'IGL03038:Ces1b'
ID 408770
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ces1b
Ensembl Gene ENSMUSG00000078964
Gene Name carboxylesterase 1B
Synonyms Gm5158
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL03038
Quality Score
Status
Chromosome 8
Chromosomal Location 93783356-93806645 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 93793680 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 303 (E303G)
Ref Sequence ENSEMBL: ENSMUSP00000105210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109582]
AlphaFold D3Z5G7
Predicted Effect probably benign
Transcript: ENSMUST00000109582
AA Change: E303G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105210
Gene: ENSMUSG00000078964
AA Change: E303G

DomainStartEndE-ValueType
Pfam:COesterase 1 547 7.6e-168 PFAM
Pfam:Abhydrolase_3 136 245 8.5e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadsb T C 7: 131,030,185 (GRCm39) Y111H probably damaging Het
Arhgef6 C T X: 56,290,966 (GRCm39) V262I probably benign Het
Arsk C A 13: 76,213,632 (GRCm39) probably benign Het
Chst9 T C 18: 15,628,360 (GRCm39) Q55R probably benign Het
Cntnap3 A T 13: 64,888,839 (GRCm39) D1153E possibly damaging Het
D130043K22Rik A G 13: 25,063,602 (GRCm39) E681G probably damaging Het
Fhad1 T C 4: 141,729,805 (GRCm39) E66G probably benign Het
Flii T C 11: 60,615,658 (GRCm39) T69A probably benign Het
Foxl1 A C 8: 121,855,158 (GRCm39) E153A probably damaging Het
Gstm3 T C 3: 107,873,485 (GRCm39) D162G possibly damaging Het
Gtpbp3 G A 8: 71,941,947 (GRCm39) V96I possibly damaging Het
Insig2 G A 1: 121,247,403 (GRCm39) T56I probably damaging Het
Kif13a A G 13: 46,926,314 (GRCm39) L264P probably damaging Het
Lama3 T G 18: 12,552,307 (GRCm39) C420G probably damaging Het
Lrp2 C T 2: 69,305,808 (GRCm39) G2918S probably damaging Het
Lrrc8b T C 5: 105,629,358 (GRCm39) L568P probably damaging Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Malrd1 G A 2: 16,132,778 (GRCm39) D1900N unknown Het
Mastl C A 2: 23,030,627 (GRCm39) probably benign Het
Med24 T G 11: 98,607,010 (GRCm39) T276P possibly damaging Het
Naip1 A C 13: 100,573,841 (GRCm39) Y239* probably null Het
Nhsl2 A G X: 101,122,491 (GRCm39) K765E probably damaging Het
Npy A G 6: 49,800,588 (GRCm39) N4S probably benign Het
Nsun2 A G 13: 69,767,703 (GRCm39) D188G probably damaging Het
Or6c88 A G 10: 129,406,790 (GRCm39) T89A probably benign Het
Pde1a C A 2: 79,718,290 (GRCm39) probably benign Het
Pik3cb G A 9: 98,947,650 (GRCm39) A509V probably damaging Het
Pou2f2 C T 7: 24,796,577 (GRCm39) S315N probably damaging Het
Prdm2 A C 4: 142,860,571 (GRCm39) S906R probably damaging Het
Prkaca C A 8: 84,721,580 (GRCm39) Q300K probably benign Het
Prox2 T C 12: 85,142,038 (GRCm39) D55G possibly damaging Het
Ryr3 T A 2: 112,498,465 (GRCm39) T3612S possibly damaging Het
S1pr1 T A 3: 115,506,343 (GRCm39) I84L possibly damaging Het
Slc47a1 C T 11: 61,243,918 (GRCm39) V384M probably benign Het
Slc6a20b T C 9: 123,426,394 (GRCm39) N497S possibly damaging Het
Spen C A 4: 141,265,550 (GRCm39) R3L unknown Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Ttll6 T C 11: 96,042,786 (GRCm39) F444S probably damaging Het
Vwce T A 19: 10,624,035 (GRCm39) Y309N possibly damaging Het
Vwf T C 6: 125,581,120 (GRCm39) L586P possibly damaging Het
Wdr35 T C 12: 9,024,185 (GRCm39) probably benign Het
Other mutations in Ces1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Ces1b APN 8 93,798,622 (GRCm39) missense probably damaging 0.98
IGL01939:Ces1b APN 8 93,806,059 (GRCm39) missense probably damaging 1.00
IGL02314:Ces1b APN 8 93,791,524 (GRCm39) missense possibly damaging 0.95
IGL02338:Ces1b APN 8 93,783,675 (GRCm39) missense possibly damaging 0.77
IGL02647:Ces1b APN 8 93,783,672 (GRCm39) missense probably benign 0.00
IGL02833:Ces1b APN 8 93,806,038 (GRCm39) missense probably damaging 1.00
IGL03149:Ces1b APN 8 93,791,502 (GRCm39) splice site probably benign
FR4548:Ces1b UTSW 8 93,794,720 (GRCm39) missense probably null
IGL02802:Ces1b UTSW 8 93,783,594 (GRCm39) missense possibly damaging 0.64
R0382:Ces1b UTSW 8 93,802,680 (GRCm39) splice site probably benign
R0893:Ces1b UTSW 8 93,806,056 (GRCm39) missense probably benign 0.11
R0959:Ces1b UTSW 8 93,794,775 (GRCm39) missense probably damaging 1.00
R1386:Ces1b UTSW 8 93,794,705 (GRCm39) missense probably benign 0.02
R1440:Ces1b UTSW 8 93,794,736 (GRCm39) missense probably damaging 0.97
R1667:Ces1b UTSW 8 93,783,532 (GRCm39) missense possibly damaging 0.75
R2113:Ces1b UTSW 8 93,794,783 (GRCm39) missense probably benign
R2193:Ces1b UTSW 8 93,806,505 (GRCm39) missense probably benign 0.00
R2508:Ces1b UTSW 8 93,799,969 (GRCm39) missense possibly damaging 0.75
R4656:Ces1b UTSW 8 93,784,042 (GRCm39) missense probably damaging 0.96
R4776:Ces1b UTSW 8 93,789,658 (GRCm39) missense possibly damaging 0.92
R5108:Ces1b UTSW 8 93,798,541 (GRCm39) missense probably damaging 1.00
R5117:Ces1b UTSW 8 93,799,837 (GRCm39) critical splice donor site probably null
R5308:Ces1b UTSW 8 93,793,645 (GRCm39) missense probably benign 0.00
R5381:Ces1b UTSW 8 93,791,647 (GRCm39) missense probably benign 0.02
R5392:Ces1b UTSW 8 93,798,590 (GRCm39) missense probably damaging 0.98
R5614:Ces1b UTSW 8 93,794,836 (GRCm39) missense probably benign 0.00
R5816:Ces1b UTSW 8 93,799,890 (GRCm39) missense probably benign 0.05
R6554:Ces1b UTSW 8 93,791,619 (GRCm39) missense probably benign 0.03
R6576:Ces1b UTSW 8 93,783,547 (GRCm39) missense probably benign 0.06
R6601:Ces1b UTSW 8 93,806,109 (GRCm39) missense probably benign
R6662:Ces1b UTSW 8 93,790,697 (GRCm39) missense probably benign 0.33
R6753:Ces1b UTSW 8 93,793,648 (GRCm39) nonsense probably null
R6904:Ces1b UTSW 8 93,787,038 (GRCm39) missense probably damaging 0.96
R7267:Ces1b UTSW 8 93,806,132 (GRCm39) missense possibly damaging 0.58
R7371:Ces1b UTSW 8 93,783,982 (GRCm39) critical splice donor site probably null
R7396:Ces1b UTSW 8 93,789,757 (GRCm39) missense probably benign 0.00
R7992:Ces1b UTSW 8 93,786,987 (GRCm39) missense probably benign 0.34
R8022:Ces1b UTSW 8 93,795,943 (GRCm39) critical splice donor site probably null
R8728:Ces1b UTSW 8 93,798,576 (GRCm39) missense probably benign
R8809:Ces1b UTSW 8 93,786,949 (GRCm39) missense probably damaging 1.00
R8809:Ces1b UTSW 8 93,786,948 (GRCm39) missense probably damaging 1.00
R9268:Ces1b UTSW 8 93,798,583 (GRCm39) missense probably damaging 1.00
R9476:Ces1b UTSW 8 93,799,890 (GRCm39) missense probably damaging 0.97
R9638:Ces1b UTSW 8 93,806,534 (GRCm39) missense probably benign
R9667:Ces1b UTSW 8 93,791,637 (GRCm39) missense probably benign 0.02
R9745:Ces1b UTSW 8 93,790,625 (GRCm39) missense probably benign
R9757:Ces1b UTSW 8 93,806,501 (GRCm39) missense probably benign 0.02
X0024:Ces1b UTSW 8 93,789,645 (GRCm39) missense probably benign
Z1088:Ces1b UTSW 8 93,791,594 (GRCm39) missense probably damaging 0.96
Z1177:Ces1b UTSW 8 93,802,782 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02