Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03038:Gstm3'

408772

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gstm3

Ensembl Gene

ENSMUSG00000004038

Gene Name

glutathione S-transferase, mu 3

Synonyms

mGSTM5, Fsc2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL03038

Quality Score

Status

Chromosome

Chromosomal Location

107963696-107969283 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107966169 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 162 (D162G)

Ref Sequence

ENSEMBL: ENSMUSP00000004136 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004136]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000004136
AA Change: D162G

PolyPhen 2 Score 0.752 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000004136
Gene: ENSMUSG00000004038
AA Change: D162G

Domain	Start	End	E-Value	Type
Pfam:GST_N	3	82	6.6e-22	PFAM
Pfam:GST_C_3	41	190	7.7e-11	PFAM
Pfam:GST_C	104	191	1.6e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	T	C	7: 131,428,456	Y111H	probably damaging	Het
Arhgef6	C	T	X: 57,245,606	V262I	probably benign	Het
Arsk	C	A	13: 76,065,513		probably benign	Het
Ces1b	T	C	8: 93,067,052	E303G	probably benign	Het
Chst9	T	C	18: 15,495,303	Q55R	probably benign	Het
Cntnap3	A	T	13: 64,741,025	D1153E	possibly damaging	Het
D130043K22Rik	A	G	13: 24,879,619	E681G	probably damaging	Het
Fhad1	T	C	4: 142,002,494	E66G	probably benign	Het
Flii	T	C	11: 60,724,832	T69A	probably benign	Het
Foxl1	A	C	8: 121,128,419	E153A	probably damaging	Het
Gtpbp3	G	A	8: 71,489,303	V96I	possibly damaging	Het
Insig2	G	A	1: 121,319,674	T56I	probably damaging	Het
Kif13a	A	G	13: 46,772,838	L264P	probably damaging	Het
Lama3	T	G	18: 12,419,250	C420G	probably damaging	Het
Lrp2	C	T	2: 69,475,464	G2918S	probably damaging	Het
Lrrc8b	T	C	5: 105,481,492	L568P	probably damaging	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Malrd1	G	A	2: 16,127,967	D1900N	unknown	Het
Mastl	C	A	2: 23,140,615		probably benign	Het
Med24	T	G	11: 98,716,184	T276P	possibly damaging	Het
Naip1	A	C	13: 100,437,333	Y239*	probably null	Het
Nhsl2	A	G	X: 102,078,885	K765E	probably damaging	Het
Npy	A	G	6: 49,823,608	N4S	probably benign	Het
Nsun2	A	G	13: 69,619,584	D188G	probably damaging	Het
Olfr794	A	G	10: 129,570,921	T89A	probably benign	Het
Pde1a	C	A	2: 79,887,946		probably benign	Het
Pik3cb	G	A	9: 99,065,597	A509V	probably damaging	Het
Pou2f2	C	T	7: 25,097,152	S315N	probably damaging	Het
Prdm2	A	C	4: 143,134,001	S906R	probably damaging	Het
Prkaca	C	A	8: 83,994,951	Q300K	probably benign	Het
Prox2	T	C	12: 85,095,264	D55G	possibly damaging	Het
Ryr3	T	A	2: 112,668,120	T3612S	possibly damaging	Het
S1pr1	T	A	3: 115,712,694	I84L	possibly damaging	Het
Slc47a1	C	T	11: 61,353,092	V384M	probably benign	Het
Slc6a20b	T	C	9: 123,597,329	N497S	possibly damaging	Het
Spen	C	A	4: 141,538,239	R3L	unknown	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Ttll6	T	C	11: 96,151,960	F444S	probably damaging	Het
Vwce	T	A	19: 10,646,671	Y309N	possibly damaging	Het
Vwf	T	C	6: 125,604,157	L586P	possibly damaging	Het
Wdr35	T	C	12: 8,974,185		probably benign	Het

Other mutations in Gstm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01585:Gstm3	APN	3	107966158	missense	probably benign	0.42
IGL01637:Gstm3	APN	3	107967633	missense	probably damaging	1.00
IGL01937:Gstm3	APN	3	107967657	missense	probably damaging	0.98
IGL01945:Gstm3	APN	3	107967657	missense	probably damaging	0.98
IGL02307:Gstm3	APN	3	107967613	missense	probably damaging	0.98
IGL02820:Gstm3	APN	3	107968758	splice site	probably benign
IGL03108:Gstm3	APN	3	107967764	critical splice donor site	probably null
IGL03271:Gstm3	APN	3	107966197	missense	possibly damaging	0.47
IGL03097:Gstm3	UTSW	3	107968801	missense	probably benign
R0009:Gstm3	UTSW	3	107967840	missense	probably damaging	1.00
R0883:Gstm3	UTSW	3	107966270	splice site	probably benign
R1623:Gstm3	UTSW	3	107967835	missense	possibly damaging	0.80
R2108:Gstm3	UTSW	3	107966134	missense	probably damaging	0.99
R3005:Gstm3	UTSW	3	107967607	missense	probably benign	0.03
R3802:Gstm3	UTSW	3	107964235	missense	probably benign	0.03
R3803:Gstm3	UTSW	3	107964235	missense	probably benign	0.03
R3804:Gstm3	UTSW	3	107964235	missense	probably benign	0.03
R4604:Gstm3	UTSW	3	107968197	missense	possibly damaging	0.73
R4837:Gstm3	UTSW	3	107964215	missense	probably benign
R6593:Gstm3	UTSW	3	107968195	missense	probably benign	0.01
R6963:Gstm3	UTSW	3	107967624	missense	probably benign	0.01
R7790:Gstm3	UTSW	3	107969239	start gained	probably benign

Posted On

2016-08-02