Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03038:Malrd1'

408780

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Malrd1

Ensembl Gene

ENSMUSG00000075520

Gene Name

MAM and LDL receptor class A domain containing 1

Synonyms

Diet1, Gm13364, Gm13318

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

IGL03038

Quality Score

Status

Chromosome

Chromosomal Location

15526479-16255555 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 16127967 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 1900 (D1900N)

Ref Sequence

ENSEMBL: ENSMUSP00000116869 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000146205]

AlphaFold

A2AJX4

Predicted Effect

unknown
Transcript: ENSMUST00000146205
AA Change: D1900N

SMART Domains

Protein: ENSMUSP00000116869
Gene: ENSMUSG00000075520
AA Change: D1900N

Domain	Start	End	E-Value	Type
Pfam:MAM	8	171	1.6e-36	PFAM
LDLa	181	219	6.89e-8	SMART
LDLa	225	262	4.37e-10	SMART
LDLa	264	303	9.55e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	T	C	7: 131,428,456 (GRCm38)	Y111H	probably damaging	Het
Arhgef6	C	T	X: 57,245,606 (GRCm38)	V262I	probably benign	Het
Arsk	C	A	13: 76,065,513 (GRCm38)		probably benign	Het
Ces1b	T	C	8: 93,067,052 (GRCm38)	E303G	probably benign	Het
Chst9	T	C	18: 15,495,303 (GRCm38)	Q55R	probably benign	Het
Cntnap3	A	T	13: 64,741,025 (GRCm38)	D1153E	possibly damaging	Het
D130043K22Rik	A	G	13: 24,879,619 (GRCm38)	E681G	probably damaging	Het
Fhad1	T	C	4: 142,002,494 (GRCm38)	E66G	probably benign	Het
Flii	T	C	11: 60,724,832 (GRCm38)	T69A	probably benign	Het
Foxl1	A	C	8: 121,128,419 (GRCm38)	E153A	probably damaging	Het
Gstm3	T	C	3: 107,966,169 (GRCm38)	D162G	possibly damaging	Het
Gtpbp3	G	A	8: 71,489,303 (GRCm38)	V96I	possibly damaging	Het
Insig2	G	A	1: 121,319,674 (GRCm38)	T56I	probably damaging	Het
Kif13a	A	G	13: 46,772,838 (GRCm38)	L264P	probably damaging	Het
Lama3	T	G	18: 12,419,250 (GRCm38)	C420G	probably damaging	Het
Lrp2	C	T	2: 69,475,464 (GRCm38)	G2918S	probably damaging	Het
Lrrc8b	T	C	5: 105,481,492 (GRCm38)	L568P	probably damaging	Het
Lyl1	C	T	8: 84,702,671 (GRCm38)	P3L	possibly damaging	Het
Mastl	C	A	2: 23,140,615 (GRCm38)		probably benign	Het
Med24	T	G	11: 98,716,184 (GRCm38)	T276P	possibly damaging	Het
Naip1	A	C	13: 100,437,333 (GRCm38)	Y239*	probably null	Het
Nhsl2	A	G	X: 102,078,885 (GRCm38)	K765E	probably damaging	Het
Npy	A	G	6: 49,823,608 (GRCm38)	N4S	probably benign	Het
Nsun2	A	G	13: 69,619,584 (GRCm38)	D188G	probably damaging	Het
Olfr794	A	G	10: 129,570,921 (GRCm38)	T89A	probably benign	Het
Pde1a	C	A	2: 79,887,946 (GRCm38)		probably benign	Het
Pik3cb	G	A	9: 99,065,597 (GRCm38)	A509V	probably damaging	Het
Pou2f2	C	T	7: 25,097,152 (GRCm38)	S315N	probably damaging	Het
Prdm2	A	C	4: 143,134,001 (GRCm38)	S906R	probably damaging	Het
Prkaca	C	A	8: 83,994,951 (GRCm38)	Q300K	probably benign	Het
Prox2	T	C	12: 85,095,264 (GRCm38)	D55G	possibly damaging	Het
Ryr3	T	A	2: 112,668,120 (GRCm38)	T3612S	possibly damaging	Het
S1pr1	T	A	3: 115,712,694 (GRCm38)	I84L	possibly damaging	Het
Slc47a1	C	T	11: 61,353,092 (GRCm38)	V384M	probably benign	Het
Slc6a20b	T	C	9: 123,597,329 (GRCm38)	N497S	possibly damaging	Het
Spen	C	A	4: 141,538,239 (GRCm38)	R3L	unknown	Het
Stxbp2	A	T	8: 3,641,971 (GRCm38)	I538F	probably benign	Het
Ttll6	T	C	11: 96,151,960 (GRCm38)	F444S	probably damaging	Het
Vwce	T	A	19: 10,646,671 (GRCm38)	Y309N	possibly damaging	Het
Vwf	T	C	6: 125,604,157 (GRCm38)	L586P	possibly damaging	Het
Wdr35	T	C	12: 8,974,185 (GRCm38)		probably benign	Het

Other mutations in Malrd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Malrd1	APN	2	16,142,186 (GRCm38)	splice site	probably benign
IGL01295:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01296:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01399:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01400:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01401:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01402:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01405:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01406:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL02105:Malrd1	APN	2	16,127,863 (GRCm38)	missense	unknown
IGL02581:Malrd1	APN	2	16,142,312 (GRCm38)	nonsense	probably null
IGL03015:Malrd1	APN	2	16,042,271 (GRCm38)	missense	unknown
R1353:Malrd1	UTSW	2	16,127,968 (GRCm38)	missense	unknown
R1385:Malrd1	UTSW	2	16,042,228 (GRCm38)	missense	unknown
R2242:Malrd1	UTSW	2	16,101,944 (GRCm38)	missense	unknown
R2888:Malrd1	UTSW	2	16,074,757 (GRCm38)	missense	unknown
R4398:Malrd1	UTSW	2	16,150,783 (GRCm38)	missense	unknown
R4982:Malrd1	UTSW	2	16,042,129 (GRCm38)	missense	probably benign	0.29
R5148:Malrd1	UTSW	2	16,142,226 (GRCm38)	missense	unknown
R5195:Malrd1	UTSW	2	16,150,810 (GRCm38)	missense	unknown
R5828:Malrd1	UTSW	2	15,526,653 (GRCm38)	missense	probably benign	0.00
R5892:Malrd1	UTSW	2	15,614,267 (GRCm38)	missense	probably benign	0.03
R6034:Malrd1	UTSW	2	15,845,326 (GRCm38)	missense	possibly damaging	0.78
R6034:Malrd1	UTSW	2	15,845,326 (GRCm38)	missense	possibly damaging	0.78
R6195:Malrd1	UTSW	2	15,695,326 (GRCm38)	missense	probably damaging	1.00
R6318:Malrd1	UTSW	2	16,042,267 (GRCm38)	missense	unknown
R6438:Malrd1	UTSW	2	15,614,206 (GRCm38)	missense
R6457:Malrd1	UTSW	2	15,667,929 (GRCm38)	missense	probably benign	0.41
R6457:Malrd1	UTSW	2	15,526,597 (GRCm38)	start gained	probably benign
R6499:Malrd1	UTSW	2	15,931,689 (GRCm38)	missense	probably benign	0.03
R6575:Malrd1	UTSW	2	15,842,628 (GRCm38)	missense	probably benign	0.00
R6792:Malrd1	UTSW	2	16,150,756 (GRCm38)	missense	unknown
R6796:Malrd1	UTSW	2	15,869,784 (GRCm38)	missense	unknown
R6930:Malrd1	UTSW	2	15,797,667 (GRCm38)	missense	unknown
R6959:Malrd1	UTSW	2	16,218,009 (GRCm38)	missense	probably damaging	0.97
R6993:Malrd1	UTSW	2	16,150,791 (GRCm38)	missense	unknown
R7102:Malrd1	UTSW	2	16,142,303 (GRCm38)	missense	unknown
R7112:Malrd1	UTSW	2	15,925,176 (GRCm38)	missense	unknown
R7248:Malrd1	UTSW	2	16,101,911 (GRCm38)	missense	unknown
R7249:Malrd1	UTSW	2	15,623,340 (GRCm38)	missense	probably damaging	0.97
R7334:Malrd1	UTSW	2	16,006,718 (GRCm38)	missense	probably damaging	0.99
R7394:Malrd1	UTSW	2	15,695,199 (GRCm38)	missense	unknown
R7399:Malrd1	UTSW	2	15,610,090 (GRCm38)	missense
R7476:Malrd1	UTSW	2	16,142,304 (GRCm38)	missense	unknown
R7582:Malrd1	UTSW	2	15,695,270 (GRCm38)	missense	unknown
R7604:Malrd1	UTSW	2	15,925,192 (GRCm38)	missense	unknown
R7662:Malrd1	UTSW	2	15,871,454 (GRCm38)	missense	unknown
R7681:Malrd1	UTSW	2	16,218,102 (GRCm38)	missense	unknown
R7740:Malrd1	UTSW	2	15,614,215 (GRCm38)	missense	not run
R7747:Malrd1	UTSW	2	16,074,835 (GRCm38)	missense	unknown
R7754:Malrd1	UTSW	2	15,797,799 (GRCm38)	splice site	probably null
R7950:Malrd1	UTSW	2	16,128,068 (GRCm38)	missense	unknown
R8194:Malrd1	UTSW	2	15,925,120 (GRCm38)	missense	unknown
R8260:Malrd1	UTSW	2	15,614,206 (GRCm38)	missense
R8314:Malrd1	UTSW	2	15,752,832 (GRCm38)	missense	unknown
R8342:Malrd1	UTSW	2	15,633,224 (GRCm38)	missense	unknown
R8386:Malrd1	UTSW	2	15,696,844 (GRCm38)	missense	unknown
R8492:Malrd1	UTSW	2	15,610,123 (GRCm38)	missense
R8728:Malrd1	UTSW	2	15,696,942 (GRCm38)	nonsense	probably null
R8756:Malrd1	UTSW	2	15,752,895 (GRCm38)	critical splice donor site	probably null
R8869:Malrd1	UTSW	2	15,565,557 (GRCm38)	critical splice donor site	probably null
R8888:Malrd1	UTSW	2	15,845,227 (GRCm38)	missense	unknown
R8895:Malrd1	UTSW	2	15,845,227 (GRCm38)	missense	unknown
R8902:Malrd1	UTSW	2	16,255,334 (GRCm38)	nonsense	probably null
R8954:Malrd1	UTSW	2	15,551,367 (GRCm38)	missense
R8960:Malrd1	UTSW	2	15,565,430 (GRCm38)	nonsense	probably null
R9005:Malrd1	UTSW	2	15,845,329 (GRCm38)	missense	unknown
R9135:Malrd1	UTSW	2	15,797,705 (GRCm38)	missense	unknown
R9267:Malrd1	UTSW	2	16,255,266 (GRCm38)	missense	unknown
R9330:Malrd1	UTSW	2	16,255,278 (GRCm38)	missense	unknown
R9359:Malrd1	UTSW	2	15,614,177 (GRCm38)	missense
R9383:Malrd1	UTSW	2	15,695,201 (GRCm38)	missense	unknown
R9389:Malrd1	UTSW	2	15,703,156 (GRCm38)	missense	unknown
R9403:Malrd1	UTSW	2	15,614,177 (GRCm38)	missense
R9454:Malrd1	UTSW	2	15,797,726 (GRCm38)	nonsense	probably null
R9454:Malrd1	UTSW	2	15,752,849 (GRCm38)	missense	unknown
R9520:Malrd1	UTSW	2	16,074,820 (GRCm38)	missense	unknown
R9544:Malrd1	UTSW	2	15,635,998 (GRCm38)	missense	unknown
R9609:Malrd1	UTSW	2	15,695,270 (GRCm38)	missense	unknown
R9667:Malrd1	UTSW	2	15,565,215 (GRCm38)	critical splice acceptor site	probably null
R9721:Malrd1	UTSW	2	15,696,827 (GRCm38)	missense	unknown
R9787:Malrd1	UTSW	2	15,620,590 (GRCm38)	missense	unknown
R9800:Malrd1	UTSW	2	15,842,594 (GRCm38)	missense	unknown
Z1176:Malrd1	UTSW	2	16,217,845 (GRCm38)	missense	unknown
Z1191:Malrd1	UTSW	2	16,042,226 (GRCm38)	missense	unknown

Posted On

2016-08-02