Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03038:Lama3'

408791

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lama3

Ensembl Gene

ENSMUSG00000024421

Gene Name

laminin, alpha 3

Synonyms

[a]3B, nicein, 150kDa

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL03038

Quality Score

Status

Chromosome

Chromosomal Location

12333819-12583013 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 12419250 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 420 (C420G)

Ref Sequence

ENSEMBL: ENSMUSP00000089703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092070]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000092070
AA Change: C420G

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000089703
Gene: ENSMUSG00000024421
AA Change: C420G

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
LamNT	38	294	1.46e-153	SMART
EGF_Lam	296	350	1.39e-4	SMART
EGF_Lam	353	420	2.66e-10	SMART
EGF_Lam	423	464	3.51e-10	SMART
EGF_Lam	488	530	1.73e-9	SMART
EGF_Lam	533	576	3.81e-11	SMART
EGF_like	579	625	1.82e-1	SMART
EGF_Lam	628	678	5.15e-8	SMART
EGF_Lam	681	725	3.54e-6	SMART
low complexity region	768	781	N/A	INTRINSIC
EGF_Lam	1263	1306	3.15e-12	SMART
EGF_Lam	1309	1350	6.3e-3	SMART
EGF_Lam	1353	1399	1.49e-13	SMART
EGF_Lam	1402	1450	8.18e-11	SMART
LamB	1509	1638	4.34e-55	SMART
Pfam:Laminin_EGF	1647	1681	7.9e-5	PFAM
EGF_Lam	1684	1728	2.66e-10	SMART
EGF_Lam	1731	1781	7.81e-8	SMART
Pfam:Laminin_I	1836	2102	2.7e-93	PFAM
low complexity region	2185	2200	N/A	INTRINSIC
coiled coil region	2211	2238	N/A	INTRINSIC
LamG	2406	2566	1.67e-2	SMART
LamG	2614	2742	1.72e-17	SMART
LamG	2785	2900	3.96e-17	SMART
LamG	3005	3133	1.12e-34	SMART
LamG	3175	3308	3.41e-30	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation develop a lethal blistering phenotype similar to human junctional epidermolysis bullosa, and die 2-3 days after birth from a failure to thrive. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	T	C	7: 131,428,456 (GRCm38)	Y111H	probably damaging	Het
Arhgef6	C	T	X: 57,245,606 (GRCm38)	V262I	probably benign	Het
Arsk	C	A	13: 76,065,513 (GRCm38)		probably benign	Het
Ces1b	T	C	8: 93,067,052 (GRCm38)	E303G	probably benign	Het
Chst9	T	C	18: 15,495,303 (GRCm38)	Q55R	probably benign	Het
Cntnap3	A	T	13: 64,741,025 (GRCm38)	D1153E	possibly damaging	Het
D130043K22Rik	A	G	13: 24,879,619 (GRCm38)	E681G	probably damaging	Het
Fhad1	T	C	4: 142,002,494 (GRCm38)	E66G	probably benign	Het
Flii	T	C	11: 60,724,832 (GRCm38)	T69A	probably benign	Het
Foxl1	A	C	8: 121,128,419 (GRCm38)	E153A	probably damaging	Het
Gstm3	T	C	3: 107,966,169 (GRCm38)	D162G	possibly damaging	Het
Gtpbp3	G	A	8: 71,489,303 (GRCm38)	V96I	possibly damaging	Het
Insig2	G	A	1: 121,319,674 (GRCm38)	T56I	probably damaging	Het
Kif13a	A	G	13: 46,772,838 (GRCm38)	L264P	probably damaging	Het
Lrp2	C	T	2: 69,475,464 (GRCm38)	G2918S	probably damaging	Het
Lrrc8b	T	C	5: 105,481,492 (GRCm38)	L568P	probably damaging	Het
Lyl1	C	T	8: 84,702,671 (GRCm38)	P3L	possibly damaging	Het
Malrd1	G	A	2: 16,127,967 (GRCm38)	D1900N	unknown	Het
Mastl	C	A	2: 23,140,615 (GRCm38)		probably benign	Het
Med24	T	G	11: 98,716,184 (GRCm38)	T276P	possibly damaging	Het
Naip1	A	C	13: 100,437,333 (GRCm38)	Y239*	probably null	Het
Nhsl2	A	G	X: 102,078,885 (GRCm38)	K765E	probably damaging	Het
Npy	A	G	6: 49,823,608 (GRCm38)	N4S	probably benign	Het
Nsun2	A	G	13: 69,619,584 (GRCm38)	D188G	probably damaging	Het
Or6c88	A	G	10: 129,570,921 (GRCm38)	T89A	probably benign	Het
Pde1a	C	A	2: 79,887,946 (GRCm38)		probably benign	Het
Pik3cb	G	A	9: 99,065,597 (GRCm38)	A509V	probably damaging	Het
Pou2f2	C	T	7: 25,097,152 (GRCm38)	S315N	probably damaging	Het
Prdm2	A	C	4: 143,134,001 (GRCm38)	S906R	probably damaging	Het
Prkaca	C	A	8: 83,994,951 (GRCm38)	Q300K	probably benign	Het
Prox2	T	C	12: 85,095,264 (GRCm38)	D55G	possibly damaging	Het
Ryr3	T	A	2: 112,668,120 (GRCm38)	T3612S	possibly damaging	Het
S1pr1	T	A	3: 115,712,694 (GRCm38)	I84L	possibly damaging	Het
Slc47a1	C	T	11: 61,353,092 (GRCm38)	V384M	probably benign	Het
Slc6a20b	T	C	9: 123,597,329 (GRCm38)	N497S	possibly damaging	Het
Spen	C	A	4: 141,538,239 (GRCm38)	R3L	unknown	Het
Stxbp2	A	T	8: 3,641,971 (GRCm38)	I538F	probably benign	Het
Ttll6	T	C	11: 96,151,960 (GRCm38)	F444S	probably damaging	Het
Vwce	T	A	19: 10,646,671 (GRCm38)	Y309N	possibly damaging	Het
Vwf	T	C	6: 125,604,157 (GRCm38)	L586P	possibly damaging	Het
Wdr35	T	C	12: 8,974,185 (GRCm38)		probably benign	Het

Other mutations in Lama3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Lama3	APN	18	12,580,292 (GRCm38)	missense	probably benign
IGL00272:Lama3	APN	18	12,491,548 (GRCm38)	missense	probably damaging	1.00
IGL00335:Lama3	APN	18	12,449,588 (GRCm38)	splice site	probably benign
IGL00836:Lama3	APN	18	12,472,228 (GRCm38)	missense	probably benign	0.01
IGL01017:Lama3	APN	18	12,441,143 (GRCm38)	critical splice donor site	probably null
IGL01025:Lama3	APN	18	12,481,037 (GRCm38)	missense	probably benign	0.09
IGL01394:Lama3	APN	18	12,531,926 (GRCm38)	missense	probably null	0.39
IGL01545:Lama3	APN	18	12,441,131 (GRCm38)	missense	probably benign	0.01
IGL01685:Lama3	APN	18	12,453,880 (GRCm38)	splice site	probably benign
IGL01863:Lama3	APN	18	12,419,936 (GRCm38)	splice site	probably benign
IGL01869:Lama3	APN	18	12,524,763 (GRCm38)	missense	possibly damaging	0.94
IGL01894:Lama3	APN	18	12,572,064 (GRCm38)	missense	probably benign	0.09
IGL02027:Lama3	APN	18	12,516,513 (GRCm38)	missense	probably damaging	1.00
IGL02106:Lama3	APN	18	12,468,314 (GRCm38)	missense	probably damaging	0.98
IGL02307:Lama3	APN	18	12,581,783 (GRCm38)	missense	probably benign	0.09
IGL02342:Lama3	APN	18	12,491,476 (GRCm38)	missense	probably damaging	1.00
IGL02377:Lama3	APN	18	12,556,750 (GRCm38)	missense	possibly damaging	0.49
IGL02401:Lama3	APN	18	12,557,727 (GRCm38)	missense	probably benign	0.02
IGL02517:Lama3	APN	18	12,537,858 (GRCm38)	critical splice donor site	probably null
IGL02644:Lama3	APN	18	12,525,853 (GRCm38)	missense	probably benign	0.12
IGL02733:Lama3	APN	18	12,578,127 (GRCm38)	missense	probably damaging	0.99
IGL02932:Lama3	APN	18	12,528,801 (GRCm38)	missense	probably damaging	1.00
IGL03006:Lama3	APN	18	12,468,368 (GRCm38)	splice site	probably benign
IGL03064:Lama3	APN	18	12,439,349 (GRCm38)	missense	possibly damaging	0.72
IGL03146:Lama3	APN	18	12,527,624 (GRCm38)	missense	possibly damaging	0.66
IGL03233:Lama3	APN	18	12,481,038 (GRCm38)	missense	probably damaging	1.00
IGL03255:Lama3	APN	18	12,539,703 (GRCm38)	missense	probably damaging	1.00
IGL03369:Lama3	APN	18	12,553,283 (GRCm38)	missense	probably benign	0.05
IGL03412:Lama3	APN	18	12,419,182 (GRCm38)	missense	probably damaging	0.99
IGL02980:Lama3	UTSW	18	12,553,231 (GRCm38)	missense	probably benign	0.01
IGL03014:Lama3	UTSW	18	12,539,967 (GRCm38)	missense	possibly damaging	0.95
R0007:Lama3	UTSW	18	12,497,881 (GRCm38)	splice site	probably benign
R0007:Lama3	UTSW	18	12,497,881 (GRCm38)	splice site	probably benign
R0050:Lama3	UTSW	18	12,404,103 (GRCm38)	missense	probably damaging	1.00
R0050:Lama3	UTSW	18	12,404,103 (GRCm38)	missense	probably damaging	1.00
R0063:Lama3	UTSW	18	12,528,705 (GRCm38)	splice site	probably benign
R0063:Lama3	UTSW	18	12,528,705 (GRCm38)	splice site	probably benign
R0106:Lama3	UTSW	18	12,403,982 (GRCm38)	missense	probably damaging	0.96
R0148:Lama3	UTSW	18	12,448,272 (GRCm38)	missense	probably damaging	1.00
R0165:Lama3	UTSW	18	12,524,810 (GRCm38)	missense	probably damaging	0.99
R0240:Lama3	UTSW	18	12,539,823 (GRCm38)	splice site	probably null
R0240:Lama3	UTSW	18	12,539,823 (GRCm38)	splice site	probably null
R0316:Lama3	UTSW	18	12,519,877 (GRCm38)	missense	probably benign	0.09
R0325:Lama3	UTSW	18	12,482,126 (GRCm38)	missense	probably damaging	1.00
R0365:Lama3	UTSW	18	12,507,007 (GRCm38)	missense	probably damaging	0.96
R0390:Lama3	UTSW	18	12,407,563 (GRCm38)	missense	probably benign	0.10
R0408:Lama3	UTSW	18	12,456,837 (GRCm38)	missense	probably benign
R0449:Lama3	UTSW	18	12,500,512 (GRCm38)	splice site	probably null
R0453:Lama3	UTSW	18	12,465,478 (GRCm38)	missense	possibly damaging	0.63
R0480:Lama3	UTSW	18	12,450,424 (GRCm38)	missense	possibly damaging	0.81
R0536:Lama3	UTSW	18	12,525,894 (GRCm38)	missense	probably damaging	1.00
R0545:Lama3	UTSW	18	12,561,701 (GRCm38)	missense	possibly damaging	0.90
R0567:Lama3	UTSW	18	12,549,252 (GRCm38)	missense	probably benign
R0605:Lama3	UTSW	18	12,506,949 (GRCm38)	missense	probably benign	0.02
R0617:Lama3	UTSW	18	12,419,258 (GRCm38)	critical splice donor site	probably null
R0629:Lama3	UTSW	18	12,419,245 (GRCm38)	missense	possibly damaging	0.79
R0671:Lama3	UTSW	18	12,477,590 (GRCm38)	missense	possibly damaging	0.80
R0730:Lama3	UTSW	18	12,456,850 (GRCm38)	splice site	probably benign
R1216:Lama3	UTSW	18	12,421,134 (GRCm38)	splice site	probably benign
R1356:Lama3	UTSW	18	12,500,577 (GRCm38)	unclassified	probably benign
R1386:Lama3	UTSW	18	12,477,370 (GRCm38)	missense	probably benign	0.04
R1424:Lama3	UTSW	18	12,519,991 (GRCm38)	missense	probably benign	0.13
R1426:Lama3	UTSW	18	12,481,098 (GRCm38)	critical splice donor site	probably null
R1437:Lama3	UTSW	18	12,549,227 (GRCm38)	missense	possibly damaging	0.46
R1468:Lama3	UTSW	18	12,441,107 (GRCm38)	missense	probably benign	0.00
R1468:Lama3	UTSW	18	12,441,107 (GRCm38)	missense	probably benign	0.00
R1472:Lama3	UTSW	18	12,482,045 (GRCm38)	missense	probably benign	0.23
R1557:Lama3	UTSW	18	12,513,731 (GRCm38)	splice site	probably benign
R1571:Lama3	UTSW	18	12,539,717 (GRCm38)	missense	probably damaging	0.98
R1599:Lama3	UTSW	18	12,450,400 (GRCm38)	nonsense	probably null
R1631:Lama3	UTSW	18	12,407,494 (GRCm38)	missense	probably damaging	1.00
R1647:Lama3	UTSW	18	12,532,199 (GRCm38)	missense	possibly damaging	0.90
R1648:Lama3	UTSW	18	12,532,199 (GRCm38)	missense	possibly damaging	0.90
R1719:Lama3	UTSW	18	12,479,872 (GRCm38)	critical splice donor site	probably null
R1757:Lama3	UTSW	18	12,465,499 (GRCm38)	missense	probably benign	0.10
R1766:Lama3	UTSW	18	12,402,062 (GRCm38)	missense	probably damaging	1.00
R1853:Lama3	UTSW	18	12,513,705 (GRCm38)	missense	possibly damaging	0.75
R1856:Lama3	UTSW	18	12,537,781 (GRCm38)	nonsense	probably null
R1909:Lama3	UTSW	18	12,581,798 (GRCm38)	missense	probably benign	0.19
R1913:Lama3	UTSW	18	12,495,279 (GRCm38)	missense	probably benign	0.15
R1975:Lama3	UTSW	18	12,453,863 (GRCm38)	missense	probably damaging	1.00
R2014:Lama3	UTSW	18	12,524,721 (GRCm38)	splice site	probably benign
R2059:Lama3	UTSW	18	12,528,333 (GRCm38)	missense	probably damaging	0.98
R2060:Lama3	UTSW	18	12,528,726 (GRCm38)	missense	probably benign	0.30
R2086:Lama3	UTSW	18	12,524,830 (GRCm38)	missense	probably benign	0.39
R2115:Lama3	UTSW	18	12,402,849 (GRCm38)	missense	possibly damaging	0.94
R2291:Lama3	UTSW	18	12,525,079 (GRCm38)	missense	probably damaging	0.98
R2860:Lama3	UTSW	18	12,453,750 (GRCm38)	missense	probably damaging	1.00
R2861:Lama3	UTSW	18	12,453,750 (GRCm38)	missense	probably damaging	1.00
R2862:Lama3	UTSW	18	12,453,750 (GRCm38)	missense	probably damaging	1.00
R3410:Lama3	UTSW	18	12,413,858 (GRCm38)	critical splice donor site	probably null
R3614:Lama3	UTSW	18	12,448,288 (GRCm38)	missense	probably benign	0.03
R3696:Lama3	UTSW	18	12,439,475 (GRCm38)	splice site	probably benign
R3752:Lama3	UTSW	18	12,507,029 (GRCm38)	missense	probably damaging	1.00
R3967:Lama3	UTSW	18	12,580,341 (GRCm38)	missense	probably damaging	1.00
R3968:Lama3	UTSW	18	12,580,341 (GRCm38)	missense	probably damaging	1.00
R3969:Lama3	UTSW	18	12,580,341 (GRCm38)	missense	probably damaging	1.00
R3970:Lama3	UTSW	18	12,580,341 (GRCm38)	missense	probably damaging	1.00
R4088:Lama3	UTSW	18	12,504,308 (GRCm38)	nonsense	probably null
R4118:Lama3	UTSW	18	12,450,431 (GRCm38)	missense	probably benign	0.01
R4222:Lama3	UTSW	18	12,450,403 (GRCm38)	missense	probably damaging	1.00
R4223:Lama3	UTSW	18	12,450,403 (GRCm38)	missense	probably damaging	1.00
R4224:Lama3	UTSW	18	12,450,403 (GRCm38)	missense	probably damaging	1.00
R4225:Lama3	UTSW	18	12,450,403 (GRCm38)	missense	probably damaging	1.00
R4367:Lama3	UTSW	18	12,513,690 (GRCm38)	missense	probably damaging	1.00
R4404:Lama3	UTSW	18	12,582,531 (GRCm38)	missense	probably benign	0.01
R4424:Lama3	UTSW	18	12,519,872 (GRCm38)	nonsense	probably null
R4483:Lama3	UTSW	18	12,549,253 (GRCm38)	missense	probably benign	0.32
R4484:Lama3	UTSW	18	12,481,088 (GRCm38)	missense	probably benign
R4516:Lama3	UTSW	18	12,495,358 (GRCm38)	missense	probably damaging	1.00
R4556:Lama3	UTSW	18	12,479,759 (GRCm38)	missense	possibly damaging	0.63
R4616:Lama3	UTSW	18	12,504,397 (GRCm38)	critical splice donor site	probably null
R4702:Lama3	UTSW	18	12,578,029 (GRCm38)	nonsense	probably null
R4704:Lama3	UTSW	18	12,553,223 (GRCm38)	missense	probably benign	0.08
R4750:Lama3	UTSW	18	12,504,359 (GRCm38)	missense	probably benign	0.25
R4753:Lama3	UTSW	18	12,482,084 (GRCm38)	missense	probably damaging	1.00
R4767:Lama3	UTSW	18	12,500,563 (GRCm38)	missense	probably benign	0.32
R4777:Lama3	UTSW	18	12,413,771 (GRCm38)	missense	probably damaging	1.00
R4782:Lama3	UTSW	18	12,411,570 (GRCm38)	nonsense	probably null
R4784:Lama3	UTSW	18	12,449,544 (GRCm38)	missense	probably benign	0.20
R4816:Lama3	UTSW	18	12,477,604 (GRCm38)	missense	possibly damaging	0.93
R4833:Lama3	UTSW	18	12,441,131 (GRCm38)	missense	probably benign	0.01
R4854:Lama3	UTSW	18	12,411,542 (GRCm38)	missense	probably benign	0.00
R4863:Lama3	UTSW	18	12,498,678 (GRCm38)	intron	probably benign
R4863:Lama3	UTSW	18	12,539,793 (GRCm38)	missense	probably damaging	0.99
R4953:Lama3	UTSW	18	12,448,305 (GRCm38)	missense	probably damaging	1.00
R4974:Lama3	UTSW	18	12,552,826 (GRCm38)	missense	probably damaging	0.98
R4996:Lama3	UTSW	18	12,518,743 (GRCm38)	missense	probably benign	0.24
R5049:Lama3	UTSW	18	12,582,611 (GRCm38)	missense	probably benign	0.19
R5057:Lama3	UTSW	18	12,531,948 (GRCm38)	missense	probably null	0.82
R5090:Lama3	UTSW	18	12,542,402 (GRCm38)	missense	possibly damaging	0.94
R5122:Lama3	UTSW	18	12,539,766 (GRCm38)	missense	possibly damaging	0.53
R5215:Lama3	UTSW	18	12,577,900 (GRCm38)	missense	probably damaging	1.00
R5245:Lama3	UTSW	18	12,419,893 (GRCm38)	missense	probably damaging	1.00
R5259:Lama3	UTSW	18	12,465,508 (GRCm38)	missense	probably damaging	1.00
R5320:Lama3	UTSW	18	12,552,855 (GRCm38)	missense	probably damaging	0.99
R5377:Lama3	UTSW	18	12,453,746 (GRCm38)	missense	probably damaging	0.99
R5432:Lama3	UTSW	18	12,572,066 (GRCm38)	missense	probably damaging	1.00
R5500:Lama3	UTSW	18	12,456,764 (GRCm38)	missense	possibly damaging	0.93
R5534:Lama3	UTSW	18	12,553,210 (GRCm38)	missense	probably benign	0.00
R5589:Lama3	UTSW	18	12,472,220 (GRCm38)	missense	possibly damaging	0.46
R5604:Lama3	UTSW	18	12,439,348 (GRCm38)	missense	probably benign
R5617:Lama3	UTSW	18	12,498,936 (GRCm38)	intron	probably benign
R5709:Lama3	UTSW	18	12,539,799 (GRCm38)	missense	probably damaging	1.00
R5965:Lama3	UTSW	18	12,429,887 (GRCm38)	missense	possibly damaging	0.67
R6042:Lama3	UTSW	18	12,574,254 (GRCm38)	missense	probably damaging	1.00
R6065:Lama3	UTSW	18	12,469,928 (GRCm38)	missense	possibly damaging	0.53
R6085:Lama3	UTSW	18	12,482,099 (GRCm38)	missense	probably benign	0.01
R6212:Lama3	UTSW	18	12,513,645 (GRCm38)	missense	probably damaging	1.00
R6268:Lama3	UTSW	18	12,524,737 (GRCm38)	missense	probably damaging	0.98
R6276:Lama3	UTSW	18	12,506,949 (GRCm38)	missense	probably benign	0.02
R6366:Lama3	UTSW	18	12,482,137 (GRCm38)	missense	probably damaging	1.00
R6393:Lama3	UTSW	18	12,479,756 (GRCm38)	missense	probably benign	0.44
R6493:Lama3	UTSW	18	12,482,148 (GRCm38)	critical splice donor site	probably null
R6505:Lama3	UTSW	18	12,495,348 (GRCm38)	missense	probably benign	0.02
R6563:Lama3	UTSW	18	12,537,766 (GRCm38)	missense	probably damaging	1.00
R6582:Lama3	UTSW	18	12,577,840 (GRCm38)	missense	probably damaging	1.00
R6585:Lama3	UTSW	18	12,419,257 (GRCm38)	critical splice donor site	probably null
R6609:Lama3	UTSW	18	12,513,678 (GRCm38)	missense	probably damaging	0.99
R6656:Lama3	UTSW	18	12,549,226 (GRCm38)	missense	possibly damaging	0.66
R6833:Lama3	UTSW	18	12,491,548 (GRCm38)	missense	probably damaging	1.00
R6834:Lama3	UTSW	18	12,491,548 (GRCm38)	missense	probably damaging	1.00
R7019:Lama3	UTSW	18	12,528,418 (GRCm38)	missense	probably damaging	0.97
R7026:Lama3	UTSW	18	12,516,548 (GRCm38)	missense	probably damaging	0.98
R7088:Lama3	UTSW	18	12,582,545 (GRCm38)	missense	possibly damaging	0.90
R7100:Lama3	UTSW	18	12,582,644 (GRCm38)	missense	possibly damaging	0.80
R7102:Lama3	UTSW	18	12,552,813 (GRCm38)	missense	possibly damaging	0.66
R7103:Lama3	UTSW	18	12,531,879 (GRCm38)	missense	probably benign	0.00
R7121:Lama3	UTSW	18	12,462,782 (GRCm38)	missense	probably benign	0.06
R7133:Lama3	UTSW	18	12,539,786 (GRCm38)	missense	probably benign	0.05
R7150:Lama3	UTSW	18	12,468,289 (GRCm38)	missense	probably damaging	1.00
R7158:Lama3	UTSW	18	12,456,812 (GRCm38)	missense	probably benign	0.20
R7170:Lama3	UTSW	18	12,404,076 (GRCm38)	missense	probably benign	0.26
R7216:Lama3	UTSW	18	12,430,000 (GRCm38)	missense	probably damaging	1.00
R7223:Lama3	UTSW	18	12,582,608 (GRCm38)	missense	possibly damaging	0.53
R7243:Lama3	UTSW	18	12,419,845 (GRCm38)	missense	probably damaging	1.00
R7282:Lama3	UTSW	18	12,439,392 (GRCm38)	missense	probably damaging	0.99
R7337:Lama3	UTSW	18	12,507,040 (GRCm38)	splice site	probably null
R7442:Lama3	UTSW	18	12,472,181 (GRCm38)	critical splice acceptor site	probably null
R7487:Lama3	UTSW	18	12,419,237 (GRCm38)	missense	probably benign
R7604:Lama3	UTSW	18	12,500,493 (GRCm38)	missense	possibly damaging	0.93
R7609:Lama3	UTSW	18	12,531,834 (GRCm38)	critical splice acceptor site	probably null
R7650:Lama3	UTSW	18	12,537,838 (GRCm38)	missense	probably benign	0.01
R7894:Lama3	UTSW	18	12,462,807 (GRCm38)	missense	probably benign	0.07
R7975:Lama3	UTSW	18	12,537,739 (GRCm38)	missense	probably damaging	1.00
R8099:Lama3	UTSW	18	12,534,063 (GRCm38)	missense	probably damaging	0.97
R8168:Lama3	UTSW	18	12,506,942 (GRCm38)	missense	probably null
R8219:Lama3	UTSW	18	12,439,360 (GRCm38)	missense	probably benign	0.07
R8227:Lama3	UTSW	18	12,407,551 (GRCm38)	missense	probably benign
R8229:Lama3	UTSW	18	12,407,551 (GRCm38)	missense	probably benign
R8298:Lama3	UTSW	18	12,525,853 (GRCm38)	missense	probably benign	0.12
R8351:Lama3	UTSW	18	12,540,613 (GRCm38)	missense	probably damaging	1.00
R8364:Lama3	UTSW	18	12,528,347 (GRCm38)	missense	probably damaging	0.99
R8463:Lama3	UTSW	18	12,449,839 (GRCm38)	missense	probably damaging	0.96
R8515:Lama3	UTSW	18	12,411,631 (GRCm38)	missense	probably null	0.01
R8784:Lama3	UTSW	18	12,421,155 (GRCm38)	missense	probably benign
R8799:Lama3	UTSW	18	12,490,943 (GRCm38)	missense	probably damaging	0.96
R8874:Lama3	UTSW	18	12,449,586 (GRCm38)	critical splice donor site	probably null
R8938:Lama3	UTSW	18	12,556,705 (GRCm38)	missense	probably damaging	1.00
R8967:Lama3	UTSW	18	12,532,039 (GRCm38)	missense	possibly damaging	0.46
R9039:Lama3	UTSW	18	12,481,063 (GRCm38)	nonsense	probably null
R9126:Lama3	UTSW	18	12,450,470 (GRCm38)	missense	probably damaging	1.00
R9200:Lama3	UTSW	18	12,472,240 (GRCm38)	missense	probably benign	0.00
R9203:Lama3	UTSW	18	12,462,812 (GRCm38)	missense	probably benign	0.04
R9246:Lama3	UTSW	18	12,577,902 (GRCm38)	missense	probably damaging	0.99
R9284:Lama3	UTSW	18	12,450,484 (GRCm38)	nonsense	probably null
R9553:Lama3	UTSW	18	12,429,962 (GRCm38)	missense	probably damaging	1.00
R9716:Lama3	UTSW	18	12,450,403 (GRCm38)	missense	probably damaging	1.00
R9734:Lama3	UTSW	18	12,549,263 (GRCm38)	missense	possibly damaging	0.94
X0019:Lama3	UTSW	18	12,582,574 (GRCm38)	missense	possibly damaging	0.94
Z1177:Lama3	UTSW	18	12,429,879 (GRCm38)	critical splice acceptor site	probably null

Posted On

2016-08-02