Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03051:Naa16'

409065

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa16

Ensembl Gene

ENSMUSG00000022020

Gene Name

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

Synonyms

Narg1l, 1300019C06Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL03051

Quality Score

Status

Chromosome

Chromosomal Location

79325269-79390778 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 79369082 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 337 (E337G)

Ref Sequence

ENSEMBL: ENSMUSP00000022597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486] [ENSMUST00000169500]

AlphaFold

Q9DBB4

Predicted Effect

probably benign
Transcript: ENSMUST00000022597
AA Change: E337G

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: E337G

Domain	Start	End	E-Value	Type
TPR	46	79	2.99e1	SMART
TPR	80	113	2.98e-3	SMART
Blast:TPR	224	257	1e-10	BLAST
TPR	374	407	9.96e0	SMART
TPR	408	441	7.47e0	SMART
low complexity region	616	633	N/A	INTRINSIC
Blast:TPR	672	705	3e-12	BLAST
low complexity region	830	841	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163486
AA Change: E303G

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: E303G

Domain	Start	End	E-Value	Type
TPR	12	45	2.99e1	SMART
TPR	46	79	2.98e-3	SMART
Blast:TPR	190	223	3e-10	BLAST
TPR	340	373	9.96e0	SMART
TPR	374	407	7.47e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000169500

SMART Domains

Protein: ENSMUSP00000127298
Gene: ENSMUSG00000022020

Domain	Start	End	E-Value	Type
PDB:4KVO\|D	1	46	1e-6	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	G	T	6: 86,987,301		probably benign	Het
Abhd14a	A	T	9: 106,443,929	F76I	possibly damaging	Het
Acvr1b	A	G	15: 101,203,078	R374G	probably damaging	Het
Akap13	T	A	7: 75,610,485	C149*	probably null	Het
Appbp2	A	T	11: 85,191,739	D555E	possibly damaging	Het
Arhgap25	T	C	6: 87,495,914	Q87R	probably null	Het
Baz1b	T	A	5: 135,217,225	N509K	probably benign	Het
Ces5a	C	A	8: 93,528,598	G156C	probably damaging	Het
Chtf18	G	A	17: 25,720,964	R723W	probably damaging	Het
Clec4e	A	G	6: 123,289,733	S6P	probably benign	Het
Dennd4a	A	G	9: 64,862,414	I468V	probably damaging	Het
Epb41l4a	A	T	18: 33,874,772	Y233N	probably damaging	Het
Fam210b	C	T	2: 172,352,692	H155Y	probably benign	Het
Frmd4b	A	T	6: 97,295,982	C770*	probably null	Het
Gpa33	A	G	1: 166,165,221	H301R	probably benign	Het
Gpr39	T	A	1: 125,677,748	C138S	probably damaging	Het
Gtf2i	T	A	5: 134,242,914	K858*	probably null	Het
Ighv7-1	A	T	12: 113,896,956		probably benign	Het
Iglv1	T	C	16: 19,085,223	T49A	possibly damaging	Het
Kif17	A	C	4: 138,289,254	D416A	probably damaging	Het
Mib2	T	C	4: 155,657,290	T431A	probably damaging	Het
Mpz	G	A	1: 171,158,811	R98H	probably damaging	Het
Odam	G	A	5: 87,892,476		probably benign	Het
Olfr397	T	A	11: 73,965,034	L142H	probably benign	Het
Parp2	T	C	14: 50,819,348		probably benign	Het
Pcdh7	T	G	5: 58,129,073	S1164A	probably damaging	Het
Pkp4	G	T	2: 59,311,762	A470S	probably benign	Het
Plin4	A	T	17: 56,105,417	M538K	possibly damaging	Het
Prex2	T	C	1: 11,142,665	V624A	probably damaging	Het
Rps6ka5	A	C	12: 100,615,991		probably null	Het
Simc1	T	C	13: 54,526,223	S795P	probably benign	Het
Slc35b4	A	T	6: 34,160,471		probably null	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Syt14	T	C	1: 192,933,220	N486S	probably benign	Het
Trim59	T	C	3: 69,036,873	N378S	probably benign	Het
Wdr17	T	A	8: 54,651,314	D908V	probably damaging	Het
Wdr74	A	G	19: 8,739,511		probably benign	Het
Wisp1	T	A	15: 66,906,550	C73*	probably null	Het

Other mutations in Naa16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Naa16	APN	14	79355729	missense	probably damaging	1.00
IGL01025:Naa16	APN	14	79384756	missense	probably damaging	1.00
IGL01155:Naa16	APN	14	79384715	missense	probably damaging	0.98
IGL01335:Naa16	APN	14	79345116	splice site	probably benign
IGL01981:Naa16	APN	14	79381516	missense	probably benign	0.05
IGL02230:Naa16	APN	14	79377361	splice site	probably benign
IGL02313:Naa16	APN	14	79384668	missense	probably damaging	1.00
IGL02418:Naa16	APN	14	79383366	missense	probably damaging	1.00
IGL02544:Naa16	APN	14	79335820	missense	probably damaging	1.00
IGL03064:Naa16	APN	14	79339628	missense	probably damaging	0.98
IGL03205:Naa16	APN	14	79356512	missense	possibly damaging	0.89
PIT4508001:Naa16	UTSW	14	79369087	missense	probably benign	0.15
R0651:Naa16	UTSW	14	79351392	missense	probably damaging	1.00
R1429:Naa16	UTSW	14	79359527	missense	probably benign	0.01
R1674:Naa16	UTSW	14	79387057	start codon destroyed	probably null	0.65
R1693:Naa16	UTSW	14	79351456	missense	probably damaging	1.00
R1874:Naa16	UTSW	14	79355743	missense	possibly damaging	0.62
R1992:Naa16	UTSW	14	79356491	missense	probably damaging	1.00
R2015:Naa16	UTSW	14	79345059	missense	probably damaging	1.00
R2391:Naa16	UTSW	14	79370049	missense	probably benign	0.16
R2847:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2848:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2877:Naa16	UTSW	14	79343298	missense	probably benign	0.00
R3884:Naa16	UTSW	14	79343262	missense	probably damaging	0.98
R4001:Naa16	UTSW	14	79343121	splice site	probably null
R4199:Naa16	UTSW	14	79355871	missense	probably damaging	1.00
R4638:Naa16	UTSW	14	79340033	splice site	probably null
R4676:Naa16	UTSW	14	79336348	unclassified	probably benign
R4690:Naa16	UTSW	14	79345057	missense	probably damaging	1.00
R4952:Naa16	UTSW	14	79345085	missense	probably damaging	1.00
R5087:Naa16	UTSW	14	79377415	missense	possibly damaging	0.68
R5104:Naa16	UTSW	14	79384700	nonsense	probably null
R5729:Naa16	UTSW	14	79355780	missense	probably damaging	1.00
R6178:Naa16	UTSW	14	79383340	missense	possibly damaging	0.93
R6960:Naa16	UTSW	14	79359471	missense	possibly damaging	0.65
R7794:Naa16	UTSW	14	79377494	missense	probably damaging	1.00
R7936:Naa16	UTSW	14	79341046	missense	possibly damaging	0.47
R8356:Naa16	UTSW	14	79359475	missense	probably benign	0.00
R8456:Naa16	UTSW	14	79359475	missense	probably benign	0.00
R8892:Naa16	UTSW	14	79390576	missense	probably benign	0.32
R8931:Naa16	UTSW	14	79344955	missense	probably damaging	1.00
R9010:Naa16	UTSW	14	79370042	missense	probably benign	0.01
R9068:Naa16	UTSW	14	79374849	missense	probably benign	0.18
R9360:Naa16	UTSW	14	79356503	missense	probably benign	0.05
R9688:Naa16	UTSW	14	79335869	nonsense	probably null
X0064:Naa16	UTSW	14	79351389	missense	probably damaging	1.00
Z1177:Naa16	UTSW	14	79344979	missense	probably damaging	1.00

Posted On

2016-08-02