Incidental Mutation 'IGL03053:Or6d15'
ID 409125
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6d15
Ensembl Gene ENSMUSG00000050654
Gene Name olfactory receptor family 6 subfamily D member 15
Synonyms GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL03053
Quality Score
Status
Chromosome 6
Chromosomal Location 116558973-116559905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 116559206 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 234 (R234G)
Ref Sequence ENSEMBL: ENSMUSP00000052425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061723]
AlphaFold Q8VF82
Predicted Effect possibly damaging
Transcript: ENSMUST00000061723
AA Change: R234G

PolyPhen 2 Score 0.503 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: R234G

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 258 1.8e-5 PFAM
Pfam:7tm_1 39 288 2.9e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 G A 4: 106,613,050 (GRCm39) Q342* probably null Het
Arglu1 T A 8: 8,733,960 (GRCm39) I119L probably benign Het
Atp1a2 G A 1: 172,105,923 (GRCm39) T914I probably damaging Het
Birc6 C T 17: 74,872,967 (GRCm39) R409C probably damaging Het
Brwd1 A T 16: 95,818,877 (GRCm39) S1318R possibly damaging Het
C1qtnf12 A T 4: 156,050,921 (GRCm39) N297Y probably damaging Het
Cgas A T 9: 78,344,719 (GRCm39) F234Y probably benign Het
Cyp2a4 A T 7: 26,012,975 (GRCm39) probably benign Het
Cyp2j7 C T 4: 96,118,274 (GRCm39) M106I probably benign Het
Dis3 A G 14: 99,336,170 (GRCm39) V112A probably benign Het
Ehd3 A G 17: 74,112,437 (GRCm39) Y67C probably damaging Het
Elavl4 A T 4: 110,108,691 (GRCm39) S16T possibly damaging Het
F2rl1 A C 13: 95,650,126 (GRCm39) V252G probably benign Het
Fggy A T 4: 95,815,046 (GRCm39) probably benign Het
Hc G T 2: 34,914,210 (GRCm39) N832K probably benign Het
Hnf1a T A 5: 115,108,792 (GRCm39) M38L probably benign Het
Kif13a T C 13: 46,905,564 (GRCm39) N793S probably benign Het
Kit A G 5: 75,771,574 (GRCm39) N244D probably benign Het
Mgat5b A G 11: 116,814,276 (GRCm39) E60G possibly damaging Het
Obsl1 T C 1: 75,469,723 (GRCm39) H1098R probably benign Het
Or2l13 A T 16: 19,305,969 (GRCm39) H127L probably benign Het
Or2n1e A C 17: 38,585,682 (GRCm39) S7R probably damaging Het
Or4c123 A C 2: 89,126,789 (GRCm39) I275S probably damaging Het
Or4p7 A G 2: 88,221,938 (GRCm39) M116V probably damaging Het
Or5ac16 A G 16: 59,022,610 (GRCm39) Y60H probably damaging Het
Or5t9 A G 2: 86,659,607 (GRCm39) I170M possibly damaging Het
Pitpnm2 A G 5: 124,281,664 (GRCm39) I42T probably damaging Het
Prkd2 A G 7: 16,584,188 (GRCm39) D347G possibly damaging Het
Prkdc A G 16: 15,652,030 (GRCm39) I3806V probably benign Het
Rasgrp2 T C 19: 6,457,362 (GRCm39) probably benign Het
Rc3h1 T A 1: 160,783,387 (GRCm39) D734E probably benign Het
Rtel1 A G 2: 180,993,737 (GRCm39) K619E probably benign Het
Tnfrsf26 T C 7: 143,168,597 (GRCm39) D147G possibly damaging Het
Ufl1 A G 4: 25,275,833 (GRCm39) I110T probably damaging Het
Ugt2b36 A G 5: 87,239,933 (GRCm39) S151P possibly damaging Het
Vmn2r25 T C 6: 123,800,077 (GRCm39) Y755C probably damaging Het
Zfhx3 T C 8: 109,673,132 (GRCm39) V1394A probably damaging Het
Zng1 T A 19: 24,932,741 (GRCm39) E97D probably damaging Het
Zzef1 G T 11: 72,722,365 (GRCm39) probably benign Het
Other mutations in Or6d15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Or6d15 APN 6 116,559,296 (GRCm39) missense possibly damaging 0.93
IGL02959:Or6d15 APN 6 116,559,505 (GRCm39) missense probably damaging 1.00
R0078:Or6d15 UTSW 6 116,559,701 (GRCm39) missense probably damaging 0.96
R0277:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0323:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0399:Or6d15 UTSW 6 116,559,742 (GRCm39) missense probably benign 0.00
R0545:Or6d15 UTSW 6 116,559,617 (GRCm39) missense probably benign 0.01
R1213:Or6d15 UTSW 6 116,559,827 (GRCm39) missense probably benign 0.00
R1775:Or6d15 UTSW 6 116,559,925 (GRCm39) start gained probably benign
R1789:Or6d15 UTSW 6 116,559,658 (GRCm39) missense probably damaging 1.00
R4724:Or6d15 UTSW 6 116,559,898 (GRCm39) missense probably damaging 1.00
R5391:Or6d15 UTSW 6 116,559,808 (GRCm39) missense probably damaging 1.00
R5392:Or6d15 UTSW 6 116,559,379 (GRCm39) missense probably damaging 1.00
R5686:Or6d15 UTSW 6 116,559,890 (GRCm39) missense probably benign 0.00
R6124:Or6d15 UTSW 6 116,559,446 (GRCm39) missense probably benign 0.05
R7080:Or6d15 UTSW 6 116,559,314 (GRCm39) missense probably damaging 1.00
R7355:Or6d15 UTSW 6 116,559,916 (GRCm39) start gained probably benign
R9084:Or6d15 UTSW 6 116,559,232 (GRCm39) missense probably benign 0.03
Z1177:Or6d15 UTSW 6 116,559,514 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02