Incidental Mutation 'IGL03053:Tnfrsf26'
ID409154
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnfrsf26
Ensembl Gene ENSMUSG00000045362
Gene Nametumor necrosis factor receptor superfamily, member 26
SynonymsTnfrh3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL03053
Quality Score
Status
Chromosome7
Chromosomal Location143607659-143628722 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 143614860 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 147 (D147G)
Ref Sequence ENSEMBL: ENSMUSP00000054938 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055723] [ENSMUST00000208124]
Predicted Effect possibly damaging
Transcript: ENSMUST00000055723
AA Change: D147G

PolyPhen 2 Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000054938
Gene: ENSMUSG00000045362
AA Change: D147G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
TNFR 27 61 1.95e0 SMART
TNFR 64 103 6.89e-8 SMART
TNFR 105 143 1.1e-6 SMART
transmembrane domain 163 185 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000208124
AA Change: D9G
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 G A 4: 106,755,853 Q342* probably null Het
Arglu1 T A 8: 8,683,960 I119L probably benign Het
Atp1a2 G A 1: 172,278,356 T914I probably damaging Het
Birc6 C T 17: 74,565,972 R409C probably damaging Het
Brwd1 A T 16: 96,017,677 S1318R possibly damaging Het
C1qtnf12 A T 4: 155,966,464 N297Y probably damaging Het
Cbwd1 T A 19: 24,955,377 E97D probably damaging Het
Cyp2a4 A T 7: 26,313,550 probably benign Het
Cyp2j7 C T 4: 96,230,037 M106I probably benign Het
Dis3 A G 14: 99,098,734 V112A probably benign Het
Ehd3 A G 17: 73,805,442 Y67C probably damaging Het
Elavl4 A T 4: 110,251,494 S16T possibly damaging Het
F2rl1 A C 13: 95,513,618 V252G probably benign Het
Fggy A T 4: 95,926,809 probably benign Het
Hc G T 2: 35,024,198 N832K probably benign Het
Hnf1a T A 5: 114,970,733 M38L probably benign Het
Kif13a T C 13: 46,752,088 N793S probably benign Het
Kit A G 5: 75,610,914 N244D probably benign Het
Mb21d1 A T 9: 78,437,437 F234Y probably benign Het
Mgat5b A G 11: 116,923,450 E60G possibly damaging Het
Obsl1 T C 1: 75,493,079 H1098R probably benign Het
Olfr1094 A G 2: 86,829,263 I170M possibly damaging Het
Olfr1178 A G 2: 88,391,594 M116V probably damaging Het
Olfr1230 A C 2: 89,296,445 I275S probably damaging Het
Olfr138 A C 17: 38,274,791 S7R probably damaging Het
Olfr166 A T 16: 19,487,219 H127L probably benign Het
Olfr198 A G 16: 59,202,247 Y60H probably damaging Het
Olfr215 T C 6: 116,582,245 R234G possibly damaging Het
Pitpnm2 A G 5: 124,143,601 I42T probably damaging Het
Prkd2 A G 7: 16,850,263 D347G possibly damaging Het
Prkdc A G 16: 15,834,166 I3806V probably benign Het
Rasgrp2 T C 19: 6,407,332 probably benign Het
Rc3h1 T A 1: 160,955,817 D734E probably benign Het
Rtel1 A G 2: 181,351,944 K619E probably benign Het
Ufl1 A G 4: 25,275,833 I110T probably damaging Het
Ugt2b36 A G 5: 87,092,074 S151P possibly damaging Het
Vmn2r25 T C 6: 123,823,118 Y755C probably damaging Het
Zfhx3 T C 8: 108,946,500 V1394A probably damaging Het
Zzef1 G T 11: 72,831,539 probably benign Het
Other mutations in Tnfrsf26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1120:Tnfrsf26 UTSW 7 143617914 missense probably damaging 1.00
R1465:Tnfrsf26 UTSW 7 143617931 missense probably damaging 1.00
R1465:Tnfrsf26 UTSW 7 143617931 missense probably damaging 1.00
R1957:Tnfrsf26 UTSW 7 143617923 missense probably damaging 1.00
R2132:Tnfrsf26 UTSW 7 143617840 critical splice donor site probably null
R6183:Tnfrsf26 UTSW 7 143611757 missense probably damaging 0.99
R6913:Tnfrsf26 UTSW 7 143618389 nonsense probably null
R7414:Tnfrsf26 UTSW 7 143614905 missense probably damaging 1.00
R8417:Tnfrsf26 UTSW 7 143614902 missense probably benign 0.26
Posted On2016-08-02