Incidental Mutation 'IGL03054:Gng7'
ID 409178
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gng7
Ensembl Gene ENSMUSG00000048240
Gene Name guanine nucleotide binding protein (G protein), gamma 7
Synonyms
Accession Numbers
Essential gene? Not available question?
Stock # IGL03054 (G1)
Quality Score
Status
Chromosome 10
Chromosomal Location 80784463-80850742 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 80787485 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 59 (F59L)
Ref Sequence ENSEMBL: ENSMUSP00000113798 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092285] [ENSMUST00000099462] [ENSMUST00000117805] [ENSMUST00000118233] [ENSMUST00000118465] [ENSMUST00000126317]
AlphaFold Q61016
Predicted Effect probably damaging
Transcript: ENSMUST00000092285
AA Change: F60L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000089936
Gene: ENSMUSG00000048240
AA Change: F60L

DomainStartEndE-ValueType
G_gamma 5 69 2.33e-26 SMART
GGL 8 69 5.94e-32 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099462
AA Change: F60L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097061
Gene: ENSMUSG00000048240
AA Change: F60L

DomainStartEndE-ValueType
G_gamma 5 69 2.33e-26 SMART
GGL 8 69 5.94e-32 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000117805
AA Change: F59L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112409
Gene: ENSMUSG00000048240
AA Change: F59L

DomainStartEndE-ValueType
G_gamma 4 68 2.33e-26 SMART
GGL 7 68 5.94e-32 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000118233
AA Change: F59L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114003
Gene: ENSMUSG00000048240
AA Change: F59L

DomainStartEndE-ValueType
G_gamma 4 68 2.33e-26 SMART
GGL 7 68 5.94e-32 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000118465
AA Change: F59L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113798
Gene: ENSMUSG00000048240
AA Change: F59L

DomainStartEndE-ValueType
G_gamma 4 68 2.33e-26 SMART
GGL 7 68 5.94e-32 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121817
Predicted Effect probably benign
Transcript: ENSMUST00000126317
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (43/44)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit an enhanced startle response, loss of dopamine- and forskolin-stimulated adenylyl cyclase activity in the striatum, and increased mean insulin levels in males. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933416I08Rik TCC TCCC X: 52,692,862 (GRCm39) noncoding transcript Het
Acsbg3 A G 17: 57,193,528 (GRCm39) T625A possibly damaging Het
Aloxe3 T C 11: 69,020,433 (GRCm39) V159A possibly damaging Het
Atp13a2 T A 4: 140,734,279 (GRCm39) C1134S possibly damaging Het
Ccdc40 G A 11: 119,154,027 (GRCm39) E1100K possibly damaging Het
Ceacam5 A T 7: 17,493,379 (GRCm39) T801S possibly damaging Het
Cilp TGGG TGG 9: 65,187,412 (GRCm39) probably null Het
Col4a2 T C 8: 11,498,270 (GRCm39) I1693T probably damaging Het
Crb1 CG C 1: 139,164,824 (GRCm39) probably null Het
Dab2 G T 15: 6,447,707 (GRCm39) probably benign Het
Dao T C 5: 114,162,963 (GRCm39) L345P probably damaging Het
Dis3l A G 9: 64,217,722 (GRCm39) probably null Het
Egr3 C T 14: 70,316,561 (GRCm39) T124M probably damaging Het
Itgb4 C A 11: 115,891,166 (GRCm39) Y1190* probably null Het
Lacc1 T C 14: 77,268,355 (GRCm39) M319V possibly damaging Het
Mapkbp1 A G 2: 119,845,881 (GRCm39) T417A probably damaging Het
Mier3 C T 13: 111,822,848 (GRCm39) probably benign Het
Mlxipl A G 5: 135,162,110 (GRCm39) D569G possibly damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mrpl15 A G 1: 4,855,794 (GRCm39) probably null Het
Neb T C 2: 52,161,334 (GRCm39) N2153D probably damaging Het
Nlrp9c A G 7: 26,081,701 (GRCm39) probably null Het
Npepps C T 11: 97,132,614 (GRCm39) probably benign Het
Or13a17 T G 7: 140,271,623 (GRCm39) S268R probably benign Het
Or1j10 A T 2: 36,266,944 (GRCm39) H52L possibly damaging Het
Or52z12 C A 7: 103,234,047 (GRCm39) H273N probably benign Het
Psmc4 T C 7: 27,746,605 (GRCm39) Y160C probably damaging Het
Rims1 T C 1: 22,360,333 (GRCm39) Y131C probably damaging Het
Riok1 G A 13: 38,231,291 (GRCm39) G183D probably damaging Het
Samd9l T A 6: 3,376,023 (GRCm39) I413F probably damaging Het
Tnfrsf22 A G 7: 143,194,532 (GRCm39) Y132H probably damaging Het
Ttn T A 2: 76,726,104 (GRCm39) probably benign Het
Tulp1 A G 17: 28,578,287 (GRCm39) probably benign Het
Usp15 C A 10: 122,961,836 (GRCm39) probably benign Het
Wdr7 G T 18: 63,958,192 (GRCm39) probably benign Het
Other mutations in Gng7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02678:Gng7 APN 10 80,787,518 (GRCm39) missense probably damaging 1.00
R0854:Gng7 UTSW 10 80,787,507 (GRCm39) missense possibly damaging 0.71
R8524:Gng7 UTSW 10 80,787,537 (GRCm39) missense possibly damaging 0.47
Posted On 2016-08-02