Incidental Mutation 'IGL03057:Olfr933'
ID409256
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr933
Ensembl Gene ENSMUSG00000058515
Gene Nameolfactory receptor 933
SynonymsGA_x6K02T2PVTD-32671531-32672457, MOR171-22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL03057
Quality Score
Status
Chromosome9
Chromosomal Location38972313-38979861 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 38976218 bp
ZygosityHeterozygous
Amino Acid Change Valine to Phenylalanine at position 181 (V181F)
Ref Sequence ENSEMBL: ENSMUSP00000149292 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075680] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
Predicted Effect probably benign
Transcript: ENSMUST00000075680
AA Change: V181F

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000075102
Gene: ENSMUSG00000058515
AA Change: V181F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-50 PFAM
Pfam:7tm_1 41 290 3.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214324
Predicted Effect probably benign
Transcript: ENSMUST00000216238
AA Change: V181F

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000216823
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,668,391 A1295V possibly damaging Het
Adgre4 T C 17: 55,799,602 probably benign Het
Atp8b2 A T 3: 89,944,186 Y901N probably damaging Het
Bud31 A G 5: 145,146,568 T74A probably benign Het
C4b C A 17: 34,737,764 probably benign Het
Ccdc92 G A 5: 124,835,689 Q259* probably null Het
Chfr C A 5: 110,143,609 Q98K probably benign Het
Ciita T A 16: 10,520,959 probably benign Het
Cnbd2 A T 2: 156,367,672 I512F possibly damaging Het
Cpa2 A G 6: 30,557,727 Y346C probably damaging Het
Cpxm1 A G 2: 130,393,189 L570P probably damaging Het
Cylc1 G A X: 111,122,601 G217D unknown Het
Dennd2a T C 6: 39,508,248 I366V probably damaging Het
Dis3 A T 14: 99,089,990 M359K possibly damaging Het
Dock10 T C 1: 80,567,371 N848S probably damaging Het
Dyrk3 C T 1: 131,129,078 V453I probably benign Het
Ercc5 A G 1: 44,167,001 E358G probably damaging Het
Fam167b C A 4: 129,578,167 C70F possibly damaging Het
Fam71a A T 1: 191,162,944 S501T probably benign Het
Flt1 G T 5: 147,681,924 Y200* probably null Het
Ggh T C 4: 20,065,770 V288A probably benign Het
Glb1l2 T C 9: 26,806,290 probably benign Het
Gm28042 A G 2: 120,032,156 Y302C probably damaging Het
Gsta2 A G 9: 78,333,910 probably benign Het
Idh3b T A 2: 130,284,401 N6I probably benign Het
Irs4 A G X: 141,722,528 S891P unknown Het
Kcmf1 G T 6: 72,843,027 R330S probably benign Het
Kif26a G T 12: 112,175,774 E821* probably null Het
L3mbtl1 A G 2: 162,967,383 E670G probably damaging Het
Met A T 6: 17,558,766 D1131V probably damaging Het
Neo1 T C 9: 58,878,059 E1428G probably damaging Het
Odf2 A G 2: 29,923,645 probably benign Het
Ogfod1 T A 8: 94,056,138 L294H possibly damaging Het
Pcdhb20 A T 18: 37,504,798 I126L possibly damaging Het
Pcdhb9 A T 18: 37,401,277 Q108L probably benign Het
Prdm10 G T 9: 31,349,185 R645L probably damaging Het
Psmb11 T A 14: 54,625,779 C151* probably null Het
Reep1 T A 6: 71,807,781 probably benign Het
Reg3a G A 6: 78,381,956 A46T possibly damaging Het
Rnf213 T A 11: 119,441,087 I2374N probably damaging Het
Slc17a7 T C 7: 45,170,939 Y273H probably damaging Het
Smg6 T A 11: 74,935,434 Y238* probably null Het
Sorcs1 T A 19: 50,259,756 K411* probably null Het
Spta1 G T 1: 174,181,058 A243S probably benign Het
Tas2r135 A T 6: 42,401,127 probably benign Het
Tbx18 T C 9: 87,730,829 R6G probably damaging Het
Timp3 A G 10: 86,300,951 D33G possibly damaging Het
Ttf1 A G 2: 29,071,345 K582E probably damaging Het
Ubr5 C A 15: 38,040,906 probably benign Het
Ugt2b1 A G 5: 86,926,341 V53A possibly damaging Het
Ush2a G T 1: 188,797,838 G3275W probably damaging Het
Usp19 G A 9: 108,499,130 V1023M probably benign Het
Usp26 T C X: 51,757,258 I47V possibly damaging Het
Vapa A G 17: 65,594,907 V76A probably damaging Het
Vmn1r202 G A 13: 22,501,470 T259I probably benign Het
Vps13a T C 19: 16,668,694 N1993S probably damaging Het
Wdr59 G A 8: 111,476,118 R598C probably damaging Het
Wisp1 T C 15: 66,891,640 probably benign Het
Other mutations in Olfr933
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02040:Olfr933 APN 9 38976614 unclassified probably benign
R0225:Olfr933 UTSW 9 38976278 missense probably benign 0.00
R0234:Olfr933 UTSW 9 38976251 splice site probably null
R0234:Olfr933 UTSW 9 38976251 splice site probably null
R1479:Olfr933 UTSW 9 38975762 missense probably benign
R1710:Olfr933 UTSW 9 38975906 missense probably damaging 0.97
R1717:Olfr933 UTSW 9 38976410 missense probably damaging 1.00
R1865:Olfr933 UTSW 9 38975904 missense probably benign 0.01
R2258:Olfr933 UTSW 9 38976000 missense probably benign 0.02
R2259:Olfr933 UTSW 9 38976000 missense probably benign 0.02
R2260:Olfr933 UTSW 9 38976000 missense probably benign 0.02
R4155:Olfr933 UTSW 9 38976155 missense probably damaging 0.99
R4299:Olfr933 UTSW 9 38975759 missense probably damaging 1.00
R4452:Olfr933 UTSW 9 38976086 missense probably benign 0.02
R5379:Olfr933 UTSW 9 38975855 missense possibly damaging 0.81
R6340:Olfr933 UTSW 9 38975766 missense probably damaging 1.00
R6497:Olfr933 UTSW 9 38976194 missense probably benign
R7039:Olfr933 UTSW 9 38975987 missense probably damaging 1.00
R7378:Olfr933 UTSW 9 38975721 missense probably benign
R7453:Olfr933 UTSW 9 38976204 missense probably damaging 1.00
R7732:Olfr933 UTSW 9 38976264 missense probably damaging 1.00
R7762:Olfr933 UTSW 9 38976194 missense probably benign
Posted On2016-08-02