Incidental Mutation 'IGL03060:Mettl11b'
ID409397
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl11b
Ensembl Gene ENSMUSG00000040113
Gene Namemethyltransferase like 11B
SynonymsLOC240879
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL03060
Quality Score
Status
Chromosome1
Chromosomal Location163702256-163725232 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 163717123 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 97 (D97G)
Ref Sequence ENSEMBL: ENSMUSP00000124211 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159679] [ENSMUST00000160495]
Predicted Effect probably damaging
Transcript: ENSMUST00000159679
AA Change: D97G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000124211
Gene: ENSMUSG00000040113
AA Change: D97G

DomainStartEndE-ValueType
Pfam:Methyltransf_PK 64 278 5.7e-74 PFAM
Pfam:Methyltransf_11 121 220 4.1e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160495
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 G A 19: 56,914,250 Q720* probably null Het
Amph A G 13: 19,094,814 E153G probably damaging Het
Atad2 T C 15: 58,122,446 probably benign Het
Cep152 C T 2: 125,619,987 probably benign Het
Cntn2 C T 1: 132,528,940 V123I probably benign Het
Dhrs2 C A 14: 55,237,318 Q137K probably benign Het
Fam124a A G 14: 62,605,904 Y287C probably benign Het
Fam214a A G 9: 75,010,168 D683G probably damaging Het
Flg2 C T 3: 93,203,613 R983W unknown Het
Gm9637 G A 14: 19,402,173 noncoding transcript Het
Helz2 A G 2: 181,229,222 probably null Het
Iars G A 13: 49,690,447 probably null Het
Igll1 A T 16: 16,862,427 probably null Het
Iqch A G 9: 63,524,914 Y361H probably damaging Het
Lrp1b A T 2: 40,637,753 H105Q probably benign Het
Mapk6 A G 9: 75,397,802 M111T probably damaging Het
Mkl1 G A 15: 81,045,322 R27W probably damaging Het
Mt1 T A 8: 94,179,894 probably benign Het
Myh7b A T 2: 155,632,751 D1768V probably damaging Het
Myo6 A T 9: 80,260,877 Q441L probably benign Het
Nt5c3b A T 11: 100,436,219 Y84N probably damaging Het
Olfr389 A G 11: 73,776,463 F288S probably damaging Het
Paxx A G 2: 25,460,184 L137P probably damaging Het
Ptprz1 T C 6: 22,972,835 V248A probably damaging Het
Rif1 T A 2: 52,112,137 C1868S probably damaging Het
Sec23a A T 12: 58,986,105 C403S probably benign Het
Skint4 G A 4: 112,118,235 V131I probably benign Het
Sugp2 T C 8: 70,243,187 V270A possibly damaging Het
Tmed9 A G 13: 55,595,508 D151G possibly damaging Het
Tubgcp4 A G 2: 121,176,590 probably benign Het
Uaca A G 9: 60,869,866 R512G probably damaging Het
Unc80 A G 1: 66,637,010 Y1999C possibly damaging Het
Vwf T A 6: 125,663,560 C2320S probably damaging Het
Other mutations in Mettl11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Mettl11b APN 1 163725003 missense probably damaging 1.00
IGL01973:Mettl11b APN 1 163717120 missense probably benign 0.00
IGL02418:Mettl11b APN 1 163703156 missense probably damaging 1.00
IGL02597:Mettl11b APN 1 163717087 missense probably benign 0.00
IGL03162:Mettl11b APN 1 163703214 missense probably damaging 0.98
R4569:Mettl11b UTSW 1 163703017 makesense probably null
R4618:Mettl11b UTSW 1 163725028 missense probably damaging 1.00
R4888:Mettl11b UTSW 1 163703064 missense probably benign 0.11
R5165:Mettl11b UTSW 1 163722523 missense probably benign 0.01
R6353:Mettl11b UTSW 1 163704111 missense possibly damaging 0.94
R6503:Mettl11b UTSW 1 163704146 missense probably damaging 1.00
R7726:Mettl11b UTSW 1 163703184 missense probably benign 0.27
R8092:Mettl11b UTSW 1 163717250 missense probably damaging 1.00
Posted On2016-08-02