Incidental Mutation 'IGL03060:Mt1'
ID 409425
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mt1
Ensembl Gene ENSMUSG00000031765
Gene Name metallothionein 1
Synonyms MT-I, Mt-1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03060
Quality Score
Status
Chromosome 8
Chromosomal Location 94905710-94906955 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to A at 94906522 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034215] [ENSMUST00000211807] [ENSMUST00000212291]
AlphaFold P02802
Predicted Effect probably benign
Transcript: ENSMUST00000034215
SMART Domains Protein: ENSMUSP00000034215
Gene: ENSMUSG00000031765

DomainStartEndE-ValueType
Pfam:Metallothio 1 61 2.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211807
Predicted Effect unknown
Transcript: ENSMUST00000212291
AA Change: L34M
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212456
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit abnormal zinc absorption and abnormal circadian rhythm response to melatonin. Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 G A 19: 56,902,682 (GRCm39) Q720* probably null Het
Amph A G 13: 19,278,984 (GRCm39) E153G probably damaging Het
Atad2 T C 15: 57,985,842 (GRCm39) probably benign Het
Atosa A G 9: 74,917,450 (GRCm39) D683G probably damaging Het
Cep152 C T 2: 125,461,907 (GRCm39) probably benign Het
Cntn2 C T 1: 132,456,678 (GRCm39) V123I probably benign Het
Dhrs2 C A 14: 55,474,775 (GRCm39) Q137K probably benign Het
Fam124a A G 14: 62,843,353 (GRCm39) Y287C probably benign Het
Flg2 C T 3: 93,110,920 (GRCm39) R983W unknown Het
Gm9637 G A 14: 19,402,173 (GRCm38) noncoding transcript Het
Helz2 A G 2: 180,871,015 (GRCm39) probably null Het
Iars1 G A 13: 49,843,923 (GRCm39) probably null Het
Igll1 A T 16: 16,680,291 (GRCm39) probably null Het
Iqch A G 9: 63,432,196 (GRCm39) Y361H probably damaging Het
Lrp1b A T 2: 40,527,765 (GRCm39) H105Q probably benign Het
Mapk6 A G 9: 75,305,084 (GRCm39) M111T probably damaging Het
Mrtfa G A 15: 80,929,523 (GRCm39) R27W probably damaging Het
Myh7b A T 2: 155,474,671 (GRCm39) D1768V probably damaging Het
Myo6 A T 9: 80,168,159 (GRCm39) Q441L probably benign Het
Nt5c3b A T 11: 100,327,045 (GRCm39) Y84N probably damaging Het
Ntmt2 T C 1: 163,544,692 (GRCm39) D97G probably damaging Het
Or1e29 A G 11: 73,667,289 (GRCm39) F288S probably damaging Het
Paxx A G 2: 25,350,196 (GRCm39) L137P probably damaging Het
Ptprz1 T C 6: 22,972,834 (GRCm39) V248A probably damaging Het
Rif1 T A 2: 52,002,149 (GRCm39) C1868S probably damaging Het
Sec23a A T 12: 59,032,891 (GRCm39) C403S probably benign Het
Skint4 G A 4: 111,975,432 (GRCm39) V131I probably benign Het
Sugp2 T C 8: 70,695,837 (GRCm39) V270A possibly damaging Het
Tmed9 A G 13: 55,743,321 (GRCm39) D151G possibly damaging Het
Tubgcp4 A G 2: 121,007,071 (GRCm39) probably benign Het
Uaca A G 9: 60,777,148 (GRCm39) R512G probably damaging Het
Unc80 A G 1: 66,676,169 (GRCm39) Y1999C possibly damaging Het
Vwf T A 6: 125,640,523 (GRCm39) C2320S probably damaging Het
Other mutations in Mt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0635:Mt1 UTSW 8 94,906,449 (GRCm39) critical splice acceptor site probably null
R1317:Mt1 UTSW 8 94,906,781 (GRCm39) utr 3 prime probably benign
R5357:Mt1 UTSW 8 94,906,732 (GRCm39) missense probably damaging 0.99
R6798:Mt1 UTSW 8 94,906,516 (GRCm39) utr 3 prime probably benign
Z1177:Mt1 UTSW 8 94,906,757 (GRCm39) missense probably damaging 0.99
Z1177:Mt1 UTSW 8 94,905,961 (GRCm39) missense unknown
Posted On 2016-08-02