Incidental Mutation 'IGL03060:Mt1'
ID409425
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mt1
Ensembl Gene ENSMUSG00000031765
Gene Namemetallothionein 1
SynonymsMT-I, Mt-1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03060
Quality Score
Status
Chromosome8
Chromosomal Location94179082-94180327 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to A at 94179894 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034215] [ENSMUST00000211807] [ENSMUST00000212291]
Predicted Effect probably benign
Transcript: ENSMUST00000034215
SMART Domains Protein: ENSMUSP00000034215
Gene: ENSMUSG00000031765

DomainStartEndE-ValueType
Pfam:Metallothio 1 61 2.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211807
Predicted Effect unknown
Transcript: ENSMUST00000212291
AA Change: L34M
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212456
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit abnormal zinc absorption and abnormal circadian rhythm response to melatonin. Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 G A 19: 56,914,250 Q720* probably null Het
Amph A G 13: 19,094,814 E153G probably damaging Het
Atad2 T C 15: 58,122,446 probably benign Het
Cep152 C T 2: 125,619,987 probably benign Het
Cntn2 C T 1: 132,528,940 V123I probably benign Het
Dhrs2 C A 14: 55,237,318 Q137K probably benign Het
Fam124a A G 14: 62,605,904 Y287C probably benign Het
Fam214a A G 9: 75,010,168 D683G probably damaging Het
Flg2 C T 3: 93,203,613 R983W unknown Het
Gm9637 G A 14: 19,402,173 noncoding transcript Het
Helz2 A G 2: 181,229,222 probably null Het
Iars G A 13: 49,690,447 probably null Het
Igll1 A T 16: 16,862,427 probably null Het
Iqch A G 9: 63,524,914 Y361H probably damaging Het
Lrp1b A T 2: 40,637,753 H105Q probably benign Het
Mapk6 A G 9: 75,397,802 M111T probably damaging Het
Mettl11b T C 1: 163,717,123 D97G probably damaging Het
Mkl1 G A 15: 81,045,322 R27W probably damaging Het
Myh7b A T 2: 155,632,751 D1768V probably damaging Het
Myo6 A T 9: 80,260,877 Q441L probably benign Het
Nt5c3b A T 11: 100,436,219 Y84N probably damaging Het
Olfr389 A G 11: 73,776,463 F288S probably damaging Het
Paxx A G 2: 25,460,184 L137P probably damaging Het
Ptprz1 T C 6: 22,972,835 V248A probably damaging Het
Rif1 T A 2: 52,112,137 C1868S probably damaging Het
Sec23a A T 12: 58,986,105 C403S probably benign Het
Skint4 G A 4: 112,118,235 V131I probably benign Het
Sugp2 T C 8: 70,243,187 V270A possibly damaging Het
Tmed9 A G 13: 55,595,508 D151G possibly damaging Het
Tubgcp4 A G 2: 121,176,590 probably benign Het
Uaca A G 9: 60,869,866 R512G probably damaging Het
Unc80 A G 1: 66,637,010 Y1999C possibly damaging Het
Vwf T A 6: 125,663,560 C2320S probably damaging Het
Other mutations in Mt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0635:Mt1 UTSW 8 94179821 critical splice acceptor site probably null
R1317:Mt1 UTSW 8 94180153 utr 3 prime probably benign
R5357:Mt1 UTSW 8 94180104 missense probably damaging 0.99
R6798:Mt1 UTSW 8 94179888 utr 3 prime probably benign
Posted On2016-08-02