Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03061:Ttc41'

409441

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc41

Ensembl Gene

ENSMUSG00000044937

Gene Name

tetratricopeptide repeat domain 41

Synonyms

Gnn, BC030307

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL03061

Quality Score

Status

Chromosome

Chromosomal Location

86705811-86776844 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 86736857 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Asparagine at position 698 (H698N)

Ref Sequence

ENSEMBL: ENSMUSP00000075059 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075632]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000070435

SMART Domains

Protein: ENSMUSP00000136633
Gene: ENSMUSG00000056366

Domain	Start	End	E-Value	Type
Pfam:Lipocalin_7	3	133	6.5e-13	PFAM
Pfam:Lipocalin	6	132	2.9e-31	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075632
AA Change: H698N

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000075059
Gene: ENSMUSG00000044937
AA Change: H698N

Domain	Start	End	E-Value	Type
low complexity region	216	229	N/A	INTRINSIC
low complexity region	307	315	N/A	INTRINSIC
Pfam:NACHT	337	515	5.4e-10	PFAM
SCOP:d1qqea_	805	1028	2e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000219476

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl1	T	A	8: 46,508,337	N106K	probably damaging	Het
Ak8	T	C	2: 28,742,755		probably benign	Het
BC016579	C	T	16: 45,629,486	G190S	probably damaging	Het
C4bp	A	G	1: 130,636,717	V410A	probably damaging	Het
Cacna2d3	T	C	14: 29,058,431	T658A	probably damaging	Het
Cadps2	T	C	6: 23,287,660		probably null	Het
Car10	G	T	11: 93,490,525	V105F	probably damaging	Het
Car15	C	T	16: 17,835,385	C306Y	possibly damaging	Het
Casr	C	T	16: 36,495,888	A530T	probably benign	Het
Col5a3	A	G	9: 20,797,572		probably null	Het
Creld1	A	G	6: 113,488,097	E95G	probably damaging	Het
Dcstamp	T	A	15: 39,760,397	D366E	possibly damaging	Het
Dnah11	T	C	12: 117,903,121	Y4095C	probably damaging	Het
Eps8l2	A	G	7: 141,357,235		probably benign	Het
Gsn	T	C	2: 35,282,459		probably benign	Het
Ifi27	T	C	12: 103,435,544	V30A	possibly damaging	Het
Ifit1bl2	C	T	19: 34,619,724	R164Q	probably benign	Het
Impg2	T	C	16: 56,268,416	S1102P	probably damaging	Het
Kif24	G	T	4: 41,394,323	P984Q	possibly damaging	Het
Krtap29-1	T	A	11: 99,978,629	Q142L	possibly damaging	Het
Lpar6	C	T	14: 73,239,070	T157I	probably benign	Het
Lrrc32	A	T	7: 98,499,422	T470S	probably benign	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Mroh9	A	T	1: 163,026,502	H776Q	probably damaging	Het
Myh7	T	C	14: 54,991,204		probably benign	Het
Myh7b	A	G	2: 155,620,111	N309S	possibly damaging	Het
Myo5b	A	T	18: 74,634,559	T313S	probably benign	Het
Myo5b	G	A	18: 74,580,544		probably benign	Het
Npas4	C	T	19: 4,986,337	V600M	probably damaging	Het
Nrxn3	T	A	12: 89,511,928	Y557*	probably null	Het
Olfr169	T	C	16: 19,566,713	T57A	possibly damaging	Het
Olfr552	A	G	7: 102,604,739	I128M	probably damaging	Het
Olfr968	T	A	9: 39,772,162	T213S	probably benign	Het
Pcdh15	A	G	10: 74,317,011	I383V	probably damaging	Het
Pdzrn3	C	A	6: 101,151,855	D617Y	probably damaging	Het
Prodh2	A	T	7: 30,512,833	K408*	probably null	Het
Ptprs	T	C	17: 56,418,830	I1052V	probably damaging	Het
Rpl14	T	C	9: 120,572,127	V12A	probably damaging	Het
Sf3a1	C	T	11: 4,175,493	R428C	probably damaging	Het
Sgsm2	G	T	11: 74,851,136	N1009K	probably damaging	Het
Slc28a2	A	T	2: 122,454,499	I323F	probably damaging	Het
Snx19	T	A	9: 30,433,632	F676I	probably damaging	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tg	A	C	15: 66,671,405	D56A	probably damaging	Het
Tln1	G	T	4: 43,545,694	A928E	probably damaging	Het
Tmem94	T	C	11: 115,792,421	S677P	possibly damaging	Het
Vcan	T	C	13: 89,703,275	T1189A	probably benign	Het
Vmn1r215	G	T	13: 23,075,918	V43F	probably damaging	Het
Vmn2r28	A	T	7: 5,484,016	N549K	probably damaging	Het
Zfp598	T	C	17: 24,679,592	V455A	probably benign	Het

Other mutations in Ttc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00846:Ttc41	APN	10	86736933	missense	possibly damaging	0.71
IGL01373:Ttc41	APN	10	86775957	missense	possibly damaging	0.61
IGL01636:Ttc41	APN	10	86776678	missense	probably benign
IGL01707:Ttc41	APN	10	86776767	missense	probably damaging	1.00
IGL01814:Ttc41	APN	10	86731026	missense	probably damaging	0.98
IGL01845:Ttc41	APN	10	86776624	missense	probably benign	0.03
IGL01918:Ttc41	APN	10	86713190	missense	probably damaging	1.00
IGL02374:Ttc41	APN	10	86775951	missense	probably damaging	1.00
IGL02489:Ttc41	APN	10	86760914	nonsense	probably null
IGL02887:Ttc41	APN	10	86733654	missense	probably damaging	1.00
IGL03077:Ttc41	APN	10	86758348	missense	probably damaging	1.00
IGL03210:Ttc41	APN	10	86724414	critical splice donor site	probably null
IGL03242:Ttc41	APN	10	86776819	makesense	probably null
IGL03307:Ttc41	APN	10	86744440	missense	possibly damaging	0.76
BB003:Ttc41	UTSW	10	86776047	missense	probably benign	0.10
BB013:Ttc41	UTSW	10	86776047	missense	probably benign	0.10
R0071:Ttc41	UTSW	10	86736846	missense	probably benign	0.01
R0071:Ttc41	UTSW	10	86736846	missense	probably benign	0.01
R0379:Ttc41	UTSW	10	86712977	missense	possibly damaging	0.65
R0384:Ttc41	UTSW	10	86763947	missense	probably damaging	1.00
R0545:Ttc41	UTSW	10	86759097	missense	probably benign	0.00
R1589:Ttc41	UTSW	10	86776390	missense	probably benign	0.01
R1599:Ttc41	UTSW	10	86776573	missense	probably benign	0.04
R1608:Ttc41	UTSW	10	86775993	missense	probably damaging	1.00
R1670:Ttc41	UTSW	10	86776252	missense	possibly damaging	0.93
R1938:Ttc41	UTSW	10	86776214	missense	probably benign
R2398:Ttc41	UTSW	10	86713386	missense	possibly damaging	0.91
R2401:Ttc41	UTSW	10	86724374	missense	probably benign	0.42
R3117:Ttc41	UTSW	10	86724320	missense	possibly damaging	0.62
R3119:Ttc41	UTSW	10	86724320	missense	possibly damaging	0.62
R4805:Ttc41	UTSW	10	86729798	missense	possibly damaging	0.62
R4840:Ttc41	UTSW	10	86731125	missense	probably benign	0.10
R4841:Ttc41	UTSW	10	86731125	missense	probably benign	0.10
R4842:Ttc41	UTSW	10	86731125	missense	probably benign	0.10
R4884:Ttc41	UTSW	10	86731018	missense	probably benign	0.00
R4885:Ttc41	UTSW	10	86759102	missense	possibly damaging	0.76
R4898:Ttc41	UTSW	10	86776192	missense	possibly damaging	0.80
R5067:Ttc41	UTSW	10	86744544	missense	probably damaging	0.96
R5253:Ttc41	UTSW	10	86730942	missense	probably benign	0.13
R5268:Ttc41	UTSW	10	86744478	missense	possibly damaging	0.76
R5297:Ttc41	UTSW	10	86776579	missense	probably benign	0.04
R5301:Ttc41	UTSW	10	86719520	missense	probably benign	0.00
R5425:Ttc41	UTSW	10	86776630	missense	probably damaging	0.96
R5567:Ttc41	UTSW	10	86760920	critical splice donor site	probably null
R5635:Ttc41	UTSW	10	86736977	missense	probably benign	0.09
R5752:Ttc41	UTSW	10	86758346	missense	probably benign	0.33
R5868:Ttc41	UTSW	10	86750264	missense	possibly damaging	0.70
R5948:Ttc41	UTSW	10	86713224	missense	probably damaging	1.00
R6116:Ttc41	UTSW	10	86759088	critical splice acceptor site	probably null
R6247:Ttc41	UTSW	10	86776663	missense	probably benign	0.00
R6260:Ttc41	UTSW	10	86731159	missense	probably benign	0.20
R6260:Ttc41	UTSW	10	86733707	missense	probably benign	0.32
R6276:Ttc41	UTSW	10	86744449	missense	probably benign	0.01
R6458:Ttc41	UTSW	10	86758270	missense	possibly damaging	0.45
R7170:Ttc41	UTSW	10	86713503	missense	probably benign	0.17
R7348:Ttc41	UTSW	10	86750348	nonsense	probably null
R7382:Ttc41	UTSW	10	86776510	missense	probably damaging	0.97
R7509:Ttc41	UTSW	10	86713432	missense	probably damaging	1.00
R7689:Ttc41	UTSW	10	86759224	missense	probably damaging	1.00
R7807:Ttc41	UTSW	10	86776631	missense	probably benign	0.02
R7926:Ttc41	UTSW	10	86776047	missense	probably benign	0.10
R7998:Ttc41	UTSW	10	86736847	missense	probably benign	0.01
R8021:Ttc41	UTSW	10	86733714	missense	probably benign
R8059:Ttc41	UTSW	10	86712978	missense	probably benign	0.01
R8170:Ttc41	UTSW	10	86776166	missense	probably damaging	1.00
R8303:Ttc41	UTSW	10	86719630	missense	probably benign	0.06
R8375:Ttc41	UTSW	10	86763980	missense	probably damaging	0.97
R8383:Ttc41	UTSW	10	86719526	missense	probably benign	0.00
R8698:Ttc41	UTSW	10	86712977	missense	probably benign	0.00
R8773:Ttc41	UTSW	10	86729815	missense	probably benign	0.35
R8902:Ttc41	UTSW	10	86713001	missense	probably benign	0.06
R8985:Ttc41	UTSW	10	86731092	missense	possibly damaging	0.80
R8988:Ttc41	UTSW	10	86713735	missense	possibly damaging	0.88
R9007:Ttc41	UTSW	10	86733761	missense	probably damaging	1.00
R9137:Ttc41	UTSW	10	86776622	missense	probably benign	0.22
R9236:Ttc41	UTSW	10	86776730	missense	probably damaging	1.00
R9248:Ttc41	UTSW	10	86731249	missense	probably benign	0.00
R9287:Ttc41	UTSW	10	86763966	missense	probably benign	0.43
R9345:Ttc41	UTSW	10	86759225	missense	probably damaging	0.99
R9386:Ttc41	UTSW	10	86713026	missense	probably damaging	0.99
R9500:Ttc41	UTSW	10	86729862	missense	probably benign	0.03
R9570:Ttc41	UTSW	10	86713734	missense	possibly damaging	0.88
R9593:Ttc41	UTSW	10	86713185	missense	probably benign	0.24
X0024:Ttc41	UTSW	10	86724250	missense	probably damaging	1.00
X0064:Ttc41	UTSW	10	86729797	missense	probably benign	0.01

Posted On

2016-08-02