Incidental Mutation 'IGL03062:Soga3'
ID409478
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Soga3
Ensembl Gene ENSMUSG00000038916
Gene NameSOGA family member 3
Synonyms6330407J23Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.170) question?
Stock #IGL03062
Quality Score
Status
Chromosome10
Chromosomal Location29143839-29199630 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 29198949 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 911 (F911Y)
Ref Sequence ENSEMBL: ENSMUSP00000090293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092629] [ENSMUST00000217011]
Predicted Effect probably damaging
Transcript: ENSMUST00000092629
AA Change: F911Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000090293
Gene: ENSMUSG00000038916
AA Change: F911Y

DomainStartEndE-ValueType
low complexity region 4 23 N/A INTRINSIC
low complexity region 72 81 N/A INTRINSIC
low complexity region 86 101 N/A INTRINSIC
low complexity region 110 126 N/A INTRINSIC
low complexity region 158 185 N/A INTRINSIC
low complexity region 214 247 N/A INTRINSIC
SCOP:d1fxkc_ 354 488 2e-4 SMART
Blast:BRLZ 356 384 6e-10 BLAST
Pfam:DUF3166 519 613 1.8e-34 PFAM
Pfam:DUF3166 639 727 4.6e-34 PFAM
transmembrane domain 917 939 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213451
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214863
Predicted Effect probably benign
Transcript: ENSMUST00000217011
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T C 3: 37,038,517 probably benign Het
Abcb10 C T 8: 123,954,315 R714Q possibly damaging Het
Abcb5 T A 12: 118,936,087 I282L probably benign Het
Aox1 A T 1: 58,078,465 E835D probably benign Het
Arhgap17 C T 7: 123,321,874 probably null Het
Calcr C T 6: 3,693,718 V359I probably benign Het
Chd9 T A 8: 91,015,267 probably benign Het
Col28a1 T C 6: 8,017,029 probably benign Het
Dnajc11 A G 4: 151,970,861 E171G possibly damaging Het
Efhd1 T C 1: 87,264,684 F79L possibly damaging Het
Fam83a A T 15: 57,993,077 probably null Het
Fam98a A G 17: 75,540,105 probably benign Het
Ficd A G 5: 113,738,253 Y163C probably damaging Het
Filip1l T C 16: 57,506,804 S66P probably damaging Het
Fmo5 A G 3: 97,635,593 Y73C probably damaging Het
Galnt12 C A 4: 47,122,566 R574S possibly damaging Het
Klc3 C A 7: 19,395,062 G461W probably damaging Het
Lmo7 A T 14: 101,912,079 T973S possibly damaging Het
Loxl1 C A 9: 58,311,910 G326V possibly damaging Het
Lrrc24 A G 15: 76,718,304 V127A probably benign Het
Lyrm1 T C 7: 119,916,131 probably benign Het
Med28 G A 5: 45,522,469 V65I probably damaging Het
Mgat4c T C 10: 102,388,461 Y179H probably damaging Het
Micall1 A C 15: 79,114,681 N58T probably damaging Het
Ncoa4 T A 14: 32,173,420 M72K possibly damaging Het
Nutm1 T C 2: 112,248,933 Q879R probably benign Het
Olfr1428 C T 19: 12,109,148 V133I probably benign Het
Olfr870 T A 9: 20,171,167 I135F probably damaging Het
Olfr965 T A 9: 39,720,035 D269E probably benign Het
Phf11b T C 14: 59,324,924 I177M probably damaging Het
Pin1rt1 T G 2: 104,714,707 I27L probably benign Het
Plxna2 T C 1: 194,762,550 V750A possibly damaging Het
Pou5f1 A T 17: 35,510,039 N126I possibly damaging Het
Ptprn A T 1: 75,247,873 H946Q possibly damaging Het
Rnf43 G T 11: 87,732,304 G744* probably null Het
Rsbn1 C A 3: 103,953,629 probably benign Het
Sars2 T A 7: 28,746,781 I145N possibly damaging Het
Sh3tc2 A T 18: 62,011,880 E1135V probably damaging Het
Shroom1 A G 11: 53,463,379 D42G probably benign Het
Sidt2 A G 9: 45,942,683 probably null Het
Slc39a8 T C 3: 135,886,797 probably benign Het
Slc9c1 T C 16: 45,599,758 S1059P probably benign Het
Socs6 A T 18: 88,869,846 M315K probably benign Het
Speer2 T C 16: 69,857,977 E200G probably damaging Het
Sult2a5 T A 7: 13,624,182 probably null Het
Tmbim1 A T 1: 74,291,699 I168N possibly damaging Het
Trim38 T C 13: 23,782,963 V131A probably damaging Het
Ube2o A G 11: 116,541,642 S833P probably damaging Het
Uggt2 T C 14: 119,075,346 I350M probably damaging Het
Unc80 A G 1: 66,509,489 D640G probably damaging Het
Vmn2r13 A G 5: 109,156,282 F761S probably damaging Het
Vmn2r54 C T 7: 12,632,428 C193Y probably damaging Het
Other mutations in Soga3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Soga3 APN 10 29196473 nonsense probably null
IGL00929:Soga3 APN 10 29148292 missense probably damaging 0.99
IGL01450:Soga3 APN 10 29196323 missense probably damaging 1.00
IGL01462:Soga3 APN 10 29148258 missense probably damaging 1.00
R0534:Soga3 UTSW 10 29180956 splice site probably benign
R1355:Soga3 UTSW 10 29147322 missense probably benign 0.01
R1450:Soga3 UTSW 10 29147740 missense probably damaging 1.00
R1654:Soga3 UTSW 10 29146935 unclassified probably null
R1680:Soga3 UTSW 10 29196839 missense probably damaging 1.00
R2134:Soga3 UTSW 10 29196399 nonsense probably null
R2570:Soga3 UTSW 10 29146765 missense possibly damaging 0.88
R4395:Soga3 UTSW 10 29147355 missense probably benign
R4859:Soga3 UTSW 10 29150394 missense probably benign 0.00
R4883:Soga3 UTSW 10 29196541 missense probably damaging 1.00
R4884:Soga3 UTSW 10 29196541 missense probably damaging 1.00
R5288:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5335:Soga3 UTSW 10 29147106 missense probably benign
R5384:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5385:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5457:Soga3 UTSW 10 29196724 missense probably benign 0.01
R5813:Soga3 UTSW 10 29150244 missense probably damaging 1.00
R5819:Soga3 UTSW 10 29197273 missense probably benign 0.00
R5950:Soga3 UTSW 10 29143648 unclassified probably benign
R6567:Soga3 UTSW 10 29147283 missense probably benign 0.00
R7312:Soga3 UTSW 10 29197244 missense probably damaging 1.00
R7313:Soga3 UTSW 10 29196879 nonsense probably null
R7445:Soga3 UTSW 10 29197003 missense possibly damaging 0.91
R7481:Soga3 UTSW 10 29196523 missense probably damaging 1.00
R7609:Soga3 UTSW 10 29148228 missense probably damaging 1.00
R7616:Soga3 UTSW 10 29146578 start gained probably benign
Posted On2016-08-02