Incidental Mutation 'IGL03062:Phf11b'
ID409482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Phf11b
Ensembl Gene ENSMUSG00000091649
Gene NamePHD finger protein 11B
SynonymsGm4902
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL03062
Quality Score
Status
Chromosome14
Chromosomal Location59320964-59341351 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59324924 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Methionine at position 177 (I177M)
Ref Sequence ENSEMBL: ENSMUSP00000127857 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166121]
Predicted Effect probably damaging
Transcript: ENSMUST00000166121
AA Change: I177M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127857
Gene: ENSMUSG00000091649
AA Change: I177M

DomainStartEndE-ValueType
PHD 92 143 1.55e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T C 3: 37,038,517 probably benign Het
Abcb10 C T 8: 123,954,315 R714Q possibly damaging Het
Abcb5 T A 12: 118,936,087 I282L probably benign Het
Aox1 A T 1: 58,078,465 E835D probably benign Het
Arhgap17 C T 7: 123,321,874 probably null Het
Calcr C T 6: 3,693,718 V359I probably benign Het
Chd9 T A 8: 91,015,267 probably benign Het
Col28a1 T C 6: 8,017,029 probably benign Het
Dnajc11 A G 4: 151,970,861 E171G possibly damaging Het
Efhd1 T C 1: 87,264,684 F79L possibly damaging Het
Fam83a A T 15: 57,993,077 probably null Het
Fam98a A G 17: 75,540,105 probably benign Het
Ficd A G 5: 113,738,253 Y163C probably damaging Het
Filip1l T C 16: 57,506,804 S66P probably damaging Het
Fmo5 A G 3: 97,635,593 Y73C probably damaging Het
Galnt12 C A 4: 47,122,566 R574S possibly damaging Het
Klc3 C A 7: 19,395,062 G461W probably damaging Het
Lmo7 A T 14: 101,912,079 T973S possibly damaging Het
Loxl1 C A 9: 58,311,910 G326V possibly damaging Het
Lrrc24 A G 15: 76,718,304 V127A probably benign Het
Lyrm1 T C 7: 119,916,131 probably benign Het
Med28 G A 5: 45,522,469 V65I probably damaging Het
Mgat4c T C 10: 102,388,461 Y179H probably damaging Het
Micall1 A C 15: 79,114,681 N58T probably damaging Het
Ncoa4 T A 14: 32,173,420 M72K possibly damaging Het
Nutm1 T C 2: 112,248,933 Q879R probably benign Het
Olfr1428 C T 19: 12,109,148 V133I probably benign Het
Olfr870 T A 9: 20,171,167 I135F probably damaging Het
Olfr965 T A 9: 39,720,035 D269E probably benign Het
Pin1rt1 T G 2: 104,714,707 I27L probably benign Het
Plxna2 T C 1: 194,762,550 V750A possibly damaging Het
Pou5f1 A T 17: 35,510,039 N126I possibly damaging Het
Ptprn A T 1: 75,247,873 H946Q possibly damaging Het
Rnf43 G T 11: 87,732,304 G744* probably null Het
Rsbn1 C A 3: 103,953,629 probably benign Het
Sars2 T A 7: 28,746,781 I145N possibly damaging Het
Sh3tc2 A T 18: 62,011,880 E1135V probably damaging Het
Shroom1 A G 11: 53,463,379 D42G probably benign Het
Sidt2 A G 9: 45,942,683 probably null Het
Slc39a8 T C 3: 135,886,797 probably benign Het
Slc9c1 T C 16: 45,599,758 S1059P probably benign Het
Socs6 A T 18: 88,869,846 M315K probably benign Het
Soga3 T A 10: 29,198,949 F911Y probably damaging Het
Speer2 T C 16: 69,857,977 E200G probably damaging Het
Sult2a5 T A 7: 13,624,182 probably null Het
Tmbim1 A T 1: 74,291,699 I168N possibly damaging Het
Trim38 T C 13: 23,782,963 V131A probably damaging Het
Ube2o A G 11: 116,541,642 S833P probably damaging Het
Uggt2 T C 14: 119,075,346 I350M probably damaging Het
Unc80 A G 1: 66,509,489 D640G probably damaging Het
Vmn2r13 A G 5: 109,156,282 F761S probably damaging Het
Vmn2r54 C T 7: 12,632,428 C193Y probably damaging Het
Other mutations in Phf11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00560:Phf11b APN 14 59324875 missense probably damaging 1.00
IGL01116:Phf11b APN 14 59323182 missense probably benign 0.02
IGL01446:Phf11b APN 14 59341291 missense probably benign 0.02
IGL02224:Phf11b APN 14 59326066 splice site probably benign
PIT4131001:Phf11b UTSW 14 59323162 splice site probably benign
R1795:Phf11b UTSW 14 59328105 missense probably benign 0.00
R3774:Phf11b UTSW 14 59326057 missense probably benign 0.45
R4553:Phf11b UTSW 14 59341285 missense probably benign 0.10
R5460:Phf11b UTSW 14 59331264 missense probably benign 0.01
R5620:Phf11b UTSW 14 59321504 missense probably benign 0.01
R5985:Phf11b UTSW 14 59321578 missense possibly damaging 0.52
R5990:Phf11b UTSW 14 59324926 missense possibly damaging 0.57
R6775:Phf11b UTSW 14 59338645 missense probably benign 0.14
R6836:Phf11b UTSW 14 59328123 missense possibly damaging 0.81
R7197:Phf11b UTSW 14 59326058 missense probably benign 0.06
Posted On2016-08-02