Incidental Mutation 'IGL03063:Ifit1'
ID409553
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifit1
Ensembl Gene ENSMUSG00000034459
Gene Nameinterferon-induced protein with tetratricopeptide repeats 1
SynonymsIfi56, ISG56
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL03063
Quality Score
Status
Chromosome19
Chromosomal Location34640871-34650009 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 34648004 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 180 (V180A)
Ref Sequence ENSEMBL: ENSMUSP00000099888 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102824]
Predicted Effect possibly damaging
Transcript: ENSMUST00000102824
AA Change: V180A

PolyPhen 2 Score 0.710 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000099888
Gene: ENSMUSG00000034459
AA Change: V180A

DomainStartEndE-ValueType
TPR 52 85 4.8e1 SMART
TPR 92 125 6.92e1 SMART
TPR 138 171 1.2e1 SMART
low complexity region 210 221 N/A INTRINSIC
low complexity region 223 234 N/A INTRINSIC
TPR 242 275 4.93e1 SMART
TPR 329 362 3.89e1 SMART
TPR 426 459 1.45e-1 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered response to vesicular stomatitis virus (VSV) infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 C T 7: 46,016,432 V255I probably benign Het
Arfgef2 T C 2: 166,859,782 probably benign Het
Bpifb2 A T 2: 153,889,124 Q205L probably damaging Het
Ccdc30 C T 4: 119,349,767 R386Q possibly damaging Het
Cdk5rap2 T A 4: 70,354,877 probably null Het
Comtd1 A G 14: 21,847,667 probably null Het
Dao T C 5: 114,021,015 C261R probably damaging Het
Dner A G 1: 84,585,338 V187A possibly damaging Het
Dsg3 T C 18: 20,533,368 probably benign Het
Eif3j2 A G 18: 43,477,379 L123P possibly damaging Het
Esf1 G A 2: 140,154,786 probably benign Het
Exo5 G A 4: 120,921,633 T345I possibly damaging Het
Fancl A T 11: 26,387,299 I29F probably damaging Het
Gadl1 C T 9: 115,966,267 H313Y probably damaging Het
Gm17190 G A 13: 96,082,762 probably benign Het
Gtf3c1 G T 7: 125,646,503 T1580N possibly damaging Het
Gtf3c6 T A 10: 40,251,159 I66L probably benign Het
Hhla1 A G 15: 65,941,790 I231T probably damaging Het
Hk2 A G 6: 82,739,649 Y273H probably damaging Het
Hk2 A G 6: 82,749,232 I83T probably benign Het
Igkv9-129 A T 6: 67,840,188 D92V probably damaging Het
Lrrc1 A G 9: 77,499,269 F36S probably damaging Het
Man1b1 A G 2: 25,334,404 E102G possibly damaging Het
Myh8 A G 11: 67,288,205 S475G probably benign Het
Olfr593 T A 7: 103,212,634 V247D probably damaging Het
Otud4 T A 8: 79,663,790 M343K probably benign Het
Peg10 A T 6: 4,756,647 probably benign Het
Plet1 T A 9: 50,504,422 N197K probably benign Het
Ppp1r12a C T 10: 108,261,254 R243C probably damaging Het
Serpinb10 A T 1: 107,542,227 K146N possibly damaging Het
Sis A G 3: 72,928,297 F911L probably benign Het
Spon1 G A 7: 114,033,025 V528M possibly damaging Het
Tdrd9 T C 12: 112,044,299 V1100A probably benign Het
Tmtc3 T C 10: 100,447,606 M696V probably benign Het
Triobp A G 15: 78,990,884 E122G probably damaging Het
Wt1 G A 2: 105,170,023 probably null Het
Other mutations in Ifit1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Ifit1 APN 19 34648133 missense possibly damaging 0.73
IGL01484:Ifit1 APN 19 34648843 missense probably damaging 0.99
IGL01505:Ifit1 APN 19 34648454 missense probably benign 0.38
IGL02663:Ifit1 APN 19 34640980 utr 5 prime probably benign
R0655:Ifit1 UTSW 19 34647647 missense probably damaging 1.00
R1524:Ifit1 UTSW 19 34647632 missense probably damaging 0.97
R1859:Ifit1 UTSW 19 34647544 missense probably benign 0.00
R3805:Ifit1 UTSW 19 34648156 missense probably damaging 0.99
R4514:Ifit1 UTSW 19 34648513 nonsense probably null
R4714:Ifit1 UTSW 19 34648163 missense probably damaging 0.99
R5310:Ifit1 UTSW 19 34648804 missense probably benign
R5620:Ifit1 UTSW 19 34647838 missense probably damaging 1.00
R5787:Ifit1 UTSW 19 34647575 missense probably benign 0.29
R5964:Ifit1 UTSW 19 34648469 missense possibly damaging 0.76
R8230:Ifit1 UTSW 19 34647668 missense probably benign 0.00
R8249:Ifit1 UTSW 19 34640989 critical splice donor site probably null
Posted On2016-08-02