Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03063:Plet1'

409560

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Plet1

Ensembl Gene

ENSMUSG00000032068

Gene Name

placenta expressed transcript 1

Synonyms

PLET1, 0610037B23Rik, 1600029D21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03063

Quality Score

Status

Chromosome

Chromosomal Location

50405825-50416782 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 50415722 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 197 (N197K)

Ref Sequence

ENSEMBL: ENSMUSP00000110118 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114474] [ENSMUST00000188047]

AlphaFold

Q8VEN2

Predicted Effect

probably benign
Transcript: ENSMUST00000114474
AA Change: N197K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000110118
Gene: ENSMUSG00000032068
AA Change: N197K

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
low complexity region	163	209	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000188047

SMART Domains

Protein: ENSMUSP00000139422
Gene: ENSMUSG00000032068

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188703

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190941

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	C	T	7: 45,665,856 (GRCm39)	V255I	probably benign	Het
Arfgef2	T	C	2: 166,701,702 (GRCm39)		probably benign	Het
Bpifb2	A	T	2: 153,731,044 (GRCm39)	Q205L	probably damaging	Het
Ccdc30	C	T	4: 119,206,964 (GRCm39)	R386Q	possibly damaging	Het
Cdk5rap2	T	A	4: 70,273,114 (GRCm39)		probably null	Het
Comtd1	A	G	14: 21,897,735 (GRCm39)		probably null	Het
Dao	T	C	5: 114,159,076 (GRCm39)	C261R	probably damaging	Het
Dner	A	G	1: 84,563,059 (GRCm39)	V187A	possibly damaging	Het
Dsg3	T	C	18: 20,666,425 (GRCm39)		probably benign	Het
Eif3j2	A	G	18: 43,610,444 (GRCm39)	L123P	possibly damaging	Het
Esf1	G	A	2: 139,996,706 (GRCm39)		probably benign	Het
Exo5	G	A	4: 120,778,830 (GRCm39)	T345I	possibly damaging	Het
Fancl	A	T	11: 26,337,299 (GRCm39)	I29F	probably damaging	Het
Gadl1	C	T	9: 115,795,335 (GRCm39)	H313Y	probably damaging	Het
Gm17190	G	A	13: 96,219,270 (GRCm39)		probably benign	Het
Gtf3c1	G	T	7: 125,245,675 (GRCm39)	T1580N	possibly damaging	Het
Gtf3c6	T	A	10: 40,127,155 (GRCm39)	I66L	probably benign	Het
Hhla1	A	G	15: 65,813,639 (GRCm39)	I231T	probably damaging	Het
Hk2	A	G	6: 82,716,630 (GRCm39)	Y273H	probably damaging	Het
Hk2	A	G	6: 82,726,213 (GRCm39)	I83T	probably benign	Het
Ifit1	T	C	19: 34,625,404 (GRCm39)	V180A	possibly damaging	Het
Igkv9-129	A	T	6: 67,817,172 (GRCm39)	D92V	probably damaging	Het
Lrrc1	A	G	9: 77,406,551 (GRCm39)	F36S	probably damaging	Het
Man1b1	A	G	2: 25,224,416 (GRCm39)	E102G	possibly damaging	Het
Myh8	A	G	11: 67,179,031 (GRCm39)	S475G	probably benign	Het
Or52s1	T	A	7: 102,861,841 (GRCm39)	V247D	probably damaging	Het
Otud4	T	A	8: 80,390,419 (GRCm39)	M343K	probably benign	Het
Peg10	A	T	6: 4,756,647 (GRCm39)		probably benign	Het
Ppp1r12a	C	T	10: 108,097,115 (GRCm39)	R243C	probably damaging	Het
Serpinb10	A	T	1: 107,469,957 (GRCm39)	K146N	possibly damaging	Het
Sis	A	G	3: 72,835,630 (GRCm39)	F911L	probably benign	Het
Spon1	G	A	7: 113,632,260 (GRCm39)	V528M	possibly damaging	Het
Tdrd9	T	C	12: 112,010,733 (GRCm39)	V1100A	probably benign	Het
Tmtc3	T	C	10: 100,283,468 (GRCm39)	M696V	probably benign	Het
Triobp	A	G	15: 78,875,084 (GRCm39)	E122G	probably damaging	Het
Wt1	G	A	2: 105,000,368 (GRCm39)		probably null	Het

Other mutations in Plet1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00949:Plet1	APN	9	50,410,523 (GRCm39)	missense	possibly damaging	0.62
IGL01458:Plet1	APN	9	50,406,017 (GRCm39)	missense	probably benign	0.21
IGL02108:Plet1	APN	9	50,410,387 (GRCm39)	splice site	probably benign
R0012:Plet1	UTSW	9	50,410,430 (GRCm39)	missense	probably benign	0.02
R1895:Plet1	UTSW	9	50,415,652 (GRCm39)	splice site	probably null
R1946:Plet1	UTSW	9	50,415,652 (GRCm39)	splice site	probably null
R5127:Plet1	UTSW	9	50,415,595 (GRCm39)	missense	probably benign	0.16
R6352:Plet1	UTSW	9	50,412,407 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02