Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03064:Or4f7'

409569

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4f7

Ensembl Gene

ENSMUSG00000093804

Gene Name

olfactory receptor family 4 subfamily F member 7

Synonyms

Olfr276, GA_x6K02T2Q125-72882187-72881249, MOR245-7, MOR245-7, MOR245-28_p, GA_x6K02T2N82Q-3465-3764, Olfr1303

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL03064

Quality Score

Status

Chromosome

Chromosomal Location

111644131-111645069 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 111644768 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 101 (I101T)

Ref Sequence

ENSEMBL: ENSMUSP00000149015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099609] [ENSMUST00000216114]

AlphaFold

A2AVW1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099609
AA Change: I101T

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097204
Gene: ENSMUSG00000093804
AA Change: I101T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	2.3e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	302	2.5e-6	PFAM
Pfam:7tm_1	41	287	2.4e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216114
AA Change: I101T

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm2	A	G	7: 119,174,864 (GRCm39)	T210A	probably damaging	Het
Adgb	T	A	10: 10,276,316 (GRCm39)	T351S	probably benign	Het
Akap9	A	G	5: 4,018,755 (GRCm39)	H1112R	probably damaging	Het
Angptl6	A	T	9: 20,786,939 (GRCm39)	Y261*	probably null	Het
Arhgef10l	A	C	4: 140,306,590 (GRCm39)	F395V	probably damaging	Het
Bub1	T	C	2: 127,659,373 (GRCm39)	N328S	probably benign	Het
Cacna1s	A	G	1: 136,039,731 (GRCm39)	N1186D	probably damaging	Het
Cacna2d2	C	A	9: 107,386,474 (GRCm39)	F200L	probably damaging	Het
Calca	G	A	7: 114,232,919 (GRCm39)	S110L	probably benign	Het
Ccdc120	G	A	X: 7,601,601 (GRCm39)	P263S	probably benign	Het
Dcaf8l	A	G	X: 88,448,857 (GRCm39)	V424A	possibly damaging	Het
Dgki	C	A	6: 37,126,599 (GRCm39)		probably benign	Het
Ear1	G	T	14: 44,056,502 (GRCm39)	S122*	probably null	Het
F5	A	T	1: 164,023,163 (GRCm39)	T1574S	probably benign	Het
Fam227b	T	C	2: 125,968,762 (GRCm39)		probably null	Het
Gm20521	T	A	14: 55,134,680 (GRCm39)	S301T	possibly damaging	Het
Hsd17b7	A	T	1: 169,787,287 (GRCm39)	I239N	probably benign	Het
Itih1	C	A	14: 30,663,514 (GRCm39)	E163D	probably benign	Het
Lama1	A	T	17: 68,086,099 (GRCm39)	Y1446F	probably benign	Het
Lama3	C	T	18: 12,572,406 (GRCm39)	T537M	possibly damaging	Het
Lars1	G	T	18: 42,354,636 (GRCm39)	Y770*	probably null	Het
Lrp2	A	T	2: 69,313,477 (GRCm39)	V2418E	probably damaging	Het
Maip1	A	G	1: 57,446,359 (GRCm39)	E143G	probably damaging	Het
Mast4	G	T	13: 102,897,472 (GRCm39)	S739*	probably null	Het
Mctp1	C	T	13: 76,949,632 (GRCm39)	Q555*	probably null	Het
Med14	A	T	X: 12,613,742 (GRCm39)	D291E	probably benign	Het
Mgat2	T	A	12: 69,231,777 (GRCm39)	V117D	probably damaging	Het
Mllt1	A	T	17: 57,207,094 (GRCm39)	M250K	probably benign	Het
Myt1	A	C	2: 181,439,594 (GRCm39)	Y372S	probably benign	Het
Naa16	T	A	14: 79,577,068 (GRCm39)	Q735H	probably damaging	Het
Ncf4	A	G	15: 78,135,102 (GRCm39)	Y53C	probably damaging	Het
Nlrp4a	A	T	7: 26,148,934 (GRCm39)	K180N	probably benign	Het
Nova1	A	G	12: 46,746,861 (GRCm39)	V472A	probably damaging	Het
Nup153	T	C	13: 46,847,315 (GRCm39)	T705A	probably benign	Het
Odf2	T	A	2: 29,791,091 (GRCm39)	N79K	probably benign	Het
Pard3b	G	A	1: 62,237,930 (GRCm39)		probably benign	Het
Pde8b	G	A	13: 95,182,906 (GRCm39)	T388I	probably damaging	Het
Phactr2	A	G	10: 13,264,457 (GRCm39)		probably benign	Het
Phf12	T	C	11: 77,874,186 (GRCm39)	S17P	probably damaging	Het
Psmg2	T	A	18: 67,779,102 (GRCm39)	L90*	probably null	Het
Ryr2	T	C	13: 11,658,788 (GRCm39)		probably null	Het
Sec23b	T	C	2: 144,423,952 (GRCm39)	F534L	probably benign	Het
Sin3b	A	G	8: 73,483,686 (GRCm39)		probably benign	Het
Slc30a5	A	T	13: 100,947,818 (GRCm39)	L463Q	probably damaging	Het
Slc35g3	T	C	11: 69,651,895 (GRCm39)	H52R	possibly damaging	Het
Slc6a3	G	T	13: 73,719,585 (GRCm39)	S538I	probably damaging	Het
Socs2	G	T	10: 95,248,713 (GRCm39)	C133*	probably null	Het
Srebf2	G	A	15: 82,076,423 (GRCm39)	R691H	probably benign	Het
Tlr11	C	A	14: 50,598,557 (GRCm39)	P181Q	probably damaging	Het
Tlr7	T	A	X: 166,089,203 (GRCm39)	Q761L	possibly damaging	Het
Tmem120b	T	A	5: 123,240,336 (GRCm39)	Y90N	possibly damaging	Het
Tpcn1	T	C	5: 120,675,631 (GRCm39)	I778V	possibly damaging	Het
Ttll8	T	C	15: 88,803,797 (GRCm39)	T385A	probably benign	Het
Vmn1r223	G	A	13: 23,434,153 (GRCm39)	R249H	probably damaging	Het
Vmn2r53	A	T	7: 12,334,937 (GRCm39)	I241N	possibly damaging	Het
Wdfy3	T	C	5: 102,083,863 (GRCm39)	R808G	probably damaging	Het
Zfyve26	T	A	12: 79,308,565 (GRCm39)	S231C	probably damaging	Het

Other mutations in Or4f7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Or4f7	APN	2	111,644,126 (GRCm39)	utr 3 prime	probably benign
IGL02442:Or4f7	APN	2	111,644,336 (GRCm39)	missense	probably benign	0.26
IGL02563:Or4f7	APN	2	111,644,162 (GRCm39)	missense	probably benign
R0081:Or4f7	UTSW	2	111,644,213 (GRCm39)	missense	probably damaging	1.00
R0139:Or4f7	UTSW	2	111,644,699 (GRCm39)	missense	possibly damaging	0.54
R0624:Or4f7	UTSW	2	111,645,056 (GRCm39)	missense	probably damaging	1.00
R0926:Or4f7	UTSW	2	111,644,892 (GRCm39)	missense	probably damaging	1.00
R1436:Or4f7	UTSW	2	111,644,906 (GRCm39)	missense	probably damaging	1.00
R2099:Or4f7	UTSW	2	111,644,177 (GRCm39)	missense	probably benign	0.18
R5255:Or4f7	UTSW	2	111,644,523 (GRCm39)	missense	probably benign	0.02
R6034:Or4f7	UTSW	2	111,644,702 (GRCm39)	missense	probably damaging	1.00
R6034:Or4f7	UTSW	2	111,644,702 (GRCm39)	missense	probably damaging	1.00
R6101:Or4f7	UTSW	2	111,644,598 (GRCm39)	missense	probably benign	0.00
R6385:Or4f7	UTSW	2	111,644,964 (GRCm39)	missense	probably benign
R6489:Or4f7	UTSW	2	111,644,405 (GRCm39)	missense	probably damaging	1.00
R6978:Or4f7	UTSW	2	111,644,155 (GRCm39)	missense	probably benign	0.03
R7410:Or4f7	UTSW	2	111,644,271 (GRCm39)	missense	probably benign	0.00
R8507:Or4f7	UTSW	2	111,645,051 (GRCm39)	missense	probably benign	0.23
R8897:Or4f7	UTSW	2	111,644,576 (GRCm39)	missense	probably benign	0.01
R9084:Or4f7	UTSW	2	111,644,996 (GRCm39)	missense	probably damaging	1.00
R9096:Or4f7	UTSW	2	111,644,196 (GRCm39)	nonsense	probably null
R9097:Or4f7	UTSW	2	111,644,196 (GRCm39)	nonsense	probably null
R9784:Or4f7	UTSW	2	111,644,604 (GRCm39)	missense	probably damaging	1.00
Z1176:Or4f7	UTSW	2	111,644,379 (GRCm39)	missense	probably benign	0.22

Posted On

2016-08-02