Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03064:Naa16'

409597

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa16

Ensembl Gene

ENSMUSG00000022020

Gene Name

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

Synonyms

Narg1l, 1300019C06Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL03064

Quality Score

Status

Chromosome

Chromosomal Location

79325269-79390778 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 79339628 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Histidine at position 735 (Q735H)

Ref Sequence

ENSEMBL: ENSMUSP00000022597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486]

Predicted Effect

probably damaging
Transcript: ENSMUST00000022597
AA Change: Q735H

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: Q735H

Domain	Start	End	E-Value	Type
TPR	46	79	2.99e1	SMART
TPR	80	113	2.98e-3	SMART
Blast:TPR	224	257	1e-10	BLAST
TPR	374	407	9.96e0	SMART
TPR	408	441	7.47e0	SMART
low complexity region	616	633	N/A	INTRINSIC
Blast:TPR	672	705	3e-12	BLAST
low complexity region	830	841	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163486

SMART Domains

Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020

Domain	Start	End	E-Value	Type
TPR	12	45	2.99e1	SMART
TPR	46	79	2.98e-3	SMART
Blast:TPR	190	223	3e-10	BLAST
TPR	340	373	9.96e0	SMART
TPR	374	407	7.47e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000171928

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227775

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm2	A	G	7: 119,575,641	T210A	probably damaging	Het
Adgb	T	A	10: 10,400,572	T351S	probably benign	Het
Akap9	A	G	5: 3,968,755	H1112R	probably damaging	Het
Angptl6	A	T	9: 20,875,643	Y261*	probably null	Het
Arhgef10l	A	C	4: 140,579,279	F395V	probably damaging	Het
Bub1	T	C	2: 127,817,453	N328S	probably benign	Het
Cacna1s	A	G	1: 136,111,993	N1186D	probably damaging	Het
Cacna2d2	C	A	9: 107,509,275	F200L	probably damaging	Het
Calca	G	A	7: 114,633,684	S110L	probably benign	Het
Ccdc120	G	A	X: 7,735,362	P263S	probably benign	Het
Dgki	C	A	6: 37,149,664		probably benign	Het
Ear1	G	T	14: 43,819,045	S122*	probably null	Het
F5	A	T	1: 164,195,594	T1574S	probably benign	Het
Fam227b	T	C	2: 126,126,842		probably null	Het
Gm20521	T	A	14: 54,897,223	S301T	possibly damaging	Het
Hsd17b7	A	T	1: 169,959,718	I239N	probably benign	Het
Itih1	C	A	14: 30,941,557	E163D	probably benign	Het
Lama1	A	T	17: 67,779,104	Y1446F	probably benign	Het
Lama3	C	T	18: 12,439,349	T537M	possibly damaging	Het
Lars	G	T	18: 42,221,571	Y770*	probably null	Het
Lrp2	A	T	2: 69,483,133	V2418E	probably damaging	Het
Maip1	A	G	1: 57,407,200	E143G	probably damaging	Het
Mast4	G	T	13: 102,760,964	S739*	probably null	Het
Mctp1	C	T	13: 76,801,513	Q555*	probably null	Het
Med14	A	T	X: 12,747,503	D291E	probably benign	Het
Mgat2	T	A	12: 69,185,003	V117D	probably damaging	Het
Mllt1	A	T	17: 56,900,094	M250K	probably benign	Het
Myt1	A	C	2: 181,797,801	Y372S	probably benign	Het
Ncf4	A	G	15: 78,250,902	Y53C	probably damaging	Het
Nlrp4a	A	T	7: 26,449,509	K180N	probably benign	Het
Nova1	A	G	12: 46,700,078	V472A	probably damaging	Het
Nup153	T	C	13: 46,693,839	T705A	probably benign	Het
Odf2	T	A	2: 29,901,079	N79K	probably benign	Het
Olfr1303	A	G	2: 111,814,423	I101T	possibly damaging	Het
Pard3b	G	A	1: 62,198,771		probably benign	Het
Pde8b	G	A	13: 95,046,398	T388I	probably damaging	Het
Pet2	A	G	X: 89,405,251	V424A	possibly damaging	Het
Phactr2	A	G	10: 13,388,713		probably benign	Het
Phf12	T	C	11: 77,983,360	S17P	probably damaging	Het
Psmg2	T	A	18: 67,646,032	L90*	probably null	Het
Ryr2	T	C	13: 11,643,902		probably null	Het
Sec23b	T	C	2: 144,582,032	F534L	probably benign	Het
Sin3b	A	G	8: 72,757,058		probably benign	Het
Slc30a5	A	T	13: 100,811,310	L463Q	probably damaging	Het
Slc35g3	T	C	11: 69,761,069	H52R	possibly damaging	Het
Slc6a3	G	T	13: 73,571,466	S538I	probably damaging	Het
Socs2	G	T	10: 95,412,851	C133*	probably null	Het
Srebf2	G	A	15: 82,192,222	R691H	probably benign	Het
Tlr11	C	A	14: 50,361,100	P181Q	probably damaging	Het
Tlr7	T	A	X: 167,306,207	Q761L	possibly damaging	Het
Tmem120b	T	A	5: 123,102,273	Y90N	possibly damaging	Het
Tpcn1	T	C	5: 120,537,566	I778V	possibly damaging	Het
Ttll8	T	C	15: 88,919,594	T385A	probably benign	Het
Vmn1r223	G	A	13: 23,249,983	R249H	probably damaging	Het
Vmn2r53	A	T	7: 12,601,010	I241N	possibly damaging	Het
Wdfy3	T	C	5: 101,935,997	R808G	probably damaging	Het
Zfyve26	T	A	12: 79,261,791	S231C	probably damaging	Het

Other mutations in Naa16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Naa16	APN	14	79355729	missense	probably damaging	1.00
IGL01025:Naa16	APN	14	79384756	missense	probably damaging	1.00
IGL01155:Naa16	APN	14	79384715	missense	probably damaging	0.98
IGL01335:Naa16	APN	14	79345116	splice site	probably benign
IGL01981:Naa16	APN	14	79381516	missense	probably benign	0.05
IGL02230:Naa16	APN	14	79377361	splice site	probably benign
IGL02313:Naa16	APN	14	79384668	missense	probably damaging	1.00
IGL02418:Naa16	APN	14	79383366	missense	probably damaging	1.00
IGL02544:Naa16	APN	14	79335820	missense	probably damaging	1.00
IGL03051:Naa16	APN	14	79369082	missense	probably benign	0.01
IGL03205:Naa16	APN	14	79356512	missense	possibly damaging	0.89
PIT4508001:Naa16	UTSW	14	79369087	missense	probably benign	0.15
R0651:Naa16	UTSW	14	79351392	missense	probably damaging	1.00
R1429:Naa16	UTSW	14	79359527	missense	probably benign	0.01
R1674:Naa16	UTSW	14	79387057	start codon destroyed	probably null	0.65
R1693:Naa16	UTSW	14	79351456	missense	probably damaging	1.00
R1874:Naa16	UTSW	14	79355743	missense	possibly damaging	0.62
R1992:Naa16	UTSW	14	79356491	missense	probably damaging	1.00
R2015:Naa16	UTSW	14	79345059	missense	probably damaging	1.00
R2391:Naa16	UTSW	14	79370049	missense	probably benign	0.16
R2847:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2848:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2877:Naa16	UTSW	14	79343298	missense	probably benign	0.00
R3884:Naa16	UTSW	14	79343262	missense	probably damaging	0.98
R4001:Naa16	UTSW	14	79343121	splice site	probably null
R4199:Naa16	UTSW	14	79355871	missense	probably damaging	1.00
R4638:Naa16	UTSW	14	79340033	splice site	probably null
R4676:Naa16	UTSW	14	79336348	unclassified	probably benign
R4690:Naa16	UTSW	14	79345057	missense	probably damaging	1.00
R4952:Naa16	UTSW	14	79345085	missense	probably damaging	1.00
R5087:Naa16	UTSW	14	79377415	missense	possibly damaging	0.68
R5104:Naa16	UTSW	14	79384700	nonsense	probably null
R5729:Naa16	UTSW	14	79355780	missense	probably damaging	1.00
R6178:Naa16	UTSW	14	79383340	missense	possibly damaging	0.93
R6960:Naa16	UTSW	14	79359471	missense	possibly damaging	0.65
R7794:Naa16	UTSW	14	79377494	missense	probably damaging	1.00
X0064:Naa16	UTSW	14	79351389	missense	probably damaging	1.00
Z1177:Naa16	UTSW	14	79344979	missense	probably damaging	1.00

Posted On

2016-08-02