Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03065:Ovgp1'

409626

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

Chit5, MOGP, muc9, mucin 9, OGP, oviductin

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03065

Quality Score

Status

Chromosome

Chromosomal Location

105973711-105987423 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 105986366 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 485 (F485S)

Ref Sequence

ENSEMBL: ENSMUSP00000000573 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

Predicted Effect

probably benign
Transcript: ENSMUST00000000573
AA Change: F485S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: F485S

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092878

Predicted Effect

probably benign
Transcript: ENSMUST00000163626

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167642

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl1	A	G	8: 83,938,514	M1322V	possibly damaging	Het
Adprh	C	T	16: 38,446,034	V249I	probably benign	Het
Als2	T	C	1: 59,215,872	S109G	probably benign	Het
Bpifa1	T	A	2: 154,147,642	N250K	probably damaging	Het
Capn9	A	C	8: 124,605,559	Y423S	probably damaging	Het
Cd200r1	T	G	16: 44,794,282	V308G	probably benign	Het
Cic	T	C	7: 25,285,821		probably benign	Het
Col5a1	T	A	2: 28,032,745	I275N	possibly damaging	Het
Col6a4	C	A	9: 106,041,164		probably benign	Het
Cpeb1	T	C	7: 81,436,290	R35G	probably benign	Het
Cul1	A	G	6: 47,495,081	Y52C	probably damaging	Het
Dctn1	T	C	6: 83,192,493	F496L	probably damaging	Het
Dock11	G	T	X: 36,047,046		probably benign	Het
Eaf2	C	T	16: 36,828,122	R12H	probably benign	Het
Gcc1	T	A	6: 28,418,402	Q644L	possibly damaging	Het
Gm44865	C	T	7: 108,565,797		probably benign	Het
Gm6614	C	A	6: 141,992,502	L230F	probably damaging	Het
Golgb1	C	T	16: 36,912,866	S825L	probably benign	Het
Gstp3	C	T	19: 4,058,730		probably null	Het
Heph	T	A	X: 96,527,567	I669N	probably benign	Het
Il12rb1	A	T	8: 70,820,558	Y635F	possibly damaging	Het
Ing3	G	A	6: 21,971,222	A331T	probably benign	Het
Ipo8	T	A	6: 148,784,707	I762F	probably benign	Het
Itpr3	G	A	17: 27,091,933	R510Q	probably damaging	Het
Kif16b	A	G	2: 142,619,913	Y1273H	probably damaging	Het
Map3k14	T	C	11: 103,225,101	E784G	probably damaging	Het
Mpdz	A	T	4: 81,292,565	N1694K	probably damaging	Het
Myh13	T	C	11: 67,344,853	F648S	probably damaging	Het
Myh4	A	G	11: 67,259,156	H1847R	probably benign	Het
Ncoa7	T	A	10: 30,647,997	D840V	probably damaging	Het
Nxpe2	T	A	9: 48,319,692	N459I	possibly damaging	Het
Olfr1297	T	C	2: 111,621,190	K295E	probably damaging	Het
Olfr1426	C	A	19: 12,088,611	L60F	possibly damaging	Het
Olfr730	C	A	14: 50,187,008	D70Y	probably damaging	Het
Parp4	G	T	14: 56,637,869	A1182S	probably benign	Het
Pkd1l2	G	A	8: 117,065,745	T436I	probably benign	Het
Pla2g15	G	A	8: 106,160,219	R114H	probably benign	Het
Plppr3	T	A	10: 79,866,046	T321S	probably benign	Het
Rnf113a1	A	G	X: 37,192,095	D235G	probably benign	Het
Rsrp1	A	G	4: 134,924,389	T155A	possibly damaging	Het
Simc1	G	T	13: 54,537,212	C87F	probably damaging	Het
Slco1a5	A	G	6: 142,248,843		probably benign	Het
Smyd5	A	G	6: 85,442,164	D276G	possibly damaging	Het
Spata5	T	C	3: 37,432,179	V350A	possibly damaging	Het
Tmem132c	A	G	5: 127,563,624	Y953C	probably damaging	Het
Trank1	T	A	9: 111,390,293	S2033T	possibly damaging	Het
Trim69	A	G	2: 122,178,634	T392A	probably damaging	Het
Tsks	T	C	7: 44,943,300	V6A	probably damaging	Het
Yjefn3	A	G	8: 69,889,556		probably benign	Het
Zfp263	T	G	16: 3,746,480	D211E	probably benign	Het
Zfp994	A	T	17: 22,202,680	F51L	probably damaging	Het
Znfx1	A	T	2: 167,055,765	M413K	probably benign	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105981277	nonsense	probably null
IGL01152:Ovgp1	APN	3	105986172	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105974991	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105978349	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105981351	critical splice donor site	probably null
IGL02712:Ovgp1	APN	3	105986513	unclassified	probably benign
IGL03140:Ovgp1	APN	3	105979906	missense	probably damaging	1.00
IGL03272:Ovgp1	APN	3	105981325	missense	probably damaging	0.99
PIT4472001:Ovgp1	UTSW	3	105986990	missense	unknown
R0277:Ovgp1	UTSW	3	105979892	intron	probably benign
R0560:Ovgp1	UTSW	3	105986410	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105974830	splice site	probably benign
R0743:Ovgp1	UTSW	3	105974932	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105986575	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105986752	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105977798	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105985068	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105974935	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105986993	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105977717	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105986912	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105986452	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105980171	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105986315	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105977711	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105980323	splice site	probably null
R4738:Ovgp1	UTSW	3	105979918	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105979953	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105977783	missense	probably damaging	1.00
R6531:Ovgp1	UTSW	3	105987071	unclassified	probably benign
R6540:Ovgp1	UTSW	3	105986581	nonsense	probably null
R6562:Ovgp1	UTSW	3	105980273	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105986431	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105986873	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105987071	missense	unknown
R7430:Ovgp1	UTSW	3	105986302	missense	probably damaging	0.99
R7430:Ovgp1	UTSW	3	105986303	missense	possibly damaging	0.62
R7566:Ovgp1	UTSW	3	105974310	start gained	probably benign
R7684:Ovgp1	UTSW	3	105979956	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105986794	missense	unknown
R7820:Ovgp1	UTSW	3	105986521	unclassified	probably benign
R7919:Ovgp1	UTSW	3	105981285	missense	probably damaging	1.00
R8039:Ovgp1	UTSW	3	105976023	missense	probably benign	0.26
R8483:Ovgp1	UTSW	3	105986995	unclassified	probably benign
Z1177:Ovgp1	UTSW	3	105986840	missense	unknown

Posted On

2016-08-02