Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03065:Zfp994'

409632

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp994

Ensembl Gene

ENSMUSG00000096433

Gene Name

zinc finger protein 994

Synonyms

Gm4944

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.162) question?

Stock #

IGL03065

Quality Score

Status

Chromosome

Chromosomal Location

22416246-22444597 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22421661 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 51 (F51L)

Ref Sequence

ENSEMBL: ENSMUSP00000136105 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179996]

AlphaFold

J3QM38

Predicted Effect

probably damaging
Transcript: ENSMUST00000179996
AA Change: F51L

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000136105
Gene: ENSMUSG00000096433
AA Change: F51L

Domain	Start	End	E-Value	Type
KRAB	13	73	3.33e-20	SMART
ZnF_C2H2	183	205	8.09e-1	SMART
ZnF_C2H2	211	233	1.84e-4	SMART
ZnF_C2H2	239	261	2.99e-4	SMART
ZnF_C2H2	267	289	1.04e-3	SMART
ZnF_C2H2	295	317	2.61e-4	SMART
ZnF_C2H2	323	345	4.3e-5	SMART
ZnF_C2H2	351	373	6.78e-3	SMART
ZnF_C2H2	379	401	1.12e-3	SMART
ZnF_C2H2	407	429	5.5e-3	SMART
ZnF_C2H2	435	457	1.3e-4	SMART
ZnF_C2H2	463	485	1.67e-2	SMART
ZnF_C2H2	491	513	1.47e-3	SMART
ZnF_C2H2	519	541	2.4e-3	SMART
ZnF_C2H2	547	569	7.67e-2	SMART
ZnF_C2H2	575	597	8.6e-5	SMART
ZnF_C2H2	603	625	8.02e-5	SMART
ZnF_C2H2	631	653	9.22e-5	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl1	A	G	8: 84,665,143 (GRCm39)	M1322V	possibly damaging	Het
Adprh	C	T	16: 38,266,396 (GRCm39)	V249I	probably benign	Het
Afg2a	T	C	3: 37,486,328 (GRCm39)	V350A	possibly damaging	Het
Als2	T	C	1: 59,255,031 (GRCm39)	S109G	probably benign	Het
Bpifa1	T	A	2: 153,989,562 (GRCm39)	N250K	probably damaging	Het
Capn9	A	C	8: 125,332,298 (GRCm39)	Y423S	probably damaging	Het
Cd200r1	T	G	16: 44,614,645 (GRCm39)	V308G	probably benign	Het
Cic	T	C	7: 24,985,246 (GRCm39)		probably benign	Het
Col5a1	T	A	2: 27,922,757 (GRCm39)	I275N	possibly damaging	Het
Col6a4	C	A	9: 105,918,363 (GRCm39)		probably benign	Het
Cpeb1	T	C	7: 81,086,038 (GRCm39)	R35G	probably benign	Het
Cul1	A	G	6: 47,472,015 (GRCm39)	Y52C	probably damaging	Het
Dctn1	T	C	6: 83,169,475 (GRCm39)	F496L	probably damaging	Het
Dock11	G	T	X: 35,310,699 (GRCm39)		probably benign	Het
Eaf2	C	T	16: 36,648,484 (GRCm39)	R12H	probably benign	Het
Gcc1	T	A	6: 28,418,401 (GRCm39)	Q644L	possibly damaging	Het
Gm44865	C	T	7: 108,165,004 (GRCm39)		probably benign	Het
Golgb1	C	T	16: 36,733,228 (GRCm39)	S825L	probably benign	Het
Gstp3	C	T	19: 4,108,730 (GRCm39)		probably null	Het
Heph	T	A	X: 95,571,173 (GRCm39)	I669N	probably benign	Het
Il12rb1	A	T	8: 71,273,202 (GRCm39)	Y635F	possibly damaging	Het
Ing3	G	A	6: 21,971,221 (GRCm39)	A331T	probably benign	Het
Ipo8	T	A	6: 148,686,205 (GRCm39)	I762F	probably benign	Het
Itpr3	G	A	17: 27,310,907 (GRCm39)	R510Q	probably damaging	Het
Kif16b	A	G	2: 142,461,833 (GRCm39)	Y1273H	probably damaging	Het
Map3k14	T	C	11: 103,115,927 (GRCm39)	E784G	probably damaging	Het
Mpdz	A	T	4: 81,210,802 (GRCm39)	N1694K	probably damaging	Het
Myh13	T	C	11: 67,235,679 (GRCm39)	F648S	probably damaging	Het
Myh4	A	G	11: 67,149,982 (GRCm39)	H1847R	probably benign	Het
Ncoa7	T	A	10: 30,523,993 (GRCm39)	D840V	probably damaging	Het
Nxpe2	T	A	9: 48,230,992 (GRCm39)	N459I	possibly damaging	Het
Or4d10c	C	A	19: 12,065,975 (GRCm39)	L60F	possibly damaging	Het
Or4k2	C	A	14: 50,424,465 (GRCm39)	D70Y	probably damaging	Het
Or4k47	T	C	2: 111,451,535 (GRCm39)	K295E	probably damaging	Het
Ovgp1	T	C	3: 105,893,682 (GRCm39)	F485S	probably benign	Het
Parp4	G	T	14: 56,875,326 (GRCm39)	A1182S	probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Pla2g15	G	A	8: 106,886,851 (GRCm39)	R114H	probably benign	Het
Plppr3	T	A	10: 79,701,880 (GRCm39)	T321S	probably benign	Het
Rnf113a1	A	G	X: 36,455,748 (GRCm39)	D235G	probably benign	Het
Rsrp1	A	G	4: 134,651,700 (GRCm39)	T155A	possibly damaging	Het
Simc1	G	T	13: 54,685,025 (GRCm39)	C87F	probably damaging	Het
Slco1a5	A	G	6: 142,194,569 (GRCm39)		probably benign	Het
Slco1a8	C	A	6: 141,938,228 (GRCm39)	L230F	probably damaging	Het
Smyd5	A	G	6: 85,419,146 (GRCm39)	D276G	possibly damaging	Het
Tmem132c	A	G	5: 127,640,688 (GRCm39)	Y953C	probably damaging	Het
Trank1	T	A	9: 111,219,361 (GRCm39)	S2033T	possibly damaging	Het
Trim69	A	G	2: 122,009,115 (GRCm39)	T392A	probably damaging	Het
Tsks	T	C	7: 44,592,724 (GRCm39)	V6A	probably damaging	Het
Yjefn3	A	G	8: 70,342,206 (GRCm39)		probably benign	Het
Zfp263	T	G	16: 3,564,344 (GRCm39)	D211E	probably benign	Het
Znfx1	A	T	2: 166,897,685 (GRCm39)	M413K	probably benign	Het

Other mutations in Zfp994

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01138:Zfp994	APN	17	22,421,649 (GRCm39)	splice site	probably benign
dreamer	UTSW	17	22,424,306 (GRCm39)	missense	probably damaging	1.00
fanciful	UTSW	17	22,420,081 (GRCm39)	missense	probably damaging	1.00
R0361:Zfp994	UTSW	17	22,419,091 (GRCm39)	missense	probably benign	0.01
R0498:Zfp994	UTSW	17	22,419,882 (GRCm39)	missense	probably damaging	0.99
R0567:Zfp994	UTSW	17	22,419,449 (GRCm39)	missense	possibly damaging	0.82
R1075:Zfp994	UTSW	17	22,419,926 (GRCm39)	missense	probably damaging	1.00
R1561:Zfp994	UTSW	17	22,420,206 (GRCm39)	missense	probably damaging	1.00
R2117:Zfp994	UTSW	17	22,419,962 (GRCm39)	missense	probably damaging	1.00
R2313:Zfp994	UTSW	17	22,420,266 (GRCm39)	missense	probably damaging	1.00
R4486:Zfp994	UTSW	17	22,420,541 (GRCm39)	missense	probably damaging	1.00
R4906:Zfp994	UTSW	17	22,419,448 (GRCm39)	nonsense	probably null
R4924:Zfp994	UTSW	17	22,419,738 (GRCm39)	missense	probably damaging	0.98
R5394:Zfp994	UTSW	17	22,419,506 (GRCm39)	missense	probably damaging	1.00
R5560:Zfp994	UTSW	17	22,420,694 (GRCm39)	missense	possibly damaging	0.62
R5746:Zfp994	UTSW	17	22,420,254 (GRCm39)	missense	probably damaging	0.99
R6275:Zfp994	UTSW	17	22,418,972 (GRCm39)	nonsense	probably null
R6459:Zfp994	UTSW	17	22,419,527 (GRCm39)	missense	possibly damaging	0.83
R6668:Zfp994	UTSW	17	22,420,081 (GRCm39)	missense	probably damaging	1.00
R7343:Zfp994	UTSW	17	22,419,049 (GRCm39)	missense	probably benign	0.12
R7625:Zfp994	UTSW	17	22,420,736 (GRCm39)	missense	possibly damaging	0.85
R7709:Zfp994	UTSW	17	22,419,406 (GRCm39)	missense	probably benign	0.00
R7725:Zfp994	UTSW	17	22,419,091 (GRCm39)	missense	probably benign	0.01
R7756:Zfp994	UTSW	17	22,419,828 (GRCm39)	missense	possibly damaging	0.89
R7758:Zfp994	UTSW	17	22,419,828 (GRCm39)	missense	possibly damaging	0.89
R7959:Zfp994	UTSW	17	22,421,761 (GRCm39)	missense	probably damaging	0.99
R8033:Zfp994	UTSW	17	22,419,665 (GRCm39)	missense	probably damaging	1.00
R8199:Zfp994	UTSW	17	22,419,204 (GRCm39)	nonsense	probably null
R8365:Zfp994	UTSW	17	22,420,227 (GRCm39)	missense	probably damaging	1.00
R8770:Zfp994	UTSW	17	22,419,980 (GRCm39)	missense	probably damaging	1.00
R8893:Zfp994	UTSW	17	22,424,306 (GRCm39)	missense	probably damaging	1.00
R9130:Zfp994	UTSW	17	22,418,981 (GRCm39)	missense	unknown
R9530:Zfp994	UTSW	17	22,420,514 (GRCm39)	missense	probably damaging	1.00
R9587:Zfp994	UTSW	17	22,421,764 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02