Incidental Mutation 'IGL03065:Zfp263'
ID409660
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp263
Ensembl Gene ENSMUSG00000022529
Gene Namezinc finger protein 263
SynonymsmFPM315, 1200014J04Rik, NT2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.131) question?
Stock #IGL03065
Quality Score
Status
Chromosome16
Chromosomal Location3744093-3750790 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 3746480 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 211 (D211E)
Ref Sequence ENSEMBL: ENSMUSP00000023176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023176] [ENSMUST00000161630] [ENSMUST00000162207]
Predicted Effect probably benign
Transcript: ENSMUST00000023176
AA Change: D211E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: D211E

DomainStartEndE-ValueType
SCAN 39 151 5.15e-71 SMART
KRAB 219 279 1.86e-9 SMART
ZnF_C2H2 378 400 1.45e-2 SMART
ZnF_C2H2 434 456 3.11e-2 SMART
ZnF_C2H2 462 484 1.2e-3 SMART
ZnF_C2H2 490 512 6.52e-5 SMART
ZnF_C2H2 518 540 1.98e-4 SMART
ZnF_C2H2 572 594 2.4e-3 SMART
ZnF_C2H2 600 622 4.87e-4 SMART
ZnF_C2H2 628 650 1.1e-2 SMART
ZnF_C2H2 656 678 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159060
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159425
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159469
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160923
Predicted Effect probably benign
Transcript: ENSMUST00000161630
SMART Domains Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529

DomainStartEndE-ValueType
SCAN 39 143 1.61e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162207
SMART Domains Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529

DomainStartEndE-ValueType
ZnF_C2H2 90 112 1.45e-2 SMART
ZnF_C2H2 146 168 3.11e-2 SMART
ZnF_C2H2 174 196 1.2e-3 SMART
ZnF_C2H2 202 224 6.52e-5 SMART
ZnF_C2H2 230 252 1.98e-4 SMART
ZnF_C2H2 284 306 2.4e-3 SMART
ZnF_C2H2 312 334 4.87e-4 SMART
ZnF_C2H2 340 362 1.1e-2 SMART
ZnF_C2H2 368 390 1.72e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl1 A G 8: 83,938,514 M1322V possibly damaging Het
Adprh C T 16: 38,446,034 V249I probably benign Het
Als2 T C 1: 59,215,872 S109G probably benign Het
Bpifa1 T A 2: 154,147,642 N250K probably damaging Het
Capn9 A C 8: 124,605,559 Y423S probably damaging Het
Cd200r1 T G 16: 44,794,282 V308G probably benign Het
Cic T C 7: 25,285,821 probably benign Het
Col5a1 T A 2: 28,032,745 I275N possibly damaging Het
Col6a4 C A 9: 106,041,164 probably benign Het
Cpeb1 T C 7: 81,436,290 R35G probably benign Het
Cul1 A G 6: 47,495,081 Y52C probably damaging Het
Dctn1 T C 6: 83,192,493 F496L probably damaging Het
Dock11 G T X: 36,047,046 probably benign Het
Eaf2 C T 16: 36,828,122 R12H probably benign Het
Gcc1 T A 6: 28,418,402 Q644L possibly damaging Het
Gm44865 C T 7: 108,565,797 probably benign Het
Gm6614 C A 6: 141,992,502 L230F probably damaging Het
Golgb1 C T 16: 36,912,866 S825L probably benign Het
Gstp3 C T 19: 4,058,730 probably null Het
Heph T A X: 96,527,567 I669N probably benign Het
Il12rb1 A T 8: 70,820,558 Y635F possibly damaging Het
Ing3 G A 6: 21,971,222 A331T probably benign Het
Ipo8 T A 6: 148,784,707 I762F probably benign Het
Itpr3 G A 17: 27,091,933 R510Q probably damaging Het
Kif16b A G 2: 142,619,913 Y1273H probably damaging Het
Map3k14 T C 11: 103,225,101 E784G probably damaging Het
Mpdz A T 4: 81,292,565 N1694K probably damaging Het
Myh13 T C 11: 67,344,853 F648S probably damaging Het
Myh4 A G 11: 67,259,156 H1847R probably benign Het
Ncoa7 T A 10: 30,647,997 D840V probably damaging Het
Nxpe2 T A 9: 48,319,692 N459I possibly damaging Het
Olfr1297 T C 2: 111,621,190 K295E probably damaging Het
Olfr1426 C A 19: 12,088,611 L60F possibly damaging Het
Olfr730 C A 14: 50,187,008 D70Y probably damaging Het
Ovgp1 T C 3: 105,986,366 F485S probably benign Het
Parp4 G T 14: 56,637,869 A1182S probably benign Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Pla2g15 G A 8: 106,160,219 R114H probably benign Het
Plppr3 T A 10: 79,866,046 T321S probably benign Het
Rnf113a1 A G X: 37,192,095 D235G probably benign Het
Rsrp1 A G 4: 134,924,389 T155A possibly damaging Het
Simc1 G T 13: 54,537,212 C87F probably damaging Het
Slco1a5 A G 6: 142,248,843 probably benign Het
Smyd5 A G 6: 85,442,164 D276G possibly damaging Het
Spata5 T C 3: 37,432,179 V350A possibly damaging Het
Tmem132c A G 5: 127,563,624 Y953C probably damaging Het
Trank1 T A 9: 111,390,293 S2033T possibly damaging Het
Trim69 A G 2: 122,178,634 T392A probably damaging Het
Tsks T C 7: 44,943,300 V6A probably damaging Het
Yjefn3 A G 8: 69,889,556 probably benign Het
Zfp994 A T 17: 22,202,680 F51L probably damaging Het
Znfx1 A T 2: 167,055,765 M413K probably benign Het
Other mutations in Zfp263
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00489:Zfp263 APN 16 3745846 missense probably benign 0.00
IGL01112:Zfp263 APN 16 3748912 missense probably benign 0.09
IGL02049:Zfp263 APN 16 3744618 missense probably damaging 0.97
IGL02534:Zfp263 APN 16 3746415 unclassified probably benign
IGL02674:Zfp263 APN 16 3746765 unclassified probably benign
IGL03105:Zfp263 APN 16 3748960 missense probably damaging 1.00
IGL03153:Zfp263 APN 16 3746880 missense possibly damaging 0.56
IGL02796:Zfp263 UTSW 16 3746876 missense probably benign 0.03
R1201:Zfp263 UTSW 16 3749430 missense probably damaging 1.00
R1414:Zfp263 UTSW 16 3749296 missense probably damaging 1.00
R1448:Zfp263 UTSW 16 3746459 missense probably benign 0.18
R3085:Zfp263 UTSW 16 3749716 missense probably damaging 1.00
R4368:Zfp263 UTSW 16 3744906 unclassified probably benign
R4989:Zfp263 UTSW 16 3749128 missense probably damaging 1.00
R5072:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5073:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5074:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5122:Zfp263 UTSW 16 3749855 missense probably damaging 0.99
R5705:Zfp263 UTSW 16 3746454 missense probably benign 0.00
R6140:Zfp263 UTSW 16 3748217 missense probably benign 0.10
R6879:Zfp263 UTSW 16 3749855 missense probably damaging 0.99
R7133:Zfp263 UTSW 16 3749391 nonsense probably null
R7216:Zfp263 UTSW 16 3744571 missense probably damaging 1.00
R8517:Zfp263 UTSW 16 3746896 critical splice donor site probably null
Posted On2016-08-02