Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03065:Zfp263'

409660

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp263

Ensembl Gene

ENSMUSG00000022529

Gene Name

zinc finger protein 263

Synonyms

mFPM315, NT2, 1200014J04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL03065

Quality Score

Status

Chromosome

Chromosomal Location

3561957-3568654 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 3564344 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 211 (D211E)

Ref Sequence

ENSEMBL: ENSMUSP00000023176 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023176] [ENSMUST00000161630] [ENSMUST00000162207]

AlphaFold

Q8CF60

Predicted Effect

probably benign
Transcript: ENSMUST00000023176
AA Change: D211E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: D211E

Domain	Start	End	E-Value	Type
SCAN	39	151	5.15e-71	SMART
KRAB	219	279	1.86e-9	SMART
ZnF_C2H2	378	400	1.45e-2	SMART
ZnF_C2H2	434	456	3.11e-2	SMART
ZnF_C2H2	462	484	1.2e-3	SMART
ZnF_C2H2	490	512	6.52e-5	SMART
ZnF_C2H2	518	540	1.98e-4	SMART
ZnF_C2H2	572	594	2.4e-3	SMART
ZnF_C2H2	600	622	4.87e-4	SMART
ZnF_C2H2	628	650	1.1e-2	SMART
ZnF_C2H2	656	678	1.72e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159060

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159425

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159469

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160923

Predicted Effect

probably benign
Transcript: ENSMUST00000161630

SMART Domains

Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529

Domain	Start	End	E-Value	Type
SCAN	39	143	1.61e-63	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000162207

SMART Domains

Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529

Domain	Start	End	E-Value	Type
ZnF_C2H2	90	112	1.45e-2	SMART
ZnF_C2H2	146	168	3.11e-2	SMART
ZnF_C2H2	174	196	1.2e-3	SMART
ZnF_C2H2	202	224	6.52e-5	SMART
ZnF_C2H2	230	252	1.98e-4	SMART
ZnF_C2H2	284	306	2.4e-3	SMART
ZnF_C2H2	312	334	4.87e-4	SMART
ZnF_C2H2	340	362	1.1e-2	SMART
ZnF_C2H2	368	390	1.72e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl1	A	G	8: 84,665,143 (GRCm39)	M1322V	possibly damaging	Het
Adprh	C	T	16: 38,266,396 (GRCm39)	V249I	probably benign	Het
Afg2a	T	C	3: 37,486,328 (GRCm39)	V350A	possibly damaging	Het
Als2	T	C	1: 59,255,031 (GRCm39)	S109G	probably benign	Het
Bpifa1	T	A	2: 153,989,562 (GRCm39)	N250K	probably damaging	Het
Capn9	A	C	8: 125,332,298 (GRCm39)	Y423S	probably damaging	Het
Cd200r1	T	G	16: 44,614,645 (GRCm39)	V308G	probably benign	Het
Cic	T	C	7: 24,985,246 (GRCm39)		probably benign	Het
Col5a1	T	A	2: 27,922,757 (GRCm39)	I275N	possibly damaging	Het
Col6a4	C	A	9: 105,918,363 (GRCm39)		probably benign	Het
Cpeb1	T	C	7: 81,086,038 (GRCm39)	R35G	probably benign	Het
Cul1	A	G	6: 47,472,015 (GRCm39)	Y52C	probably damaging	Het
Dctn1	T	C	6: 83,169,475 (GRCm39)	F496L	probably damaging	Het
Dock11	G	T	X: 35,310,699 (GRCm39)		probably benign	Het
Eaf2	C	T	16: 36,648,484 (GRCm39)	R12H	probably benign	Het
Gcc1	T	A	6: 28,418,401 (GRCm39)	Q644L	possibly damaging	Het
Gm44865	C	T	7: 108,165,004 (GRCm39)		probably benign	Het
Golgb1	C	T	16: 36,733,228 (GRCm39)	S825L	probably benign	Het
Gstp3	C	T	19: 4,108,730 (GRCm39)		probably null	Het
Heph	T	A	X: 95,571,173 (GRCm39)	I669N	probably benign	Het
Il12rb1	A	T	8: 71,273,202 (GRCm39)	Y635F	possibly damaging	Het
Ing3	G	A	6: 21,971,221 (GRCm39)	A331T	probably benign	Het
Ipo8	T	A	6: 148,686,205 (GRCm39)	I762F	probably benign	Het
Itpr3	G	A	17: 27,310,907 (GRCm39)	R510Q	probably damaging	Het
Kif16b	A	G	2: 142,461,833 (GRCm39)	Y1273H	probably damaging	Het
Map3k14	T	C	11: 103,115,927 (GRCm39)	E784G	probably damaging	Het
Mpdz	A	T	4: 81,210,802 (GRCm39)	N1694K	probably damaging	Het
Myh13	T	C	11: 67,235,679 (GRCm39)	F648S	probably damaging	Het
Myh4	A	G	11: 67,149,982 (GRCm39)	H1847R	probably benign	Het
Ncoa7	T	A	10: 30,523,993 (GRCm39)	D840V	probably damaging	Het
Nxpe2	T	A	9: 48,230,992 (GRCm39)	N459I	possibly damaging	Het
Or4d10c	C	A	19: 12,065,975 (GRCm39)	L60F	possibly damaging	Het
Or4k2	C	A	14: 50,424,465 (GRCm39)	D70Y	probably damaging	Het
Or4k47	T	C	2: 111,451,535 (GRCm39)	K295E	probably damaging	Het
Ovgp1	T	C	3: 105,893,682 (GRCm39)	F485S	probably benign	Het
Parp4	G	T	14: 56,875,326 (GRCm39)	A1182S	probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Pla2g15	G	A	8: 106,886,851 (GRCm39)	R114H	probably benign	Het
Plppr3	T	A	10: 79,701,880 (GRCm39)	T321S	probably benign	Het
Rnf113a1	A	G	X: 36,455,748 (GRCm39)	D235G	probably benign	Het
Rsrp1	A	G	4: 134,651,700 (GRCm39)	T155A	possibly damaging	Het
Simc1	G	T	13: 54,685,025 (GRCm39)	C87F	probably damaging	Het
Slco1a5	A	G	6: 142,194,569 (GRCm39)		probably benign	Het
Slco1a8	C	A	6: 141,938,228 (GRCm39)	L230F	probably damaging	Het
Smyd5	A	G	6: 85,419,146 (GRCm39)	D276G	possibly damaging	Het
Tmem132c	A	G	5: 127,640,688 (GRCm39)	Y953C	probably damaging	Het
Trank1	T	A	9: 111,219,361 (GRCm39)	S2033T	possibly damaging	Het
Trim69	A	G	2: 122,009,115 (GRCm39)	T392A	probably damaging	Het
Tsks	T	C	7: 44,592,724 (GRCm39)	V6A	probably damaging	Het
Yjefn3	A	G	8: 70,342,206 (GRCm39)		probably benign	Het
Zfp994	A	T	17: 22,421,661 (GRCm39)	F51L	probably damaging	Het
Znfx1	A	T	2: 166,897,685 (GRCm39)	M413K	probably benign	Het

Other mutations in Zfp263

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00489:Zfp263	APN	16	3,563,710 (GRCm39)	missense	probably benign	0.00
IGL01112:Zfp263	APN	16	3,566,776 (GRCm39)	missense	probably benign	0.09
IGL02049:Zfp263	APN	16	3,562,482 (GRCm39)	missense	probably damaging	0.97
IGL02534:Zfp263	APN	16	3,564,279 (GRCm39)	unclassified	probably benign
IGL02674:Zfp263	APN	16	3,564,629 (GRCm39)	unclassified	probably benign
IGL03105:Zfp263	APN	16	3,566,824 (GRCm39)	missense	probably damaging	1.00
IGL03153:Zfp263	APN	16	3,564,744 (GRCm39)	missense	possibly damaging	0.56
IGL02796:Zfp263	UTSW	16	3,564,740 (GRCm39)	missense	probably benign	0.03
R1201:Zfp263	UTSW	16	3,567,294 (GRCm39)	missense	probably damaging	1.00
R1414:Zfp263	UTSW	16	3,567,160 (GRCm39)	missense	probably damaging	1.00
R1448:Zfp263	UTSW	16	3,564,323 (GRCm39)	missense	probably benign	0.18
R3085:Zfp263	UTSW	16	3,567,580 (GRCm39)	missense	probably damaging	1.00
R4368:Zfp263	UTSW	16	3,562,770 (GRCm39)	unclassified	probably benign
R4989:Zfp263	UTSW	16	3,566,992 (GRCm39)	missense	probably damaging	1.00
R5072:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5073:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5074:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5122:Zfp263	UTSW	16	3,567,719 (GRCm39)	missense	probably damaging	0.99
R5705:Zfp263	UTSW	16	3,564,318 (GRCm39)	missense	probably benign	0.00
R6140:Zfp263	UTSW	16	3,566,081 (GRCm39)	missense	probably benign	0.10
R6879:Zfp263	UTSW	16	3,567,719 (GRCm39)	missense	probably damaging	0.99
R7133:Zfp263	UTSW	16	3,567,255 (GRCm39)	nonsense	probably null
R7216:Zfp263	UTSW	16	3,562,435 (GRCm39)	missense	probably damaging	1.00
R8517:Zfp263	UTSW	16	3,564,760 (GRCm39)	critical splice donor site	probably null
R8822:Zfp263	UTSW	16	3,562,004 (GRCm39)	unclassified	probably benign
R9130:Zfp263	UTSW	16	3,567,701 (GRCm39)	missense	probably benign	0.06
R9172:Zfp263	UTSW	16	3,567,323 (GRCm39)	missense	probably benign	0.22
R9512:Zfp263	UTSW	16	3,564,306 (GRCm39)	missense	probably damaging	1.00
R9616:Zfp263	UTSW	16	3,567,482 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02