Incidental Mutation 'IGL03065:Dock11'
ID409677
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dock11
Ensembl Gene ENSMUSG00000031093
Gene Namededicator of cytokinesis 11
SynonymsZizimin2, 5033414A21Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.155) question?
Stock #IGL03065
Quality Score
Status
ChromosomeX
Chromosomal Location35888832-36076562 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to T at 36047046 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115264] [ENSMUST00000115266]
Predicted Effect probably benign
Transcript: ENSMUST00000033419
SMART Domains Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093

DomainStartEndE-ValueType
Pfam:DUF3398 52 145 4.2e-39 PFAM
PH 166 274 1.4e-17 SMART
Blast:PH 329 440 4e-58 BLAST
Pfam:DOCK-C2 636 827 2.4e-53 PFAM
low complexity region 1254 1270 N/A INTRINSIC
Pfam:DHR-2 1510 2029 7.3e-210 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115264
SMART Domains Protein: ENSMUSP00000110919
Gene: ENSMUSG00000031093

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
low complexity region 184 192 N/A INTRINSIC
Pfam:Ded_cyto 344 521 1.6e-69 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115266
SMART Domains Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093

DomainStartEndE-ValueType
PH 1 90 6.82e-7 SMART
Blast:PH 145 256 5e-58 BLAST
Pfam:DOCK-C2 451 644 1.3e-60 PFAM
low complexity region 1083 1099 N/A INTRINSIC
low complexity region 1521 1529 N/A INTRINSIC
Pfam:Ded_cyto 1681 1858 1.2e-68 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl1 A G 8: 83,938,514 M1322V possibly damaging Het
Adprh C T 16: 38,446,034 V249I probably benign Het
Als2 T C 1: 59,215,872 S109G probably benign Het
Bpifa1 T A 2: 154,147,642 N250K probably damaging Het
Capn9 A C 8: 124,605,559 Y423S probably damaging Het
Cd200r1 T G 16: 44,794,282 V308G probably benign Het
Cic T C 7: 25,285,821 probably benign Het
Col5a1 T A 2: 28,032,745 I275N possibly damaging Het
Col6a4 C A 9: 106,041,164 probably benign Het
Cpeb1 T C 7: 81,436,290 R35G probably benign Het
Cul1 A G 6: 47,495,081 Y52C probably damaging Het
Dctn1 T C 6: 83,192,493 F496L probably damaging Het
Eaf2 C T 16: 36,828,122 R12H probably benign Het
Gcc1 T A 6: 28,418,402 Q644L possibly damaging Het
Gm44865 C T 7: 108,565,797 probably benign Het
Gm6614 C A 6: 141,992,502 L230F probably damaging Het
Golgb1 C T 16: 36,912,866 S825L probably benign Het
Gstp3 C T 19: 4,058,730 probably null Het
Heph T A X: 96,527,567 I669N probably benign Het
Il12rb1 A T 8: 70,820,558 Y635F possibly damaging Het
Ing3 G A 6: 21,971,222 A331T probably benign Het
Ipo8 T A 6: 148,784,707 I762F probably benign Het
Itpr3 G A 17: 27,091,933 R510Q probably damaging Het
Kif16b A G 2: 142,619,913 Y1273H probably damaging Het
Map3k14 T C 11: 103,225,101 E784G probably damaging Het
Mpdz A T 4: 81,292,565 N1694K probably damaging Het
Myh13 T C 11: 67,344,853 F648S probably damaging Het
Myh4 A G 11: 67,259,156 H1847R probably benign Het
Ncoa7 T A 10: 30,647,997 D840V probably damaging Het
Nxpe2 T A 9: 48,319,692 N459I possibly damaging Het
Olfr1297 T C 2: 111,621,190 K295E probably damaging Het
Olfr1426 C A 19: 12,088,611 L60F possibly damaging Het
Olfr730 C A 14: 50,187,008 D70Y probably damaging Het
Ovgp1 T C 3: 105,986,366 F485S probably benign Het
Parp4 G T 14: 56,637,869 A1182S probably benign Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Pla2g15 G A 8: 106,160,219 R114H probably benign Het
Plppr3 T A 10: 79,866,046 T321S probably benign Het
Rnf113a1 A G X: 37,192,095 D235G probably benign Het
Rsrp1 A G 4: 134,924,389 T155A possibly damaging Het
Simc1 G T 13: 54,537,212 C87F probably damaging Het
Slco1a5 A G 6: 142,248,843 probably benign Het
Smyd5 A G 6: 85,442,164 D276G possibly damaging Het
Spata5 T C 3: 37,432,179 V350A possibly damaging Het
Tmem132c A G 5: 127,563,624 Y953C probably damaging Het
Trank1 T A 9: 111,390,293 S2033T possibly damaging Het
Trim69 A G 2: 122,178,634 T392A probably damaging Het
Tsks T C 7: 44,943,300 V6A probably damaging Het
Yjefn3 A G 8: 69,889,556 probably benign Het
Zfp263 T G 16: 3,746,480 D211E probably benign Het
Zfp994 A T 17: 22,202,680 F51L probably damaging Het
Znfx1 A T 2: 167,055,765 M413K probably benign Het
Other mutations in Dock11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Dock11 APN X 35994434 missense probably benign 0.15
IGL00650:Dock11 APN X 36006593 splice site probably benign
IGL00769:Dock11 APN X 36004062 missense possibly damaging 0.74
IGL00963:Dock11 APN X 36032382 missense possibly damaging 0.63
IGL01389:Dock11 APN X 35993048 missense probably benign 0.43
IGL01410:Dock11 APN X 36037643 missense probably damaging 1.00
IGL01519:Dock11 APN X 35963353 missense probably benign
IGL02023:Dock11 APN X 35968769 missense probably benign 0.09
IGL02253:Dock11 APN X 36041128 missense probably damaging 1.00
IGL02416:Dock11 APN X 36020086 missense probably damaging 0.97
IGL02583:Dock11 APN X 36006717 missense possibly damaging 0.48
IGL03014:Dock11 APN X 36047046 splice site probably benign
IGL03037:Dock11 APN X 36047046 splice site probably benign
IGL03277:Dock11 APN X 36013950 missense probably benign 0.32
R0816:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0819:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0820:Dock11 UTSW X 36020035 missense probably damaging 1.00
R1430:Dock11 UTSW X 36069912 missense probably benign 0.00
R1512:Dock11 UTSW X 36020035 missense probably damaging 1.00
Z1088:Dock11 UTSW X 36002533 missense probably benign 0.01
Z1176:Dock11 UTSW X 35984848 missense possibly damaging 0.69
Posted On2016-08-02