Incidental Mutation 'IGL03066:Or4x11'
ID 409680
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4x11
Ensembl Gene ENSMUSG00000059910
Gene Name olfactory receptor family 4 subfamily X member 11
Synonyms MOR228-2, GA_x6K02T2Q125-51469027-51469956, Olfr1265
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL03066
Quality Score
Status
Chromosome 2
Chromosomal Location 89867265-89868194 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89867778 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 172 (I172F)
Ref Sequence ENSEMBL: ENSMUSP00000149684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080311] [ENSMUST00000214855]
AlphaFold Q8VEZ3
Predicted Effect probably damaging
Transcript: ENSMUST00000080311
AA Change: I172F

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000079190
Gene: ENSMUSG00000059910
AA Change: I172F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.9e-49 PFAM
Pfam:7tm_1 39 285 1.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214855
AA Change: I172F

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brd4 A C 17: 32,418,062 (GRCm39) probably benign Het
Cd209d C A 8: 3,928,437 (GRCm39) probably null Het
Cela2a T A 4: 141,548,765 (GRCm39) I124F probably damaging Het
Cemip2 G A 19: 21,801,207 (GRCm39) D775N possibly damaging Het
Cnot2 A T 10: 116,335,262 (GRCm39) N245K probably benign Het
Cpt2 A G 4: 107,765,183 (GRCm39) F148L probably benign Het
Ctsj A C 13: 61,152,302 (GRCm39) H21Q possibly damaging Het
Cul4a A G 8: 13,183,776 (GRCm39) N388S probably benign Het
Dnah12 A G 14: 26,418,553 (GRCm39) D147G probably benign Het
Dnhd1 A G 7: 105,369,089 (GRCm39) T4287A probably damaging Het
Dock10 C A 1: 80,562,758 (GRCm39) C534F probably benign Het
Efcab14 A G 4: 115,596,001 (GRCm39) E49G probably benign Het
Fancm G T 12: 65,171,888 (GRCm39) E86* probably null Het
Galnt17 A T 5: 130,929,486 (GRCm39) S440R probably benign Het
Hectd4 T A 5: 121,503,116 (GRCm39) Y4362N possibly damaging Het
Lctl T G 9: 64,025,017 (GRCm39) M1R probably null Het
Llgl1 A G 11: 60,596,860 (GRCm39) T154A possibly damaging Het
Mink1 G T 11: 70,499,715 (GRCm39) V750F probably benign Het
Mroh7 A G 4: 106,549,595 (GRCm39) V950A possibly damaging Het
Myg1 G A 15: 102,242,801 (GRCm39) probably benign Het
Or6b2b T A 1: 92,419,305 (GRCm39) R57S probably damaging Het
Or7d10 A G 9: 19,831,667 (GRCm39) H54R probably benign Het
Pask A T 1: 93,258,588 (GRCm39) S253R probably benign Het
Pkd1 C A 17: 24,805,208 (GRCm39) H3253Q probably damaging Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Rapgef4 A G 2: 71,971,523 (GRCm39) probably benign Het
Rnf169 G T 7: 99,574,760 (GRCm39) R612S possibly damaging Het
Sclt1 A T 3: 41,672,278 (GRCm39) D104E probably benign Het
Shh G T 5: 28,666,369 (GRCm39) D172E probably damaging Het
Sil1 G T 18: 35,402,259 (GRCm39) probably benign Het
Slc19a3 A G 1: 82,992,557 (GRCm39) I388T probably damaging Het
Spink5 A G 18: 44,149,457 (GRCm39) Y946C probably damaging Het
Sulf1 A T 1: 12,878,168 (GRCm39) I219F probably damaging Het
Tcf3 T C 10: 80,248,879 (GRCm39) D529G probably damaging Het
Txnip G A 3: 96,466,934 (GRCm39) E203K probably damaging Het
Ubc G T 5: 125,465,327 (GRCm39) probably benign Het
Ubxn4 A T 1: 128,188,591 (GRCm39) probably null Het
Usp16 T C 16: 87,268,721 (GRCm39) V284A probably damaging Het
Vmn2r6 T A 3: 64,472,574 (GRCm39) N49I probably damaging Het
Ythdf1 A T 2: 180,553,339 (GRCm39) I292N probably damaging Het
Zfp128 A G 7: 12,624,044 (GRCm39) I137M probably benign Het
Other mutations in Or4x11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Or4x11 APN 2 89,867,812 (GRCm39) missense probably damaging 1.00
IGL01470:Or4x11 APN 2 89,868,162 (GRCm39) missense possibly damaging 0.81
IGL01878:Or4x11 APN 2 89,867,478 (GRCm39) missense probably damaging 0.97
IGL02716:Or4x11 APN 2 89,868,138 (GRCm39) missense probably benign 0.05
R1310:Or4x11 UTSW 2 89,868,047 (GRCm39) missense probably benign 0.02
R4986:Or4x11 UTSW 2 89,867,772 (GRCm39) missense probably damaging 1.00
R5101:Or4x11 UTSW 2 89,867,391 (GRCm39) missense probably benign 0.00
R6149:Or4x11 UTSW 2 89,867,860 (GRCm39) missense probably benign 0.01
R6400:Or4x11 UTSW 2 89,867,739 (GRCm39) missense probably benign 0.00
R7367:Or4x11 UTSW 2 89,868,156 (GRCm39) missense probably benign 0.02
R7432:Or4x11 UTSW 2 89,867,528 (GRCm39) missense probably damaging 0.99
R7645:Or4x11 UTSW 2 89,868,091 (GRCm39) missense possibly damaging 0.90
R7849:Or4x11 UTSW 2 89,867,626 (GRCm39) missense probably damaging 1.00
R9265:Or4x11 UTSW 2 89,867,842 (GRCm39) missense probably benign 0.01
R9634:Or4x11 UTSW 2 89,867,907 (GRCm39) missense probably damaging 1.00
R9756:Or4x11 UTSW 2 89,867,674 (GRCm39) missense probably benign 0.02
X0019:Or4x11 UTSW 2 89,867,988 (GRCm39) missense probably benign 0.02
Posted On 2016-08-02