Incidental Mutation 'IGL03067:Il10ra'
ID 409727
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il10ra
Ensembl Gene ENSMUSG00000032089
Gene Name interleukin 10 receptor, alpha
Synonyms Il10r, mIL-10R, CDw210
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03067
Quality Score
Status
Chromosome 9
Chromosomal Location 45165135-45180447 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45167157 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 465 (T465A)
Ref Sequence ENSEMBL: ENSMUSP00000135461 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034594] [ENSMUST00000176222] [ENSMUST00000176808]
AlphaFold Q61727
Predicted Effect probably benign
Transcript: ENSMUST00000034594
AA Change: T467A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000034594
Gene: ENSMUSG00000032089
AA Change: T467A

DomainStartEndE-ValueType
Pfam:Tissue_fac 5 114 3.3e-29 PFAM
SCOP:d1lqsr2 125 231 5e-59 SMART
transmembrane domain 239 261 N/A INTRINSIC
low complexity region 482 491 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176222
AA Change: T465A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000135461
Gene: ENSMUSG00000032089
AA Change: T465A

DomainStartEndE-ValueType
Pfam:Tissue_fac 2 112 3.5e-26 PFAM
SCOP:d1lqsr2 123 229 5e-59 SMART
transmembrane domain 237 259 N/A INTRINSIC
low complexity region 480 489 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176808
SMART Domains Protein: ENSMUSP00000135361
Gene: ENSMUSG00000032089

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
PHENOTYPE: Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A T 11: 119,900,909 (GRCm39) D1162E probably benign Het
Abhd2 T C 7: 79,009,782 (GRCm39) F386L probably benign Het
Adamts6 C T 13: 104,433,783 (GRCm39) R71W probably damaging Het
Adgrv1 T C 13: 81,590,599 (GRCm39) Y4403C probably damaging Het
Aldoart1 A T 4: 72,770,194 (GRCm39) C205S possibly damaging Het
Ap2a1 C A 7: 44,552,935 (GRCm39) A711S probably benign Het
Arhgef28 A G 13: 98,124,794 (GRCm39) I496T probably benign Het
Cyp27a1 A G 1: 74,771,068 (GRCm39) probably null Het
Cyp2c69 C T 19: 39,869,537 (GRCm39) G161S probably benign Het
Dpy19l1 A G 9: 24,349,956 (GRCm39) V428A probably benign Het
Foxk2 C T 11: 121,176,394 (GRCm39) T180M possibly damaging Het
Gm3402 C A 5: 146,451,399 (GRCm39) H86N possibly damaging Het
Gm3543 A G 14: 41,802,830 (GRCm39) probably benign Het
Gnai3 T C 3: 108,025,609 (GRCm39) probably benign Het
Hmcn2 C T 2: 31,236,642 (GRCm39) P395L probably damaging Het
Igsf10 T C 3: 59,226,339 (GRCm39) I2445V probably benign Het
Itpr2 G A 6: 146,226,680 (GRCm39) L1322F probably damaging Het
Man1b1 T C 2: 25,239,344 (GRCm39) Y536H probably benign Het
P3h1 A G 4: 119,092,477 (GRCm39) H170R probably damaging Het
Pakap A T 4: 57,648,038 (GRCm39) T59S probably benign Het
Parp14 A G 16: 35,676,878 (GRCm39) V1030A probably benign Het
Pdzd2 A G 15: 12,388,628 (GRCm39) probably null Het
Pilra T C 5: 137,821,843 (GRCm39) Y264C probably damaging Het
Ptprf A G 4: 118,067,910 (GRCm39) V1799A possibly damaging Het
Rap1gap2 A G 11: 74,284,238 (GRCm39) S649P possibly damaging Het
Rasgrf2 T C 13: 92,159,413 (GRCm39) M426V probably damaging Het
Rpl9 A G 5: 65,548,191 (GRCm39) I18T possibly damaging Het
Slc6a19 C A 13: 73,837,849 (GRCm39) E217* probably null Het
Smtn C A 11: 3,480,165 (GRCm39) R352L possibly damaging Het
Supv3l1 C A 10: 62,265,600 (GRCm39) D647Y probably damaging Het
Sv2a A G 3: 96,092,498 (GRCm39) Y66C probably damaging Het
Upk1b A G 16: 38,605,272 (GRCm39) I107T probably damaging Het
Yif1a T C 19: 5,139,813 (GRCm39) V86A possibly damaging Het
Zfp820 T C 17: 22,038,801 (GRCm39) T176A possibly damaging Het
Other mutations in Il10ra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01874:Il10ra APN 9 45,178,458 (GRCm39) missense probably damaging 1.00
IGL01916:Il10ra APN 9 45,167,444 (GRCm39) missense probably damaging 1.00
R0081:Il10ra UTSW 9 45,167,247 (GRCm39) missense probably benign 0.04
R0266:Il10ra UTSW 9 45,176,950 (GRCm39) missense probably benign 0.11
R1734:Il10ra UTSW 9 45,167,241 (GRCm39) missense probably benign 0.02
R1901:Il10ra UTSW 9 45,167,654 (GRCm39) missense probably benign 0.39
R1991:Il10ra UTSW 9 45,167,109 (GRCm39) missense probably benign 0.28
R2103:Il10ra UTSW 9 45,167,109 (GRCm39) missense probably benign 0.28
R2218:Il10ra UTSW 9 45,176,914 (GRCm39) missense probably benign
R4686:Il10ra UTSW 9 45,180,357 (GRCm39) missense probably damaging 1.00
R4908:Il10ra UTSW 9 45,166,919 (GRCm39) missense probably benign 0.21
R4982:Il10ra UTSW 9 45,180,357 (GRCm39) missense probably damaging 1.00
R5590:Il10ra UTSW 9 45,176,924 (GRCm39) nonsense probably null
R5739:Il10ra UTSW 9 45,167,368 (GRCm39) missense possibly damaging 0.65
R5872:Il10ra UTSW 9 45,166,951 (GRCm39) missense possibly damaging 0.92
R6053:Il10ra UTSW 9 45,167,601 (GRCm39) missense probably damaging 0.99
R6282:Il10ra UTSW 9 45,171,703 (GRCm39) missense probably damaging 0.98
R6798:Il10ra UTSW 9 45,167,730 (GRCm39) missense probably damaging 0.99
R7060:Il10ra UTSW 9 45,167,522 (GRCm39) missense probably benign 0.00
R7561:Il10ra UTSW 9 45,167,117 (GRCm39) missense probably benign 0.00
R7630:Il10ra UTSW 9 45,167,369 (GRCm39) missense probably damaging 1.00
R7709:Il10ra UTSW 9 45,171,697 (GRCm39) missense probably benign 0.01
R8880:Il10ra UTSW 9 45,175,631 (GRCm39) missense probably damaging 1.00
R8939:Il10ra UTSW 9 45,177,802 (GRCm39) missense unknown
R9069:Il10ra UTSW 9 45,167,396 (GRCm39) missense probably damaging 0.98
R9511:Il10ra UTSW 9 45,167,690 (GRCm39) missense probably benign 0.06
Z1176:Il10ra UTSW 9 45,177,930 (GRCm39) missense possibly damaging 0.66
Posted On 2016-08-02