Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03068:Ttc29'

409777

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc29

Ensembl Gene

ENSMUSG00000037101

Gene Name

tetratricopeptide repeat domain 29

Synonyms

1700031F13Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL03068

Quality Score

Status

Chromosome

Chromosomal Location

78939926-79120955 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79052180 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 354 (I354V)

Ref Sequence

ENSEMBL: ENSMUSP00000105528 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049395] [ENSMUST00000109902]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000049395
AA Change: I354V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000041919
Gene: ENSMUSG00000037101
AA Change: I354V

Domain	Start	End	E-Value	Type
low complexity region	189	199	N/A	INTRINSIC
Blast:TPR	234	267	2e-7	BLAST
TPR	274	307	4.1e1	SMART
TPR	314	347	2.48e0	SMART
TPR	354	387	2.48e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109902
AA Change: I354V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000105528
Gene: ENSMUSG00000037101
AA Change: I354V

Domain	Start	End	E-Value	Type
low complexity region	189	199	N/A	INTRINSIC
Blast:TPR	234	267	2e-7	BLAST
TPR	274	307	4.1e1	SMART
TPR	314	347	2.48e0	SMART
TPR	354	387	2.48e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ago3	A	G	4: 126,311,171 (GRCm39)	L14P	probably damaging	Het
Ak2	G	T	4: 128,901,819 (GRCm39)		probably benign	Het
Appbp2	T	C	11: 85,092,246 (GRCm39)	Y311C	probably damaging	Het
Arl9	C	A	5: 77,155,225 (GRCm39)	L119I	possibly damaging	Het
Atp1a1	T	C	3: 101,491,175 (GRCm39)	H620R	probably benign	Het
Cfap52	T	C	11: 67,826,682 (GRCm39)	D381G	probably benign	Het
Cngb3	T	C	4: 19,375,246 (GRCm39)	F292S	possibly damaging	Het
Comtd1	G	A	14: 21,897,711 (GRCm39)	R203C	probably damaging	Het
Crmp1	G	T	5: 37,422,633 (GRCm39)	A147S	possibly damaging	Het
Csmd3	T	A	15: 47,710,517 (GRCm39)	H1586L	possibly damaging	Het
Ctnna1	G	A	18: 35,382,785 (GRCm39)	E644K	possibly damaging	Het
Dock3	T	C	9: 106,841,958 (GRCm39)	D957G	possibly damaging	Het
Ear1	G	T	14: 44,056,502 (GRCm39)	S122*	probably null	Het
Eefsec	G	T	6: 88,235,209 (GRCm39)	Q576K	probably benign	Het
Efcab5	T	A	11: 76,994,927 (GRCm39)	I1215L	probably benign	Het
Etfa	A	T	9: 55,394,766 (GRCm39)	D160E	probably benign	Het
Exoc7	G	A	11: 116,191,960 (GRCm39)	R197C	possibly damaging	Het
G6pc1	A	G	11: 101,261,576 (GRCm39)	D92G	probably benign	Het
Gm3182	T	A	14: 4,483,921 (GRCm38)		probably null	Het
Gm4952	A	G	19: 12,601,068 (GRCm39)	N96S	probably damaging	Het
Gpr156	G	A	16: 37,812,491 (GRCm39)	V276M	probably damaging	Het
Irs2	A	G	8: 11,054,974 (GRCm39)	S1153P	probably damaging	Het
Kif21b	T	C	1: 136,086,093 (GRCm39)		probably benign	Het
Lmo7	A	T	14: 102,112,928 (GRCm39)		probably benign	Het
Mapk4	G	T	18: 74,103,415 (GRCm39)	N31K	probably damaging	Het
Mccc2	T	C	13: 100,100,319 (GRCm39)	T357A	probably damaging	Het
Mpeg1	A	G	19: 12,439,570 (GRCm39)	T343A	probably benign	Het
Myo3b	G	T	2: 70,257,160 (GRCm39)		probably benign	Het
Pald1	T	C	10: 61,156,963 (GRCm39)	E829G	possibly damaging	Het
Pde11a	A	G	2: 75,848,208 (GRCm39)	I873T	probably damaging	Het
Samd9l	T	A	6: 3,375,348 (GRCm39)	K638*	probably null	Het
Sema4d	A	G	13: 51,862,922 (GRCm39)	S479P	probably damaging	Het
Slc12a2	T	C	18: 58,037,407 (GRCm39)		probably benign	Het
Slc47a2	T	C	11: 61,194,769 (GRCm39)	N470S	probably damaging	Het
Spag17	C	T	3: 99,987,521 (GRCm39)	P1604S	probably benign	Het
Taf8	C	A	17: 47,812,290 (GRCm39)	V39L	probably damaging	Het
Tlr11	A	G	14: 50,598,941 (GRCm39)	E309G	probably benign	Het
Tmem260	A	G	14: 48,724,371 (GRCm39)		probably benign	Het
Tsc1	A	T	2: 28,571,270 (GRCm39)	K816M	probably damaging	Het
Ttll3	A	T	6: 113,386,158 (GRCm39)	N665Y	probably damaging	Het
Ubr4	A	G	4: 139,137,041 (GRCm39)	T971A	probably benign	Het
Vmn2r96	T	A	17: 18,803,137 (GRCm39)	I349N	probably benign	Het
Vwa5a	A	G	9: 38,646,143 (GRCm39)	T504A	probably benign	Het
Ythdf3	T	A	3: 16,258,882 (GRCm39)	V354E	possibly damaging	Het
Zan	C	A	5: 137,474,677 (GRCm39)	G13V	probably damaging	Het

Other mutations in Ttc29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00839:Ttc29	APN	8	79,060,385 (GRCm39)	missense	probably benign	0.13
IGL01785:Ttc29	APN	8	79,008,970 (GRCm39)	missense	probably damaging	1.00
IGL02412:Ttc29	APN	8	79,003,569 (GRCm39)	missense	possibly damaging	0.47
PIT4519001:Ttc29	UTSW	8	79,052,106 (GRCm39)	missense	probably benign	0.04
R0523:Ttc29	UTSW	8	79,003,466 (GRCm39)	missense	probably benign	0.01
R1214:Ttc29	UTSW	8	79,052,211 (GRCm39)	missense	probably damaging	1.00
R1869:Ttc29	UTSW	8	79,009,014 (GRCm39)	missense	probably benign
R1902:Ttc29	UTSW	8	78,978,361 (GRCm39)	missense	probably benign	0.03
R1903:Ttc29	UTSW	8	78,978,361 (GRCm39)	missense	probably benign	0.03
R4612:Ttc29	UTSW	8	79,052,175 (GRCm39)	missense	probably benign	0.02
R4649:Ttc29	UTSW	8	79,060,208 (GRCm39)	missense	probably benign	0.12
R4892:Ttc29	UTSW	8	79,060,274 (GRCm39)	missense	probably damaging	0.98
R5306:Ttc29	UTSW	8	78,978,539 (GRCm39)	critical splice donor site	probably null
R5649:Ttc29	UTSW	8	78,972,942 (GRCm39)	missense	possibly damaging	0.47
R5996:Ttc29	UTSW	8	79,003,525 (GRCm39)	missense	probably damaging	0.99
R6036:Ttc29	UTSW	8	79,052,205 (GRCm39)	missense	probably benign	0.03
R6036:Ttc29	UTSW	8	79,052,205 (GRCm39)	missense	probably benign	0.03
R6495:Ttc29	UTSW	8	79,008,963 (GRCm39)	missense	possibly damaging	0.79
R6813:Ttc29	UTSW	8	79,060,249 (GRCm39)	missense	probably benign	0.01
R6961:Ttc29	UTSW	8	79,003,545 (GRCm39)	missense	possibly damaging	0.77
R7686:Ttc29	UTSW	8	79,119,759 (GRCm39)	missense	probably benign	0.15
R8714:Ttc29	UTSW	8	79,060,331 (GRCm39)	missense	possibly damaging	0.85
R8962:Ttc29	UTSW	8	79,042,336 (GRCm39)	missense	probably damaging	0.98
R9420:Ttc29	UTSW	8	79,060,390 (GRCm39)	missense	probably benign
R9676:Ttc29	UTSW	8	79,060,384 (GRCm39)	missense	probably benign	0.06
R9691:Ttc29	UTSW	8	78,972,895 (GRCm39)	missense	possibly damaging	0.63

Posted On

2016-08-02