Incidental Mutation 'IGL03118:Olfr323'
ID 409882
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr323
Ensembl Gene ENSMUSG00000043880
Gene Name olfactory receptor 323
Synonyms MOR107-1, GA_x6K02T2NKPP-794386-795357
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # IGL03118
Quality Score
Status
Chromosome 11
Chromosomal Location 58624159-58630501 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58625443 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 201 (V201D)
Ref Sequence ENSEMBL: ENSMUSP00000151137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070804] [ENSMUST00000203173] [ENSMUST00000214132]
AlphaFold Q5NCD0
Predicted Effect probably damaging
Transcript: ENSMUST00000070804
AA Change: V201D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000068147
Gene: ENSMUSG00000043880
AA Change: V201D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-54 PFAM
Pfam:7tm_1 41 290 3.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203173
SMART Domains Protein: ENSMUSP00000145459
Gene: ENSMUSG00000043880

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214132
AA Change: V201D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 G A 17: 24,400,450 G921S probably benign Het
Abca8b T C 11: 109,947,181 T1082A possibly damaging Het
AF366264 C T 8: 13,838,096 probably benign Het
B9d2 T C 7: 25,681,476 probably null Het
Bfsp1 T C 2: 143,827,333 E442G possibly damaging Het
Bpifb5 C T 2: 154,236,753 probably benign Het
Ccl1 A G 11: 82,178,070 I47T probably damaging Het
Cln3 T C 7: 126,575,397 I285V probably null Het
Cyp4a12b G T 4: 115,432,976 R242I possibly damaging Het
Dcc T C 18: 71,420,273 T771A probably benign Het
Erbb4 T C 1: 68,042,719 D1052G probably benign Het
Fcnb T C 2: 28,076,618 N301S probably benign Het
Gm28043 A C 17: 29,634,731 E403A probably damaging Het
Gria4 A G 9: 4,793,804 probably benign Het
Ighv5-12 T A 12: 113,702,578 M1L probably benign Het
Il17rd A G 14: 27,093,395 probably null Het
Kcnn3 T A 3: 89,667,161 L660Q probably damaging Het
Lcor C T 19: 41,558,369 P131S probably damaging Het
Leng1 T C 7: 3,665,410 N13S probably damaging Het
Loxhd1 T C 18: 77,380,464 V827A probably damaging Het
Mapk13 A G 17: 28,777,735 Y208C probably benign Het
Mybpc3 T C 2: 91,124,503 V453A probably damaging Het
Odam T C 5: 87,885,754 S15P unknown Het
Olfr26 A T 9: 38,855,230 H56L probably damaging Het
Pcdhb19 T C 18: 37,499,565 probably benign Het
Per2 G T 1: 91,444,619 Y244* probably null Het
Pik3ca A T 3: 32,459,935 I857F probably damaging Het
Pold1 T A 7: 44,539,400 I447F probably benign Het
Ppm1f T A 16: 16,914,078 W131R probably null Het
Ppp2r2c A G 5: 36,926,316 Y67C probably damaging Het
Psmb10 A T 8: 105,936,900 H155Q probably damaging Het
Ptbp3 G A 4: 59,501,470 A149V probably benign Het
Pygb T A 2: 150,820,811 V566E probably benign Het
Rictor G A 15: 6,759,518 R205Q possibly damaging Het
Ryr1 T A 7: 29,015,786 R4638W unknown Het
Sept3 G A 15: 82,284,514 probably null Het
Serpina3b A T 12: 104,131,054 D198V probably benign Het
Slc27a6 C A 18: 58,556,743 H94N probably benign Het
Taf2 C T 15: 55,052,163 V456M probably damaging Het
Tbpl2 T C 2: 24,087,289 E238G probably benign Het
Ttn C T 2: 76,754,207 V20440I possibly damaging Het
Zfp638 T A 6: 83,935,018 probably benign Het
Zfp865 T C 7: 5,034,645 probably benign Het
Other mutations in Olfr323
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02995:Olfr323 APN 11 58625281 missense possibly damaging 0.92
R0058:Olfr323 UTSW 11 58625668 missense probably damaging 1.00
R0335:Olfr323 UTSW 11 58625740 missense probably damaging 1.00
R1127:Olfr323 UTSW 11 58625458 missense probably damaging 0.98
R2029:Olfr323 UTSW 11 58625493 missense probably damaging 1.00
R2434:Olfr323 UTSW 11 58625111 missense possibly damaging 0.95
R5483:Olfr323 UTSW 11 58625957 missense possibly damaging 0.95
R6423:Olfr323 UTSW 11 58625363 missense probably damaging 1.00
R6990:Olfr323 UTSW 11 58625458 missense probably damaging 0.98
R7472:Olfr323 UTSW 11 58625434 missense probably damaging 1.00
R7539:Olfr323 UTSW 11 58625956 missense probably damaging 1.00
R7635:Olfr323 UTSW 11 58625164 missense unknown
R7647:Olfr323 UTSW 11 58625203 missense probably damaging 1.00
R8519:Olfr323 UTSW 11 58625974 missense probably damaging 1.00
R8869:Olfr323 UTSW 11 58625168 missense unknown
R9180:Olfr323 UTSW 11 58625236 missense probably benign 0.36
R9262:Olfr323 UTSW 11 58625456 missense probably benign 0.00
R9788:Olfr323 UTSW 11 58625866 missense probably benign 0.03
Z1186:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1186:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1186:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1186:Olfr323 UTSW 11 58625793 missense probably benign
Z1186:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1187:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1187:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1187:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1187:Olfr323 UTSW 11 58625793 missense probably benign
Z1187:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1188:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1188:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1188:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1188:Olfr323 UTSW 11 58625793 missense probably benign
Z1188:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1189:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1189:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1189:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1189:Olfr323 UTSW 11 58625793 missense probably benign
Z1189:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1190:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1190:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1190:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1190:Olfr323 UTSW 11 58625793 missense probably benign
Z1190:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1191:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1191:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1191:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1191:Olfr323 UTSW 11 58625793 missense probably benign
Z1191:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Z1192:Olfr323 UTSW 11 58625249 missense probably benign 0.16
Z1192:Olfr323 UTSW 11 58625304 missense probably benign 0.16
Z1192:Olfr323 UTSW 11 58625762 missense probably benign 0.00
Z1192:Olfr323 UTSW 11 58625793 missense probably benign
Z1192:Olfr323 UTSW 11 58625906 missense possibly damaging 0.87
Posted On 2016-08-02