Incidental Mutation 'IGL03118:Or11l3'
ID 409882
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11l3
Ensembl Gene ENSMUSG00000043880
Gene Name olfactory receptor family 11 subfamily L member 3
Synonyms MOR107-1, Olfr323, GA_x6K02T2NKPP-794386-795357
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL03118
Quality Score
Status
Chromosome 11
Chromosomal Location 58515899-58516870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58516269 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 201 (V201D)
Ref Sequence ENSEMBL: ENSMUSP00000151137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070804] [ENSMUST00000203173] [ENSMUST00000214132]
AlphaFold Q5NCD0
Predicted Effect probably damaging
Transcript: ENSMUST00000070804
AA Change: V201D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000068147
Gene: ENSMUSG00000043880
AA Change: V201D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-54 PFAM
Pfam:7tm_1 41 290 3.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203173
SMART Domains Protein: ENSMUSP00000145459
Gene: ENSMUSG00000043880

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214132
AA Change: V201D

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 G A 17: 24,619,424 (GRCm39) G921S probably benign Het
Abca8b T C 11: 109,838,007 (GRCm39) T1082A possibly damaging Het
B9d2 T C 7: 25,380,901 (GRCm39) probably null Het
Bfsp1 T C 2: 143,669,253 (GRCm39) E442G possibly damaging Het
Bpifb5 C T 2: 154,078,673 (GRCm39) probably benign Het
Ccl1 A G 11: 82,068,896 (GRCm39) I47T probably damaging Het
Cln3 T C 7: 126,174,569 (GRCm39) I285V probably null Het
Cyp4a12b G T 4: 115,290,173 (GRCm39) R242I possibly damaging Het
Dcc T C 18: 71,553,344 (GRCm39) T771A probably benign Het
Erbb4 T C 1: 68,081,878 (GRCm39) D1052G probably benign Het
Fcnb T C 2: 27,966,630 (GRCm39) N301S probably benign Het
Gm28043 A C 17: 29,853,705 (GRCm39) E403A probably damaging Het
Gria4 A G 9: 4,793,804 (GRCm39) probably benign Het
Ighv5-12 T A 12: 113,666,198 (GRCm39) M1L probably benign Het
Il17rd A G 14: 26,815,352 (GRCm39) probably null Het
Kcnn3 T A 3: 89,574,468 (GRCm39) L660Q probably damaging Het
Lcor C T 19: 41,546,808 (GRCm39) P131S probably damaging Het
Leng1 T C 7: 3,668,409 (GRCm39) N13S probably damaging Het
Loxhd1 T C 18: 77,468,160 (GRCm39) V827A probably damaging Het
Mapk13 A G 17: 28,996,709 (GRCm39) Y208C probably benign Het
Mybpc3 T C 2: 90,954,848 (GRCm39) V453A probably damaging Het
Odam T C 5: 88,033,613 (GRCm39) S15P unknown Het
Or8d1 A T 9: 38,766,526 (GRCm39) H56L probably damaging Het
Pcdhb19 T C 18: 37,632,618 (GRCm39) probably benign Het
Per2 G T 1: 91,372,341 (GRCm39) Y244* probably null Het
Pik3ca A T 3: 32,514,084 (GRCm39) I857F probably damaging Het
Pold1 T A 7: 44,188,824 (GRCm39) I447F probably benign Het
Ppm1f T A 16: 16,731,942 (GRCm39) W131R probably null Het
Ppp2r2c A G 5: 37,083,660 (GRCm39) Y67C probably damaging Het
Psmb10 A T 8: 106,663,532 (GRCm39) H155Q probably damaging Het
Ptbp3 G A 4: 59,501,470 (GRCm39) A149V probably benign Het
Pygb T A 2: 150,662,731 (GRCm39) V566E probably benign Het
Rictor G A 15: 6,788,999 (GRCm39) R205Q possibly damaging Het
Ryr1 T A 7: 28,715,211 (GRCm39) R4638W unknown Het
Semp2l2a C T 8: 13,888,096 (GRCm39) probably benign Het
Septin3 G A 15: 82,168,715 (GRCm39) probably null Het
Serpina3b A T 12: 104,097,313 (GRCm39) D198V probably benign Het
Slc27a6 C A 18: 58,689,815 (GRCm39) H94N probably benign Het
Taf2 C T 15: 54,915,559 (GRCm39) V456M probably damaging Het
Tbpl2 T C 2: 23,977,301 (GRCm39) E238G probably benign Het
Ttn C T 2: 76,584,551 (GRCm39) V20440I possibly damaging Het
Zfp638 T A 6: 83,912,000 (GRCm39) probably benign Het
Zfp865 T C 7: 5,037,644 (GRCm39) probably benign Het
Other mutations in Or11l3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02995:Or11l3 APN 11 58,516,107 (GRCm39) missense possibly damaging 0.92
R0058:Or11l3 UTSW 11 58,516,494 (GRCm39) missense probably damaging 1.00
R0335:Or11l3 UTSW 11 58,516,566 (GRCm39) missense probably damaging 1.00
R1127:Or11l3 UTSW 11 58,516,284 (GRCm39) missense probably damaging 0.98
R2029:Or11l3 UTSW 11 58,516,319 (GRCm39) missense probably damaging 1.00
R2434:Or11l3 UTSW 11 58,515,937 (GRCm39) missense possibly damaging 0.95
R5483:Or11l3 UTSW 11 58,516,783 (GRCm39) missense possibly damaging 0.95
R6423:Or11l3 UTSW 11 58,516,189 (GRCm39) missense probably damaging 1.00
R6990:Or11l3 UTSW 11 58,516,284 (GRCm39) missense probably damaging 0.98
R7472:Or11l3 UTSW 11 58,516,260 (GRCm39) missense probably damaging 1.00
R7539:Or11l3 UTSW 11 58,516,782 (GRCm39) missense probably damaging 1.00
R7635:Or11l3 UTSW 11 58,515,990 (GRCm39) missense unknown
R7647:Or11l3 UTSW 11 58,516,029 (GRCm39) missense probably damaging 1.00
R8519:Or11l3 UTSW 11 58,516,800 (GRCm39) missense probably damaging 1.00
R8869:Or11l3 UTSW 11 58,515,994 (GRCm39) missense unknown
R9180:Or11l3 UTSW 11 58,516,062 (GRCm39) missense probably benign 0.36
R9262:Or11l3 UTSW 11 58,516,282 (GRCm39) missense probably benign 0.00
R9788:Or11l3 UTSW 11 58,516,692 (GRCm39) missense probably benign 0.03
Z1186:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1186:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1186:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1186:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1186:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1187:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1187:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1188:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1189:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1189:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1189:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1190:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1190:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1190:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1191:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1191:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1191:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1192:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1192:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1192:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Posted On 2016-08-02