Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03119:Zfp574'

409905

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp574

Ensembl Gene

ENSMUSG00000045252

Gene Name

zinc finger protein 574

Synonyms

A630056B21Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL03119

Quality Score

Status

Chromosome

Chromosomal Location

25072567-25083492 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 25080473 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 307 (A307T)

Ref Sequence

ENSEMBL: ENSMUSP00000136547 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]

AlphaFold

Q8BY46

Predicted Effect

probably benign
Transcript: ENSMUST00000053410
AA Change: A307T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: A307T

Domain	Start	End	E-Value	Type
ZnF_C2H2	16	38	4.98e-1	SMART
ZnF_C2H2	76	98	4.05e-1	SMART
low complexity region	107	118	N/A	INTRINSIC
ZnF_C2H2	126	148	1.99e0	SMART
low complexity region	156	173	N/A	INTRINSIC
ZnF_C2H2	213	235	4.4e-2	SMART
low complexity region	237	254	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
ZnF_C2H2	312	334	7.15e-2	SMART
ZnF_C2H2	339	361	1.04e-3	SMART
ZnF_C2H2	367	389	4.12e0	SMART
ZnF_C2H2	395	416	2.12e1	SMART
low complexity region	418	434	N/A	INTRINSIC
ZnF_C2H2	469	492	1.03e-2	SMART
ZnF_C2H2	498	520	2.75e-3	SMART
ZnF_C2H2	526	548	3.39e-3	SMART
ZnF_C2H2	554	576	2.75e-3	SMART
ZnF_C2H2	582	604	2.86e-1	SMART
ZnF_C2H2	610	633	1.25e-1	SMART
ZnF_C2H2	639	659	4.5e1	SMART
low complexity region	660	666	N/A	INTRINSIC
ZnF_C2H2	670	692	2.29e0	SMART
ZnF_C2H2	742	764	2.91e-2	SMART
ZnF_C2H2	770	792	5.59e-4	SMART
ZnF_C2H2	798	820	3.34e-2	SMART
ZnF_C2H2	826	848	4.24e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000179556
AA Change: A307T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: A307T

Domain	Start	End	E-Value	Type
ZnF_C2H2	16	38	4.98e-1	SMART
ZnF_C2H2	76	98	4.05e-1	SMART
low complexity region	107	118	N/A	INTRINSIC
ZnF_C2H2	126	148	1.99e0	SMART
low complexity region	156	173	N/A	INTRINSIC
ZnF_C2H2	213	235	4.4e-2	SMART
low complexity region	237	254	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
ZnF_C2H2	312	334	7.15e-2	SMART
ZnF_C2H2	339	361	1.04e-3	SMART
ZnF_C2H2	367	389	4.12e0	SMART
ZnF_C2H2	395	416	2.12e1	SMART
low complexity region	418	434	N/A	INTRINSIC
ZnF_C2H2	469	492	1.03e-2	SMART
ZnF_C2H2	498	520	2.75e-3	SMART
ZnF_C2H2	526	548	3.39e-3	SMART
ZnF_C2H2	554	576	2.75e-3	SMART
ZnF_C2H2	582	604	2.86e-1	SMART
ZnF_C2H2	610	633	1.25e-1	SMART
ZnF_C2H2	639	659	4.5e1	SMART
low complexity region	660	666	N/A	INTRINSIC
ZnF_C2H2	670	692	2.29e0	SMART
ZnF_C2H2	742	764	2.91e-2	SMART
ZnF_C2H2	770	792	5.59e-4	SMART
ZnF_C2H2	798	820	3.34e-2	SMART
ZnF_C2H2	826	848	4.24e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206530

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206733

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	A	G	5: 8,714,887	T626A	probably benign	Het
Adcy1	C	T	11: 7,109,051	T319I	probably damaging	Het
Adgrv1	A	G	13: 81,382,373	S5861P	probably damaging	Het
Adgrv1	A	C	13: 81,433,700	C4742G	probably benign	Het
Arid5b	A	T	10: 68,243,227	D93E	probably damaging	Het
Atp6v1h	A	G	1: 5,095,669	T121A	probably benign	Het
Atxn7	C	T	14: 14,100,734	L807F	probably damaging	Het
Cep104	A	C	4: 153,981,724	K126N	probably damaging	Het
Dcaf6	T	C	1: 165,339,976	E708G	probably damaging	Het
Dst	A	G	1: 34,161,062	Y107C	probably damaging	Het
E2f3	A	G	13: 29,985,365	S102P	probably benign	Het
Eif3e	A	C	15: 43,265,604	S207A	probably benign	Het
Etl4	A	G	2: 20,713,387	Y313C	probably damaging	Het
Fyttd1	T	C	16: 32,900,695	V121A	probably benign	Het
Gstk1	T	C	6: 42,249,899	S200P	probably damaging	Het
Ifrd1	A	T	12: 40,212,334	F244L	probably null	Het
Ints7	T	C	1: 191,610,365	V491A	probably damaging	Het
Kcnd2	G	T	6: 21,216,509	E71*	probably null	Het
Ltbp3	A	T	19: 5,757,443	Q1123L	probably damaging	Het
Myo5a	A	G	9: 75,174,015	T961A	probably benign	Het
Naa25	T	A	5: 121,434,978	V720E	probably null	Het
Olfr1480	T	C	19: 13,530,435	I298T	probably benign	Het
Olfr599	A	G	7: 103,338,722	I223V	probably damaging	Het
Pcdhb15	C	A	18: 37,475,014	T433N	probably damaging	Het
Peli1	T	C	11: 21,140,560		probably benign	Het
Ptbp1	T	C	10: 79,859,624	V209A	probably damaging	Het
Ranbp2	A	G	10: 58,452,003	Y31C	probably damaging	Het
Smg1	G	A	7: 118,195,113		probably benign	Het
Stat2	A	G	10: 128,283,517	M457V	probably benign	Het
Trpm6	G	T	19: 18,838,017	E1156*	probably null	Het
Usp53	T	A	3: 122,961,415	R130S	possibly damaging	Het
Vwa5b1	A	G	4: 138,606,541	S193P	probably benign	Het
Xrn2	A	G	2: 147,042,872	I626V	probably damaging	Het

Other mutations in Zfp574

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Zfp574	APN	7	25081590	missense	probably benign	0.00
IGL02370:Zfp574	APN	7	25079589	missense	possibly damaging	0.95
IGL02706:Zfp574	APN	7	25081365	missense	probably damaging	0.98
glue	UTSW	7	25081090	missense
BB004:Zfp574	UTSW	7	25080147	missense	probably benign
BB014:Zfp574	UTSW	7	25080147	missense	probably benign
R0866:Zfp574	UTSW	7	25079898	missense	probably damaging	1.00
R2429:Zfp574	UTSW	7	25080057	nonsense	probably null
R3123:Zfp574	UTSW	7	25081601	missense	possibly damaging	0.88
R3124:Zfp574	UTSW	7	25081601	missense	possibly damaging	0.88
R3125:Zfp574	UTSW	7	25081601	missense	possibly damaging	0.88
R4581:Zfp574	UTSW	7	25081313	missense	probably damaging	0.98
R4591:Zfp574	UTSW	7	25079544	start gained	probably benign
R4915:Zfp574	UTSW	7	25080726	missense	probably damaging	0.98
R4953:Zfp574	UTSW	7	25080963	missense	probably damaging	0.97
R5305:Zfp574	UTSW	7	25081090	missense
R5541:Zfp574	UTSW	7	25081950	missense	probably damaging	0.99
R5934:Zfp574	UTSW	7	25080332	missense	probably benign
R6088:Zfp574	UTSW	7	25080339	missense	probably benign	0.01
R7061:Zfp574	UTSW	7	25080197	missense	possibly damaging	0.95
R7563:Zfp574	UTSW	7	25081352	missense	possibly damaging	0.94
R7615:Zfp574	UTSW	7	25080576	missense	possibly damaging	0.95
R7927:Zfp574	UTSW	7	25080147	missense	probably benign
R8017:Zfp574	UTSW	7	25080670	nonsense	probably null
R8019:Zfp574	UTSW	7	25080670	nonsense	probably null
R8788:Zfp574	UTSW	7	25080391	missense	unknown
R8871:Zfp574	UTSW	7	25081137	missense	probably damaging	0.99
R8915:Zfp574	UTSW	7	25081344	missense	probably damaging	1.00
R9484:Zfp574	UTSW	7	25081979	missense	possibly damaging	0.77
R9533:Zfp574	UTSW	7	25080954	missense	probably damaging	1.00
R9606:Zfp574	UTSW	7	25081215	missense	probably damaging	1.00
R9623:Zfp574	UTSW	7	25081090	missense
X0026:Zfp574	UTSW	7	25081052	missense	probably damaging	0.99

Posted On

2016-08-02