Incidental Mutation 'IGL03119:Zfp574'
ID 409905
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp574
Ensembl Gene ENSMUSG00000045252
Gene Name zinc finger protein 574
Synonyms A630056B21Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03119
Quality Score
Status
Chromosome 7
Chromosomal Location 24775099-24782917 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24779898 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 307 (A307T)
Ref Sequence ENSEMBL: ENSMUSP00000136547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]
AlphaFold Q8BY46
Predicted Effect probably benign
Transcript: ENSMUST00000053410
AA Change: A307T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: A307T

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179556
AA Change: A307T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: A307T

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206530
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206733
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,764,887 (GRCm39) T626A probably benign Het
Adcy1 C T 11: 7,059,051 (GRCm39) T319I probably damaging Het
Adgrv1 A G 13: 81,530,492 (GRCm39) S5861P probably damaging Het
Adgrv1 A C 13: 81,581,819 (GRCm39) C4742G probably benign Het
Arid5b A T 10: 68,079,057 (GRCm39) D93E probably damaging Het
Atp6v1h A G 1: 5,165,892 (GRCm39) T121A probably benign Het
Atxn7 C T 14: 14,100,734 (GRCm38) L807F probably damaging Het
Cep104 A C 4: 154,066,181 (GRCm39) K126N probably damaging Het
Dcaf6 T C 1: 165,167,545 (GRCm39) E708G probably damaging Het
Dst A G 1: 34,200,143 (GRCm39) Y107C probably damaging Het
E2f3 A G 13: 30,169,348 (GRCm39) S102P probably benign Het
Eif3e A C 15: 43,129,000 (GRCm39) S207A probably benign Het
Etl4 A G 2: 20,718,198 (GRCm39) Y313C probably damaging Het
Fyttd1 T C 16: 32,721,065 (GRCm39) V121A probably benign Het
Gstk1 T C 6: 42,226,833 (GRCm39) S200P probably damaging Het
Ifrd1 A T 12: 40,262,333 (GRCm39) F244L probably null Het
Ints7 T C 1: 191,342,477 (GRCm39) V491A probably damaging Het
Kcnd2 G T 6: 21,216,508 (GRCm39) E71* probably null Het
Ltbp3 A T 19: 5,807,471 (GRCm39) Q1123L probably damaging Het
Myo5a A G 9: 75,081,297 (GRCm39) T961A probably benign Het
Naa25 T A 5: 121,573,041 (GRCm39) V720E probably null Het
Or52ab4 A G 7: 102,987,929 (GRCm39) I223V probably damaging Het
Or5b121 T C 19: 13,507,799 (GRCm39) I298T probably benign Het
Pcdhb15 C A 18: 37,608,067 (GRCm39) T433N probably damaging Het
Peli1 T C 11: 21,090,560 (GRCm39) probably benign Het
Ptbp1 T C 10: 79,695,458 (GRCm39) V209A probably damaging Het
Ranbp2 A G 10: 58,287,825 (GRCm39) Y31C probably damaging Het
Smg1 G A 7: 117,794,336 (GRCm39) probably benign Het
Stat2 A G 10: 128,119,386 (GRCm39) M457V probably benign Het
Trpm6 G T 19: 18,815,381 (GRCm39) E1156* probably null Het
Usp53 T A 3: 122,755,064 (GRCm39) R130S possibly damaging Het
Vwa5b1 A G 4: 138,333,852 (GRCm39) S193P probably benign Het
Xrn2 A G 2: 146,884,792 (GRCm39) I626V probably damaging Het
Other mutations in Zfp574
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Zfp574 APN 7 24,781,015 (GRCm39) missense probably benign 0.00
IGL02370:Zfp574 APN 7 24,779,014 (GRCm39) missense possibly damaging 0.95
IGL02706:Zfp574 APN 7 24,780,790 (GRCm39) missense probably damaging 0.98
glue UTSW 7 24,780,515 (GRCm39) missense
BB004:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
BB014:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R0866:Zfp574 UTSW 7 24,779,323 (GRCm39) missense probably damaging 1.00
R2429:Zfp574 UTSW 7 24,779,482 (GRCm39) nonsense probably null
R3123:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3124:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3125:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R4581:Zfp574 UTSW 7 24,780,738 (GRCm39) missense probably damaging 0.98
R4591:Zfp574 UTSW 7 24,778,969 (GRCm39) start gained probably benign
R4915:Zfp574 UTSW 7 24,780,151 (GRCm39) missense probably damaging 0.98
R4953:Zfp574 UTSW 7 24,780,388 (GRCm39) missense probably damaging 0.97
R5305:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
R5541:Zfp574 UTSW 7 24,781,375 (GRCm39) missense probably damaging 0.99
R5934:Zfp574 UTSW 7 24,779,757 (GRCm39) missense probably benign
R6088:Zfp574 UTSW 7 24,779,764 (GRCm39) missense probably benign 0.01
R7061:Zfp574 UTSW 7 24,779,622 (GRCm39) missense possibly damaging 0.95
R7563:Zfp574 UTSW 7 24,780,777 (GRCm39) missense possibly damaging 0.94
R7615:Zfp574 UTSW 7 24,780,001 (GRCm39) missense possibly damaging 0.95
R7927:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R8017:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8019:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8788:Zfp574 UTSW 7 24,779,816 (GRCm39) missense unknown
R8871:Zfp574 UTSW 7 24,780,562 (GRCm39) missense probably damaging 0.99
R8915:Zfp574 UTSW 7 24,780,769 (GRCm39) missense probably damaging 1.00
R9484:Zfp574 UTSW 7 24,781,404 (GRCm39) missense possibly damaging 0.77
R9533:Zfp574 UTSW 7 24,780,379 (GRCm39) missense probably damaging 1.00
R9606:Zfp574 UTSW 7 24,780,640 (GRCm39) missense probably damaging 1.00
R9623:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
X0026:Zfp574 UTSW 7 24,780,477 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02