Incidental Mutation 'IGL03119:Zfp574'
ID |
409905 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp574
|
Ensembl Gene |
ENSMUSG00000045252 |
Gene Name |
zinc finger protein 574 |
Synonyms |
A630056B21Rik |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL03119
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
24775099-24782917 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 24779898 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 307
(A307T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136547
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053410]
[ENSMUST00000179556]
|
AlphaFold |
Q8BY46 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000053410
AA Change: A307T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000057817 Gene: ENSMUSG00000045252 AA Change: A307T
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
16 |
38 |
4.98e-1 |
SMART |
ZnF_C2H2
|
76 |
98 |
4.05e-1 |
SMART |
low complexity region
|
107 |
118 |
N/A |
INTRINSIC |
ZnF_C2H2
|
126 |
148 |
1.99e0 |
SMART |
low complexity region
|
156 |
173 |
N/A |
INTRINSIC |
ZnF_C2H2
|
213 |
235 |
4.4e-2 |
SMART |
low complexity region
|
237 |
254 |
N/A |
INTRINSIC |
low complexity region
|
289 |
298 |
N/A |
INTRINSIC |
ZnF_C2H2
|
312 |
334 |
7.15e-2 |
SMART |
ZnF_C2H2
|
339 |
361 |
1.04e-3 |
SMART |
ZnF_C2H2
|
367 |
389 |
4.12e0 |
SMART |
ZnF_C2H2
|
395 |
416 |
2.12e1 |
SMART |
low complexity region
|
418 |
434 |
N/A |
INTRINSIC |
ZnF_C2H2
|
469 |
492 |
1.03e-2 |
SMART |
ZnF_C2H2
|
498 |
520 |
2.75e-3 |
SMART |
ZnF_C2H2
|
526 |
548 |
3.39e-3 |
SMART |
ZnF_C2H2
|
554 |
576 |
2.75e-3 |
SMART |
ZnF_C2H2
|
582 |
604 |
2.86e-1 |
SMART |
ZnF_C2H2
|
610 |
633 |
1.25e-1 |
SMART |
ZnF_C2H2
|
639 |
659 |
4.5e1 |
SMART |
low complexity region
|
660 |
666 |
N/A |
INTRINSIC |
ZnF_C2H2
|
670 |
692 |
2.29e0 |
SMART |
ZnF_C2H2
|
742 |
764 |
2.91e-2 |
SMART |
ZnF_C2H2
|
770 |
792 |
5.59e-4 |
SMART |
ZnF_C2H2
|
798 |
820 |
3.34e-2 |
SMART |
ZnF_C2H2
|
826 |
848 |
4.24e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000179556
AA Change: A307T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000136547 Gene: ENSMUSG00000045252 AA Change: A307T
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
16 |
38 |
4.98e-1 |
SMART |
ZnF_C2H2
|
76 |
98 |
4.05e-1 |
SMART |
low complexity region
|
107 |
118 |
N/A |
INTRINSIC |
ZnF_C2H2
|
126 |
148 |
1.99e0 |
SMART |
low complexity region
|
156 |
173 |
N/A |
INTRINSIC |
ZnF_C2H2
|
213 |
235 |
4.4e-2 |
SMART |
low complexity region
|
237 |
254 |
N/A |
INTRINSIC |
low complexity region
|
289 |
298 |
N/A |
INTRINSIC |
ZnF_C2H2
|
312 |
334 |
7.15e-2 |
SMART |
ZnF_C2H2
|
339 |
361 |
1.04e-3 |
SMART |
ZnF_C2H2
|
367 |
389 |
4.12e0 |
SMART |
ZnF_C2H2
|
395 |
416 |
2.12e1 |
SMART |
low complexity region
|
418 |
434 |
N/A |
INTRINSIC |
ZnF_C2H2
|
469 |
492 |
1.03e-2 |
SMART |
ZnF_C2H2
|
498 |
520 |
2.75e-3 |
SMART |
ZnF_C2H2
|
526 |
548 |
3.39e-3 |
SMART |
ZnF_C2H2
|
554 |
576 |
2.75e-3 |
SMART |
ZnF_C2H2
|
582 |
604 |
2.86e-1 |
SMART |
ZnF_C2H2
|
610 |
633 |
1.25e-1 |
SMART |
ZnF_C2H2
|
639 |
659 |
4.5e1 |
SMART |
low complexity region
|
660 |
666 |
N/A |
INTRINSIC |
ZnF_C2H2
|
670 |
692 |
2.29e0 |
SMART |
ZnF_C2H2
|
742 |
764 |
2.91e-2 |
SMART |
ZnF_C2H2
|
770 |
792 |
5.59e-4 |
SMART |
ZnF_C2H2
|
798 |
820 |
3.34e-2 |
SMART |
ZnF_C2H2
|
826 |
848 |
4.24e-4 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206530
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206733
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb1a |
A |
G |
5: 8,764,887 (GRCm39) |
T626A |
probably benign |
Het |
Adcy1 |
C |
T |
11: 7,059,051 (GRCm39) |
T319I |
probably damaging |
Het |
Adgrv1 |
A |
G |
13: 81,530,492 (GRCm39) |
S5861P |
probably damaging |
Het |
Adgrv1 |
A |
C |
13: 81,581,819 (GRCm39) |
C4742G |
probably benign |
Het |
Arid5b |
A |
T |
10: 68,079,057 (GRCm39) |
D93E |
probably damaging |
Het |
Atp6v1h |
A |
G |
1: 5,165,892 (GRCm39) |
T121A |
probably benign |
Het |
Atxn7 |
C |
T |
14: 14,100,734 (GRCm38) |
L807F |
probably damaging |
Het |
Cep104 |
A |
C |
4: 154,066,181 (GRCm39) |
K126N |
probably damaging |
Het |
Dcaf6 |
T |
C |
1: 165,167,545 (GRCm39) |
E708G |
probably damaging |
Het |
Dst |
A |
G |
1: 34,200,143 (GRCm39) |
Y107C |
probably damaging |
Het |
E2f3 |
A |
G |
13: 30,169,348 (GRCm39) |
S102P |
probably benign |
Het |
Eif3e |
A |
C |
15: 43,129,000 (GRCm39) |
S207A |
probably benign |
Het |
Etl4 |
A |
G |
2: 20,718,198 (GRCm39) |
Y313C |
probably damaging |
Het |
Fyttd1 |
T |
C |
16: 32,721,065 (GRCm39) |
V121A |
probably benign |
Het |
Gstk1 |
T |
C |
6: 42,226,833 (GRCm39) |
S200P |
probably damaging |
Het |
Ifrd1 |
A |
T |
12: 40,262,333 (GRCm39) |
F244L |
probably null |
Het |
Ints7 |
T |
C |
1: 191,342,477 (GRCm39) |
V491A |
probably damaging |
Het |
Kcnd2 |
G |
T |
6: 21,216,508 (GRCm39) |
E71* |
probably null |
Het |
Ltbp3 |
A |
T |
19: 5,807,471 (GRCm39) |
Q1123L |
probably damaging |
Het |
Myo5a |
A |
G |
9: 75,081,297 (GRCm39) |
T961A |
probably benign |
Het |
Naa25 |
T |
A |
5: 121,573,041 (GRCm39) |
V720E |
probably null |
Het |
Or52ab4 |
A |
G |
7: 102,987,929 (GRCm39) |
I223V |
probably damaging |
Het |
Or5b121 |
T |
C |
19: 13,507,799 (GRCm39) |
I298T |
probably benign |
Het |
Pcdhb15 |
C |
A |
18: 37,608,067 (GRCm39) |
T433N |
probably damaging |
Het |
Peli1 |
T |
C |
11: 21,090,560 (GRCm39) |
|
probably benign |
Het |
Ptbp1 |
T |
C |
10: 79,695,458 (GRCm39) |
V209A |
probably damaging |
Het |
Ranbp2 |
A |
G |
10: 58,287,825 (GRCm39) |
Y31C |
probably damaging |
Het |
Smg1 |
G |
A |
7: 117,794,336 (GRCm39) |
|
probably benign |
Het |
Stat2 |
A |
G |
10: 128,119,386 (GRCm39) |
M457V |
probably benign |
Het |
Trpm6 |
G |
T |
19: 18,815,381 (GRCm39) |
E1156* |
probably null |
Het |
Usp53 |
T |
A |
3: 122,755,064 (GRCm39) |
R130S |
possibly damaging |
Het |
Vwa5b1 |
A |
G |
4: 138,333,852 (GRCm39) |
S193P |
probably benign |
Het |
Xrn2 |
A |
G |
2: 146,884,792 (GRCm39) |
I626V |
probably damaging |
Het |
|
Other mutations in Zfp574 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00228:Zfp574
|
APN |
7 |
24,781,015 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02370:Zfp574
|
APN |
7 |
24,779,014 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02706:Zfp574
|
APN |
7 |
24,780,790 (GRCm39) |
missense |
probably damaging |
0.98 |
glue
|
UTSW |
7 |
24,780,515 (GRCm39) |
missense |
|
|
BB004:Zfp574
|
UTSW |
7 |
24,779,572 (GRCm39) |
missense |
probably benign |
|
BB014:Zfp574
|
UTSW |
7 |
24,779,572 (GRCm39) |
missense |
probably benign |
|
R0866:Zfp574
|
UTSW |
7 |
24,779,323 (GRCm39) |
missense |
probably damaging |
1.00 |
R2429:Zfp574
|
UTSW |
7 |
24,779,482 (GRCm39) |
nonsense |
probably null |
|
R3123:Zfp574
|
UTSW |
7 |
24,781,026 (GRCm39) |
missense |
possibly damaging |
0.88 |
R3124:Zfp574
|
UTSW |
7 |
24,781,026 (GRCm39) |
missense |
possibly damaging |
0.88 |
R3125:Zfp574
|
UTSW |
7 |
24,781,026 (GRCm39) |
missense |
possibly damaging |
0.88 |
R4581:Zfp574
|
UTSW |
7 |
24,780,738 (GRCm39) |
missense |
probably damaging |
0.98 |
R4591:Zfp574
|
UTSW |
7 |
24,778,969 (GRCm39) |
start gained |
probably benign |
|
R4915:Zfp574
|
UTSW |
7 |
24,780,151 (GRCm39) |
missense |
probably damaging |
0.98 |
R4953:Zfp574
|
UTSW |
7 |
24,780,388 (GRCm39) |
missense |
probably damaging |
0.97 |
R5305:Zfp574
|
UTSW |
7 |
24,780,515 (GRCm39) |
missense |
|
|
R5541:Zfp574
|
UTSW |
7 |
24,781,375 (GRCm39) |
missense |
probably damaging |
0.99 |
R5934:Zfp574
|
UTSW |
7 |
24,779,757 (GRCm39) |
missense |
probably benign |
|
R6088:Zfp574
|
UTSW |
7 |
24,779,764 (GRCm39) |
missense |
probably benign |
0.01 |
R7061:Zfp574
|
UTSW |
7 |
24,779,622 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7563:Zfp574
|
UTSW |
7 |
24,780,777 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7615:Zfp574
|
UTSW |
7 |
24,780,001 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7927:Zfp574
|
UTSW |
7 |
24,779,572 (GRCm39) |
missense |
probably benign |
|
R8017:Zfp574
|
UTSW |
7 |
24,780,095 (GRCm39) |
nonsense |
probably null |
|
R8019:Zfp574
|
UTSW |
7 |
24,780,095 (GRCm39) |
nonsense |
probably null |
|
R8788:Zfp574
|
UTSW |
7 |
24,779,816 (GRCm39) |
missense |
unknown |
|
R8871:Zfp574
|
UTSW |
7 |
24,780,562 (GRCm39) |
missense |
probably damaging |
0.99 |
R8915:Zfp574
|
UTSW |
7 |
24,780,769 (GRCm39) |
missense |
probably damaging |
1.00 |
R9484:Zfp574
|
UTSW |
7 |
24,781,404 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9533:Zfp574
|
UTSW |
7 |
24,780,379 (GRCm39) |
missense |
probably damaging |
1.00 |
R9606:Zfp574
|
UTSW |
7 |
24,780,640 (GRCm39) |
missense |
probably damaging |
1.00 |
R9623:Zfp574
|
UTSW |
7 |
24,780,515 (GRCm39) |
missense |
|
|
X0026:Zfp574
|
UTSW |
7 |
24,780,477 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2016-08-02 |